ATE279922T1 - Behandlung von zns-wirkungen des hiv mit vx-478, allein oder kombiniert mit azt oder 3tc - Google Patents

Behandlung von zns-wirkungen des hiv mit vx-478, allein oder kombiniert mit azt oder 3tc

Info

Publication number
ATE279922T1
ATE279922T1 AT96942917T AT96942917T ATE279922T1 AT E279922 T1 ATE279922 T1 AT E279922T1 AT 96942917 T AT96942917 T AT 96942917T AT 96942917 T AT96942917 T AT 96942917T AT E279922 T1 ATE279922 T1 AT E279922T1
Authority
AT
Austria
Prior art keywords
azt
hiv
alone
treatment
combined
Prior art date
Application number
AT96942917T
Other languages
English (en)
Inventor
Pravin Ramsewak Chaturvedi
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE279922T1 publication Critical patent/ATE279922T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT96942917T 1995-12-05 1996-12-05 Behandlung von zns-wirkungen des hiv mit vx-478, allein oder kombiniert mit azt oder 3tc ATE279922T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/567,199 US5646180A (en) 1995-12-05 1995-12-05 Treatment of the CNS effects of HIV
PCT/US1996/019447 WO1997020554A1 (en) 1995-12-05 1996-12-05 Treatment of the cns effects of hiv with vx-478, alone or in combination with azt or 3tc

Publications (1)

Publication Number Publication Date
ATE279922T1 true ATE279922T1 (de) 2004-11-15

Family

ID=24266147

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942917T ATE279922T1 (de) 1995-12-05 1996-12-05 Behandlung von zns-wirkungen des hiv mit vx-478, allein oder kombiniert mit azt oder 3tc

Country Status (23)

Country Link
US (1) US5646180A (de)
EP (1) EP0866696B1 (de)
JP (1) JP2000501713A (de)
KR (1) KR19990071750A (de)
CN (1) CN1203530A (de)
AP (1) AP864A (de)
AT (1) ATE279922T1 (de)
AU (1) AU722850B2 (de)
BR (1) BR9611861A (de)
CA (1) CA2238471A1 (de)
CZ (1) CZ291994B6 (de)
DE (1) DE69633680T2 (de)
ES (1) ES2231828T3 (de)
HU (1) HUP9903673A3 (de)
NO (1) NO317837B1 (de)
NZ (1) NZ324603A (de)
OA (1) OA10691A (de)
PL (1) PL187747B1 (de)
PT (1) PT866696E (de)
RU (1) RU2203658C2 (de)
UA (1) UA61902C2 (de)
WO (1) WO1997020554A1 (de)
ZA (1) ZA9610139B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
AU727983B2 (en) * 1996-06-25 2001-01-04 Glaxo Group Limited Combinations comprising VX478, zidovudine, FTC and/or 3TC for use in the treatment of HIV
DE69718168T2 (de) * 1996-06-25 2003-10-23 Glaxo Group Ltd., Greenford Zusammensetzungen enthaltend vx478, zidovudine und 159u89 für die verwendung in der behandlung von hiv
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
JP2001525840A (ja) * 1997-05-17 2001-12-11 グラクソ、グループ、リミテッド 炭素環式ヌクレオシド１５９２ｕ８９を含有する抗ウイルス的組合せ
WO1998057648A1 (en) * 1997-06-16 1998-12-23 Vertex Pharmaceuticals Incorporated Methods of increasing the bioavailability of stable crystal polymorphs of a compound
US6576231B2 (en) * 1997-09-12 2003-06-10 Schering Ag Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6197764B1 (en) 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US6436989B1 (en) * 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6309632B1 (en) * 1998-04-28 2001-10-30 Immunex Corporation Methods for treating HIV-infected patients by administering GM-CSF
US6875773B1 (en) * 1998-05-29 2005-04-05 Ben M. Dunn Combination therapy for treatment of FIV infection
US20090197827A1 (en) * 1998-05-29 2009-08-06 Dunn Ben M Combination Therapy for Treatment of FIV Infection
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
MXPA02006134A (es) 1999-12-21 2002-12-13 Guilford Pharm Inc Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos.
ATE300255T1 (de) * 2000-10-16 2005-08-15 Conor Medsystems Inc Expandierbare medizinische vorrichtung zum zuführen eines heilmittels
EP1423107B1 (de) * 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fettalkohol-arzneimittel-konjugate
JP2005500988A (ja) 2001-03-23 2005-01-13 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド 脂肪族アミン薬物複合体
EP2316468A1 (de) 2002-02-22 2011-05-04 Shire LLC Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
DE602005027466D1 (de) 2004-07-27 2011-05-26 Gilead Sciences Inc Nukleosid phosphonat konjugate als anti hiv mittel
US20080269161A1 (en) * 2005-01-20 2008-10-30 Seth Perry Compositions and Methods Relating to Mitochondrial Hyperpolarization in Neurological Disease
US20090081318A1 (en) * 2005-12-23 2009-03-26 Gelbard Harris A Treatment of neuroads using inhibitors of glycogen synthase kinase (gsk)-3
BRPI0710177A2 (pt) * 2006-04-19 2012-05-29 Abbott Gmbh & Co Kg arilsulfonas heterocìclicas adequadas para tratar distúrbios que respondem à modulação do receptor 5ht6 de serotonina
DK2364314T3 (da) 2008-12-09 2014-05-12 Gilead Sciences Inc Modulatorer af toll-lignende receptorer
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
CN106232073B (zh) 2014-02-28 2020-11-03 阿坦斯医疗保健产品公司 具有多层折叠吸收芯的吸收性用品
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
TWI733652B (zh) 2014-07-11 2021-07-21 美商基利科學股份有限公司 用於治療ＨＩＶ之ｔｏｌｌ樣受體調節劑
WO2017048727A1 (en) 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulators of toll-like recptors for the treatment of hiv
US12303369B2 (en) 2016-12-14 2025-05-20 Attends Healthcare Products, Inc. Absorbent laminates, absorbent cores and disposable articles utilizing the absorbent laminates, and related methods
US11744748B2 (en) 2018-05-28 2023-09-05 Attends Healthcare Products, Inc. Dryness layer laminate for absorbent articles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428849A3 (en) * 1989-09-28 1991-07-31 Hoechst Aktiengesellschaft Retroviral protease inhibitors
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
AU5748194A (en) * 1992-12-11 1994-07-04 Vertex Pharmaceuticals Incorporated Mannitol derivatives and their use as inhibitors of aspartyl protease

Also Published As

Publication number Publication date
AP864A (en) 2000-08-11
DE69633680T2 (de) 2006-02-23
NO982556L (no) 1998-06-04
BR9611861A (pt) 1999-05-18
US5646180A (en) 1997-07-08
KR19990071750A (ko) 1999-09-27
AU722850B2 (en) 2000-08-10
OA10691A (en) 2001-05-04
JP2000501713A (ja) 2000-02-15
HUP9903673A3 (en) 2000-08-28
DE69633680D1 (de) 2004-11-25
RU2203658C2 (ru) 2003-05-10
AU1148697A (en) 1997-06-27
CZ170898A3 (cs) 1998-09-16
WO1997020554A1 (en) 1997-06-12
HUP9903673A2 (hu) 2000-03-28
UA61902C2 (en) 2003-12-15
ES2231828T3 (es) 2005-05-16
CN1203530A (zh) 1998-12-30
CZ291994B6 (cs) 2003-07-16
EP0866696A1 (de) 1998-09-30
AP9801340A0 (en) 1998-09-30
NO317837B1 (no) 2004-12-20
EP0866696B1 (de) 2004-10-20
CA2238471A1 (en) 1997-06-12
PT866696E (pt) 2005-03-31
NO982556D0 (no) 1998-06-04
NZ324603A (en) 2000-08-25
ZA9610139B (en) 1997-06-17
PL327061A1 (en) 1998-11-23
PL187747B1 (pl) 2004-09-30

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