ATE280162T1 - Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten - Google Patents

Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten

Info

Publication number: ATE280162T1
Authority: AT; Austria
Prior art keywords: lactames; aminoalkyl; substituted; receptor antagonists; muscarine receptor
Prior art date: 2000-05-25

Application number

AT01933980T

Other languages

English (en)

Inventor

Ann Marie Madera

Russell Stephen Stabler

Robert James Weikert

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-25

Filing date

2001-05-17

Publication date

2004-11-15

2001-05-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE280162T1 publication Critical patent/ATE280162T1/de

Links

UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT01933980T 2000-05-25 2001-05-17 Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten ATE280162T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20748300P	2000-05-25	2000-05-25
US26761701P	2001-02-09	2001-02-09
PCT/EP2001/005631 WO2001090082A1 (en)	2000-05-25	2001-05-17	Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE280162T1 true ATE280162T1 (de)	2004-11-15

Family

ID=26902274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01933980T ATE280162T1 (de)	2000-05-25	2001-05-17	Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten

Country Status (25)

Country	Link
US (3)	US6500822B2 (de)
EP (1)	EP1289964B1 (de)
JP (1)	JP3955211B2 (de)
KR (1)	KR100599125B1 (de)
CN (1)	CN1187342C (de)
AR (1)	AR033377A1 (de)
AT (1)	ATE280162T1 (de)
AU (2)	AU6031001A (de)
BR (1)	BR0111019A (de)
CA (1)	CA2408934C (de)
CZ (1)	CZ20024199A3 (de)
DE (1)	DE60106607T2 (de)
ES (1)	ES2230310T3 (de)
HU (1)	HUP0302015A2 (de)
IL (1)	IL152700A0 (de)
MA (1)	MA26904A1 (de)
MX (1)	MXPA02011417A (de)
NO (1)	NO20025641L (de)
NZ (1)	NZ522410A (de)
PE (1)	PE20011258A1 (de)
PL (1)	PL361361A1 (de)
RU (1)	RU2243222C2 (de)
UY (1)	UY26728A1 (de)
WO (1)	WO2001090082A1 (de)
YU (1)	YU89002A (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6640155B2 (en)	2000-08-22	2003-10-28	Lam Research Corporation	Chemical mechanical polishing apparatus and methods with central control of polishing pressure applied by polishing head
PL370799A1 (en) *	2001-12-03	2005-05-30	F.Hoffmann-La Roche Ag	Aminotetralin derivatives as muscarinic receptor antagonists
PL370765A1 (en)	2001-12-03	2005-05-30	F.Hoffmann-La Roche Ag	4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists
US7109230B2 (en) *	2002-01-07	2006-09-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
EA200500173A1 (ru)	2002-07-08	2005-08-25	Рэнбакси Лабораториз Лимитед	Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов
AU2003293834A1 (en) *	2002-12-23	2004-07-14	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with muscarinic acetylcholine receptor m2 (m2)
RS20050532A (sr)	2003-01-14	2007-12-31	Arena Pharmaceuticals Inc.,	Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija
EP1618091A1 (de)	2003-04-09	2006-01-25	Ranbaxy Laboratories, Ltd.	Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
WO2004089900A1 (en)	2003-04-11	2004-10-21	Ranbaxy Laboratories Limited	Azabicyclo derivatives as muscarinic receptor antagonists
EP1849465A4 (de) *	2005-02-18	2008-12-24	Takeda Pharmaceutical	Agens zur kontrolle der funktion des gpr34-rezeptors
US7736310B2 (en) *	2006-01-30	2010-06-15	Abbott Diabetes Care Inc.	On-body medical device securement
WO2008130151A1 (en) *	2007-04-19	2008-10-30	Dong-A Pharm. Co., Ltd.	Dpp-iv inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes or an obesity
JP5368556B2 (ja) *	2008-07-16	2013-12-18	エフ．ホフマン−ラロシュアーゲー	心臓血管疾患の処置のための新規ヘテロシクリル化合物
EP2321285A1 (de) *	2008-07-28	2011-05-18	F. Hoffmann-La Roche AG	Diazepan- und piperazinderivate als chemokinrezeptormodulatoren
US8214928B1 (en)	2008-10-29	2012-07-10	Full90 Sports, Inc.	Headguard with an eccentric dimple for accommodating the occipital bone
US20100101006A1 (en) *	2008-10-29	2010-04-29	Cleveland William K	Headguard with temple protecting scallop that does not cover the ears
US8042198B1 (en)	2008-10-29	2011-10-25	Full90 Sports, Inc.	Headguard with independently adjustable upper and lower bands
EP2427243A4 (de)	2009-05-05	2012-11-21	Vapogenix Inc	Neue formulierungen flüchtiger anästhetika und anwendungsverfahren zur entzündungslinderung
CN103221410B (zh)	2010-09-22	2017-09-15	艾尼纳制药公司	Gpr119受体调节剂和对与其相关的障碍的治疗
WO2012092990A2 (de)	2011-01-05	2012-07-12	Udo Wenske	Medizinprodukt zur verbesserung der konzeptionsfähigkeit eines säugetiers
US8476221B2 (en)	2011-03-18	2013-07-02	Halimed Pharmaceuticals, Inc.	Methods and compositions for the treatment of metabolic disorders
CA3002540C (en)	2015-01-06	2023-11-07	Arena Pharmaceuticals, Inc.	Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
MA41629A (fr)	2015-03-04	2018-01-09	Center For Human Reproduction	Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité
WO2016149628A1 (en) *	2015-03-19	2016-09-22	Chembridge Corporation	Tgr5 agonists
JP6838744B2 (ja)	2015-06-22	2021-03-03	アリーナファーマシューティカルズ，インコーポレイテッド	Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
US20210330599A1 (en)	2016-08-01	2021-10-28	University Of Rochester	Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use
CN110520124A (zh)	2017-02-16	2019-11-29	艾尼纳制药公司	用于治疗原发性胆汁性胆管炎的化合物和方法
JP7397011B2 (ja)	2018-06-06	2023-12-12	アリーナファーマシューティカルズ，インコーポレイテッド	Ｓ１ｐ１受容体に関連する状態を治療する方法
CA3114750A1 (en)	2018-10-09	2020-04-16	University Of Rochester	Treatment of vulvovaginal disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3418270A1 (de)	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4748182A (en)	1986-03-05	1988-05-31	Merrell Dow Pharmaceuticals Inc.	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
DE3718317A1 (de)	1986-12-10	1988-06-16	Bayer Ag	Substituierte basische 2-aminotetraline
FI892362L (fi)	1988-06-01	1989-12-02	Eisai Co Ltd	Buten- eller propensyraderivat.
US5177089A (en)	1988-06-01	1993-01-05	Eisai Co., Ltd.	Butenoic or propenoic acid derivative
US5545755A (en)	1989-05-31	1996-08-13	The Upjohn Company	Therapeutically useful 2-aminotetralin derivatives
US5118704A (en)	1989-08-30	1992-06-02	Whitby Research, Inc.	Substituted 2-aminotetralins useful as dopaminergics
RU2067579C1 (ru) *	1994-10-07	1996-10-10	Пермский фармацевтический институт	3-(2'-нафтоилметилен)-пиперазинон-2 и 1-n-фенил-3-фенацилиденпиперазинон-2, проявляющие противовоспалительную активность
US6319920B1 (en) *	1998-02-27	2001-11-20	Syntex (U.S.A.) Llc	2-arylethyl-(piperidin-4-ylmethyl)amine derivatives

2001
- 2001-05-17 CN CNB018100368A patent/CN1187342C/zh not_active Expired - Fee Related
- 2001-05-17 MX MXPA02011417A patent/MXPA02011417A/es active IP Right Grant
- 2001-05-17 KR KR1020027015824A patent/KR100599125B1/ko not_active Expired - Fee Related
- 2001-05-17 DE DE60106607T patent/DE60106607T2/de not_active Expired - Lifetime
- 2001-05-17 RU RU2002133220/04A patent/RU2243222C2/ru not_active IP Right Cessation
- 2001-05-17 BR BR0111019-5A patent/BR0111019A/pt not_active IP Right Cessation
- 2001-05-17 AU AU6031001A patent/AU6031001A/xx active Pending
- 2001-05-17 AU AU2001260310A patent/AU2001260310B2/en not_active Ceased
- 2001-05-17 CA CA002408934A patent/CA2408934C/en not_active Expired - Fee Related
- 2001-05-17 ES ES01933980T patent/ES2230310T3/es not_active Expired - Lifetime
- 2001-05-17 NZ NZ522410A patent/NZ522410A/en unknown
- 2001-05-17 PL PL36136101A patent/PL361361A1/xx not_active Application Discontinuation
- 2001-05-17 AT AT01933980T patent/ATE280162T1/de not_active IP Right Cessation
- 2001-05-17 YU YU89002A patent/YU89002A/sh unknown
- 2001-05-17 EP EP01933980A patent/EP1289964B1/de not_active Expired - Lifetime
- 2001-05-17 CZ CZ20024199A patent/CZ20024199A3/cs unknown
- 2001-05-17 WO PCT/EP2001/005631 patent/WO2001090082A1/en not_active Ceased
- 2001-05-17 HU HU0302015A patent/HUP0302015A2/hu unknown
- 2001-05-17 IL IL15270001A patent/IL152700A0/xx unknown
- 2001-05-17 JP JP2001586271A patent/JP3955211B2/ja not_active Expired - Fee Related
- 2001-05-22 US US09/862,522 patent/US6500822B2/en not_active Expired - Fee Related
- 2001-05-22 PE PE2001000464A patent/PE20011258A1/es not_active Application Discontinuation
- 2001-05-24 AR ARP010102492A patent/AR033377A1/es not_active Application Discontinuation
- 2001-05-24 UY UY26728A patent/UY26728A1/es not_active Application Discontinuation
2002
- 2002-11-06 US US10/289,055 patent/US6645958B2/en not_active Expired - Fee Related
- 2002-11-22 NO NO20025641A patent/NO20025641L/no not_active Application Discontinuation
- 2002-11-22 MA MA26920A patent/MA26904A1/fr unknown
2003
- 2003-08-01 US US10/632,734 patent/US6818645B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR0111019A (pt)	2003-06-17
CA2408934A1 (en)	2001-11-29
EP1289964A1 (de)	2003-03-12
EP1289964B1 (de)	2004-10-20
PL361361A1 (en)	2004-10-04
RU2243222C2 (ru)	2004-12-27
WO2001090082A1 (en)	2001-11-29
AU2001260310B2 (en)	2007-04-05
JP2003534331A (ja)	2003-11-18
CZ20024199A3 (cs)	2004-01-14
US6500822B2 (en)	2002-12-31
US20040034018A1 (en)	2004-02-19
DE60106607T2 (de)	2006-02-09
US6645958B2 (en)	2003-11-11
KR100599125B1 (ko)	2006-07-12
KR20030003758A (ko)	2003-01-10
IL152700A0 (en)	2003-06-24
US20030109524A1 (en)	2003-06-12
ES2230310T3 (es)	2005-05-01
AU6031001A (en)	2001-12-03
YU89002A (sh)	2006-01-16
NZ522410A (en)	2004-09-24
CN1430609A (zh)	2003-07-16
US6818645B2 (en)	2004-11-16
UY26728A1 (es)	2001-12-28
DE60106607D1 (de)	2004-11-25
MXPA02011417A (es)	2003-04-25
CA2408934C (en)	2009-04-14
US20020004494A1 (en)	2002-01-10
CN1187342C (zh)	2005-02-02
JP3955211B2 (ja)	2007-08-08
PE20011258A1 (es)	2001-12-11
NO20025641D0 (no)	2002-11-22
MA26904A1 (fr)	2004-12-20
NO20025641L (no)	2002-12-17
HUP0302015A2 (hu)	2003-10-28
AR033377A1 (es)	2003-12-17

Legal Events

Date

Code

Title

Description

2005-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1289964

Country of ref document: EP

2009-02-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE307806T1 (de)	2005-11-15	Substituierte 1-aminoalkyl-lactame und deren verwendung als muscarinrezeptor-antagonisten
DE60106607D1 (de)	2004-11-25	Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten
DE60015296D1 (de)	2004-12-02	Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten
ATE439344T1 (de)	2009-08-15	Muscarin-antagonisten
ATE494285T1 (de)	2011-01-15	Muscarinische acetylcholin-rezeptor-antagonisten
DE69925730D1 (de)	2005-07-14	4-benzyl-piperidin-alkylsulfoxid-heterozyklen und ihre verwendung als subtyp-selektive nmda rezeptor antagonisten
DE60022386D1 (de)	2005-10-06	Substituierte imidazole als neuropeptide y y5 rezeptor antagonisten
ATE414074T1 (de)	2008-11-15	2-oxo-1,2,4,5-tetrahydro-1,3-benzdiazepin-3-yl- piperidine als cgrp-antagonisten
ATE328871T1 (de)	2006-06-15	4-phenyl-pyridin-derivate verwendbar als neurokinin-1 rezeptor antagonisten
ATE288898T1 (de)	2005-02-15	Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
DE60137461D1 (de)	2009-03-05	Substituierte Piperidinverbindungen zur Verwendung als H3 Histaminerezeptorantagonisten
NO20032861D0 (no)	2003-06-20	Heteroarylurea nevropeptid YY5-reseptorantagonister
ATE525378T1 (de)	2011-10-15	Himbacinanaloga als thrombinrezeptorantagonisten
ATE389648T1 (de)	2008-04-15	4-(heterocyclylsulfonamido)-5-methoxy-6-(2- methoxyphenoxy)-2-phenyl- oder pyridylpyrimidine als endothelinrezeptorantagonisten
DE60314600D1 (de)	2007-08-09	O-cyclopropyl-carboxanilide und ihre verwendung als fungizide
DE60216229D1 (de)	2007-01-04	Il-8-rezeptorantagonisten
DE69919171D1 (de)	2004-09-09	Muskarin-rezeptor antagonisten
ATE329906T1 (de)	2006-07-15	Substituierte 2-anilino-benzimidazole und ihre verwendung als nhe-inhibitoren
ATE400554T1 (de)	2008-07-15	2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten
DE602004022458D1 (de)	2009-09-17	Pyrazolderivate und ihre verwendung als orexin-rezeptor-antagonisten
ATE299698T1 (de)	2005-08-15	Il-8 rezeptor antagonisten
DK1261336T3 (da)	2007-06-04	IL-8-receptorantagonister
ATE244716T1 (de)	2003-07-15	Neue n-triazolylmethyl-piperazinderivate als neurokininrezeptor-antagonisten
DE60130000D1 (de)	2007-09-27	Zwitterionische tachykinin-rezeptor-antagonisten
ATE464893T1 (de)	2010-05-15	N,n'-diarylguanidine als il-8-rezeptor- antagonisten