ATE280218T1 - Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung - Google Patents
Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendungInfo
- Publication number
- ATE280218T1 ATE280218T1 AT97937861T AT97937861T ATE280218T1 AT E280218 T1 ATE280218 T1 AT E280218T1 AT 97937861 T AT97937861 T AT 97937861T AT 97937861 T AT97937861 T AT 97937861T AT E280218 T1 ATE280218 T1 AT E280218T1
- Authority
- AT
- Austria
- Prior art keywords
- encode
- genes
- methods
- carbonyl reductase
- enzyme
- Prior art date
Links
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 title 1
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 230000010757 Reduction Activity Effects 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2566797 | 1997-02-07 | ||
| JP11305297 | 1997-04-30 | ||
| PCT/JP1997/003051 WO1998035025A1 (en) | 1997-02-07 | 1997-09-01 | Novel carbonyl reductase, gene that encodes the same, and method of utilizing these |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE280218T1 true ATE280218T1 (de) | 2004-11-15 |
Family
ID=26363321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97937861T ATE280218T1 (de) | 1997-02-07 | 1997-09-01 | Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6218156B1 (de) |
| EP (1) | EP0967271B1 (de) |
| JP (1) | JP4012257B2 (de) |
| KR (1) | KR100506134B1 (de) |
| AT (1) | ATE280218T1 (de) |
| AU (1) | AU4032997A (de) |
| CA (1) | CA2280502A1 (de) |
| CZ (1) | CZ298236B6 (de) |
| DE (1) | DE69731317T2 (de) |
| ES (1) | ES2235246T3 (de) |
| IL (2) | IL131241A0 (de) |
| SI (1) | SI20120A (de) |
| SK (1) | SK105699A3 (de) |
| WO (1) | WO1998035025A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242253B1 (en) * | 1997-10-09 | 2001-06-05 | Regents Of The University Of California | IkB kinase, subunits thereof, and methods of using same |
| JP2000189170A (ja) | 1998-05-08 | 2000-07-11 | Daicel Chem Ind Ltd | 光学活性４―ハロ―３―ヒドロキシ酪酸エステルの製造方法 |
| JP2000175693A (ja) * | 1998-12-18 | 2000-06-27 | Kanegafuchi Chem Ind Co Ltd | （ｒ）−２−ヒドロキシ−１−フェノキシプロパン誘導体の製造方法 |
| JP2000236883A (ja) | 1998-12-21 | 2000-09-05 | Daicel Chem Ind Ltd | 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法 |
| KR20010103017A (ko) * | 1999-02-19 | 2001-11-17 | 플레믹 크리스티안 | 글루코스 데히드로게나제 융합 단백질 및 발현계에서의그의 용도 |
| TWI275645B (en) * | 2000-02-16 | 2007-03-11 | Daicel Chemical Industries Ltd. | (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes |
| US6682916B2 (en) * | 2000-06-27 | 2004-01-27 | Kaneka Corporation | Chlorohydroxyacetone derivative and process for producing optically active chloropropanediol derivative from the same |
| US6884607B2 (en) * | 2000-12-07 | 2005-04-26 | Sumitomo Chemical Company, Limited | Process for producing optically active 4-halo-3-hydroxybutanoate |
| RU2004102689A (ru) * | 2001-07-02 | 2005-05-10 | Канека Корпорейшн (Jp) | Способ модифицирования фермента и вариант оксидоредуктазы |
| JPWO2003040382A1 (ja) * | 2001-11-09 | 2005-03-03 | 株式会社カネカ | 光学活性クロマン誘導体の製造法および中間体 |
| KR100522133B1 (ko) * | 2002-01-26 | 2005-10-18 | 한국과학기술연구원 | 클루이베로마이세스 마르시아누스로부터 분리 및 정제된 카르보닐 환원효소 및 그 제조 방법 |
| DE60323215D1 (de) * | 2002-03-19 | 2008-10-09 | Mitsubishi Chem Corp | Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit |
| JP4228605B2 (ja) * | 2002-07-02 | 2009-02-25 | 住友化学株式会社 | 改変型還元酵素、その遺伝子及びそれらの利用 |
| JP4228606B2 (ja) * | 2002-07-03 | 2009-02-25 | 住友化学株式会社 | 改変型還元酵素、その遺伝子及びそれらの利用 |
| US20050272136A1 (en) * | 2002-07-15 | 2005-12-08 | Sumitomo Chemical Company, Limited | Process for producing 3-hydroxycyclohexanone |
| US7132267B2 (en) * | 2002-08-09 | 2006-11-07 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
| WO2004015132A2 (en) * | 2002-08-09 | 2004-02-19 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| JP2007502124A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
| WO2006046455A1 (ja) * | 2004-10-27 | 2006-05-04 | Kaneka Corporation | 新規カルボニル還元酵素、その遺伝子、およびその利用法 |
| JPWO2006129628A1 (ja) | 2005-05-31 | 2009-01-08 | 株式会社カネカ | 光学活性２−置換プロパナール誘導体の製造法 |
| JP2009114065A (ja) * | 2006-02-21 | 2009-05-28 | Kaneka Corp | （２ｒ，３ｒ）および（２ｓ，３ｓ）−３−フェニルイソセリン誘導体の製造法 |
| WO2007138928A1 (ja) | 2006-05-26 | 2007-12-06 | Kaneka Corporation | 光学活性３－アミノ－２－ヒドロキシプロピオン酸シクロプロピルアミド誘導体およびその塩の製造方法 |
| WO2008042876A2 (en) | 2006-10-02 | 2008-04-10 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| EP2123769B1 (de) * | 2007-02-19 | 2016-05-18 | Kaneka Corporation | Verfahren zur herstellung von optisch aktivem 3-aminopiperidin oder salz davon |
| JP5603076B2 (ja) | 2007-09-26 | 2014-10-08 | 株式会社カネカ | 新規グルコース脱水素酵素 |
| PL2445890T3 (pl) * | 2009-06-22 | 2016-02-29 | Sk Biopharmaceuticals Co Ltd | Sposób wytwarzania estru (R)-1-arylo-2-tetrazoliloetylowego kwasu karbaminowego |
| US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| CN102686558A (zh) | 2009-12-25 | 2012-09-19 | 株式会社钟化 | 光学活性3-取代戊二酸单酰胺的制造方法 |
| CN111172124B (zh) * | 2020-02-26 | 2022-07-22 | 复旦大学 | 一种羰基还原酶突变体及其在制备(r)-4-氯-3-羟基-丁酸酯中的应用 |
| CN115433721B (zh) * | 2022-06-24 | 2024-01-23 | 山东理工大学 | 一种羰基还原酶突变体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61146191A (ja) * | 1984-12-20 | 1986-07-03 | Kanegafuchi Chem Ind Co Ltd | （Ｓ）−γ−ハロ−β−ヒドロキシ酪酸エステルの製造法 |
| JP2566960B2 (ja) | 1987-06-08 | 1996-12-25 | 電気化学工業株式会社 | （Ｒ）−ｒ−置換−β−ハイドロキシ酪酸エステルの製造法 |
| JP3163338B2 (ja) | 1992-05-28 | 2001-05-08 | 味の素株式会社 | （Ｓ）−γ−ハロゲン化−β−ハイドロキシ酪酸エステルの製造方法 |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法 |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
-
1997
- 1997-09-01 JP JP53409498A patent/JP4012257B2/ja not_active Expired - Fee Related
- 1997-09-01 CA CA002280502A patent/CA2280502A1/en not_active Abandoned
- 1997-09-01 US US09/367,012 patent/US6218156B1/en not_active Expired - Lifetime
- 1997-09-01 ES ES97937861T patent/ES2235246T3/es not_active Expired - Lifetime
- 1997-09-01 CZ CZ0276199A patent/CZ298236B6/cs not_active IP Right Cessation
- 1997-09-01 WO PCT/JP1997/003051 patent/WO1998035025A1/ja not_active Ceased
- 1997-09-01 IL IL13124197A patent/IL131241A0/xx active IP Right Grant
- 1997-09-01 AT AT97937861T patent/ATE280218T1/de active
- 1997-09-01 AU AU40329/97A patent/AU4032997A/en not_active Abandoned
- 1997-09-01 DE DE69731317T patent/DE69731317T2/de not_active Expired - Lifetime
- 1997-09-01 KR KR10-1999-7007161A patent/KR100506134B1/ko not_active Expired - Fee Related
- 1997-09-01 EP EP97937861A patent/EP0967271B1/de not_active Expired - Lifetime
- 1997-09-01 SI SI9720093A patent/SI20120A/sl not_active IP Right Cessation
-
1998
- 1998-09-01 SK SK1056-99A patent/SK105699A3/sk unknown
-
1999
- 1999-08-04 IL IL131241A patent/IL131241A/en not_active IP Right Cessation
-
2001
- 2001-02-05 US US09/777,157 patent/US6448052B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL131241A (en) | 2006-12-31 |
| EP0967271B1 (de) | 2004-10-20 |
| KR20000070896A (ko) | 2000-11-25 |
| EP0967271A1 (de) | 1999-12-29 |
| EP0967271A4 (de) | 2002-09-25 |
| US6448052B2 (en) | 2002-09-10 |
| CZ298236B6 (cs) | 2007-08-01 |
| US20020006651A1 (en) | 2002-01-17 |
| SK105699A3 (en) | 2000-06-12 |
| CZ276199A3 (cs) | 2000-03-15 |
| CA2280502A1 (en) | 1998-08-13 |
| WO1998035025A1 (en) | 1998-08-13 |
| IL131241A0 (en) | 2001-01-28 |
| DE69731317T2 (de) | 2006-02-23 |
| US6218156B1 (en) | 2001-04-17 |
| AU4032997A (en) | 1998-08-26 |
| JP4012257B2 (ja) | 2007-11-21 |
| DE69731317D1 (de) | 2004-11-25 |
| ES2235246T3 (es) | 2005-07-01 |
| KR100506134B1 (ko) | 2005-08-08 |
| SI20120A (sl) | 2000-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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