ATE284403T1 - Triazolopyridazinderivate als liganden für gaba- rezeptoren - Google Patents

Triazolopyridazinderivate als liganden für gaba- rezeptoren

Info

Publication number
ATE284403T1
ATE284403T1 AT00900748T AT00900748T ATE284403T1 AT E284403 T1 ATE284403 T1 AT E284403T1 AT 00900748 T AT00900748 T AT 00900748T AT 00900748 T AT00900748 T AT 00900748T AT E284403 T1 ATE284403 T1 AT E284403T1
Authority
AT
Austria
Prior art keywords
ligands
gaba receptors
triazolopyridazine derivatives
derivatives
substituted
Prior art date
Application number
AT00900748T
Other languages
English (en)
Inventor
William Robert Carling
Piniero Jose Luis Castro
Richard Thomas Lewis
Kevin William Moore
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9901744.4A external-priority patent/GB9901744D0/en
Priority claimed from GBGB9901743.6A external-priority patent/GB9901743D0/en
Priority claimed from GBGB9912429.9A external-priority patent/GB9912429D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE284403T1 publication Critical patent/ATE284403T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00900748T 1999-01-27 2000-01-19 Triazolopyridazinderivate als liganden für gaba- rezeptoren ATE284403T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9901744.4A GB9901744D0 (en) 1999-01-27 1999-01-27 Therapeutic agents
GBGB9901743.6A GB9901743D0 (en) 1999-01-27 1999-01-27 Therapeutic agents
GBGB9912429.9A GB9912429D0 (en) 1999-05-27 1999-05-27 Therapeutic agents
PCT/GB2000/000183 WO2000044752A1 (en) 1999-01-27 2000-01-19 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE284403T1 true ATE284403T1 (de) 2004-12-15

Family

ID=27269629

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900748T ATE284403T1 (de) 1999-01-27 2000-01-19 Triazolopyridazinderivate als liganden für gaba- rezeptoren

Country Status (9)

Country Link
US (2) US6500828B1 (de)
EP (1) EP1149102B1 (de)
JP (1) JP2002535407A (de)
AT (1) ATE284403T1 (de)
AU (1) AU772947B2 (de)
CA (1) CA2359008C (de)
DE (1) DE60016566T2 (de)
ES (1) ES2232416T3 (de)
WO (1) WO2000044752A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
WO2002083139A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
US6960584B2 (en) 2001-04-10 2005-11-01 Merck & Co., Inc. Inhibitors of Akt activity
WO2002083140A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
DE60315876T2 (de) * 2002-11-28 2008-05-21 Neurosearch A/S Verfahren zum screening für verbindungen mit sedativer oder anxiolytischer potenz
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2275096A3 (de) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
HRP20140195T1 (hr) * 2008-08-29 2014-04-11 Concert Pharmaceuticals Inc. Supstituirani derivati triazolopiridazina
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2454259A1 (de) 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modifizierte triazolpyridinderivate als gaba-rezeptormodulatoren
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
US20150099753A1 (en) * 2012-05-11 2015-04-09 Concert Pharmaceuticals Inc. Form 5 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
JP2015516440A (ja) * 2012-05-11 2015-06-11 コンサート ファーマシューティカルズ インコーポレイテッド ７−（ｔｅｒｔ−ブチル−ｄ９）−３−（２，５−ジフルオロフェニル）−６−（（１−メチル−１Ｈ−１，２，４−トリアゾール−５−イル）メトキシ）−［１，２，４］トリアゾロ［４，３−ｂ］ピリダジンの２型多形
WO2013170241A1 (en) * 2012-05-11 2013-11-14 Concert Pharmaceuticals, Inc. Polymorphs of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolol[4,3b]pyridazine
WO2015095549A1 (en) * 2013-12-18 2015-06-25 Concert Pharmaceuticals, Inc. Dosage regimen for gabaa receptor subtype selective drug
HUE060943T2 (hu) * 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
AU2023258030A1 (en) * 2022-04-20 2024-10-17 Engrail Therapeutics, Inc. Gabaa receptor modulator salts, particles, and uses thereof
CN115837022B (zh) * 2023-02-20 2023-04-25 中山大学附属第八医院（深圳福田） 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用
AU2024411621A1 (en) 2023-12-27 2026-06-18 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0915875B1 (de) * 1996-07-25 2003-04-09 MERCK SHARP & DOHME LTD. Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren

Also Published As

Publication number Publication date
CA2359008A1 (en) 2000-08-03
CA2359008C (en) 2008-05-20
ES2232416T3 (es) 2005-06-01
US20030158203A1 (en) 2003-08-21
DE60016566T2 (de) 2005-12-15
WO2000044752A1 (en) 2000-08-03
JP2002535407A (ja) 2002-10-22
EP1149102A1 (de) 2001-10-31
DE60016566D1 (de) 2005-01-13
AU772947B2 (en) 2004-05-13
AU3066900A (en) 2000-08-18
US6500828B1 (en) 2002-12-31
EP1149102B1 (de) 2004-12-08

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