DK1202977T3 - Fremgangsmåde til fremstilling af diazepinderivater - Google Patents

Fremgangsmåde til fremstilling af diazepinderivater

Info

Publication number: DK1202977T3
Authority: DK; Denmark
Prior art keywords: diazepine derivatives; lower alkyl; imidazo; hydrogen; preparation
Prior art date: 1999-05-12

Application number

DK00929501T

Other languages

English (en)

Inventor

Fabienne Hoffmann-Emery

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-12

Filing date

2000-05-05

Publication date

2004-04-05

2000-05-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK1202977T3 publication Critical patent/DK1202977T3/da

Links

125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
IMXWNWBXKWASOM-UHFFFAOYSA-N 3h-imidazo[1,5-a][1,4]diazepine Chemical class N1=CC=CN2CN=CC2=C1 IMXWNWBXKWASOM-UHFFFAOYSA-N 0.000 abstract 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
JCYLWUVDHLVGER-UHFFFAOYSA-N evt-201 Chemical compound O1C(CN(C)C)=NC(C2=C3N(C4=CC=CC(Cl)=C4C(=O)N(C)C3)C=N2)=N1 JCYLWUVDHLVGER-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
230000001003 psychopharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK00929501T 1999-05-12 2000-05-05 Fremgangsmåde til fremstilling af diazepinderivater DK1202977T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99109514		1999-05-12
PCT/EP2000/004033 WO2000069835A2 (en)	1999-05-12	2000-05-05	Process for manufacturing diazepine derivatives

Publications (1)

Publication Number	Publication Date
DK1202977T3 true DK1202977T3 (da)	2004-04-05

Family

ID=8238166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00929501T DK1202977T3 (da)	1999-05-12	2000-05-05	Fremgangsmåde til fremstilling af diazepinderivater

Country Status (14)

Country	Link
US (1)	US6281353B1 (da)
EP (1)	EP1202977B1 (da)
JP (1)	JP3590590B2 (da)
KR (1)	KR100469813B1 (da)
CN (1)	CN101426771B (da)
AT (1)	ATE256669T1 (da)
AU (1)	AU4755500A (da)
CA (1)	CA2373506C (da)
DE (1)	DE60007324T2 (da)
DK (1)	DK1202977T3 (da)
ES (1)	ES2209880T3 (da)
JO (1)	JO2259B1 (da)
MX (1)	MXPA01011445A (da)
WO (1)	WO2000069835A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
WO2009024325A2 (en) *	2007-08-20	2009-02-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
CN109134471B (zh) *	2017-06-27	2020-05-15	浙江京新药业股份有限公司	一种苯并二氮杂*化合物的固态形式及其制备方法和应用
CN111620834B (zh) *	2019-10-15	2022-05-24	浙江京新药业股份有限公司	一种苯并二氮杂䓬化合物的制备方法和中间体
CN113045574B (zh) *	2019-12-26	2024-06-07	浙江京新药业股份有限公司	二氮杂䓬衍生物的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1184175A (en)	1981-02-27	1985-03-19	Walter Hunkeler	Imidazodiazepines
US4352817A (en) *	1981-02-27	1982-10-05	Hoffmann-La Roche Inc.	Imidazo-diazepines and their use
CA1174673A (en) *	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
CA1185602A (en) *	1981-02-27	1985-04-16	Emilio Kyburz	Imidazodiazepines

2000
- 2000-05-04 JO JO200069A patent/JO2259B1/en active
- 2000-05-05 EP EP00929501A patent/EP1202977B1/en not_active Expired - Lifetime
- 2000-05-05 MX MXPA01011445A patent/MXPA01011445A/es active IP Right Grant
- 2000-05-05 DK DK00929501T patent/DK1202977T3/da active
- 2000-05-05 AT AT00929501T patent/ATE256669T1/de active
- 2000-05-05 DE DE60007324T patent/DE60007324T2/de not_active Expired - Lifetime
- 2000-05-05 ES ES00929501T patent/ES2209880T3/es not_active Expired - Lifetime
- 2000-05-05 CN CN008074224A patent/CN101426771B/zh not_active Expired - Lifetime
- 2000-05-05 KR KR10-2001-7014340A patent/KR100469813B1/ko not_active Expired - Lifetime
- 2000-05-05 CA CA002373506A patent/CA2373506C/en not_active Expired - Lifetime
- 2000-05-05 JP JP2000618252A patent/JP3590590B2/ja not_active Expired - Lifetime
- 2000-05-05 AU AU47555/00A patent/AU4755500A/en not_active Abandoned
- 2000-05-05 WO PCT/EP2000/004033 patent/WO2000069835A2/en not_active Ceased
- 2000-05-08 US US09/566,831 patent/US6281353B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60007324D1 (de)	2004-01-29
JO2259B1 (en)	2004-10-07
DE60007324T2 (de)	2004-10-21
KR20010112485A (ko)	2001-12-20
CA2373506A1 (en)	2000-11-23
ES2209880T3 (es)	2004-07-01
JP3590590B2 (ja)	2004-11-17
CA2373506C (en)	2007-09-11
ATE256669T1 (de)	2004-01-15
WO2000069835A3 (en)	2002-03-07
KR100469813B1 (ko)	2005-02-02
US6281353B1 (en)	2001-08-28
JP2002544265A (ja)	2002-12-24
EP1202977B1 (en)	2003-12-17
MXPA01011445A (es)	2002-06-04
AU4755500A (en)	2000-12-05
CN101426771A (zh)	2009-05-06
WO2000069835A2 (en)	2000-11-23
CN101426771B (zh)	2011-11-16
EP1202977A2 (en)	2002-05-08

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