ATE284409T1 - Synthese von sulfurierten oligonukleotiden - Google Patents

Synthese von sulfurierten oligonukleotiden

Info

Publication number: ATE284409T1
Authority: AT; Austria
Prior art keywords: oligonucleotides; sulfurated; synthesis; methods; formation
Prior art date: 1997-10-15

Application number

AT98953408T

Other languages

English (en)

Inventor

Douglas L Cole

Vasulinga T Ravikumar

Zacharia S Cheruvallath

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-15

Filing date

1998-10-13

Publication date

2004-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25490845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE284409(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-10-13 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE284409T1 publication Critical patent/ATE284409T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 4
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 4
230000015572 biosynthetic process Effects 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000011877 solvent mixture Substances 0.000 abstract 1
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT98953408T 1997-10-15 1998-10-13 Synthese von sulfurierten oligonukleotiden ATE284409T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/950,779 US6114519A (en)	1997-10-15	1997-10-15	Synthesis of sulfurized oligonucleotides
PCT/US1998/021502 WO1999019340A1 (en)	1997-10-15	1998-10-13	Improved synthesis of sulfurized oligonucleotides

Publications (1)

Publication Number	Publication Date
ATE284409T1 true ATE284409T1 (de)	2004-12-15

Family

ID=25490845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98953408T ATE284409T1 (de)	1997-10-15	1998-10-13	Synthese von sulfurierten oligonukleotiden

Country Status (8)

Country	Link
US (1)	US6114519A (de)
EP (1)	EP1023310B2 (de)
AT (1)	ATE284409T1 (de)
AU (1)	AU1079499A (de)
DE (1)	DE69828076T3 (de)
ES (1)	ES2235372T5 (de)
PT (1)	PT1023310E (de)
WO (1)	WO1999019340A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998008809A1 (en) *	1996-08-30	1998-03-05	Hybridon, Inc.	Novel sulfur transfer reagents for oligonucleotide synthesis
US6242591B1 (en) *	1997-10-15	2001-06-05	Isis Pharmaceuticals, Inc.	Synthesis of sulfurized 2'-substituted oligonucleotides
WO2002081476A1 (en) *	2001-04-06	2002-10-17	Micrologix Biotech, Inc.	Thiophosphate nucleic acid-based compounds
US20040054162A1 (en) *	2001-10-30	2004-03-18	Hanna Michelle M.	Molecular detection systems utilizing reiterative oligonucleotide synthesis
US7045319B2 (en) *	2001-10-30	2006-05-16	Ribomed Biotechnologies, Inc.	Molecular detection systems utilizing reiterative oligonucleotide synthesis
KR20070012779A (ko) *	2003-10-29	2007-01-29	리보메드 바이오테그놀로지스 인코포레이티드	반복적 올리고뉴클레오티드 합성을 위한 조성물, 방법 및검출 기법
EP2708541B1 (de)	2003-11-13	2015-01-28	Isis Pharmaceuticals, Inc.	5,6-Dihydroxy-Isoindol-Derivate als Linker für Oligomer-Festphasensynthese
JP2007531794A (ja)	2004-04-05	2007-11-08	アルニラムファーマスーティカルズインコーポレイテッド	オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
US7427675B2 (en) *	2004-08-23	2008-09-23	Isis Pharmaceuticals, Inc.	Compounds and methods for the characterization of oligonucleotides
US20060275792A1 (en) *	2004-11-15	2006-12-07	Lee Jun E	Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) *	2004-11-15	2006-05-18	Lee Jun E	Compositions and methods for the detection and discrimination of nucleic acids
EP2297346B1 (de)	2008-05-15	2015-04-15	Ribomed Biotechnologies, Inc.	VERFAHREN UND REAGENZIEN FÜR DEN NACHWEIS VON CpG-METHYLIERUNG MIT EINEM METHYL-CpG-BINDENDEN PROTEIN (MBP)
US8211644B2 (en) *	2008-07-13	2012-07-03	Ribomed Biotechnologies, Inc.	Molecular beacon-based methods for detection of targets using abscription
AU2010225937B2 (en)	2009-03-15	2014-09-18	Ribomed Biotechnologies, Inc.	Abscription based molecular detection
US8309710B2 (en) *	2009-06-29	2012-11-13	Agilent Technologies, Inc.	Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
US8642755B2 (en) *	2009-06-30	2014-02-04	Agilent Technologies, Inc.	Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide
MA42157A (fr)	2015-04-23	2018-02-28	Geron Corp	Procédés de préparation de polynucléotides à l'aide de compositions de sel cationique multivalent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3923763A (en) *	1972-09-15	1975-12-02	Petro Tex Chem Corp	Novel sulfur compound modifiers for chloroprene polymerization
JPS5442617B2 (de) *	1974-12-28	1979-12-15
US4959463A (en) *	1985-10-15	1990-09-25	Genentech, Inc.	Intermediates
NL8902521A (nl) *	1989-10-11	1991-05-01	Rijksuniversiteit	Werkwijze voor het bereiden van fosforothioaatesters.
US5151510A (en) *	1990-04-20	1992-09-29	Applied Biosystems, Inc.	Method of synethesizing sulfurized oligonucleotide analogs
GB9127243D0 (en) *	1991-12-23	1992-02-19	King S College London	Synthesis of phosphorothioate analogues of oligonucleotides
US5574146A (en) †	1994-08-30	1996-11-12	Beckman Instruments, Inc.	Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
US6001555A (en) *	1994-09-23	1999-12-14	The United States Of America As Represented By The Department Of Health And Human Services	Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein

1997
- 1997-10-15 US US08/950,779 patent/US6114519A/en not_active Expired - Lifetime
1998
- 1998-10-13 WO PCT/US1998/021502 patent/WO1999019340A1/en not_active Ceased
- 1998-10-13 EP EP98953408.6A patent/EP1023310B2/de not_active Expired - Lifetime
- 1998-10-13 PT PT98953408T patent/PT1023310E/pt unknown
- 1998-10-13 AU AU10794/99A patent/AU1079499A/en not_active Abandoned
- 1998-10-13 DE DE69828076.8T patent/DE69828076T3/de not_active Expired - Lifetime
- 1998-10-13 ES ES98953408.6T patent/ES2235372T5/es not_active Expired - Lifetime
- 1998-10-13 AT AT98953408T patent/ATE284409T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69828076T2 (de)	2005-11-24
DE69828076T3 (de)	2014-07-10
EP1023310A4 (de)	2001-05-16
WO1999019340A1 (en)	1999-04-22
ES2235372T5 (es)	2014-06-23
AU1079499A (en)	1999-05-03
ES2235372T3 (es)	2005-07-01
EP1023310A1 (de)	2000-08-02
US6114519A (en)	2000-09-05
EP1023310B2 (de)	2014-05-21
PT1023310E (pt)	2005-02-28
DE69828076D1 (de)	2005-01-13
EP1023310B1 (de)	2004-12-08

Legal Events

Date	Code	Title	Description
2005-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69828076D1 (de)	2005-01-13	Synthese von sulfurierten oligonukleotiden
DE69403642D1 (de)	1997-07-10	7-deazapurin modifizierte oligonukleotide
FI924964L (fi)	1992-11-03	Modulering av genexpression genom stoerande inverkan pao sekundaerstrukturen hos rna
DK0866071T3 (da)	2005-01-17	Modificerede primere
ATE82281T1 (de)	1992-11-15	Aryl-substituierte(n-piperidinyl)methyl und (npiperazinyl)methylazole mit antipsychotischer wirkung.
BR0016380A (pt)	2002-09-03	Complexo metálico,processo de hidrossililação de olefinas ou de derivados acetilênicos e composição catalìtica
ATE342911T1 (de)	2006-11-15	Synthese von nukleosiden und polynukleotiden
ATE160572T1 (de)	1997-12-15	Oligonucleotide mit amidverkettungen die phosphoesterverkettungen einsetzen
DE69109100D1 (de)	1995-05-24	Oligonukleotid-analoge.
ATE356824T1 (de)	2007-04-15	L-ribo-lna analoge
DE69638183D1 (de)	2010-06-17	Verwendung von nukleinsäureliganden in der durchflusszytometrie
ATE212997T1 (de)	2002-02-15	Festphasensynthese von oligonucleotid n3'-p5'- phosphoramidaten
EP1072678A4 (de)	2006-09-27	Verfahren zum synthetisieren von dna
DK1054860T3 (da)	2007-07-02	Proces for syntesen af 1,3-dioler
BR9811854B1 (pt)	2009-08-11	processo de preparação de 3,3-dimetilbutiraldeìdo por oxidação de 3,3-dimetilbutanol.
ATE412052T1 (de)	2008-11-15	Synthetische polynukleotide
PL340449A1 (en)	2001-02-12	Highly efficient method of functionally classifying proteins identified by gnomic techniques
DE69934998D1 (de)	2007-03-15	Antisense modulation der expression von integrin alpha 4
ATE233318T1 (de)	2003-03-15	Spezifische oligonukleotide für hepatitis b virus
ATE195320T1 (de)	2000-08-15	Neue polymerträger zur nukleinsäuresynthese
DE59004501D1 (de)	1994-03-17	Verfahren zur katalytischen Gasphasen-Dehydrierung von Kohlenwasserstoffen, insbesondere von Alkylaromaten.
DE69402177D1 (de)	1997-04-24	Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
NZ501492A (en)	2002-09-27	Di-amine and tetra-amine derivatives and pharmaceuticals thereof, useful for treating cardiac arrhythmia
ATE278702T1 (de)	2004-10-15	Verfahren zur synthese von phosphorothioat- oligonukelotiden
ATE313627T1 (de)	2006-01-15	Frazzled nukleotidsequenzen, expressionsprodukte, zusammensetzungen und verwendungen