ATE285416T1 - Expression und reinigung von kloniertem humanen alpha-fetoprotein - Google Patents

Expression und reinigung von kloniertem humanen alpha-fetoprotein

Info

Publication number
ATE285416T1
ATE285416T1 AT93915109T AT93915109T ATE285416T1 AT E285416 T1 ATE285416 T1 AT E285416T1 AT 93915109 T AT93915109 T AT 93915109T AT 93915109 T AT93915109 T AT 93915109T AT E285416 T1 ATE285416 T1 AT E285416T1
Authority
AT
Austria
Prior art keywords
human alpha
fetoprotein
expression
purification
cloned human
Prior art date
Application number
AT93915109T
Other languages
English (en)
Inventor
Robert A Murgita
Original Assignee
Martinex R & D Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martinex R & D Inc filed Critical Martinex R & D Inc
Application granted granted Critical
Publication of ATE285416T1 publication Critical patent/ATE285416T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93915109T 1991-09-27 1992-10-30 Expression und reinigung von kloniertem humanen alpha-fetoprotein ATE285416T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76743591A 1991-09-27 1991-09-27
PCT/US1992/008317 WO1994010199A1 (en) 1991-09-27 1992-10-30 Expression and purification of cloned human alpha-fetoprotein

Publications (1)

Publication Number Publication Date
ATE285416T1 true ATE285416T1 (de) 2005-01-15

Family

ID=26785055

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93915109T ATE285416T1 (de) 1991-09-27 1992-10-30 Expression und reinigung von kloniertem humanen alpha-fetoprotein

Country Status (8)

Country Link
US (1) US5384250A (de)
EP (1) EP0749441B1 (de)
JP (1) JPH08511677A (de)
AT (1) ATE285416T1 (de)
CA (1) CA2120131A1 (de)
DE (1) DE69233463T2 (de)
ES (1) ES2235156T3 (de)
WO (1) WO1994010199A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288034B1 (en) 1995-01-24 2001-09-11 Martinex R & D Inc. Recombinant human alpha-fetoprotein as an immunosuppressive agent
US6331611B1 (en) 1991-09-27 2001-12-18 Mcgill University Expression and purification of cloned human alpha-fetoprotein
US5965528A (en) * 1991-09-27 1999-10-12 Mcgill University Recombinant human alph-fetoprotein as an immunosuppressive agent
US5674842A (en) * 1994-10-26 1997-10-07 Health Research, Incorporated Growth inhibitory peptide
US7101837B1 (en) 1995-01-24 2006-09-05 Martinex R & D Inc. Recombinant human alpha-fetoprotein as a cell proliferative agent
WO1996022787A1 (en) * 1995-01-24 1996-08-01 Murgita Robert A Recombinant human alpha-fetoprotein and uses thereof
US6534479B1 (en) 1995-01-24 2003-03-18 Martinex R & D Inc. Recombinant alpha-fetoprotein hybrid cytotoxins for treating and diagnosing cancers
US5866329A (en) * 1995-09-27 1999-02-02 Demetriou; Achilles A. Method and probe for detection of gene associated with liver neoplastic disease
US6087334A (en) * 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
US7208576B2 (en) * 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
EP1148779B1 (de) * 1999-01-06 2007-12-12 Merrimack Pharmaceuticals, Inc. Expression von ausgeschiedenem, menschlichem alpha-fetoprotein in transgenen tieren
DE60215823T2 (de) * 2001-08-07 2007-09-06 Novozymes A/S Kohlhydrate und polyole zum lösen der proteinkristalle
EA011606B1 (ru) * 2004-07-14 2009-04-28 Эдуард Борисович Татулов Способы получения и применения рекомбинантного альфа-фетопротеина
KR20090104041A (ko) * 2006-12-19 2009-10-05 메리맥 파마슈티컬즈, 인크. 다발성 경화증을 치료하기 위한 α페토프로테인 및 면역조절제의 병용투여
EP2510941A3 (de) 2007-02-20 2013-01-23 Merrimack Pharmaceuticals, Inc. Verfahren zur Behandlung von multipler Sklerose mittels Verabreichung eines alpha-Fetoproteins in Kombination mit einem Integrinantagonisten
US20100304873A1 (en) * 2009-05-28 2010-12-02 Lipa Markowitz Bowling Ball and Football Game Controller
CN105732795A (zh) * 2016-03-21 2016-07-06 海南医学院 一种获得人类甲胎蛋白的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH025866A (ja) * 1988-06-27 1990-01-10 Kansai Shin Gijutsu Kenkyusho:Kk ヒトアルファフェトプロテインドメインｉ遺伝子、対応プラスミド組換体、対応形質転換体、該ドメインｉの製造法及び製造された該ドメインｉ
US5206153A (en) * 1990-06-27 1993-04-27 Snow Brand Milk Products Co., Ltd. Method of producing human α-fetoprotein and product produced thereby

Also Published As

Publication number Publication date
WO1994010199A1 (en) 1994-05-11
CA2120131A1 (en) 1994-05-11
EP0749441A4 (de) 1998-12-30
EP0749441A1 (de) 1996-12-27
EP0749441B1 (de) 2004-12-22
US5384250A (en) 1995-01-24
JPH08511677A (ja) 1996-12-10
DE69233463T2 (de) 2005-12-22
DE69233463D1 (de) 2005-01-27
ES2235156T3 (es) 2005-07-01

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