ATE286740T1 - Zyklische peptide mit breitspektrum antimikrobieller aktivität - Google Patents

Zyklische peptide mit breitspektrum antimikrobieller aktivität

Info

Publication number
ATE286740T1
ATE286740T1 AT97937009T AT97937009T ATE286740T1 AT E286740 T1 ATE286740 T1 AT E286740T1 AT 97937009 T AT97937009 T AT 97937009T AT 97937009 T AT97937009 T AT 97937009T AT E286740 T1 ATE286740 T1 AT E286740T1
Authority
AT
Austria
Prior art keywords
antimicrobial activity
broad spectrum
cyclic peptides
spectrum antimicrobial
peptides
Prior art date
Application number
AT97937009T
Other languages
English (en)
Inventor
Conway Chang
Leo Gu
Jie Chen
Original Assignee
Intrabiotics Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrabiotics Pharmaceuticals filed Critical Intrabiotics Pharmaceuticals
Application granted granted Critical
Publication of ATE286740T1 publication Critical patent/ATE286740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97937009T 1996-07-24 1997-07-23 Zyklische peptide mit breitspektrum antimikrobieller aktivität ATE286740T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/685,589 US5916872A (en) 1996-07-24 1996-07-24 Cyclic peptides having broad spectrum antimicrobial activity
PCT/US1997/012974 WO1998003192A1 (en) 1996-07-24 1997-07-23 Cyclic peptides having broad spectrum antimicrobial activity

Publications (1)

Publication Number Publication Date
ATE286740T1 true ATE286740T1 (de) 2005-01-15

Family

ID=24752864

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97937009T ATE286740T1 (de) 1996-07-24 1997-07-23 Zyklische peptide mit breitspektrum antimikrobieller aktivität

Country Status (8)

Country Link
US (1) US5916872A (de)
EP (1) EP0956029B1 (de)
JP (1) JP2001503020A (de)
AT (1) ATE286740T1 (de)
AU (1) AU720100B2 (de)
CA (1) CA2261797A1 (de)
DE (1) DE69732250D1 (de)
WO (1) WO1998003192A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7553929B2 (en) * 1994-06-13 2009-06-30 Vanderbilt University Cell permeable peptides for inhibition of inflammatory reactions and methods of use
US6495518B1 (en) * 1994-06-13 2002-12-17 Vanderbilt University Method for importing biologically active molecules into cells
USRE38828E1 (en) * 1995-07-06 2005-10-11 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
US6307016B1 (en) 1995-07-06 2001-10-23 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
US6043220A (en) * 1997-12-03 2000-03-28 Intrabiotics Pharmaceuticals, Inc. Threonine-containing protegrins
AU757658B2 (en) * 1998-03-09 2003-02-27 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
ES2316356T3 (es) * 1999-03-09 2009-04-16 Fornix Biosciences N.V. Peptidos sinteticos complementarios y sus utilizaciones oftalmologicas.
US6335318B1 (en) 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
US6337317B1 (en) * 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
BRPI0207502B1 (pt) * 2001-02-23 2018-10-09 Polyphor Ltd compostos, enanciômeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos
US7314858B2 (en) 2001-04-18 2008-01-01 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
US6713078B2 (en) 2001-04-18 2004-03-30 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
US7119070B2 (en) * 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
WO2003102538A2 (en) * 2002-05-30 2003-12-11 European Molecular Biology Laboratory Combinatorial chemical library ii
AU2003273578A1 (en) * 2002-05-30 2003-12-19 European Molecular Biology Laboratory Combinatorial chemical library i
CA2489292A1 (en) 2002-06-13 2003-12-24 Chiron Corporation Vectors for expression of hml-2 polypeptides
EP1532164B1 (de) 2002-08-20 2012-09-26 Polyphor Ltd. Template-fixierte peptidmimetika mit antibakterieller wirkung
ATE516045T1 (de) * 2003-01-24 2011-07-15 Univ Massachusetts Medical Identifikation von vaccinia-virus-dominanten t- zell-epitopen
US8067535B2 (en) 2003-01-24 2011-11-29 The University Of Massachusetts Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
JP2006524232A (ja) 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
EP1804823A4 (de) 2004-09-29 2010-06-09 Amr Technology Inc Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US20080255052A1 (en) * 2004-12-23 2008-10-16 The Regents Of The University Of California Immunologic regulation by theta defensins
CA2610791C (en) * 2005-06-08 2015-12-01 Cangene Corporation Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
KR101410685B1 (ko) * 2005-10-04 2014-06-24 솔리제닉스, 인크. 선천적 면역을 조절함으로써 감염을 치료 및 예방하는 것을 포함하는, 면역 관련 장애를 치료 및 예방하기 위한 신규한 펩티드
WO2008040111A1 (en) * 2006-10-04 2008-04-10 Inimex Pharmaceuticals Inc. Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity
US9181303B2 (en) * 2005-12-22 2015-11-10 Novabiotics Limited Treatment of bacterial infections with cyclic antimicrobial peptides
AU2012203804B2 (en) * 2005-12-22 2014-10-16 Novabiotics Limited Cyclic antimicrobial peptides
EP1976863B1 (de) 2005-12-22 2012-12-12 Novabiotics Limited Cyclische antimikrobielle peptide
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
FR2943345B1 (fr) * 2009-03-19 2011-05-27 Univ Paris Curie Analogues de la temporine-sha et leurs utilisations
EP2853538A1 (de) 2013-09-27 2015-04-01 Université Pierre et Marie Curie (Paris 6) Analoge von Temporin-SHa und Verwendungen davon
AU2020302913B2 (en) * 2019-06-26 2023-02-23 The University Of Southern California Novel theta defensin analogs
JP2023117892A (ja) * 2022-02-14 2023-08-24 公益財団法人 鷹揚郷 ヘプシジン結合ペプチド

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543252A (en) * 1982-01-21 1985-09-24 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4659692A (en) * 1982-11-19 1987-04-21 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US4705777A (en) * 1985-02-25 1987-11-10 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US5126257A (en) * 1986-11-26 1992-06-30 Cornell Research Foundation Antimicrobial proteins, compositions containing same and uses thereof
US5087569A (en) * 1986-11-26 1992-02-11 Cornell Research Foundation, Inc. And The Rockefeller University Antimicrobial proteins, compositions containing same and uses thereof
US5338724A (en) * 1986-11-26 1994-08-16 Cornell Research Foundation, Inc. Antimicrobial proteins, compositions containing same and uses thereof
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US5032574A (en) * 1988-05-26 1991-07-16 Invitron Corporation Novel antimicrobial peptide
US5334584A (en) * 1989-02-14 1994-08-02 Incyte Pharamaceuticals, Inc. Recombinant, non-glycosylated bpi protein and uses thereof
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
US5234912A (en) * 1989-02-14 1993-08-10 Incyte Pharmaceuticals, Inc. Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
US5308834A (en) * 1989-02-14 1994-05-03 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and prevention thereof using a BPI protein
US5708154A (en) * 1989-02-24 1998-01-13 City Of Hope RNA-DNA hybrid molecules of nucleic acid
US5484885A (en) * 1989-07-05 1996-01-16 Emory University Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of CAP37
US5447914A (en) * 1990-06-21 1995-09-05 Emory University Antimicrobial peptides
US5432270A (en) * 1990-10-25 1995-07-11 Zasloff; Michael A. DNA encoding tracheal antimicrobial peptides
US5488035A (en) * 1991-12-06 1996-01-30 Pioneer Hi-Bred International, Inc. Peptide with inhibitory activity towards plant pathogenic fungi
CA2136103C (en) * 1992-05-26 2004-03-30 The General Hospital Corporation Antibiotic cryptdin peptides and methods of their use
US5422424A (en) * 1992-05-26 1995-06-06 The Regents Of The University Of California Antibiotic cryptdin peptides and methods of their use
US5459235A (en) * 1993-03-19 1995-10-17 The Regents Of The University Of California Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils
US5693486A (en) * 1993-07-20 1997-12-02 Intrabiotics DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
US5464823A (en) * 1993-07-20 1995-11-07 The Regents Of The University Of California Mammalian antibiotic peptides
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
US5708145A (en) * 1993-07-20 1998-01-13 University Of California Immunglobulins reactive with protegrins
CZ287239B6 (en) * 1993-10-14 2000-10-11 Seikagaku Kogyo Co Ltd Polypeptides exhibiting antimicrobial and antiviral activity and pharmaceutical preparations containing thereof
US5635594A (en) * 1994-03-11 1997-06-03 University Of California, Los Angeles Gallinacins - antibiotic peptides

Also Published As

Publication number Publication date
DE69732250D1 (de) 2005-02-17
US5916872A (en) 1999-06-29
JP2001503020A (ja) 2001-03-06
WO1998003192A1 (en) 1998-01-29
AU3963097A (en) 1998-02-10
CA2261797A1 (en) 1998-01-29
AU720100B2 (en) 2000-05-25
EP0956029A1 (de) 1999-11-17
EP0956029B1 (de) 2005-01-12
EP0956029A4 (de) 2001-09-05

Similar Documents

Publication Publication Date Title
DE69732250D1 (de) Zyklische peptide mit breitspektrum antimikrobieller aktivität
DK1091975T3 (da) Ny cyclosporin med forbedret aktivitetsprofil
UY24572A1 (es) Conjugados peg - interferon alfa
FI940807L (fi) Peptidejä, joilla on kasvuhormonia vapauttavaa aktiivisuutta
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
DE69435105D1 (de) Derivate therapeutischer Peptide
NL1010890A1 (nl) Stabilisatormengsel.
DE69911579D1 (de) Antimikrobielle peptide
FI961044A0 (fi) Kininogeeni-inhibiittorit
EP0644769A4 (de) Biologisch aktive peptide mit n-terminalen substitutionen.
ITRM990803A0 (it) Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
DE69413606D1 (de) Endothelinantagonistische Peptide
ATE323722T1 (de) Antimikrobiell wirkendes peptid
NO944256L (no) Stabil, lyofilisert tiotepablanding
IL139604A (en) Fibrinogen-beta chain derived peptide, compositions comprising same and use thereof
AU5153598A (en) Cyclic peptides having broad spectrum antimicrobial activity
ATE118016T1 (de) Peptid mit einer aktivität gegen metastasen.
EP0612847A3 (de) Antimikrobielle Proteine.
WO2001011937A3 (en) Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
MX9804043A (es) Composiciones parasiticidas a base de polisiloxanos ciclicos.
NO20020064D0 (no) Chlamysin B antibakterielt protein, gen som koder for dette samt et ekspresjonssystem for dette
FI960119A7 (fi) Peptidit, joilla on oksitosiinin vastaista aktiivisuutta
RU95114858A (ru) Новый пептидный фрагмент, обладающий биологической активностью инсулина
ITTO980659A0 (it) Compressore alternativo.
WO2000014254A3 (en) Component of bromelain

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties