DK1551835T3 - Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse - Google Patents

Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse

Info

Publication number
DK1551835T3
DK1551835T3 DK03798094T DK03798094T DK1551835T3 DK 1551835 T3 DK1551835 T3 DK 1551835T3 DK 03798094 T DK03798094 T DK 03798094T DK 03798094 T DK03798094 T DK 03798094T DK 1551835 T3 DK1551835 T3 DK 1551835T3
Authority
DK
Denmark
Prior art keywords
diseases
disorders
compounds
nervous system
disorders related
Prior art date
Application number
DK03798094T
Other languages
English (en)
Inventor
Dan Neurosearch A S Peters
Gunnar M Olsen
Elsebet Stergaard Nielsen
Tino Dyhring Joergensen
Philip K Ahring
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK1551835T3 publication Critical patent/DK1551835T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03798094T 2002-09-30 2003-09-29 Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse DK1551835T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
DK1551835T3 true DK1551835T3 (da) 2007-06-04

Family

ID=32045613

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03798094T DK1551835T3 (da) 2002-09-30 2003-09-29 Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse

Country Status (11)

Country Link
US (1) US7220741B2 (da)
EP (2) EP1785425B1 (da)
AT (2) ATE353899T1 (da)
AU (1) AU2003266222B2 (da)
CA (1) CA2496585C (da)
DE (2) DE60326894D1 (da)
DK (1) DK1551835T3 (da)
ES (1) ES2280836T3 (da)
NZ (1) NZ538512A (da)
PL (1) PL375025A1 (da)
WO (1) WO2004029053A1 (da)

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US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
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CN101952288A (zh) 2008-03-11 2011-01-19 神经研究公司 可用作烟碱乙酰胆碱受体的调节剂的新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
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WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
WO2010043539A1 (en) * 2008-10-13 2010-04-22 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
US20120028967A1 (en) 2009-01-21 2012-02-02 Neurosearch A/S Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use
WO2010084120A1 (en) 2009-01-21 2010-07-29 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
US20120004215A1 (en) * 2009-01-26 2012-01-05 Neurosearch A/S N-oxides of diazabicyclononyl pyrimidine derivatives and their medical use
MX2011007449A (es) * 2009-01-26 2011-10-24 Neurosearch As Derivados de indolil-oxadiazolil-diazabiciclononano y su uso medico y diagnostico.
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086278A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
US20120288443A1 (en) 2009-11-11 2012-11-15 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
EP2513097A1 (en) * 2009-12-18 2012-10-24 NeuroSearch AS Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
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JP7551629B2 (ja) 2019-02-05 2024-09-17 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
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JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7649257B2 (ja) 2019-05-13 2025-03-19 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物

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Also Published As

Publication number Publication date
US20060122172A1 (en) 2006-06-08
EP1785425A3 (en) 2007-06-06
AU2003266222A1 (en) 2004-04-19
EP1785425A2 (en) 2007-05-16
ES2280836T3 (es) 2007-09-16
ATE353899T1 (de) 2007-03-15
DE60326894D1 (de) 2009-05-07
EP1551835A1 (en) 2005-07-13
EP1551835B1 (en) 2007-02-14
EP1785425B1 (en) 2009-03-25
PL375025A1 (en) 2005-11-14
NZ538512A (en) 2006-12-22
CA2496585C (en) 2012-05-29
DE60311853D1 (de) 2007-03-29
ATE426602T1 (de) 2009-04-15
AU2003266222B2 (en) 2009-10-01
CA2496585A1 (en) 2004-04-08
DE60311853T2 (de) 2007-06-21
WO2004029053A1 (en) 2004-04-08
US7220741B2 (en) 2007-05-22

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