ATE287899T1 - Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen - Google Patents
Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogenInfo
- Publication number
- ATE287899T1 ATE287899T1 AT99942321T AT99942321T ATE287899T1 AT E287899 T1 ATE287899 T1 AT E287899T1 AT 99942321 T AT99942321 T AT 99942321T AT 99942321 T AT99942321 T AT 99942321T AT E287899 T1 ATE287899 T1 AT E287899T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- cyclic peptide
- new
- amino acid
- decrease
- Prior art date
Links
- 108010069514 Cyclic Peptides Proteins 0.000 title abstract 5
- 102000001189 Cyclic Peptides Human genes 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010049047 Echinocandins Proteins 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 229940125687 antiparasitic agent Drugs 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N ornithyl group Chemical group N[C@@H](CCCN)C(=O)O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- 108090000765 processed proteins & peptides Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9722898P | 1998-08-20 | 1998-08-20 | |
| PCT/US1999/018908 WO2000011023A2 (en) | 1998-08-20 | 1999-08-18 | Ring modified cyclic peptide analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE287899T1 true ATE287899T1 (de) | 2005-02-15 |
Family
ID=22262272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99942321T ATE287899T1 (de) | 1998-08-20 | 1999-08-18 | Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6653281B1 (de) |
| EP (1) | EP1107981B1 (de) |
| JP (1) | JP2002528388A (de) |
| AT (1) | ATE287899T1 (de) |
| AU (1) | AU765660B2 (de) |
| CA (1) | CA2340676A1 (de) |
| DE (1) | DE69923460T2 (de) |
| DK (1) | DK1107981T3 (de) |
| ES (1) | ES2233070T3 (de) |
| PT (1) | PT1107981E (de) |
| WO (1) | WO2000011023A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743777B1 (en) * | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| US6323176B1 (en) | 1998-02-25 | 2001-11-27 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| ES2233070T3 (es) | 1998-08-20 | 2005-06-01 | ELI LILLY & COMPANY | Sintesis de analogos peptidicos ciclicos modificados en el anillo. |
| DE69933046T2 (de) | 1998-12-09 | 2007-09-13 | Eli Lilly And Co., Indianapolis | Reinigung von echinocandin cyclopeptiden |
| EP1582204B1 (de) | 1999-03-03 | 2013-09-25 | Eli Lilly & Company | Echinocandin pharmazeutische Zusammensetzungen enthaltend Mizellen bildende Tenside |
| WO2000051567A1 (en) | 1999-03-03 | 2000-09-08 | Eli Lilly And Company | Processes for making pharmaceutical oral ecb formulations and compositions |
| AU767956B2 (en) | 1999-03-03 | 2003-11-27 | Eli Lilly And Company | Formation and anion-exchange of crystalline echinocandin ammonium salts |
| KR20020003864A (ko) * | 1999-03-03 | 2002-01-15 | 피터 지. 스트링거 | 에키노칸딘/탄수화물 착물 |
| TWI232102B (en) | 2001-07-17 | 2005-05-11 | Shionogi & Co | A pharmaceutical formulation for injection |
| US6991800B2 (en) | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| WO2011047192A2 (en) * | 2009-10-14 | 2011-04-21 | Dana-Farber Cancer Institute, Inc. | Protected amine labels and use in detecting analytes |
| PL243656B1 (pl) * | 2018-05-30 | 2023-09-25 | Boruta Zachem Biochemia Spolka Z Ograniczona Odpowiedzialnoscia | Sposób usuwania lipopeptydów z roztworów i zmiana ich struktury |
| IL299163A (en) * | 2020-06-23 | 2023-02-01 | Genentech Inc | Macrocyclic compounds and methods of using them |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4320052A (en) | 1979-12-13 | 1982-03-16 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US4293489A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US5166135A (en) | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
| DK173802B1 (da) | 1988-09-12 | 2001-11-05 | Merck & Co Inc | Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner |
| CA2037957A1 (en) | 1990-03-12 | 1991-09-13 | Merck & Co., Inc. | N-acylated cyclohexapeptide compounds |
| GB2241956A (en) | 1990-03-16 | 1991-09-18 | Merck & Co Inc | N-acylated cyclohexapeptide compounds |
| US5049546A (en) | 1990-03-19 | 1991-09-17 | Merck & Co., Inc. | Antibiotic agents |
| US5330973A (en) | 1990-03-19 | 1994-07-19 | Merck & Co., Inc. | Lipopeptide derivatives |
| IL97347A0 (en) | 1990-03-19 | 1992-05-25 | Merck & Co Inc | Lipopeptide derivatives and antimicrobial compositions containing them |
| US5386009A (en) | 1990-03-19 | 1995-01-31 | Merck & Co. Inc. | Lipopeptide derivatives |
| US5310726A (en) | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| IE990233A1 (en) | 1990-06-18 | 2000-11-15 | Fujisawa Pharmaceutical Co | New Polypeptide Compound and a Process for Preparation thereof |
| US5337405A (en) | 1990-10-02 | 1994-08-09 | Hewlett-Packard Company | Guided data presentation |
| US5369093A (en) | 1991-03-15 | 1994-11-29 | Merck & Co., Inc. | Lipopeptide derivatives |
| US5233023A (en) | 1991-07-30 | 1993-08-03 | Merck & Co., Inc. | Process for phosphate ester compounds of certain cyclohexapeptides |
| NZ247149A (en) | 1992-03-19 | 1996-10-28 | Lilly Co Eli | Cyclic peptide antifungal agents and compositions thereof |
| US5965525A (en) | 1992-03-19 | 1999-10-12 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5541160A (en) | 1994-04-04 | 1996-07-30 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
| US5646111A (en) | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
| AU710502B2 (en) | 1995-05-10 | 1999-09-23 | Darwin Discovery Limited | Peptidyl compounds which inhibit metalloproteinase and TNF liberation and their therapeutic use |
| US5618787A (en) | 1995-05-26 | 1997-04-08 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5652213A (en) | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5786325A (en) | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
| US5629290A (en) | 1995-05-26 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629289A (en) | 1995-07-25 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| WO1997027864A1 (en) | 1996-02-01 | 1997-08-07 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5696084A (en) | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
| WO1999006062A1 (en) | 1997-08-04 | 1999-02-11 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US6323176B1 (en) | 1998-02-25 | 2001-11-27 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| ES2233070T3 (es) * | 1998-08-20 | 2005-06-01 | ELI LILLY & COMPANY | Sintesis de analogos peptidicos ciclicos modificados en el anillo. |
| WO2000012540A1 (en) | 1998-08-28 | 2000-03-09 | Eli Lilly And Company | Reversible boronate complexes of 1,2-cis-diol cyclic-peptides |
| AU767357B2 (en) | 1998-12-16 | 2003-11-06 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| JP2002532513A (ja) | 1998-12-16 | 2002-10-02 | イーライ リリー アンド カンパニー | 糖置換基を有する環式ペプチド抗真菌剤 |
-
1999
- 1999-08-18 ES ES99942321T patent/ES2233070T3/es not_active Expired - Lifetime
- 1999-08-18 US US09/763,114 patent/US6653281B1/en not_active Expired - Fee Related
- 1999-08-18 AT AT99942321T patent/ATE287899T1/de not_active IP Right Cessation
- 1999-08-18 EP EP99942321A patent/EP1107981B1/de not_active Expired - Lifetime
- 1999-08-18 DE DE69923460T patent/DE69923460T2/de not_active Expired - Fee Related
- 1999-08-18 AU AU55726/99A patent/AU765660B2/en not_active Ceased
- 1999-08-18 PT PT99942321T patent/PT1107981E/pt unknown
- 1999-08-18 JP JP2000566295A patent/JP2002528388A/ja not_active Abandoned
- 1999-08-18 WO PCT/US1999/018908 patent/WO2000011023A2/en not_active Ceased
- 1999-08-18 DK DK99942321T patent/DK1107981T3/da active
- 1999-08-18 CA CA002340676A patent/CA2340676A1/en not_active Abandoned
-
2003
- 2003-09-30 US US10/676,575 patent/US6939946B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002528388A (ja) | 2002-09-03 |
| ES2233070T3 (es) | 2005-06-01 |
| WO2000011023A2 (en) | 2000-03-02 |
| US6939946B2 (en) | 2005-09-06 |
| DE69923460D1 (de) | 2005-03-03 |
| PT1107981E (pt) | 2005-05-31 |
| DK1107981T3 (da) | 2005-05-30 |
| WO2000011023A3 (en) | 2000-06-15 |
| US20040068094A1 (en) | 2004-04-08 |
| CA2340676A1 (en) | 2000-03-02 |
| EP1107981B1 (de) | 2005-01-26 |
| AU5572699A (en) | 2000-03-14 |
| AU765660B2 (en) | 2003-09-25 |
| US6653281B1 (en) | 2003-11-25 |
| EP1107981A2 (de) | 2001-06-20 |
| DE69923460T2 (de) | 2007-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1107981 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |