DK1107981T3 - Syntese af ringmodificerede, cykliske peptidanaloger - Google Patents

Syntese af ringmodificerede, cykliske peptidanaloger

Info

Publication number: DK1107981T3
Authority: DK; Denmark
Prior art keywords: ring; cyclic peptide; new; synthesis; amino acid
Prior art date: 1998-08-20

Application number

DK99942321T

Other languages

Danish (da)

English (en)

Inventor

Peter Stanley Borromeo

Jeffrey Daniel Cohen

George Stuart Gregory

Stacy Kay Henle

Stephen Andrew Hitchcock

Louis Nickolaus Jungheim

Daniel Ray Mayhugh

Timothy Alan Shepherd

William Wilson Turner Jr

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-20

Filing date

1999-08-18

Publication date

2005-05-30

1999-08-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2005-05-30 Application granted granted Critical

2005-05-30 Publication of DK1107981T3 publication Critical patent/DK1107981T3/da

Links

108010069514 Cyclic Peptides Proteins 0.000 title abstract 5
102000001189 Cyclic Peptides Human genes 0.000 title abstract 5
125000004122 cyclic group Chemical group 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 2
230000000843 anti-fungal effect Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
108010049047 Echinocandins Proteins 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
239000003429 antifungal agent Substances 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
229940125687 antiparasitic agent Drugs 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
AHLPHDHHMVZTML-BYPYZUCNSA-N ornithyl group Chemical group N[C@@H](CCCN)C(=O)O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
108090000765 processed proteins & peptides Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK99942321T 1998-08-20 1999-08-18 Syntese af ringmodificerede, cykliske peptidanaloger DK1107981T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9722898P	1998-08-20	1998-08-20
PCT/US1999/018908 WO2000011023A2 (en)	1998-08-20	1999-08-18	Ring modified cyclic peptide analogs

Publications (1)

Publication Number	Publication Date
DK1107981T3 true DK1107981T3 (da)	2005-05-30

Family

ID=22262272

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99942321T DK1107981T3 (da)	1998-08-20	1999-08-18	Syntese af ringmodificerede, cykliske peptidanaloger

Country Status (11)

Country	Link
US (2)	US6653281B1 (de)
EP (1)	EP1107981B1 (de)
JP (1)	JP2002528388A (de)
AT (1)	ATE287899T1 (de)
AU (1)	AU765660B2 (de)
CA (1)	CA2340676A1 (de)
DE (1)	DE69923460T2 (de)
DK (1)	DK1107981T3 (de)
ES (1)	ES2233070T3 (de)
PT (1)	PT1107981E (de)
WO (1)	WO2000011023A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6743777B1 (en) *	1992-03-19	2004-06-01	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US6323176B1 (en)	1998-02-25	2001-11-27	Eli Lilly And Company	Cyclic peptide antifungal agents
EP1107981B1 (de)	1998-08-20	2005-01-26	Eli Lilly & Company	Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
AU766091B2 (en)	1998-12-09	2003-10-09	Eli Lilly And Company	Purification of echinocandin cyclopeptide compounds
KR20020002476A (ko)	1999-03-03	2002-01-09	피터 지. 스트링거	결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
EP1582204B1 (de) *	1999-03-03	2013-09-25	Eli Lilly & Company	Echinocandin pharmazeutische Zusammensetzungen enthaltend Mizellen bildende Tenside
JP2002538097A (ja)	1999-03-03	2002-11-12	イーライリリーアンドカンパニー	薬学的経口ｅｃｂ処方物および組成物の作製方法
WO2000052037A1 (en) *	1999-03-03	2000-09-08	Eli Lilly And Company	Echinocandin/carbohydrate complexes
TWI232102B (en)	2001-07-17	2005-05-11	Shionogi & Co	A pharmaceutical formulation for injection
US6991800B2 (en) *	2002-06-13	2006-01-31	Vicuron Pharmaceuticals Inc.	Antifungal parenteral products
US9678083B2 (en) *	2009-10-14	2017-06-13	Dana-Farber Cancer Institute, Inc.	Protected amine labels and use in detecting analytes
PL243656B1 (pl) *	2018-05-30	2023-09-25	Boruta Zachem Biochemia Spolka Z Ograniczona Odpowiedzialnoscia	Sposób usuwania lipopeptydów z roztworów i zmiana ich struktury
AR122707A1 (es) *	2020-06-23	2022-09-28	Genentech Inc	Compuestos macrocíclicos y métodos de uso de los mismos

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4320052A (en)	1979-12-13	1982-03-16	Eli Lilly And Company	Derivatives of A-30912A nucleus
US4293489A (en)	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912A nucleus
US5166135A (en)	1988-09-12	1992-11-24	Merck & Company, Inc.	Method for the control of pneumocystis carinii
DK173802B1 (da)	1988-09-12	2001-11-05	Merck & Co Inc	Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
CA2037957A1 (en)	1990-03-12	1991-09-13	Merck & Co., Inc.	N-acylated cyclohexapeptide compounds
GB2241956A (en)	1990-03-16	1991-09-18	Merck & Co Inc	N-acylated cyclohexapeptide compounds
IL97347A0 (en)	1990-03-19	1992-05-25	Merck & Co Inc	Lipopeptide derivatives and antimicrobial compositions containing them
US5330973A (en)	1990-03-19	1994-07-19	Merck & Co., Inc.	Lipopeptide derivatives
US5310726A (en)	1990-03-19	1994-05-10	Merck & Co., Inc.	Lipopeptide compounds
US5386009A (en)	1990-03-19	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
US5049546A (en)	1990-03-19	1991-09-17	Merck & Co., Inc.	Antibiotic agents
IL98506A (en)	1990-06-18	1996-09-12	Fujisawa Pharmaceutical Co	Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
US5337405A (en)	1990-10-02	1994-08-09	Hewlett-Packard Company	Guided data presentation
US5369093A (en)	1991-03-15	1994-11-29	Merck & Co., Inc.	Lipopeptide derivatives
US5233023A (en)	1991-07-30	1993-08-03	Merck & Co., Inc.	Process for phosphate ester compounds of certain cyclohexapeptides
IL122315A (en)	1992-03-19	2002-03-10	Lilly Co Eli	Cyclic peptides and antifungal pharmaceutical compositions containing them
US5965525A (en)	1992-03-19	1999-10-12	Eli Lilly And Company	Cyclic peptide antifungal agents
US5541160A (en)	1994-04-04	1996-07-30	Merck & Co., Inc.	Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en)	1995-04-07	1997-07-08	Eli Lilly And Company	Cyclic peptide antifungal Agents
CA2217859A1 (en)	1995-05-10	1996-11-14	David Alan Owen	Peptidyl compounds which inhibit metalloproteinase and tnf liberation and their therapeutic use
US5618787A (en)	1995-05-26	1997-04-08	Eli Lilly And Company	Cyclic peptide antifungal agents
US5652213A (en)	1995-05-26	1997-07-29	Eli Lilly And Company	Cyclic peptide antifungal agents
US5786325A (en)	1995-05-26	1998-07-28	Eli Lilly And Company	Cyclic peptide antifungal agents and methods of making and using
US5629290A (en)	1995-05-26	1997-05-13	Eli Lilly And Company	Cyclic peptide antifungal agents
US5629289A (en)	1995-07-25	1997-05-13	Eli Lilly And Company	Cyclic peptide antifungal agents
AU1851797A (en)	1996-02-01	1997-08-22	Eli Lilly And Company	Cyclic peptide antifungal agents
US5696084A (en)	1996-08-16	1997-12-09	Abbott Laboratories	Amino-lipopetide antifungal agents
WO1999006062A1 (en)	1997-08-04	1999-02-11	Eli Lilly And Company	Cyclic peptide antifungal agents
US6323176B1 (en)	1998-02-25	2001-11-27	Eli Lilly And Company	Cyclic peptide antifungal agents
EP1107981B1 (de) *	1998-08-20	2005-01-26	Eli Lilly & Company	Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
EP1107982B1 (de)	1998-08-28	2004-05-19	Eli Lilly & Company	Reversible borkomplexe von 1,2-(cis)-diol zyklischen peptiden
JP2002535248A (ja)	1998-12-16	2002-10-22	イーライリリーアンドカンパニー	環式ペプチド抗真菌剤
JP2002532513A (ja)	1998-12-16	2002-10-02	イーライリリーアンドカンパニー	糖置換基を有する環式ペプチド抗真菌剤

1999
- 1999-08-18 EP EP99942321A patent/EP1107981B1/de not_active Expired - Lifetime
- 1999-08-18 AT AT99942321T patent/ATE287899T1/de not_active IP Right Cessation
- 1999-08-18 PT PT99942321T patent/PT1107981E/pt unknown
- 1999-08-18 DK DK99942321T patent/DK1107981T3/da active
- 1999-08-18 US US09/763,114 patent/US6653281B1/en not_active Expired - Fee Related
- 1999-08-18 ES ES99942321T patent/ES2233070T3/es not_active Expired - Lifetime
- 1999-08-18 DE DE69923460T patent/DE69923460T2/de not_active Expired - Fee Related
- 1999-08-18 CA CA002340676A patent/CA2340676A1/en not_active Abandoned
- 1999-08-18 AU AU55726/99A patent/AU765660B2/en not_active Ceased
- 1999-08-18 JP JP2000566295A patent/JP2002528388A/ja not_active Abandoned
- 1999-08-18 WO PCT/US1999/018908 patent/WO2000011023A2/en not_active Ceased
2003
- 2003-09-30 US US10/676,575 patent/US6939946B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU765660B2 (en)	2003-09-25
ES2233070T3 (es)	2005-06-01
US6653281B1 (en)	2003-11-25
US6939946B2 (en)	2005-09-06
WO2000011023A3 (en)	2000-06-15
CA2340676A1 (en)	2000-03-02
DE69923460T2 (de)	2007-01-11
EP1107981A2 (de)	2001-06-20
ATE287899T1 (de)	2005-02-15
US20040068094A1 (en)	2004-04-08
PT1107981E (pt)	2005-05-31
WO2000011023A2 (en)	2000-03-02
DE69923460D1 (de)	2005-03-03
AU5572699A (en)	2000-03-14
JP2002528388A (ja)	2002-09-03
EP1107981B1 (de)	2005-01-26

Publication	Publication Date	Title
PT1107981E (pt)	2005-05-31	Sintese de analogos peptidicos ciclicos de anel modificado
TR199800011T1 (xx)	1998-04-21	Benzo$g] kuinolin t�revleri
ATE203025T1 (de)	2001-07-15	Reverse-turnmimetika und damit zusammenhängendes verfahren
EA199900278A1 (ru)	1999-10-28	Модифицированные аминокислоты, содержащие эти соединения лекарственные средства и способ их получения
TR200001012T2 (tr)	2000-09-21	Yeni ariloksi-alkil-dialkilaminler.
TR200201638T2 (tr)	2002-11-21	Yeni imidazo[1,3,5]triazinonlar ve kullanımları
ATE266030T1 (de)	2004-05-15	1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen
DK0703788T3 (da)	2002-05-21	Stabiliseret phenylalaninammoniaklyase
ATE245435T1 (de)	2003-08-15	Totalsynthese des amino hip analogen von didemnin a
DK0775160T3 (da)	2004-10-25	Cycliske hexapeptidsomatostatin-analoger
HUP9900935A2 (hu)	1999-07-28	Baktériumellenes és gombaellenes hatású peptid és eljárás az előállítására
UA42819C2 (uk)	2001-11-15	Ін`єкційний та інфузійний розчин, що містить енрофлокcацин
ATE228535T1 (de)	2002-12-15	Zyklische hexapeptide mit fungizider aktivität
ES2180699T3 (es)	2003-02-16	Agentes antifungicos peptidicos ciclicos.
EA199800034A1 (ru)	1998-08-27	Способ получения n-монозамещенных и n,n'-дизамещенных асимметричных циклических мочевин
DE69319733D1 (de)	1998-08-20	In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation
DE69623635D1 (de)	2002-10-17	Mu-opioidligande: agonisten und antagonisten
NO981340L (no)	1998-03-24	Stabiliserte fosfolipidsammensetninger
SE9800865D0 (sv)	1998-03-16	New Process
FR2766489B1 (fr)	1999-08-27	Derives de streptogramines, leur preparation et les compositions qui les contiennent
NO962620L (no)	1996-08-19	Nye mellomprodukter for syntese av L-aspartyl-D--aminoalkanoyl-(S)-N--alkylbenzylamider anvendbare son kunstige sötningsmidler
NZ506667A (en)	2003-02-28	A process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues
PT946538E (pt)	2003-12-31	Derivados de indano ou de di-hidroindole
NO20014937D0 (no)	2001-10-10	Naturlige pseudomycinprodukter
RU94017615A (ru)	1997-02-27	Способ получения пептида