ZA983618B - Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them - Google Patents

Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them

Info

Publication number: ZA983618B
Authority: ZA; South Africa
Prior art keywords: contain; preparation; pharmaceutical compositions; cyclosporin derivatives; novel cyclosporin
Prior art date: 1997-04-30

Application number

ZA983618A

Other languages

English (en)

Inventor

Michel Evers

Jean-Christophe Carry

Georges Bashiardes

Jean-Christophe Gueguen

Serge Mignani

Bruno Filoche

Claude Bensoussan

Jean-Claude Barriere

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-30

Filing date

1998-04-29

Publication date

1998-11-04

1998-04-29 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1998-11-04 Publication of ZA983618B publication Critical patent/ZA983618B/xx

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA983618A 1997-04-30 1998-04-29 Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them ZA983618B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9705351A FR2762843B1 (fr)	1997-04-30	1997-04-30	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA983618B true ZA983618B (en)	1998-11-04

Family

ID=9506467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA983618A ZA983618B (en)	1997-04-30	1998-04-29	Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them

Country Status (13)

Country	Link
US (1)	US5977067A (de)
EP (1)	EP0979244B1 (de)
JP (1)	JP2001524105A (de)
AT (1)	ATE290015T1 (de)
AU (1)	AU7535798A (de)
DE (1)	DE69829175T2 (de)
ES (1)	ES2236902T3 (de)
FR (1)	FR2762843B1 (de)
MA (1)	MA26488A1 (de)
PT (1)	PT979244E (de)
TN (1)	TNSN98057A1 (de)
WO (1)	WO1998049193A1 (de)
ZA (1)	ZA983618B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
EP2116228A1 (de) *	2001-10-19	2009-11-11	Isotechnika Inc.	Neuartige Cyclosporinanalog-Mikroemulsionspräkonzentrate
WO2003033526A2 (en)	2001-10-19	2003-04-24	Isotechnika Inc.	Synthesis of cyclosporin analogs
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US20060130158A1 (en) *	2002-08-30	2006-06-15	Turner Andrew J	Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains
JP2006524232A (ja)	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	新規サイクロスポリン
ATE488252T1 (de) *	2003-05-05	2010-12-15	Virxsys Corp	Erhöhte transduktion mit abc- transportersubstratenhemmern
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
EP1804823A4 (de)	2004-09-29	2010-06-09	Amr Technology Inc	Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
JP5139065B2 (ja) *	2004-10-01	2013-02-06	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
US8329658B2 (en) *	2005-09-30	2012-12-11	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
BRPI0616476A2 (pt) *	2005-09-30	2011-06-21	Scynexis Inc	uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
EP3103468B1 (de) *	2005-10-14	2020-07-15	Allergan, Inc.	Prävention von mit arzneimitteln in zusammenhang stehenden keratokonjunctivitis mit cyclosporin
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
ATE502633T1 (de)	2006-05-19	2011-04-15	Scynexis Inc	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (de) *	2006-06-02	2009-02-25	Claude Annie Perrichon	Verwaltung von aktieven elektronen
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
US20080255038A1 (en) *	2007-04-11	2008-10-16	Samuel Earl Hopkins	Pharmaceutical compositions
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
US9090671B2 (en)	2008-06-06	2015-07-28	Scynexis, Inc.	Macrocyclic peptides
BRPI0911709A2 (pt) *	2008-07-30	2017-06-20	Isotechnika Labs Inc	composto, processo para a produção de um composto, composição farmacêutica e método de tratar uma doença mediada a ciclofilina em um mamífero
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (de) *	2008-12-31	2017-03-15	Cypralis Limited	Derivate von cyclosporin a
SG173180A1 (en)	2009-01-30	2011-09-29	Enanta Pharm Inc	Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) *	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
WO2010138422A1 (en) *	2009-05-27	2010-12-02	Allergan, Inc.	Cyclosporin derivatives for enhancing the growth of hair
AU2010254316A1 (en) *	2009-05-27	2011-12-22	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
AU2010339460A1 (en)	2009-12-30	2012-07-19	Scynexis Inc.	Cyclosporine analogues
US9175042B2 (en) *	2010-10-12	2015-11-03	Allergan, Inc.	Cyclosporin analogs
RU2013119869A (ru)	2010-10-12	2014-11-20	Аллерган, Инк.	Аналоги циклоспорина
JP6144627B2 (ja)	2010-12-15	2017-06-07	コントラヴィアファーマシューティカルズ、インク．	アミノ酸１および３で修飾されたシクロスポリン類似体分子
DE102011111991A1 (de) *	2011-08-30	2013-02-28	Lead Discovery Center Gmbh	Neue Cyclosporin-Derivate
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
WO2014049540A2 (en)	2012-09-29	2014-04-03	Novartis Ag	Cyclic peptides and use as medicines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
US4798823A (en) *	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
US4885276A (en) *	1987-06-03	1989-12-05	Merck & Co., Inc.	Cyclosporin analogs with modified "C-9 amino acids"
ATE148469T1 (de) *	1990-11-02	1997-02-15	Sandoz Ag	Zyklosporine
US5512555A (en) *	1994-07-21	1996-04-30	Merck & Co., Inc.	Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
PL324531A1 (en) *	1995-07-17	1998-06-08	Chem Ag C	Derivatives of cyclosporin effective against hiv virus

1997
- 1997-04-30 FR FR9705351A patent/FR2762843B1/fr not_active Expired - Fee Related
1998
- 1998-04-27 MA MA25048A patent/MA26488A1/fr unknown
- 1998-04-27 EP EP98922872A patent/EP0979244B1/de not_active Expired - Lifetime
- 1998-04-27 ES ES98922872T patent/ES2236902T3/es not_active Expired - Lifetime
- 1998-04-27 AT AT98922872T patent/ATE290015T1/de active
- 1998-04-27 PT PT98922872T patent/PT979244E/pt unknown
- 1998-04-27 AU AU75357/98A patent/AU7535798A/en not_active Abandoned
- 1998-04-27 WO PCT/FR1998/000838 patent/WO1998049193A1/fr not_active Ceased
- 1998-04-27 DE DE69829175T patent/DE69829175T2/de not_active Expired - Lifetime
- 1998-04-27 JP JP54666498A patent/JP2001524105A/ja active Pending
- 1998-04-29 ZA ZA983618A patent/ZA983618B/xx unknown
- 1998-04-29 TN TNTNSN98057A patent/TNSN98057A1/fr unknown
- 1998-04-30 US US09/069,959 patent/US5977067A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0979244A1 (de)	2000-02-16
DE69829175T2 (de)	2006-02-16
ES2236902T3 (es)	2005-07-16
WO1998049193A1 (fr)	1998-11-05
MA26488A1 (fr)	2004-12-20
ATE290015T1 (de)	2005-03-15
FR2762843A1 (fr)	1998-11-06
PT979244E (pt)	2005-06-30
DE69829175D1 (de)	2005-04-07
TNSN98057A1 (fr)	2005-03-15
AU7535798A (en)	1998-11-24
US5977067A (en)	1999-11-02
FR2762843B1 (fr)	1999-12-10
EP0979244B1 (de)	2005-03-02
JP2001524105A (ja)	2001-11-27

Publication	Publication Date	Title
AU7535798A (en)	1998-11-24	Novel cyclosporin derivatives, preparation and pharmaceutical compositions containing same
ZA9711607B (en)	1998-06-24	Novel cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
ZA9711606B (en)	1998-06-25	Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
AUPR213700A0 (en)	2001-01-25	Antiviral agents
CA2293823A1 (en)	1998-12-17	4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
ZA200104396B (en)	2002-11-29	Compositions and methods for stimulating gastrointestinal motility.
LTIP862A (en)	1995-03-27	Method for preparing amino acid derivatives and pharmaceuthical compositions thereof
BG103947A (en)	2000-07-31	Derivatives of 9-oxymerythromycin
CA2292359A1 (en)	2000-07-28	Novel azalides and methods of making same
KR0141913B1 (en)	1998-06-01	Anti-virus agents
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
CZ77995A3 (en)	1995-10-18	Derivatives of lipopeptides, process of their preparation and use
HU9601649D0 (en)	1996-08-28	Hiv protease inhibitors
MD1560F2 (en)	2000-11-30	Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
GR3019274T3 (en)	1996-06-30	Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use
CA2282279A1 (en)	1998-09-03	Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions
PH31395A (en)	1998-10-29	Bis-naphthalimides for the treatment of cancer.
ZA981430B (en)	1998-08-24	Anticancer composition
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
IL112110A0 (en)	1995-03-15	Octahydro-1h-isoindoles and pharmaceutical compositions containing them
GR3023941T3 (en)	1997-09-30	Cyclic derivatives of angiopeptin, their preparation and their pharmaceutical compositions.
AP2002002494A0 (en)	2002-06-30	Hygromycin derivatives.
CA2352332A1 (en)	2000-06-08	Hygromycin a derivatives
EP1451184A4 (de)	2005-02-02	Dimere verbindungen und deren verwendung als antivirale mittel
MXPA99003849A (es)	2003-09-23	Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina.