ATE290880T1 - Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält - Google Patents
Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthältInfo
- Publication number
- ATE290880T1 ATE290880T1 AT01936440T AT01936440T ATE290880T1 AT E290880 T1 ATE290880 T1 AT E290880T1 AT 01936440 T AT01936440 T AT 01936440T AT 01936440 T AT01936440 T AT 01936440T AT E290880 T1 ATE290880 T1 AT E290880T1
- Authority
- AT
- Austria
- Prior art keywords
- inosine
- cytosine
- composition containing
- polycationic peptide
- antigen composition
- Prior art date
Links
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229930010555 Inosine Natural products 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 229940104302 cytosine Drugs 0.000 title 1
- 229960003786 inosine Drugs 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
| PCT/EP2001/006437 WO2001093903A1 (en) | 2000-06-08 | 2001-06-07 | Antigenic composition comprising a polycationic peptide and inosine and cytosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290880T1 true ATE290880T1 (de) | 2005-04-15 |
Family
ID=3683921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
| AT01936440T ATE290880T1 (de) | 2000-06-08 | 2001-06-07 | Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7148191B2 (de) |
| EP (1) | EP1286695B1 (de) |
| AT (2) | AT410173B (de) |
| AU (1) | AU2001262345A1 (de) |
| DE (1) | DE60109443T2 (de) |
| WO (1) | WO2001093903A1 (de) |
| ZA (1) | ZA200209479B (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ520200A (en) * | 1999-12-22 | 2004-04-30 | Aventis Pasteur | Polynucleotides encoding the Clamydia pneumoniae polypeptides omp P6 precursor gene product |
| DE60100814T2 (de) | 2000-06-08 | 2004-07-01 | Intercell Biomedizinische Forschungs- Und Entwicklungs Gmbh | Immunstimulierende oligodeoxynukleotide |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| AU2001297693A1 (en) * | 2000-12-08 | 2002-09-12 | Coley Pharmaceutical Gmbh | Cpg-like nucleic acids and methods of use thereof |
| CA2433561C (en) * | 2001-01-03 | 2014-04-01 | Willmar Poultry Company, Inc. | Compositions including gram negative siderophore receptor proteins and methods of use |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| JP2004519453A (ja) * | 2001-01-05 | 2004-07-02 | インターツェル・アクチェンゲゼルシャフト | ポリカチオン性化合物の用途 |
| WO2003047602A1 (en) * | 2001-12-07 | 2003-06-12 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US20050221381A1 (en) * | 2002-02-28 | 2005-10-06 | Christof Klade | Method for isolating ligands |
| US20060057104A1 (en) * | 2002-04-24 | 2006-03-16 | The Regents Of The University Of California Office Of The President | Methods for stimulating tlr irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses |
| US7439349B2 (en) * | 2002-07-03 | 2008-10-21 | Andres Salazar | Method for preparation of large volume batches of poly-ICLC with increased biological potency; therapeutic, clinical and veterinary uses thereof |
| WO2004011650A2 (en) * | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| WO2004024182A2 (en) * | 2002-09-13 | 2004-03-25 | Intercell Ag | Method for isolating hepatitis c virus peptides |
| EP2314604A3 (de) | 2002-10-15 | 2011-05-25 | Intercell AG | Bindungdsfaktoren von Gruppe B-Streptococcus, dafür kodierende Nukleinsäuren und Verwendungen davon |
| WO2004055041A2 (en) * | 2002-12-13 | 2004-07-01 | Case Western Reserve University | Defensin-inducing peptides from fusobacterium |
| EP2287314A1 (de) | 2003-03-04 | 2011-02-23 | Intercell AG | Streptococcus-pyogenes-Antigene |
| US7704514B2 (en) | 2003-03-24 | 2010-04-27 | Intercell Ag | Vaccines |
| CN101214375B (zh) * | 2003-03-24 | 2011-04-06 | 英特塞尔股份公司 | 改进的疫苗 |
| ATE449177T1 (de) | 2003-03-31 | 2009-12-15 | Intercell Ag | Staphylococcus epidermidis antigene |
| JP2007525157A (ja) | 2003-04-15 | 2007-09-06 | インターツェル・アクチェンゲゼルシャフト | 肺炎連鎖球菌抗原 |
| CN101864431A (zh) | 2003-05-07 | 2010-10-20 | 英特塞尔股份公司 | 无乳链球菌抗原ⅰ和ⅱ |
| WO2004106367A2 (en) | 2003-05-30 | 2004-12-09 | Intercell Ag | Enterococcus antigens |
| EP1678316B1 (de) * | 2003-09-19 | 2011-08-17 | Epitopix, LLC | Campylobacter-polypeptide und verwendungsverfahren |
| US20090060875A1 (en) * | 2004-10-29 | 2009-03-05 | Intercell Ag | HCV Vaccines for Chronic HCV Patients |
| NZ560612A (en) * | 2005-02-14 | 2011-01-28 | Epitopix Llc | Polypeptides from staphylococcus aureus and methods of use |
| AU2007264205B2 (en) | 2006-06-28 | 2013-04-18 | Statens Serum Institut | Expanding the T cell repertoire to include subdominant epitopes by vaccination with antigens delivered as protein fragments or peptide cocktails |
| US8529911B2 (en) | 2006-07-07 | 2013-09-10 | Intercell Austria Ag | Small Streptococcus pyogenes antigens and their use |
| CA2661224A1 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
| EP1923069A1 (de) | 2006-11-20 | 2008-05-21 | Intercell AG | Schutzpeptide gegen S. pneumoniae und diesbezügliche Zusammensetzungen, Verfahren und Verwendungen |
| EP2269624A3 (de) | 2007-01-12 | 2012-08-08 | Intercell AG | Schützende Proteine von S. agalactiae, Kombinationen davon und Verwendungsverfahren dafür |
| MX2009009530A (es) * | 2007-03-07 | 2010-05-19 | Nventa Biopharmaceuticals Corp | Composiciones de acidos nucleicos cerrados bicatenarios. |
| EP2152731A2 (de) * | 2007-05-02 | 2010-02-17 | Intercell AG | Klebsiella-antigene |
| EP2012122A1 (de) | 2007-07-06 | 2009-01-07 | Medigene AG | Strukturproteine von mutierten Parvoviren als Impfstoffe |
| US20100203083A1 (en) | 2007-05-31 | 2010-08-12 | Medigene Ag | Mutated structural protein of a parvovirus |
| AU2008265218A1 (en) | 2007-06-18 | 2008-12-24 | Intercell Ag | Chlamydia antigens |
| ES2588705T3 (es) | 2007-09-27 | 2016-11-04 | Immunovaccine Technologies Inc. | Uso de liposomas en un vehículo que comprende una fase hidrófoba continua para la entrega de polinucleótidos in vivo |
| US20110038888A1 (en) * | 2008-01-10 | 2011-02-17 | Peter Emtage | Adjuvant compositions comprising poly-ic and a cationic polymer |
| EP2265634A2 (de) | 2008-03-17 | 2010-12-29 | Intercell AG | Peptide schutzmittel gegen s. pneumoniae und zusammensetzungen, verfahren und anwendung im zusammenhang damit |
| CA2723918C (en) | 2008-06-05 | 2018-01-09 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
| CN102076358B (zh) | 2008-06-27 | 2016-08-17 | 硕腾有限责任公司 | 新颖的佐剂组合物 |
| US20130243779A1 (en) | 2009-02-05 | 2013-09-19 | Intercell Ag | Peptides protective against e. faecalis, methods and uses relating thereto |
| WO2010092176A2 (en) | 2009-02-13 | 2010-08-19 | Intercell Ag | Nontypable haemophilus influenzae antigens |
| EP2411046B1 (de) | 2009-03-23 | 2017-12-06 | Epitopix, LLC | Polypeptide und immunisierungszusammensetzungen mit gram-prositiven polypeptiden und anwendungsverfahren |
| EP2319871A1 (de) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptide zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| WO2011042548A1 (en) | 2009-10-09 | 2011-04-14 | Sanofi-Aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
| EP2308896A1 (de) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| CN103957931B (zh) | 2010-09-03 | 2017-10-24 | 瓦尔内瓦奥地利有限责任公司 | 艰难梭状芽胞杆菌毒素a和毒素b蛋白的分离多肽及其用途 |
| WO2012031760A1 (en) | 2010-09-08 | 2012-03-15 | Medigene Ag | Parvovirus mutated structural proteins comprising cross - protective b - cell epitopes of a hpv l2 protein as well as products and methods relating thereto |
| WO2012139094A2 (en) | 2011-04-08 | 2012-10-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of developing a vaccine using peptide-poly ic complexes |
| RU2730011C2 (ru) | 2013-09-19 | 2020-08-14 | Зоэтис Сервисиз Ллс | Адъюванты на масляной основе |
| FI3244920T3 (fi) | 2015-01-16 | 2023-08-04 | Zoetis Services Llc | Suu- ja sorkkatautirokote |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| WO2019158636A1 (en) | 2018-02-16 | 2019-08-22 | 2A Pharma Ab | Parvovirus structural protein for the treatment of autoimmune diseases |
| EP3527223A1 (de) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutiertes parvovirus-strukturprotein |
| CN114127101A (zh) | 2019-05-20 | 2022-03-01 | 瓦尔尼瓦公司 | 用于治疗或预防呼吸道感染的亚单位疫苗 |
| US12214028B2 (en) | 2019-05-31 | 2025-02-04 | Universidad De Chile | Immunogenic formulation that induces protection against shiga toxin-producing Escherichia coli (STEC) |
| EP4058056A1 (de) | 2020-10-07 | 2022-09-21 | Valneva Sweden AB | Cholera-impfstoffformulierung |
| EP4319804A2 (de) | 2021-04-09 | 2024-02-14 | Valneva SE | Impfstoff gegen humanes metapneumovirus |
| WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
| US20250213667A1 (en) | 2022-06-01 | 2025-07-03 | Valneva Austria Gmbh | Clostridium difficile vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6801650D0 (pt) | 1968-08-20 | 1973-03-07 | R Maes | Processo para preparacao de complexos geradores de interferon |
| US3725545A (en) * | 1971-02-03 | 1973-04-03 | R Maes | Enhancement of antibody production by nucleic acid-polycation complexes |
| CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
| AU3891097A (en) | 1996-07-24 | 1998-02-10 | Michelle M. Hanna | Base-protected nucleotide analogs with protected thiol groups |
| EP1272215B1 (de) * | 2000-04-14 | 2007-10-10 | Intercell AG | Modifizierte peptide enthaltende pharmazeutische präparationen |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
-
2000
- 2000-06-08 AT AT0100000A patent/AT410173B/de not_active IP Right Cessation
-
2001
- 2001-06-07 DE DE60109443T patent/DE60109443T2/de not_active Expired - Lifetime
- 2001-06-07 EP EP01936440A patent/EP1286695B1/de not_active Expired - Lifetime
- 2001-06-07 AT AT01936440T patent/ATE290880T1/de active
- 2001-06-07 AU AU2001262345A patent/AU2001262345A1/en not_active Abandoned
- 2001-06-07 US US10/297,497 patent/US7148191B2/en not_active Expired - Lifetime
- 2001-06-07 WO PCT/EP2001/006437 patent/WO2001093903A1/en not_active Ceased
-
2002
- 2002-11-21 ZA ZA200209479A patent/ZA200209479B/en unknown
-
2006
- 2006-12-12 US US11/609,777 patent/US20070218073A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60109443T2 (de) | 2006-04-13 |
| ZA200209479B (en) | 2003-11-21 |
| WO2001093903A1 (en) | 2001-12-13 |
| AU2001262345A1 (en) | 2001-12-17 |
| EP1286695A1 (de) | 2003-03-05 |
| US20070218073A1 (en) | 2007-09-20 |
| US7148191B2 (en) | 2006-12-12 |
| US20030162738A1 (en) | 2003-08-28 |
| AT410173B (de) | 2003-02-25 |
| DE60109443D1 (de) | 2005-04-21 |
| ATA10002000A (de) | 2002-07-15 |
| EP1286695B1 (de) | 2005-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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