ATE290880T1 - Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält - Google Patents
Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthältInfo
- Publication number
- ATE290880T1 ATE290880T1 AT01936440T AT01936440T ATE290880T1 AT E290880 T1 ATE290880 T1 AT E290880T1 AT 01936440 T AT01936440 T AT 01936440T AT 01936440 T AT01936440 T AT 01936440T AT E290880 T1 ATE290880 T1 AT E290880T1
- Authority
- AT
- Austria
- Prior art keywords
- inosine
- cytosine
- composition containing
- polycationic peptide
- antigen composition
- Prior art date
Links
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229930010555 Inosine Natural products 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 229940104302 cytosine Drugs 0.000 title 1
- 229960003786 inosine Drugs 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
| PCT/EP2001/006437 WO2001093903A1 (en) | 2000-06-08 | 2001-06-07 | Antigenic composition comprising a polycationic peptide and inosine and cytosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290880T1 true ATE290880T1 (de) | 2005-04-15 |
Family
ID=3683921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
| AT01936440T ATE290880T1 (de) | 2000-06-08 | 2001-06-07 | Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7148191B2 (de) |
| EP (1) | EP1286695B1 (de) |
| AT (2) | AT410173B (de) |
| AU (1) | AU2001262345A1 (de) |
| DE (1) | DE60109443T2 (de) |
| WO (1) | WO2001093903A1 (de) |
| ZA (1) | ZA200209479B (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1240331B1 (de) * | 1999-12-22 | 2010-04-07 | Aventis Pasteur Limited | Chlamydia antigene, entsprechende dns fragmente und ihre verwendungen |
| HU228264B1 (en) | 2000-06-08 | 2013-02-28 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| WO2002069369A2 (en) * | 2000-12-08 | 2002-09-06 | Coley Pharmaceutical Gmbh | Cpg-like nucleic acids and methods of use thereof |
| DK1353689T3 (da) * | 2001-01-03 | 2006-07-31 | Epitopix Llc | Immuniseringspræparater og anvendelse deraf |
| EP1347775B1 (de) | 2001-01-05 | 2016-11-30 | Valneva Austria GmbH | Gebrauch von polykationischen substanzen als adjuvantien für impfstoffe |
| WO2002053185A2 (en) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Anti-inflammatory use of polycationic compounds |
| US20050250716A1 (en) * | 2001-12-07 | 2005-11-10 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| EP1483575A2 (de) * | 2002-02-28 | 2004-12-08 | Intercell AG | Verfahren zur isolierung von liganden z.b. t zell epitopen |
| WO2003090685A2 (en) * | 2002-04-24 | 2003-11-06 | The Regents Of The University Of California | Methods for stimulating tlr/irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses |
| EP1778186B1 (de) * | 2002-07-03 | 2011-11-30 | Oncovir, Inc. | Verfahren zur herstellung von poly-iclc und seine verwendung |
| JP2005533855A (ja) | 2002-07-24 | 2005-11-10 | インターツェル・アクチェンゲゼルシャフト | 病原性ウイルスからの別のリーディングフレームによりコードされる抗原 |
| EP1537418A2 (de) | 2002-09-13 | 2005-06-08 | Intercell AG | Verfahren zur isolierung von hepatitis c virus peptiden |
| JP5116971B2 (ja) | 2002-10-15 | 2013-01-09 | インターセル アーゲー | Ｂ群連鎖球菌の接着因子をコードする核酸、ｂ群連鎖球菌の接着因子、およびその使用 |
| AU2003297317A1 (en) * | 2002-12-13 | 2004-07-09 | Case Western Reserve University | Defensin-inducing peptides from fusobacterium |
| CN1756843B (zh) | 2003-03-04 | 2012-03-21 | 英特塞尔股份公司 | 化脓链球菌抗原 |
| AU2004224746B2 (en) | 2003-03-24 | 2009-04-23 | Valneva Austria Gmbh | Improved vaccines |
| ES2351489T3 (es) * | 2003-03-24 | 2011-02-07 | Intercell Ag | Vacunas mejoradas. |
| AU2004226262A1 (en) | 2003-03-31 | 2004-10-14 | Intercell Ag | Staphylococcus epidermidis antigens |
| US7635487B2 (en) | 2003-04-15 | 2009-12-22 | Intercell Ag | S. pneumoniae antigens |
| EP1620460A2 (de) | 2003-05-07 | 2006-02-01 | Intercell AG | Streptococcus agalactiae-antigene i + ii |
| EP1629005A2 (de) | 2003-05-30 | 2006-03-01 | Intercell AG | Antigene aus enterococcus |
| US8329192B2 (en) | 2003-09-19 | 2012-12-11 | Epitopix Llc | Campylobacter polypeptides and methods of use |
| WO2006045677A1 (en) * | 2004-10-29 | 2006-05-04 | Intercell Ag | Hcv vaccines for chronic hcv patients |
| NZ597997A (en) | 2005-02-14 | 2013-10-25 | Epitopix Llc | Antibody compositions that bind polypeptides from staphylococcus aureus |
| KR20090024292A (ko) | 2006-06-28 | 2009-03-06 | 스태튼스 세룸 인스티튜트 | 단백질 단편 또는 펩타이드 혼합물로서 전달되는 항원을 가진 백신접종에 의해 준우성 항원결정기를 포함하는 ｔ세포 레퍼토리 확장 |
| EP2292647A3 (de) | 2006-07-07 | 2011-06-08 | Intercell AG | Kleine Streptococcus-pyogenes-Antigene und Verwendung dafür |
| EP2289906A1 (de) | 2006-09-15 | 2011-03-02 | Intercell AG | Borrelia-Antigene |
| EP1923069A1 (de) | 2006-11-20 | 2008-05-21 | Intercell AG | Schutzpeptide gegen S. pneumoniae und diesbezügliche Zusammensetzungen, Verfahren und Verwendungen |
| EP2266592A3 (de) | 2007-01-12 | 2012-08-08 | Intercell AG | Schützende Proteine von S. agalactiae, Kombinationen davon und Verwendungsverfahren dafür |
| CN101687900A (zh) * | 2007-03-07 | 2010-03-31 | 恩文塔生物制药公司 | 双链锁核酸组合物 |
| CA2685805A1 (en) | 2007-05-02 | 2008-11-13 | Intercell Ag | Klebsiella antigens |
| EP2158211B1 (de) | 2007-05-31 | 2016-08-10 | Medigene AG | Mutiertes strukturprotein eines parvovirus |
| EP2012122A1 (de) | 2007-07-06 | 2009-01-07 | Medigene AG | Strukturproteine von mutierten Parvoviren als Impfstoffe |
| EP2511291A3 (de) | 2007-06-18 | 2012-11-07 | Intercell AG | Chlamydia-Antigene |
| ES2588705T3 (es) | 2007-09-27 | 2016-11-04 | Immunovaccine Technologies Inc. | Uso de liposomas en un vehículo que comprende una fase hidrófoba continua para la entrega de polinucleótidos in vivo |
| US20110038888A1 (en) * | 2008-01-10 | 2011-02-17 | Peter Emtage | Adjuvant compositions comprising poly-ic and a cationic polymer |
| AU2009226949A1 (en) | 2008-03-17 | 2009-09-24 | Intercell Ag | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
| CA2723918C (en) | 2008-06-05 | 2018-01-09 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| EP2424882A2 (de) | 2009-02-05 | 2012-03-07 | Intercell AG | Gegen e.-faecalis schützende peptide, verfahren und anwendungen, die damit in zusammenhang stehen |
| EP2405938A2 (de) | 2009-02-13 | 2012-01-18 | Intercell AG | Nicht typisierbare haemophilus influenza-antigene |
| NZ614557A (en) | 2009-03-23 | 2015-03-27 | Epitopix Llc | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use |
| PH12012500564A1 (en) | 2009-10-09 | 2012-10-22 | Sanofi Sa | Polypeptides for binding to the receptor for advanced glycation endproducts as well as compositions and methods involving the same |
| EP2308896A1 (de) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| EP2319871A1 (de) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptide zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| KR101907434B1 (ko) | 2010-09-03 | 2018-10-12 | 발네바 오스트리아 게엠베하 | C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도 |
| AR082925A1 (es) | 2010-09-08 | 2013-01-16 | Medigene Ag | Proteinas estructurales mutadas por parvovirus con epitopo de celulas b de proteccion cruzada, producto y metodos relacionados |
| WO2012139094A2 (en) | 2011-04-08 | 2012-10-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of developing a vaccine using peptide-poly ic complexes |
| KR20200039025A (ko) | 2013-09-19 | 2020-04-14 | 조에티스 서비시즈 엘엘씨 | 유성 아쥬반트 |
| MX391930B (es) | 2015-01-16 | 2025-03-21 | Zoetis Services Llc | Vacuna contra la fiebre aftosa. |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| EP3527223A1 (de) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutiertes parvovirus-strukturprotein |
| CN112074295A (zh) | 2018-02-16 | 2020-12-11 | 2A制药公司 | 用于治疗自身免疫性疾病的细小病毒结构蛋白 |
| KR20220010478A (ko) | 2019-05-20 | 2022-01-25 | 발네바 에스이 | 기도 감염의 치료 또는 예방용 서브유닛 백신 |
| WO2020240268A1 (en) | 2019-05-31 | 2020-12-03 | Universidad De Chile | An immunogenic formulation that induces protection against shiga toxin-producing escherichia coli (stec) |
| WO2022074061A1 (en) | 2020-10-07 | 2022-04-14 | Valneva Sweden Ab | Cholera vaccine formulation |
| KR20230167017A (ko) | 2021-04-09 | 2023-12-07 | 발네바 에스이 | 인간 메타뉴모 바이러스 백신 |
| WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
| WO2023232901A1 (en) | 2022-06-01 | 2023-12-07 | Valneva Austria Gmbh | Clostridium difficile vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6801650D0 (pt) * | 1968-08-20 | 1973-03-07 | R Maes | Processo para preparacao de complexos geradores de interferon |
| US3725545A (en) * | 1971-02-03 | 1973-04-03 | R Maes | Enhancement of antibody production by nucleic acid-polycation complexes |
| CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
| CA2261892A1 (en) * | 1996-07-24 | 1998-01-29 | Michelle M. Hanna | Base-protected nucleotide analogs with protected thiol groups |
| EP1272215B1 (de) * | 2000-04-14 | 2007-10-10 | Intercell AG | Modifizierte peptide enthaltende pharmazeutische präparationen |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
-
2000
- 2000-06-08 AT AT0100000A patent/AT410173B/de not_active IP Right Cessation
-
2001
- 2001-06-07 US US10/297,497 patent/US7148191B2/en not_active Expired - Lifetime
- 2001-06-07 AT AT01936440T patent/ATE290880T1/de active
- 2001-06-07 EP EP01936440A patent/EP1286695B1/de not_active Expired - Lifetime
- 2001-06-07 AU AU2001262345A patent/AU2001262345A1/en not_active Abandoned
- 2001-06-07 WO PCT/EP2001/006437 patent/WO2001093903A1/en not_active Ceased
- 2001-06-07 DE DE60109443T patent/DE60109443T2/de not_active Expired - Lifetime
-
2002
- 2002-11-21 ZA ZA200209479A patent/ZA200209479B/en unknown
-
2006
- 2006-12-12 US US11/609,777 patent/US20070218073A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATA10002000A (de) | 2002-07-15 |
| AT410173B (de) | 2003-02-25 |
| ZA200209479B (en) | 2003-11-21 |
| US20070218073A1 (en) | 2007-09-20 |
| US20030162738A1 (en) | 2003-08-28 |
| US7148191B2 (en) | 2006-12-12 |
| DE60109443T2 (de) | 2006-04-13 |
| DE60109443D1 (de) | 2005-04-21 |
| EP1286695A1 (de) | 2003-03-05 |
| EP1286695B1 (de) | 2005-03-16 |
| WO2001093903A1 (en) | 2001-12-13 |
| AU2001262345A1 (en) | 2001-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60109443D1 (de) | Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält | |
| CY1118443T1 (el) | Anti-tnf αντισωματα, συνθεσεις, μεθοδοι και χρησεις | |
| ATE500323T1 (de) | Subtilisin-variante | |
| NZ503763A (en) | Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use | |
| ATE404583T1 (de) | Funktionelle antagonisten von hedgehog-aktivität | |
| TR200003513T2 (tr) | Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları | |
| AR038568A1 (es) | Anticuerpos anti-a beta y su uso | |
| DE60037450D1 (de) | Funf-helix protein | |
| SE0002102D0 (sv) | Chemical compound | |
| IL195338A (en) | An antibody comprising an FC variant containing amino acid replaces d or e at position 239, a medicament containing it and its use | |
| CL2009000575A1 (es) | Anticuerpos aislados anti-interleuquina 12 (anti il-12) de mamiferos, secuencia de nucleotidos, vector, celula y metodo de produccion, composicion y dispositivo medico que contienen, util en el diagnostico y tratamiento de condicones relacionadas con il-12. | |
| YU9403A (sh) | Anti-dualna antitela integrina, kompozicije, postupci i primene | |
| CY1117746T1 (el) | Αντιγονα αιμοφιλου της γριπης και αντιστοιχα θραυσματα dna | |
| ATE247484T1 (de) | Von der telomerase abgeleitete antigene peptide | |
| BR9710968A (pt) | Antìgenos de célula b humana; reagentes correlatos | |
| BR0114646A (pt) | anticorpos anti-lt-beta-r humanizados | |
| NI200800193A (es) | Anticuerpos humanos anti-il-23, composiciones, métodos y usos. | |
| ATE267211T1 (de) | Impfstoff gegen hpv | |
| TR199900267T2 (xx) | GnRH-L�kotoksin kimeralar�. | |
| DE69111440D1 (de) | Methoden und zusammensetzungen zur impfung gegen hiv. | |
| ATE384119T1 (de) | Isoprenoidproduktion | |
| DE50112802D1 (de) | Peptide, deren herstellung und verwendung zur bindung von immunglobulinen | |
| DE60129572D1 (de) | Verwendung von antikörpern gegen spezifische mhc-peptidkomplexe | |
| DK1417222T3 (da) | Isolerede polypeptider baseret på den neutraliserende epitop af p17-proteinet fra HIV egnet til vacciner samt neutraliserende anti-p17-antistoffer, der specifikt genkender nævnte neutraliserende epitop | |
| TR200103339T2 (tr) | Geliştirilmiş çözülürlük özelliklerine sahip yeni LHRH-antagonistleri. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1286695 Country of ref document: EP |