ATE291003T1 - Synthese von vicinalen difluoraromaten und zwischenprodukte davon - Google Patents

Synthese von vicinalen difluoraromaten und zwischenprodukte davon

Info

Publication number
ATE291003T1
ATE291003T1 AT02001040T AT02001040T ATE291003T1 AT E291003 T1 ATE291003 T1 AT E291003T1 AT 02001040 T AT02001040 T AT 02001040T AT 02001040 T AT02001040 T AT 02001040T AT E291003 T1 ATE291003 T1 AT E291003T1
Authority
AT
Austria
Prior art keywords
vicinal
difluorous
aromatics
synthesis
intermediate products
Prior art date
Application number
AT02001040T
Other languages
English (en)
Inventor
Gauri Sankar Lal
Kathryn Sue Hayes
Original Assignee
Air Prod & Chem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Prod & Chem filed Critical Air Prod & Chem
Application granted granted Critical
Publication of ATE291003T1 publication Critical patent/ATE291003T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C19/00—Acyclic saturated compounds containing halogen atoms
    • C07C19/08—Acyclic saturated compounds containing halogen atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/18—Preparation of halogenated hydrocarbons by replacement by halogens of oxygen atoms of carbonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/23—Preparation of halogenated hydrocarbons by dehalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT02001040T 2001-01-23 2002-01-18 Synthese von vicinalen difluoraromaten und zwischenprodukte davon ATE291003T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76763601A 2001-01-23 2001-01-23
US09/985,786 US6455744B1 (en) 2001-01-23 2001-11-06 Synthesis of vicinal difluoro aromatics and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE291003T1 true ATE291003T1 (de) 2005-04-15

Family

ID=27117937

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02001040T ATE291003T1 (de) 2001-01-23 2002-01-18 Synthese von vicinalen difluoraromaten und zwischenprodukte davon

Country Status (7)

Country Link
US (3) US6455744B1 (de)
EP (1) EP1225162B1 (de)
JP (1) JP3898515B2 (de)
KR (1) KR100462665B1 (de)
AT (1) ATE291003T1 (de)
DE (1) DE60203200T2 (de)
TW (1) TWI245031B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6894200B2 (en) * 2001-01-23 2005-05-17 Air Products And Chemicals, Inc. Synthesis of vicinal difluoro aromatics and intermediates thereof
US7259150B2 (en) 2001-08-07 2007-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein (a) expression
DE10225427A1 (de) * 2002-06-07 2003-12-18 Merck Patent Gmbh Fluorierte Naphthaline, diese enthaltende Flüssigkristallmischungen und Flüssigkristallanzeigen
DE102004022728B4 (de) * 2004-05-07 2018-08-23 Merck Patent Gmbh Fluorierte Phenanthrene und ihre Verwendung in Flüssigkristallmischungen
CN100372519C (zh) * 2005-01-06 2008-03-05 辽宁绿丹药业有限公司 左炔诺孕酮硅胶棒药物填充方法
US7939575B2 (en) * 2007-02-23 2011-05-10 Dentsply International, Inc. Methods for making dental restorations using two-phase light-curing materials
US20160002624A1 (en) 2012-05-17 2016-01-07 Isis Pharmaceuticals, Inc. Antisense oligonucleotide compositions
US9574193B2 (en) 2012-05-17 2017-02-21 Ionis Pharmaceuticals, Inc. Methods and compositions for modulating apolipoprotein (a) expression
US9512108B2 (en) * 2013-12-31 2016-12-06 Nanjing Sanhome Pharmaceutical Co., Ltd. 9,9,10,10-Tetrafluoro-9,10-dihydrophenanthrene hepatitis C virus inhibitor and application thereof
CN108191647B (zh) * 2018-02-22 2020-09-29 江苏尚莱特医药化工材料有限公司 2,2-二氟二羧酸二烷基酯的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498807A (en) * 1992-11-18 1996-03-12 Hoechst Aktiengesellschaft Process for the preparation of aromatic fluoro compounds
GB9325757D0 (en) * 1993-12-16 1994-02-16 Zeneca Ltd Fluorination process
DE19653008A1 (de) * 1996-12-19 1998-06-25 Hoechst Ag Fluorierte Phenanthren-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
CA2269561C (en) * 1998-04-22 2007-06-05 Dainippon Ink And Chemicals, Inc. Naphthalene derivative and liquid crystal composition comprising the same
US6008407A (en) * 1998-11-03 1999-12-28 Zelinsky Institute Of Organic Chemistry Method of preparing fluoroaromatic compounds
JP5093829B2 (ja) * 1999-06-30 2012-12-12 Ｄｉｃ株式会社 液晶中間体及び製造方法
JP2001026561A (ja) * 1999-07-09 2001-01-30 Dainippon Ink & Chem Inc フルオロナフタレン誘導体
US7067179B1 (en) * 1999-08-03 2006-06-27 Dainippon Ink And Chemicals, Inc. Fused ring compound
JP4517458B2 (ja) * 2000-06-14 2010-08-04 Ｄｉｃ株式会社 ６−ブロモ−１，２−ジフルオロナフタレンの製造方法

Also Published As

Publication number Publication date
US20030100806A1 (en) 2003-05-29
DE60203200D1 (de) 2005-04-21
TWI245031B (en) 2005-12-11
EP1225162B1 (de) 2005-03-16
JP3898515B2 (ja) 2007-03-28
DE60203200T2 (de) 2005-08-04
KR100462665B1 (ko) 2004-12-20
KR20020062696A (ko) 2002-07-29
US20020198417A1 (en) 2002-12-26
US6455744B1 (en) 2002-09-24
US6706933B2 (en) 2004-03-16
US6515191B2 (en) 2003-02-04
US20020099247A1 (en) 2002-07-25
JP2002255870A (ja) 2002-09-11
EP1225162A1 (de) 2002-07-24

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Legal Events

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