ATE291006T1 - Verfahren zur herstellung von salbutamolisomeren - Google Patents

Verfahren zur herstellung von salbutamolisomeren

Info

Publication number: ATE291006T1
Authority: AT; Austria
Prior art keywords: salbutamol; precursor; optically; optically pure; salbutamolisomers
Prior art date: 2000-12-11

Application number

AT01270520T

Other languages

English (en)

Inventor

Yusuf Khwaja Windsor Vi Hamied

Rajendra Narayanrao Kankan

Dharmaraj Ramachandra Rao

Original Assignee

Cipla Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-11

Filing date

2001-12-10

Publication date

2005-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9904845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE291006(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-12-10 Application filed by Cipla Ltd filed Critical Cipla Ltd

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291006T1 publication Critical patent/ATE291006T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 abstract 4
229960002052 salbutamol Drugs 0.000 abstract 4
NDAUXUAQIAJITI-LBPRGKRZSA-N (R)-salbutamol Chemical compound CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-LBPRGKRZSA-N 0.000 abstract 3
NDAUXUAQIAJITI-GFCCVEGCSA-N 4-[(1s)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol Chemical compound CC(C)(C)NC[C@@H](O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-GFCCVEGCSA-N 0.000 abstract 3
239000002243 precursor Substances 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Analytical Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT01270520T 2000-12-11 2001-12-10 Verfahren zur herstellung von salbutamolisomeren ATE291006T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0030171.3A GB0030171D0 (en)	2000-12-11	2000-12-11	Process for preparing isomers of salbutamol
PCT/GB2001/005444 WO2002048090A1 (en)	2000-12-11	2001-12-10	Process for preparing isomers of salbutamol

Publications (1)

Publication Number	Publication Date
ATE291006T1 true ATE291006T1 (de)	2005-04-15

Family

ID=9904845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01270520T ATE291006T1 (de)	2000-12-11	2001-12-10	Verfahren zur herstellung von salbutamolisomeren

Country Status (10)

Country	Link
US (3)	USRE43844E1 (de)
EP (1)	EP1349828B1 (de)
AT (1)	ATE291006T1 (de)
AU (1)	AU2002220918A1 (de)
CA (1)	CA2431400C (de)
DE (1)	DE60109494T2 (de)
ES (1)	ES2240335T3 (de)
GB (1)	GB0030171D0 (de)
PT (1)	PT1349828E (de)
WO (1)	WO2002048090A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0030171D0 (en)	2000-12-11	2001-01-24	Cipla Ltd	Process for preparing isomers of salbutamol
DE60336089D1 (de)	2002-12-10	2011-03-31	Sunovion Pharmaceuticals Inc	Aerosolformulierung umfassend Levalbuterol L-Tartratsalz
NZ547178A (en) *	2003-11-20	2008-06-30	Alteragon Pty Ltd	Method of decreasing fat deposits and body weight in mammals and birdsusing the R-isomer of Salbutamol
US7488758B2 (en)	2004-05-20	2009-02-10	Teva Pharmaceutical Fine Chemicals, S.R.L.	Levalbuterol hydrochloride polymorph B
BRPI0515103A (pt) *	2004-09-09	2008-07-08	Cipla Ltd	composição farmacêutica, inalador, processos para preparar o mesmo, e uma composição farmacêutica, e, uso de uma composição farmacêutica
EP2311793A1 (de) *	2004-12-17	2011-04-20	Cipla Ltd.	Kristallines Levosalbutamol-sulphate (Form II)
US7579505B2 (en) *	2004-12-17	2009-08-25	Cipla Limited	Crystalline levosalbutamol sulphate and polymorphic forms thereof
TW200740779A (en)	2005-07-22	2007-11-01	Mitsubishi Pharma Corp	Intermediate compound for synthesizing pharmaceutical agent and production method thereof
WO2008015689A1 (en)	2006-08-02	2008-02-07	Aarti Healthcare Limited	A process for the preparation of optically pure r (-) salbutamol and its pharmaceutically acceptable salts
EP1935872A1 (de) *	2006-12-11	2008-06-25	Stirling Products Limited	Verfahren zur Gewinnung des R-Enantiomers von Salbutamol
EP2242364A4 (de) *	2008-01-15	2011-09-21	Targacept Inc	Zubereitung und enantiomere trennung von 7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonan und neue salzformen des racemats und der enantiomere
CN102260179A (zh) *	2010-05-24	2011-11-30	苏州睿克气雾医药有限公司	硫酸沙丁胺醇拆分新工艺
CN108947854B (zh) *	2018-06-30	2020-09-08	常州市阳光药业有限公司	重酒石酸间羟胺及其异构体的拆分方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1200886A (en)	1966-09-23	1970-08-05	Allen & Hanburys Ltd	Phenylaminoethanol derivatives
JPH0285247A (ja)	1988-09-22	1990-03-26	Kohjin Co Ltd	光学活性チオウレア誘導体
US5399765A (en)	1994-05-23	1995-03-21	Sepracor, Inc.	Enantioselective preparation of optically pure albuterol
US5545745A (en)	1994-05-23	1996-08-13	Sepracor, Inc.	Enantioselective preparation of optically pure albuterol
WO1999042460A1 (en)	1998-02-20	1999-08-26	Fine Chemicals Corporation (Proprietary) Limited	Process for the production of optically enriched (r)- or (s)-albuterol
CN1173929C (zh) *	1999-10-19	2004-11-03	中国科学院成都有机化学研究所	光学纯肾上腺素类β-激动剂的组合拆分制备法
GB0030171D0 (en)	2000-12-11	2001-01-24	Cipla Ltd	Process for preparing isomers of salbutamol

2000
- 2000-12-11 GB GBGB0030171.3A patent/GB0030171D0/en not_active Ceased
2001
- 2001-12-10 US US12/026,790 patent/USRE43844E1/en not_active Expired - Lifetime
- 2001-12-10 PT PT01270520T patent/PT1349828E/pt unknown
- 2001-12-10 EP EP01270520A patent/EP1349828B1/de not_active Expired - Lifetime
- 2001-12-10 DE DE60109494T patent/DE60109494T2/de not_active Expired - Lifetime
- 2001-12-10 ES ES01270520T patent/ES2240335T3/es not_active Expired - Lifetime
- 2001-12-10 AT AT01270520T patent/ATE291006T1/de not_active IP Right Cessation
- 2001-12-10 WO PCT/GB2001/005444 patent/WO2002048090A1/en not_active Ceased
- 2001-12-10 AU AU2002220918A patent/AU2002220918A1/en not_active Abandoned
- 2001-12-10 US US10/450,155 patent/US6995286B2/en not_active Ceased
- 2001-12-10 CA CA002431400A patent/CA2431400C/en not_active Expired - Fee Related
- 2001-12-10 US US12/402,752 patent/USRE43984E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2240335T3 (es)	2005-10-16
DE60109494T2 (de)	2005-08-04
WO2002048090A1 (en)	2002-06-20
CA2431400C (en)	2008-01-22
USRE43844E1 (en)	2012-12-04
US6995286B2 (en)	2006-02-07
DE60109494D1 (de)	2005-04-21
EP1349828A1 (de)	2003-10-08
USRE43984E1 (en)	2013-02-05
EP1349828B1 (de)	2005-03-16
GB0030171D0 (en)	2001-01-24
PT1349828E (pt)	2005-07-29
HK1060345A1 (en)	2004-08-06
CA2431400A1 (en)	2002-06-20
AU2002220918A1 (en)	2002-06-24
US20040054215A1 (en)	2004-03-18

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