ATE226931T1 - Verfahren zur herstellung von reinem cis-tramadol - Google Patents
Verfahren zur herstellung von reinem cis-tramadolInfo
- Publication number
- ATE226931T1 ATE226931T1 AT98932479T AT98932479T ATE226931T1 AT E226931 T1 ATE226931 T1 AT E226931T1 AT 98932479 T AT98932479 T AT 98932479T AT 98932479 T AT98932479 T AT 98932479T AT E226931 T1 ATE226931 T1 AT E226931T1
- Authority
- AT
- Austria
- Prior art keywords
- tramadol
- cis
- pure cis
- producing pure
- base
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE970519 | 1997-07-15 | ||
| PCT/IE1998/000051 WO1999003820A1 (en) | 1997-07-15 | 1998-06-26 | Tramadol, salts thereof and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226931T1 true ATE226931T1 (de) | 2002-11-15 |
Family
ID=11041532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98932479T ATE226931T1 (de) | 1997-07-15 | 1998-06-26 | Verfahren zur herstellung von reinem cis-tramadol |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6469213B1 (de) |
| EP (1) | EP0996613B1 (de) |
| JP (1) | JP2001510180A (de) |
| CN (1) | CN1151122C (de) |
| AT (1) | ATE226931T1 (de) |
| AU (1) | AU730530B2 (de) |
| CA (1) | CA2295884A1 (de) |
| DE (1) | DE69809055T2 (de) |
| DK (1) | DK0996613T3 (de) |
| GB (1) | GB2342352B (de) |
| IE (1) | IE980512A1 (de) |
| WO (1) | WO1999003820A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9800657D0 (en) * | 1998-01-14 | 1998-03-11 | Macfarlan Smith Ltd | Improved purification process |
| CA2375234A1 (en) * | 1999-06-22 | 2000-12-28 | Grunenthal Gmbh | Process for the separation of the diastereomeric bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol |
| DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| EP1346978A1 (de) * | 2002-03-21 | 2003-09-24 | Jubilant Organosys Limited | Verfahren zur Herstellung von Tramadol-Hydrochloride und/oder Tramadol-Monohydrat |
| DE10236510A1 (de) | 2002-08-09 | 2004-02-19 | Grünenthal GmbH | Verfahren zur Herstellung von 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| CN101257894A (zh) | 2005-07-07 | 2008-09-03 | 法纳姆公司 | 高水溶性药物的缓释药物组合物 |
| EP1785412A1 (de) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Verfahren zur Rückgewinnung von Tramadol |
| KR20220051164A (ko) | 2019-07-05 | 2022-04-26 | 아이오엠엑스 테라퓨틱스 아게 | Igsf11 (vsig3)의 항체 결합 igc2 및 이의 용도 |
| WO2022008027A1 (en) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1199764B (de) | 1963-04-02 | 1965-09-02 | Gruenenthal Chemie | Verfahren zur Herstellung von basisch substituierten Phenolaethern |
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| DE69215316T2 (de) | 1991-09-06 | 1997-03-20 | Mcneilab Inc | Zusammensetzungen, die Tramadol und irgendein Kodein, Oxykoden oder Hydrokoden enthalten, und deren Verwendung |
| HU219332B (hu) | 1991-09-06 | 2001-03-28 | Mcneilab Inc | Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények |
| US5223541A (en) | 1991-09-13 | 1993-06-29 | Mcneilab, Inc. | Tramadol n-oxide material, enantiomers and compositions thereof, and their use |
| US5516803A (en) | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| IL103096A (en) * | 1992-09-08 | 1996-12-05 | Chemagis Ltd | Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts. |
| IL116281A (en) * | 1995-12-07 | 1999-06-20 | Chemagis Ltd | Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts |
| DE19601745C1 (de) * | 1996-01-19 | 1997-10-09 | Gruenenthal Gmbh | Verfahren zur Racematspaltung von Tramadol |
| IL119121A (en) * | 1996-08-22 | 2000-11-21 | Chemagis Ltd | Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride |
| CA2330142A1 (en) * | 1998-05-22 | 1999-12-02 | Mallinckrodt, Inc. | An improved synthesis and purification of (r*,r*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride |
-
1998
- 1998-06-26 WO PCT/IE1998/000051 patent/WO1999003820A1/en not_active Ceased
- 1998-06-26 IE IE980512A patent/IE980512A1/en not_active IP Right Cessation
- 1998-06-26 DK DK98932479T patent/DK0996613T3/da active
- 1998-06-26 EP EP98932479A patent/EP0996613B1/de not_active Expired - Lifetime
- 1998-06-26 AT AT98932479T patent/ATE226931T1/de not_active IP Right Cessation
- 1998-06-26 CN CNB988072793A patent/CN1151122C/zh not_active Expired - Fee Related
- 1998-06-26 JP JP2000503051A patent/JP2001510180A/ja active Pending
- 1998-06-26 DE DE69809055T patent/DE69809055T2/de not_active Expired - Fee Related
- 1998-06-26 GB GB9929485A patent/GB2342352B/en not_active Expired - Fee Related
- 1998-06-26 AU AU82383/98A patent/AU730530B2/en not_active Ceased
- 1998-06-26 CA CA002295884A patent/CA2295884A1/en not_active Abandoned
-
2000
- 2000-01-14 US US09/482,889 patent/US6469213B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6469213B1 (en) | 2002-10-22 |
| EP0996613B1 (de) | 2002-10-30 |
| AU8238398A (en) | 1999-02-10 |
| CN1264363A (zh) | 2000-08-23 |
| DK0996613T3 (da) | 2003-03-03 |
| GB9929485D0 (en) | 2000-02-09 |
| CN1151122C (zh) | 2004-05-26 |
| GB2342352B (en) | 2002-03-27 |
| AU730530B2 (en) | 2001-03-08 |
| IE980512A1 (en) | 1999-10-20 |
| CA2295884A1 (en) | 1999-01-28 |
| JP2001510180A (ja) | 2001-07-31 |
| WO1999003820A1 (en) | 1999-01-28 |
| EP0996613A1 (de) | 2000-05-03 |
| GB2342352A (en) | 2000-04-12 |
| DE69809055D1 (de) | 2002-12-05 |
| DE69809055T2 (de) | 2003-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |