ATE294178T1 - Spiro verbindungen mit antihistaminischer aktivität - Google Patents

Spiro verbindungen mit antihistaminischer aktivität

Info

Publication number: ATE294178T1
Authority: AT; Austria
Prior art keywords: spiro compounds; antihistaminic activity; antihistaminic; activity; spiro
Prior art date: 1998-12-19

Application number

AT99964625T

Other languages

English (en)

Inventor

Frans Eduard Janssens

Joseph Elisabeth Leenaerts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-19

Filing date

1999-12-15

Publication date

2005-05-15

1999-12-15 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE294178T1 publication Critical patent/ATE294178T1/de

Links

230000001387 anti-histamine Effects 0.000 title 1
150000003413 spiro compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Immunology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Dental Preparations (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

AT99964625T 1998-12-19 1999-12-15 Spiro verbindungen mit antihistaminischer aktivität ATE294178T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98204347		1998-12-19
PCT/EP1999/010176 WO2000037470A1 (en)	1998-12-19	1999-12-15	Antihistaminic spiro compounds

Publications (1)

Publication Number	Publication Date
ATE294178T1 true ATE294178T1 (de)	2005-05-15

Family

ID=8234498

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99964625T ATE294178T1 (de)	1998-12-19	1999-12-15	Spiro verbindungen mit antihistaminischer aktivität

Country Status (37)

Country	Link
US (2)	US7148214B1 (de)
EP (1)	EP1144411B1 (de)
JP (1)	JP4601175B2 (de)
KR (1)	KR100598725B1 (de)
CN (1)	CN1258533C (de)
AR (1)	AR021888A1 (de)
AT (1)	ATE294178T1 (de)
AU (1)	AU764820C (de)
BG (1)	BG65133B1 (de)
BR (1)	BR9916371A (de)
CA (1)	CA2355939C (de)
CO (1)	CO5140116A1 (de)
CZ (1)	CZ301953B6 (de)
DE (1)	DE69925036T2 (de)
DK (1)	DK1144411T3 (de)
EA (1)	EA004500B1 (de)
EE (1)	EE04917B1 (de)
EG (1)	EG24605A (de)
ES (1)	ES2242443T3 (de)
HK (1)	HK1043128B (de)
HR (1)	HRP20010453B1 (de)
HU (1)	HU229406B1 (de)
ID (1)	ID29268A (de)
IL (1)	IL143767A0 (de)
MY (1)	MY129663A (de)
NO (1)	NO318891B1 (de)
NZ (1)	NZ512870A (de)
PL (1)	PL196262B1 (de)
PT (1)	PT1144411E (de)
SA (1)	SA00210113B1 (de)
SI (1)	SI1144411T1 (de)
SK (1)	SK286158B6 (de)
TR (1)	TR200101711T2 (de)
TW (1)	TWI250981B (de)
UA (1)	UA74537C2 (de)
WO (1)	WO2000037470A1 (de)
ZA (1)	ZA200104977B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2462374C (en) *	2001-10-15	2011-01-18	Janssen Pharmaceutica N.V.	Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage
JP4417108B2 (ja) *	2001-10-15	2010-02-17	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	新規な置換された４−フェニル−４−［１ｈ−イミダゾール−２−イル］−ピペリジン誘導体および選択的非ペプチドデルタオピオイドアゴニストとしてのそれらの使用
EP1765052A4 (de) *	2004-05-11	2012-06-20	George E Alliss	Pflanzentrimmer
CA2579204A1 (en) *	2004-09-07	2006-03-16	Banyu Pharmaceutical Co., Ltd.	Carbamoyl-substituted spiro derivative
EP2285808B1 (de)	2008-04-29	2013-11-20	Novartis AG	Spiro-indolderivate zur behandlung parasitischer krankheiten
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP3964507A1 (de)	2013-10-04	2022-03-09	Infinity Pharmaceuticals, Inc.	Heterocyclische verbindungen und verwendungen davon
WO2015051241A1 (en)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN106456628A (zh)	2014-03-19	2017-02-22	无限药品股份有限公司	用于治疗PI3K‑γ介导的障碍的杂环化合物
BR112017003745A2 (pt)	2014-08-29	2017-12-05	Tes Pharma S R L	inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN114230571B (zh)	2015-09-14	2025-07-08	无限药品股份有限公司	异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017088080A1 (es)	2015-11-25	2017-06-01	Natural Response S.A.	Método para la obtención de saponinas a partir de plantas
WO2017161116A1 (en)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en)	2016-06-08	2021-02-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
KR102806793B1 (ko)	2022-10-14	2025-05-12	지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드.	여과 장치
KR102806794B1 (ko)	2022-10-14	2025-05-12	지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드.	여과 장치용 커버
CN117624052B (zh) *	2024-01-26	2024-04-12	四川益能康生环保科技有限公司	一种用于捕集二氧化碳的离子液体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4464380A (en)	1983-05-25	1984-08-07	Pfizer Inc.	Imidazolidinedione derivatives
PH30434A (en) *	1989-04-07	1997-05-09	Janssen Pharmaceutica Nv	Hydroxyalkylfuranyl derivatives
EP0552292B1 (de) *	1990-10-10	1995-06-21	Schering Corporation	Substituierte imidazobenzazepine und imidazopyridoazepine
IL101851A (en) *	1991-06-13	1996-05-14	Janssen Pharmaceutica Nv	10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
IL101850A (en) *	1991-06-13	1996-01-31	Janssen Pharmaceutica Nv	11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
US5106844A (en) *	1991-09-10	1992-04-21	Sterling Drug Inc.	Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine antiarrhythmic agents
TW382017B (en) *	1995-12-27	2000-02-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

1999
- 1999-12-15 BR BR9916371-3A patent/BR9916371A/pt not_active Application Discontinuation
- 1999-12-15 SI SI9930798T patent/SI1144411T1/xx unknown
- 1999-12-15 ID IDW00200101298A patent/ID29268A/id unknown
- 1999-12-15 EA EA200100681A patent/EA004500B1/ru not_active IP Right Cessation
- 1999-12-15 HR HR20010453A patent/HRP20010453B1/xx not_active IP Right Cessation
- 1999-12-15 HU HU0104779A patent/HU229406B1/hu unknown
- 1999-12-15 ES ES99964625T patent/ES2242443T3/es not_active Expired - Lifetime
- 1999-12-15 PL PL348295A patent/PL196262B1/pl unknown
- 1999-12-15 KR KR1020017005016A patent/KR100598725B1/ko not_active Expired - Lifetime
- 1999-12-15 WO PCT/EP1999/010176 patent/WO2000037470A1/en not_active Ceased
- 1999-12-15 IL IL14376799A patent/IL143767A0/xx not_active IP Right Cessation
- 1999-12-15 JP JP2000589540A patent/JP4601175B2/ja not_active Expired - Lifetime
- 1999-12-15 DE DE69925036T patent/DE69925036T2/de not_active Expired - Lifetime
- 1999-12-15 US US09/868,535 patent/US7148214B1/en not_active Expired - Lifetime
- 1999-12-15 NZ NZ512870A patent/NZ512870A/en not_active IP Right Cessation
- 1999-12-15 CA CA2355939A patent/CA2355939C/en not_active Expired - Lifetime
- 1999-12-15 CN CNB998147052A patent/CN1258533C/zh not_active Expired - Lifetime
- 1999-12-15 AT AT99964625T patent/ATE294178T1/de active
- 1999-12-15 EE EEP200100328A patent/EE04917B1/xx unknown
- 1999-12-15 PT PT99964625T patent/PT1144411E/pt unknown
- 1999-12-15 CZ CZ20012069A patent/CZ301953B6/cs not_active IP Right Cessation
- 1999-12-15 SK SK814-2001A patent/SK286158B6/sk not_active IP Right Cessation
- 1999-12-15 DK DK99964625T patent/DK1144411T3/da active
- 1999-12-15 AU AU30412/00A patent/AU764820C/en not_active Expired
- 1999-12-15 TR TR2001/01711T patent/TR200101711T2/xx unknown
- 1999-12-15 UA UA2001064351A patent/UA74537C2/uk unknown
- 1999-12-15 HK HK02104999.1A patent/HK1043128B/zh unknown
- 1999-12-15 EP EP99964625A patent/EP1144411B1/de not_active Expired - Lifetime
- 1999-12-17 MY MYPI99005537A patent/MY129663A/en unknown
- 1999-12-17 TW TW088122194A patent/TWI250981B/zh not_active IP Right Cessation
- 1999-12-17 AR ARP990106513A patent/AR021888A1/es active IP Right Grant
- 1999-12-17 CO CO99079021A patent/CO5140116A1/es unknown
- 1999-12-18 EG EG162699A patent/EG24605A/xx active
2000
- 2000-05-21 SA SA00210113A patent/SA00210113B1/ar unknown
2001
- 2001-05-29 BG BG105546A patent/BG65133B1/bg unknown
- 2001-06-01 NO NO20012710A patent/NO318891B1/no not_active IP Right Cessation
- 2001-06-18 ZA ZA200104977A patent/ZA200104977B/en unknown
2004
- 2004-07-26 US US10/898,844 patent/US7087595B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EA200100681A1 (ru)	2001-12-24
JP4601175B2 (ja)	2010-12-22
SI1144411T1 (en)	2005-10-31
WO2000037470A8 (en)	2000-08-24
HUP0104779A2 (hu)	2002-04-29
PL196262B1 (pl)	2007-12-31
HK1043128A1 (en)	2002-09-06
NO20012710D0 (no)	2001-06-01
ES2242443T3 (es)	2005-11-01
TWI250981B (en)	2006-03-11
HUP0104779A3 (en)	2003-12-29
EE04917B1 (et)	2007-10-15
KR20010075655A (ko)	2001-08-09
AU764820C (en)	2004-11-18
EP1144411A1 (de)	2001-10-17
KR100598725B1 (ko)	2006-07-11
AR021888A1 (es)	2002-08-07
ID29268A (id)	2001-08-16
EP1144411B1 (de)	2005-04-27
PT1144411E (pt)	2005-09-30
SA00210113B1 (ar)	2006-09-13
CN1331694A (zh)	2002-01-16
NZ512870A (en)	2003-11-28
HRP20010453A2 (en)	2002-06-30
BR9916371A (pt)	2001-09-18
NO20012710L (no)	2001-06-01
PL348295A1 (en)	2002-05-20
HK1043128B (zh)	2007-01-19
BG65133B1 (bg)	2007-03-30
TR200101711T2 (tr)	2001-12-21
CN1258533C (zh)	2006-06-07
DE69925036T2 (de)	2006-01-26
US7148214B1 (en)	2006-12-12
JP2002533344A (ja)	2002-10-08
CZ20012069A3 (cs)	2002-02-13
UA74537C2 (uk)	2006-01-16
ZA200104977B (en)	2002-06-18
EE200100328A (et)	2002-08-15
SK286158B6 (sk)	2008-04-07
EG24605A (en)	2010-01-10
DE69925036D1 (de)	2005-06-02
AU764820B2 (en)	2003-08-28
HRP20010453B1 (hr)	2010-07-31
WO2000037470A1 (en)	2000-06-29
HU229406B1 (en)	2013-12-30
MY129663A (en)	2007-04-30
EA004500B1 (ru)	2004-04-29
CA2355939C (en)	2010-12-14
DK1144411T3 (da)	2005-09-19
SK8142001A3 (en)	2002-04-04
CO5140116A1 (es)	2002-03-22
NO318891B1 (no)	2005-05-18
US7087595B2 (en)	2006-08-08
CA2355939A1 (en)	2000-06-29
US20050026901A1 (en)	2005-02-03
AU3041200A (en)	2000-07-12
IL143767A0 (en)	2002-04-21
BG105546A (en)	2001-12-29
CZ301953B6 (cs)	2010-08-11

Legal Events

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2006-01-15

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Publication	Publication Date	Title
IS6267A (is)	2002-02-13	Ný spíróefnasambönd
DE69925036D1 (de)	2005-06-02	Spiro verbindungen mit antihistaminischer aktivität
DE69905038D1 (de)	2003-02-27	Cyclische boroprolinverbindungen
DE60031682D1 (de)	2006-12-14	Antibakterielle verbindungen
BR9909681B1 (pt)	2009-05-05	estrutura de seringa.
DE69733649D1 (de)	2005-08-04	Calcylitische verbindungen
DE69005858D1 (de)	1994-02-24	Heterocyclische Verbindungen.
IT1308096B1 (it)	2001-11-29	Convertiplano
EP0746326A4 (de)	2000-06-14	Oiligomere verbindungen mit stickstoff enthaltenden verbindungen
ATE222893T1 (de)	2002-09-15	Triazinylaminostilben verbindungen
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DE69531522D1 (de)	2003-09-25	Heterozyklische Verbindungen
NO20013769D0 (no)	2001-08-01	Kalsilytiske forbindelser
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IT1299046B1 (it)	2000-02-07	Iniettore per coiniezione