ATE296828T1 - Verbindungen zur floureszenz-kennzeichnung - Google Patents
Verbindungen zur floureszenz-kennzeichnungInfo
- Publication number
- ATE296828T1 ATE296828T1 AT00961100T AT00961100T ATE296828T1 AT E296828 T1 ATE296828 T1 AT E296828T1 AT 00961100 T AT00961100 T AT 00961100T AT 00961100 T AT00961100 T AT 00961100T AT E296828 T1 ATE296828 T1 AT E296828T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- represent
- compounds
- alkyl group
- bind
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000007850 fluorescent dye Substances 0.000 title 1
- 238000001215 fluorescent labelling Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000524 functional group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000001712 DNA sequencing Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C09B23/107—The polymethine chain containing an even number of >CH- groups four >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/145—Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/16—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms
- C09B23/162—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms only nitrogen atoms
- C09B23/164—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms only nitrogen atoms containing one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26484599 | 1999-09-20 | ||
| JP26484499 | 1999-09-20 | ||
| JP29491199 | 1999-10-18 | ||
| JP29491099 | 1999-10-18 | ||
| JP2000117451 | 2000-04-19 | ||
| PCT/JP2000/006401 WO2001021624A1 (en) | 1999-09-20 | 2000-09-20 | Compounds for fluorescence labeling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296828T1 true ATE296828T1 (de) | 2005-06-15 |
Family
ID=27530441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00961100T ATE296828T1 (de) | 1999-09-20 | 2000-09-20 | Verbindungen zur floureszenz-kennzeichnung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6794509B1 (de) |
| EP (1) | EP1219626B1 (de) |
| AT (1) | ATE296828T1 (de) |
| AU (1) | AU7316900A (de) |
| DE (1) | DE60020584T2 (de) |
| WO (1) | WO2001021624A1 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60006634T2 (de) | 1999-12-07 | 2004-04-15 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Fluoreszente materialen |
| EP1801165B1 (de) | 2000-09-29 | 2012-08-01 | Life Technologies Corporation | Modifizierte Carbocyanin-Farbstoffe und ihre Konjugate |
| EP2325263B1 (de) | 2000-09-29 | 2013-01-23 | Life Technologies Corporation | Modifizierte Carbocyaninfarbstoffe und deren Konjugate |
| JP4676654B2 (ja) * | 2001-07-19 | 2011-04-27 | 富士フイルム株式会社 | 蛍光ヌクレオチド及びそれを用いた標識法 |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
| DE10356130A1 (de) * | 2003-11-28 | 2005-06-23 | Dyomics Gmbh | Neue Polymethinfarbstoffe auf Cumarin-Basis mit einstellbarem Stokes-Shift |
| WO2005050206A2 (en) | 2003-09-17 | 2005-06-02 | Molecular Probes, Inc. | Competitive immunoassay |
| JP2005145921A (ja) * | 2003-11-19 | 2005-06-09 | Konica Minolta Medical & Graphic Inc | 診断用蛍光造影剤及び蛍光造影診断方法 |
| US7767834B2 (en) * | 2004-08-13 | 2010-08-03 | Elitech Holding B.V. | Phosphonylated fluorescent dyes and conjugates |
| ES2612738T3 (es) | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| JP5106397B2 (ja) | 2005-09-02 | 2012-12-26 | ビセン メディカル， インコーポレイテッド | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
| US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| ES2434491T3 (es) | 2005-10-13 | 2013-12-16 | Funda��O D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | An�lisis inmunohistoqu�mico multiplex in situ |
| EP1973575B1 (de) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biokompatibele fluoreszierende metalloxide nanopartikel |
| WO2007111669A2 (en) | 2005-12-22 | 2007-10-04 | Visen Medical, Inc. | Combined x-ray and optical tomographic imaging system |
| USD580285S1 (en) | 2006-01-13 | 2008-11-11 | Invitrogen Corporation | Fluorometer |
| WO2007087582A1 (en) | 2006-01-24 | 2007-08-02 | Invitrogen Corporation | Device and methods for quantifying analytes |
| US20070249014A1 (en) | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| US8562802B1 (en) | 2006-02-13 | 2013-10-22 | Life Technologies Corporation | Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems |
| BRPI0709102A2 (pt) | 2006-03-23 | 2011-06-28 | Absorber Ab | antìgenos de grupo sanguìneo de diferentes tipos para aplicações diagnósticas e terapêuticas |
| WO2007124464A2 (en) | 2006-04-20 | 2007-11-01 | Becton, Dickinson And Company | Thermostable proteins and methods of making and using thereof |
| CA2740602C (en) | 2007-10-19 | 2017-05-02 | Visen Medical, Inc. | Imaging systems featuring waveguiding compensation |
| EP2244741B1 (de) | 2008-01-18 | 2015-03-25 | VisEn Medical, Inc. | Fluoreszierende bildgebungsmittel |
| EP3673922A1 (de) | 2008-03-14 | 2020-07-01 | VisEn Medical, Inc. | Auf integrin abzielende mittel und verfahren zur verwendung davon |
| CN104263816B (zh) | 2008-05-16 | 2018-10-19 | 生命技术公司 | 用于测量细胞增殖的双标记法 |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| ES2488821T3 (es) * | 2009-03-24 | 2014-08-29 | Abbvie Bahamas Ltd. | Proceso de preparación de un compuesto antiviral |
| DK2470887T3 (da) | 2009-08-28 | 2020-04-06 | Visen Medical Inc | Systemer til tomografisk billeddannelse i diffuse medier ved at anvende en hybrid inversionsteknik |
| JP5730311B2 (ja) | 2009-08-31 | 2015-06-10 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 反応性シアニン化合物 |
| EP2480126B1 (de) | 2009-09-22 | 2017-01-04 | VisEn Medical, Inc. | Systeme und verfahren für virtuellen indexabgleich diffuser medien |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| USD653981S1 (en) | 2010-08-06 | 2012-02-14 | Life Technologies Corporation | Fluorometer |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| EP2630196B1 (de) | 2010-10-20 | 2017-09-06 | Li-Cor, Inc. | Cyaninfarbstoffe und deren konjugate |
| EP2707102B1 (de) | 2011-05-09 | 2019-11-13 | Visen Medical, Inc. | Auf carboanhydrase zielende wirkstoffe sowie verfahren zu ihrer verwendung |
| EP2831264B1 (de) | 2012-03-30 | 2019-07-10 | VisEn Medical, Inc. | Bakterielle bildgebungsmittel und verfahren zur verwendung davon |
| WO2014028057A1 (en) | 2012-08-15 | 2014-02-20 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| CN104853669B (zh) | 2012-10-15 | 2017-07-21 | 文森医学公司 | 具有荧光及生物发光源的交叉形态加权特征的漫射介质成像的系统、方法及设备 |
| CN104704359A (zh) | 2012-10-25 | 2015-06-10 | 生命科技公司 | 糖蛋白酶介导位点特异性放射性标记的方法和组合物 |
| WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
| SG11201602522VA (en) | 2013-10-02 | 2016-04-28 | Medimmune Llc | Neutralizing anti-influenza a antibodies and uses thereof |
| US9504405B2 (en) | 2013-10-23 | 2016-11-29 | Verily Life Sciences Llc | Spatial modulation of magnetic particles in vasculature by external magnetic field |
| US10542918B2 (en) | 2013-10-23 | 2020-01-28 | Verily Life Sciences Llc | Modulation of a response signal to distinguish between analyte and background signals |
| CN113349707A (zh) | 2013-12-31 | 2021-09-07 | 纪念斯隆-凯特琳癌症中心 | 用于荧光源实时多通道成像的系统、方法和设备 |
| WO2016011035A2 (en) | 2014-07-15 | 2016-01-21 | Medlmmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| ES2794778T3 (es) | 2014-12-15 | 2020-11-19 | Memorial Sloan Kettering Cancer Center | Péptidos cíclicos con selectividad mejorada de unión a los nervios, nanoparticulos unidas con dichos péptidos cíclicos y uso de los mismos para imágenes en vivo de tejidos nerviosos en tiempo real |
| US9861710B1 (en) | 2015-01-16 | 2018-01-09 | Verily Life Sciences Llc | Composite particles, methods, and in vivo diagnostic system |
| US10028659B2 (en) | 2015-03-26 | 2018-07-24 | Verily Life Sciences Llc | Aptamer-based sensors, implantable devices and detection system |
| JP2019509252A (ja) | 2015-12-15 | 2019-04-04 | メモリアル スローン ケタリング キャンサー センター | 組織の区別、例えば、手術中の可視化のための、イメージングシステムおよび方法 |
| WO2017181176A1 (en) | 2016-04-15 | 2017-10-19 | Lcahn School Of Medicine At Mount Sinai | Tissue profiling using multiplexed immunohistochemical consecutive staining |
| EP3548096B1 (de) | 2016-11-30 | 2024-11-20 | Memorial Sloan Kettering Cancer Center | Inhibitorfunktionalisierte ultrakleine nanopartikel und verfahren dafür |
| EP3601608A1 (de) | 2017-03-30 | 2020-02-05 | Life Technologies Corporation | Quantifizierung von ngs-dna durch adaptersequenz |
| US11989803B2 (en) | 2018-03-30 | 2024-05-21 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography |
| WO2022006368A2 (en) | 2020-07-02 | 2022-01-06 | Life Technologies Corporation | Trinucleotide cap analogs, preparation and uses thereof |
| EP4015004A1 (de) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglykanspezifische verzweigte peptide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB870753A (en) * | 1957-07-04 | 1961-06-21 | Ilford Ltd | Improvements in or relating to methine dyes |
| US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5057406A (en) * | 1988-05-07 | 1991-10-15 | Konica Corporation | Silver halide photographic material |
| US5246989A (en) * | 1990-03-29 | 1993-09-21 | Tokuyama Soda Kabishiki Kaisha | Photochromic compound, composition and use thereof |
| JPH0480747A (ja) * | 1990-07-23 | 1992-03-13 | Konica Corp | ハロゲン化銀写真感光材料の処理方法 |
| JPH05287209A (ja) * | 1992-04-09 | 1993-11-02 | Hitachi Chem Co Ltd | 蛍光標識用色素、蛍光標識用色素で標識された生物由来物質、及びそれらを含有する試薬 |
| JPH07145148A (ja) * | 1992-06-02 | 1995-06-06 | Bio Sensor Kenkyusho:Kk | ポリメチン系化合物およびそれを用いる測定方法 |
| DE60006634T2 (de) * | 1999-12-07 | 2004-04-15 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Fluoreszente materialen |
-
2000
- 2000-09-20 DE DE60020584T patent/DE60020584T2/de not_active Expired - Lifetime
- 2000-09-20 AT AT00961100T patent/ATE296828T1/de not_active IP Right Cessation
- 2000-09-20 US US10/088,232 patent/US6794509B1/en not_active Expired - Fee Related
- 2000-09-20 AU AU73169/00A patent/AU7316900A/en not_active Abandoned
- 2000-09-20 EP EP00961100A patent/EP1219626B1/de not_active Expired - Lifetime
- 2000-09-20 WO PCT/JP2000/006401 patent/WO2001021624A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1219626A1 (de) | 2002-07-03 |
| AU7316900A (en) | 2001-04-24 |
| EP1219626B1 (de) | 2005-06-01 |
| DE60020584D1 (de) | 2005-07-07 |
| EP1219626A4 (de) | 2003-04-16 |
| DE60020584T2 (de) | 2006-04-27 |
| US6794509B1 (en) | 2004-09-21 |
| WO2001021624A1 (en) | 2001-03-29 |
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