ATE297461T1 - Reguliertes autokrines wachstum von säugerzellen - Google Patents
Reguliertes autokrines wachstum von säugerzellenInfo
- Publication number
- ATE297461T1 ATE297461T1 AT96924714T AT96924714T ATE297461T1 AT E297461 T1 ATE297461 T1 AT E297461T1 AT 96924714 T AT96924714 T AT 96924714T AT 96924714 T AT96924714 T AT 96924714T AT E297461 T1 ATE297461 T1 AT E297461T1
- Authority
- AT
- Austria
- Prior art keywords
- growth
- host cells
- regulated
- autocrine growth
- mammal cells
- Prior art date
Links
- 230000001105 regulatory effect Effects 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 230000003305 autocrine Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
- YKYOUMDCQGMQQO-UHFFFAOYSA-L cadmium dichloride Chemical compound Cl[Cd]Cl YKYOUMDCQGMQQO-UHFFFAOYSA-L 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102000013275 Somatomedins Human genes 0.000 abstract 1
- 102000004338 Transferrin Human genes 0.000 abstract 1
- 108090000901 Transferrin Proteins 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000004017 serum-free culture medium Substances 0.000 abstract 1
- 239000012581 transferrin Substances 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPN4422A AUPN442295A0 (en) | 1995-07-26 | 1995-07-26 | Regulated autocrine growth of mammalian cells |
| PCT/AU1996/000472 WO1997005240A1 (en) | 1995-07-26 | 1996-07-26 | Regulated autocrine growth of mammalian cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297461T1 true ATE297461T1 (de) | 2005-06-15 |
Family
ID=3788757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96924714T ATE297461T1 (de) | 1995-07-26 | 1996-07-26 | Reguliertes autokrines wachstum von säugerzellen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6340574B1 (de) |
| EP (1) | EP0843722B1 (de) |
| JP (1) | JP3961567B2 (de) |
| AT (1) | ATE297461T1 (de) |
| AU (1) | AUPN442295A0 (de) |
| DE (1) | DE69634819T2 (de) |
| WO (1) | WO1997005240A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT407255B (de) * | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| ATE330003T1 (de) * | 1999-08-05 | 2006-07-15 | Baxter Ag | Rekombinanter stabiler zellklon, seine herstellung und verwendung |
| NZ529329A (en) | 1999-08-25 | 2005-06-24 | Immunex Corp | Compositions and methods for improved cell culture |
| UA74557C2 (en) * | 1999-09-03 | 2006-01-16 | Applied Research Systems | A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers |
| EP1754784A3 (de) * | 1999-09-03 | 2007-02-28 | Applied Research Systems ARS Holding N.V. | Verfahren zur Produktion eines heterologen sezernierten Proteins aus auf Mikroträgern gewachsenen Cho-Zellen |
| DK1520008T3 (da) | 2002-07-09 | 2012-10-15 | Baxter Int | Medium frit for dyreprotein til dyrkning af celler |
| CU23097A1 (es) | 2002-10-23 | 2005-11-18 | Centro Inmunologia Molecular | Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método |
| US8058156B2 (en) * | 2004-07-20 | 2011-11-15 | Applied Materials, Inc. | Plasma immersion ion implantation reactor having multiple ion shower grids |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| TWI406870B (zh) * | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
| ES2474573T3 (es) | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
| EP1970441A1 (de) * | 2007-03-06 | 2008-09-17 | BioAlliance Pharma | Plasmid mit einer Sequenz, die eine Disintegrin-Domäne von Metargidin (RDD) kodiert |
| CA2682543A1 (en) * | 2007-03-26 | 2008-10-02 | The University Of Chicago | Immunoassays and characterization of biomolecular interactions using self- assembled monolayers |
| WO2009115495A1 (de) * | 2008-03-19 | 2009-09-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methode zur steigerung der reklonierungseffizienz |
| US20110016548A1 (en) * | 2009-07-16 | 2011-01-20 | University Of Southern California | Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems |
| EP2606119A1 (de) | 2010-08-20 | 2013-06-26 | Wyeth LLC | Zellkultur aus wachstumsfaktorfreien adaptierten zellen |
| CN103768611B (zh) * | 2012-10-19 | 2016-12-28 | 河南师范大学 | 植物源性醇溶蛋白共轭ZnO/Cd(OH)C1纳米抗癌药物及其制备方法 |
| CA2904146C (en) | 2013-03-08 | 2023-03-21 | Neuclone Biologics Pty Ltd | A cell expression system |
| CA2904167A1 (en) * | 2013-03-08 | 2014-09-12 | Neuclone Biologics Pty Ltd | Cell culture media composition and methods of producing thereof |
| TWI656839B (zh) | 2013-03-15 | 2019-04-21 | 健臻公司 | 高密度細胞儲存方法 |
| EP3957173A1 (de) | 2014-09-18 | 2022-02-23 | Genzyme Corporation | Verfahren für ultrahochdichte zellbanken |
| JP6245299B2 (ja) * | 2016-04-27 | 2017-12-13 | バクスアルタ ゲーエムベーハー | 組換え安定細胞クローン、その産生およびその使用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0136907A3 (de) * | 1983-10-03 | 1986-12-30 | Genentech, Inc. | Xenogeneisches Expressionskontrollsystem, Verfahren zu dessen Verwendung, dieses enthaltende Expressionsvektoren, mit denselben transformierte Zellen und daraus hergestellte heterolose Proteine |
| ATE89314T1 (de) * | 1985-02-13 | 1993-05-15 | Scios Nova Inc | Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen. |
| IL87737A (en) * | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| AU612404B2 (en) * | 1987-09-11 | 1991-07-11 | Genentech Inc. | Method for increasing the expression of polypeptides in recombinant cell culture |
| AU6432090A (en) * | 1989-09-01 | 1991-04-08 | Genentech Inc. | Cells transfected with nucleic acid encoding gtp |
| CA2123430C (en) * | 1991-12-06 | 2004-02-10 | Cornelia M. Gorman | Prohormone convertase transformed cells |
| US5262308A (en) | 1992-01-28 | 1993-11-16 | Thomas Jefferson University | Cell lines which constitutively express IGF-1 and IGF-1 R |
| GB9216151D0 (en) * | 1992-07-29 | 1992-09-09 | Ici Plc | Containment of plant germplasm |
| US5856179A (en) * | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5723333A (en) * | 1995-02-10 | 1998-03-03 | Regents Of The University Of California | Human pancreatic cell lines: developments and uses |
-
1995
- 1995-07-26 AU AUPN4422A patent/AUPN442295A0/en not_active Abandoned
-
1996
- 1996-07-26 US US09/000,442 patent/US6340574B1/en not_active Expired - Lifetime
- 1996-07-26 AT AT96924714T patent/ATE297461T1/de not_active IP Right Cessation
- 1996-07-26 JP JP50701097A patent/JP3961567B2/ja not_active Expired - Fee Related
- 1996-07-26 EP EP96924714A patent/EP0843722B1/de not_active Expired - Lifetime
- 1996-07-26 WO PCT/AU1996/000472 patent/WO1997005240A1/en not_active Ceased
- 1996-07-26 DE DE69634819T patent/DE69634819T2/de not_active Expired - Lifetime
-
2001
- 2001-09-28 US US09/964,338 patent/US6797515B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3961567B2 (ja) | 2007-08-22 |
| WO1997005240A1 (en) | 1997-02-13 |
| US20020102650A1 (en) | 2002-08-01 |
| AUPN442295A0 (en) | 1995-08-17 |
| EP0843722A1 (de) | 1998-05-27 |
| US6340574B1 (en) | 2002-01-22 |
| JPH11509734A (ja) | 1999-08-31 |
| US6797515B2 (en) | 2004-09-28 |
| EP0843722A4 (de) | 2002-05-02 |
| DE69634819T2 (de) | 2006-03-23 |
| EP0843722B1 (de) | 2005-06-08 |
| DE69634819D1 (de) | 2005-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |