ATE297915T1 - Piperazinderivate und deren verwendung als 5-ht1b liganden - Google Patents
Piperazinderivate und deren verwendung als 5-ht1b ligandenInfo
- Publication number
- ATE297915T1 ATE297915T1 AT02727391T AT02727391T ATE297915T1 AT E297915 T1 ATE297915 T1 AT E297915T1 AT 02727391 T AT02727391 T AT 02727391T AT 02727391 T AT02727391 T AT 02727391T AT E297915 T1 ATE297915 T1 AT E297915T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- alkyl
- ht1b
- ligands
- Prior art date
Links
- 102100027499 5-hydroxytryptamine receptor 1B Human genes 0.000 title 1
- 101710138639 5-hydroxytryptamine receptor 1B Proteins 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0106419.5A GB0106419D0 (en) | 2001-03-15 | 2001-03-15 | Novel compounds |
| PCT/EP2002/002632 WO2002074764A2 (en) | 2001-03-15 | 2002-03-11 | Piperazine derivatives and their use as 5-ht1b ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297915T1 true ATE297915T1 (de) | 2005-07-15 |
Family
ID=9910758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02727391T ATE297915T1 (de) | 2001-03-15 | 2002-03-11 | Piperazinderivate und deren verwendung als 5-ht1b liganden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7109201B2 (de) |
| EP (1) | EP1368337B1 (de) |
| JP (1) | JP2004529124A (de) |
| AT (1) | ATE297915T1 (de) |
| AU (1) | AU2002257644A1 (de) |
| DE (1) | DE60204668T2 (de) |
| ES (1) | ES2240737T3 (de) |
| GB (1) | GB0106419D0 (de) |
| WO (1) | WO2002074764A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0316915D0 (en) * | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| PE20060574A1 (es) | 2004-07-28 | 2006-06-24 | Glaxo Group Ltd | Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs) |
| PE20080176A1 (es) | 2006-03-31 | 2008-04-25 | Glaxo Group Ltd | Compuestos de arilpiperazina sulfonamida como agonista de los receptores de secretagogos de la hormona de crecimiento (ghs) |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3328936B2 (ja) | 1993-09-03 | 2002-09-30 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ｄレセプター拮抗薬用インドールおよびインドリン誘導体 |
| EP0975593A1 (de) | 1997-04-18 | 2000-02-02 | Smithkline Beecham Plc | Indolderivate mit gleichzeitiger 5ht1a, 5ht1b und 5ht1d rezeptor antagonistischer aktivität |
| GB9725931D0 (en) * | 1997-12-05 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
| TR200200795T2 (tr) | 1999-09-25 | 2002-07-22 | Smithkline Beecham P. L. C. | 5-HT1B antagonistleri olarak piperazin türevleri |
-
2001
- 2001-03-15 GB GBGB0106419.5A patent/GB0106419D0/en not_active Ceased
-
2002
- 2002-03-11 AT AT02727391T patent/ATE297915T1/de not_active IP Right Cessation
- 2002-03-11 DE DE60204668T patent/DE60204668T2/de not_active Expired - Fee Related
- 2002-03-11 EP EP02727391A patent/EP1368337B1/de not_active Expired - Lifetime
- 2002-03-11 ES ES02727391T patent/ES2240737T3/es not_active Expired - Lifetime
- 2002-03-11 JP JP2002573773A patent/JP2004529124A/ja active Pending
- 2002-03-11 US US10/471,433 patent/US7109201B2/en not_active Expired - Fee Related
- 2002-03-11 AU AU2002257644A patent/AU2002257644A1/en not_active Abandoned
- 2002-03-11 WO PCT/EP2002/002632 patent/WO2002074764A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60204668D1 (de) | 2005-07-21 |
| EP1368337B1 (de) | 2005-06-15 |
| WO2002074764A3 (en) | 2002-11-14 |
| WO2002074764A2 (en) | 2002-09-26 |
| US7109201B2 (en) | 2006-09-19 |
| ES2240737T3 (es) | 2005-10-16 |
| AU2002257644A1 (en) | 2002-10-03 |
| JP2004529124A (ja) | 2004-09-24 |
| US20040142925A1 (en) | 2004-07-22 |
| EP1368337A2 (de) | 2003-12-10 |
| GB0106419D0 (en) | 2001-05-02 |
| DE60204668T2 (de) | 2005-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |