ATE297933T1 - Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil - Google Patents

Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil

Info

Publication number: ATE297933T1
Authority: AT; Austria
Prior art keywords: high purity; producing high; proxetil; cefpodoxim; cefpodoxim proxetil
Prior art date: 1999-11-08

Application number

AT00976419T

Other languages

English (en)

Inventor

Gwan Sun Lee

Young Kil Chang

Jae Heon Lee

Chul Hyun Park

Gha Seung Park

Keum Shin Jung

Original Assignee

Hanmi Pharm Ind Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-08

Filing date

2000-11-07

Publication date

2005-07-15

2000-11-07 Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE297933T1 publication Critical patent/ATE297933T1/de

Links

LTINZAODLRIQIX-ZFEISNGRSA-N 1-propan-2-yloxycarbonyloxyethyl (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(=O)OC(C)OC(=O)OC(C)C)C(=O)C(=N\OC)\C1=CSC(N)=N1 LTINZAODLRIQIX-ZFEISNGRSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
XZVBIIRIWFZJOE-UHFFFAOYSA-N 1-iodoethyl propan-2-yl carbonate Chemical compound CC(C)OC(=O)OC(C)I XZVBIIRIWFZJOE-UHFFFAOYSA-N 0.000 abstract 1
WYUSVOMTXWRGEK-HBWVYFAYSA-N cefpodoxime Chemical class N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(O)=O)C(=O)C(=N/OC)\C1=CSC(N)=N1 WYUSVOMTXWRGEK-HBWVYFAYSA-N 0.000 abstract 1
LTINZAODLRIQIX-FBXRGJNPSA-N cefpodoxime proxetil Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(=O)OC(C)OC(=O)OC(C)C)C(=O)C(=N/OC)\C1=CSC(N)=N1 LTINZAODLRIQIX-FBXRGJNPSA-N 0.000 abstract 1
229960004797 cefpodoxime proxetil Drugs 0.000 abstract 1
150000003983 crown ethers Chemical class 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00976419T 1999-11-08 2000-11-07 Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil ATE297933T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1019990049174A KR100342944B1 (ko)	1999-11-08	1999-11-08	고순도 세프포독심 프록세틸의 제조방법
PCT/KR2000/001272 WO2001034611A1 (en)	1999-11-08	2000-11-07	Method of preparing highly pure cefpodoxime proxetil

Publications (1)

Publication Number	Publication Date
ATE297933T1 true ATE297933T1 (de)	2005-07-15

Family

ID=19618994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00976419T ATE297933T1 (de)	1999-11-08	2000-11-07	Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil

Country Status (14)

Country	Link
US (1)	US6639068B1 (de)
EP (1)	EP1228074B1 (de)
JP (1)	JP3751880B2 (de)
KR (1)	KR100342944B1 (de)
CN (1)	CN1160361C (de)
AT (1)	ATE297933T1 (de)
AU (1)	AU755284B2 (de)
BR (1)	BR0015411A (de)
CA (1)	CA2389039A1 (de)
DE (1)	DE60020869T2 (de)
ES (1)	ES2240200T3 (de)
RU (1)	RU2217434C1 (de)
TR (1)	TR200201243T2 (de)
WO (1)	WO2001034611A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT408226B (de) *	1999-05-05	2001-09-25	Biochemie Gmbh	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
EP1373276A4 (de)	2001-02-27	2005-03-02	Ranbaxy Lab Ltd	Verfahren zur herstellung von cefpodoxim-proxetil
US20060009639A1 (en) *	2002-11-22	2006-01-12	Orchid Chemicals & Pharmaceuticals Limited	Process for the preparation of cefpodoxime proxetil
DE60222945T2 (de) *	2002-12-20	2008-02-07	Lupin Ltd., Mumbai	Verfahren zur herstellung von cefpodoxim-proxetil
WO2004060896A1 (en) *	2003-01-06	2004-07-22	Lupin Limited	A process for the manufacture of cefpodoxime proxetil
CN1305876C (zh) *	2004-01-08	2007-03-21	上海三维制药有限公司	制备高纯度头孢泊肟酯的方法
MX2007014363A (es) *	2005-05-16	2009-04-15	Elan Pharma Int Ltd	Composiciones de liberacion controlada y en forma de nanoparticulas que comprenden una cefalosporina.
WO2010097675A1 (en)	2009-02-27	2010-09-02	Dhanuka Laboratories Ltd.	An improved preparation process for cefpodoxime proxetil
EP2520578A1 (de)	2011-05-06	2012-11-07	Lupin Limited	Verfahren zur Reinigung von Cephalosporinen
CN109232609B (zh) *	2018-09-27	2021-07-02	浙江普洛得邦制药有限公司	一种制备高纯度头孢泊肟酯的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1598568A (en) *	1977-04-19	1981-09-23	Glaxo Lab Ltd	Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
US4486425A (en) *	1980-09-30	1984-12-04	Sankyo Company Limited	7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
EP0531875B1 (de) *	1991-09-07	2004-03-24	Aventis Pharma Deutschland GmbH	Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
ES2185634T3 (es)	1993-04-16	2003-05-01	Basilea Pharmaceutica Ag	Derivados de cefalosporina.
TW293010B (en) *	1994-04-20	1996-12-11	Hui-Po Wang	Method for preparing cephalosporin derivatives
US5705689A (en) *	1995-06-19	1998-01-06	Associated Universities, Inc.	Aza compounds as anion receptors
AT413383B (de) *	1998-01-09	2006-02-15	Sandoz Ag	Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil

1999
- 1999-11-08 KR KR1019990049174A patent/KR100342944B1/ko not_active Expired - Fee Related
2000
- 2000-11-07 EP EP00976419A patent/EP1228074B1/de not_active Expired - Lifetime
- 2000-11-07 AU AU14202/01A patent/AU755284B2/en not_active Ceased
- 2000-11-07 JP JP2001537324A patent/JP3751880B2/ja not_active Expired - Fee Related
- 2000-11-07 TR TR2002/01243T patent/TR200201243T2/xx unknown
- 2000-11-07 WO PCT/KR2000/001272 patent/WO2001034611A1/en not_active Ceased
- 2000-11-07 BR BR0015411-3A patent/BR0015411A/pt not_active IP Right Cessation
- 2000-11-07 ES ES00976419T patent/ES2240200T3/es not_active Expired - Lifetime
- 2000-11-07 RU RU2002115289/04A patent/RU2217434C1/ru not_active IP Right Cessation
- 2000-11-07 CN CNB008153205A patent/CN1160361C/zh not_active Expired - Fee Related
- 2000-11-07 AT AT00976419T patent/ATE297933T1/de not_active IP Right Cessation
- 2000-11-07 CA CA002389039A patent/CA2389039A1/en not_active Abandoned
- 2000-11-07 US US10/111,557 patent/US6639068B1/en not_active Expired - Lifetime
- 2000-11-07 DE DE60020869T patent/DE60020869T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60020869T2 (de)	2005-11-03
DE60020869D1 (de)	2005-07-21
AU755284B2 (en)	2002-12-05
ES2240200T3 (es)	2005-10-16
BR0015411A (pt)	2002-06-25
KR20010045748A (ko)	2001-06-05
CN1387533A (zh)	2002-12-25
WO2001034611A1 (en)	2001-05-17
TR200201243T2 (tr)	2002-09-23
RU2217434C1 (ru)	2003-11-27
AU1420201A (en)	2001-06-06
EP1228074A1 (de)	2002-08-07
CA2389039A1 (en)	2001-05-17
EP1228074B1 (de)	2005-06-15
US6639068B1 (en)	2003-10-28
CN1160361C (zh)	2004-08-04
JP3751880B2 (ja)	2006-03-01
JP2003513983A (ja)	2003-04-15
KR100342944B1 (ko)	2002-07-02
EP1228074A4 (de)	2003-02-26

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE297933T1 (de)	2005-07-15	Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil
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ATE375355T1 (de)	2007-10-15	Verfahren zur herstellung von cefpodoxim-proxetil
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