ATE440105T1 - Verfahren zur herstellung von dem bicyclischen hexapeptide nepadutant - Google Patents
Verfahren zur herstellung von dem bicyclischen hexapeptide nepadutantInfo
- Publication number
- ATE440105T1 ATE440105T1 AT03782304T AT03782304T ATE440105T1 AT E440105 T1 ATE440105 T1 AT E440105T1 AT 03782304 T AT03782304 T AT 03782304T AT 03782304 T AT03782304 T AT 03782304T AT E440105 T1 ATE440105 T1 AT E440105T1
- Authority
- AT
- Austria
- Prior art keywords
- nepadutant
- producing
- bicyclic
- hexapeptide
- bicyclic hexapeptide
- Prior art date
Links
- 108010092101 MEN 11420 Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- NGCNKEZHGRXHNL-WVWQGFTISA-N n-[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-2-[(1s,4s,7s,10s,13s,16s)-13-benzyl-16-(1h-indol-3-ylmethyl)-7-(2-methylpropyl)-3,6,9,12,15,18,20-heptaoxo-2,5,8,11,14,17,21-heptazabicyclo[8.8.4]docosan-4-yl]acetamide Chemical compound C([C@H]1C(=O)N[C@H]2CC(=O)NC[C@H](NC(=O)[C@H](CC=3C=CC=CC=3)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC2=O)C(=O)N[C@H](C(N1)=O)CC(C)C)C(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O NGCNKEZHGRXHNL-WVWQGFTISA-N 0.000 title 1
- 229950000640 nepadutant Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000239A ITFI20020239A1 (it) | 2002-12-06 | 2002-12-06 | Processo per la preparazione di composti peptidici biciclici. |
| PCT/EP2003/013696 WO2004052923A2 (en) | 2002-12-06 | 2003-12-04 | Process for the preparation of bicyclic hexa-peptide nepadutant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440105T1 true ATE440105T1 (de) | 2009-09-15 |
Family
ID=32500550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03782304T ATE440105T1 (de) | 2002-12-06 | 2003-12-04 | Verfahren zur herstellung von dem bicyclischen hexapeptide nepadutant |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7999068B2 (de) |
| EP (1) | EP1576000B1 (de) |
| JP (1) | JP4593284B2 (de) |
| KR (1) | KR101081256B1 (de) |
| CN (1) | CN1318445C (de) |
| AT (1) | ATE440105T1 (de) |
| AU (1) | AU2003289958A1 (de) |
| BR (1) | BR0317029A (de) |
| CA (1) | CA2508696C (de) |
| DE (1) | DE60328915D1 (de) |
| ES (1) | ES2330102T3 (de) |
| IT (1) | ITFI20020239A1 (de) |
| MX (1) | MXPA05005969A (de) |
| PL (1) | PL207850B1 (de) |
| RU (1) | RU2330045C9 (de) |
| WO (1) | WO2004052923A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1996609B1 (de) * | 2006-03-22 | 2016-08-03 | The Scripps Research Institute | Verfahren zur herstellung von glycopeptiden |
| CN103864901B (zh) * | 2012-12-17 | 2017-02-08 | 深圳翰宇药业股份有限公司 | 一种制备奈帕坦特及其中间体的方法及所述中间体 |
| CN109503698B (zh) * | 2018-12-13 | 2021-01-01 | 无限极（中国）有限公司 | 一种多肽及其制备方法与应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1277835B1 (it) * | 1995-03-13 | 1997-11-12 | Menarini Farma Ind | Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche |
-
2002
- 2002-12-06 IT IT000239A patent/ITFI20020239A1/it unknown
-
2003
- 2003-12-04 JP JP2004557990A patent/JP4593284B2/ja not_active Expired - Fee Related
- 2003-12-04 BR BR0317029-2A patent/BR0317029A/pt unknown
- 2003-12-04 CA CA2508696A patent/CA2508696C/en not_active Expired - Fee Related
- 2003-12-04 US US10/537,731 patent/US7999068B2/en not_active Expired - Fee Related
- 2003-12-04 WO PCT/EP2003/013696 patent/WO2004052923A2/en not_active Ceased
- 2003-12-04 AT AT03782304T patent/ATE440105T1/de not_active IP Right Cessation
- 2003-12-04 MX MXPA05005969A patent/MXPA05005969A/es unknown
- 2003-12-04 DE DE60328915T patent/DE60328915D1/de not_active Expired - Lifetime
- 2003-12-04 CN CNB200380105180XA patent/CN1318445C/zh not_active Expired - Fee Related
- 2003-12-04 AU AU2003289958A patent/AU2003289958A1/en not_active Abandoned
- 2003-12-04 PL PL377635A patent/PL207850B1/pl unknown
- 2003-12-04 ES ES03782304T patent/ES2330102T3/es not_active Expired - Lifetime
- 2003-12-04 KR KR1020057009808A patent/KR101081256B1/ko not_active Expired - Fee Related
- 2003-12-04 RU RU2005117345/04A patent/RU2330045C9/ru not_active IP Right Cessation
- 2003-12-04 EP EP03782304A patent/EP1576000B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| RU2330045C2 (ru) | 2008-07-27 |
| RU2330045C9 (ru) | 2008-11-20 |
| CN1318445C (zh) | 2007-05-30 |
| RU2005117345A (ru) | 2006-02-27 |
| WO2004052923A3 (en) | 2005-02-24 |
| PL377635A1 (pl) | 2006-02-06 |
| AU2003289958A8 (en) | 2004-06-30 |
| AU2003289958A1 (en) | 2004-06-30 |
| ES2330102T3 (es) | 2009-12-04 |
| KR101081256B1 (ko) | 2011-11-08 |
| US7999068B2 (en) | 2011-08-16 |
| BR0317029A (pt) | 2005-10-25 |
| KR20050089966A (ko) | 2005-09-09 |
| EP1576000A2 (de) | 2005-09-21 |
| PL207850B1 (pl) | 2011-02-28 |
| CA2508696C (en) | 2014-05-06 |
| CN1720260A (zh) | 2006-01-11 |
| DE60328915D1 (de) | 2009-10-01 |
| US20090163695A1 (en) | 2009-06-25 |
| JP4593284B2 (ja) | 2010-12-08 |
| WO2004052923A2 (en) | 2004-06-24 |
| CA2508696A1 (en) | 2004-06-24 |
| EP1576000B1 (de) | 2009-08-19 |
| JP2006520743A (ja) | 2006-09-14 |
| MXPA05005969A (es) | 2005-11-17 |
| ITFI20020239A1 (it) | 2004-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |