ATE297946T1 - Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease - Google Patents

Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease

Info

Publication number
ATE297946T1
ATE297946T1 AT01924516T AT01924516T ATE297946T1 AT E297946 T1 ATE297946 T1 AT E297946T1 AT 01924516 T AT01924516 T AT 01924516T AT 01924516 T AT01924516 T AT 01924516T AT E297946 T1 ATE297946 T1 AT E297946T1
Authority
AT
Austria
Prior art keywords
hepatitis
protease
virus
compounds
inhibitors
Prior art date
Application number
AT01924516T
Other languages
English (en)
Inventor
Robert Perni
John Court
Ethan O'malley
Govinda Rao Bhisetti
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE297946T1 publication Critical patent/ATE297946T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01924516T 2000-04-03 2001-03-29 Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease ATE297946T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19456300P 2000-04-03 2000-04-03
US19833000P 2000-04-18 2000-04-18
PCT/US2001/010367 WO2001074768A2 (en) 2000-04-03 2001-03-29 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (1)

Publication Number Publication Date
ATE297946T1 true ATE297946T1 (de) 2005-07-15

Family

ID=26890159

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01924516T ATE297946T1 (de) 2000-04-03 2001-03-29 Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease

Country Status (11)

Country Link
US (1) US7494988B2 (de)
EP (1) EP1268519B1 (de)
JP (1) JP4806154B2 (de)
AT (1) ATE297946T1 (de)
AU (1) AU2001251165A1 (de)
CA (1) CA2405043A1 (de)
DE (1) DE60111509T2 (de)
ES (1) ES2240446T3 (de)
IL (2) IL152022A0 (de)
PT (1) PT1268519E (de)
WO (1) WO2001074768A2 (de)

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CZ298749B6 (cs) * 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
DK1066247T3 (da) * 1998-03-31 2007-04-02 Vertex Pharma Inhibitorer af serinproteaser, især hepatitis C virus NS3 protease
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BRPI0412761A (pt) * 2003-07-18 2006-09-26 Vertex Pharma inibidores de serino proteases, particularmente a protease ns3-ns4a do vhc
PE20050374A1 (es) * 2003-09-05 2005-05-30 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
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Also Published As

Publication number Publication date
JP2003529583A (ja) 2003-10-07
DE60111509D1 (de) 2005-07-21
PT1268519E (pt) 2005-08-31
ES2240446T3 (es) 2005-10-16
AU2001251165A1 (en) 2001-10-15
EP1268519A2 (de) 2003-01-02
DE60111509T2 (de) 2006-05-11
US20030236242A1 (en) 2003-12-25
EP1268519B1 (de) 2005-06-15
WO2001074768A2 (en) 2001-10-11
IL152022A0 (en) 2003-04-10
CA2405043A1 (en) 2001-10-11
IL152022A (en) 2008-07-08
WO2001074768A3 (en) 2002-06-06
JP4806154B2 (ja) 2011-11-02
US7494988B2 (en) 2009-02-24

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