ATE297948T1 - Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten - Google Patents

Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten

Info

Publication number: ATE297948T1
Authority: AT; Austria
Prior art keywords: beta; igf; tgf; fraction; preparations
Prior art date: 1999-10-06

Application number

AT99949462T

Other languages

English (en)

Inventor

Marinus Gerardus Cornel Kivits

Andor Wilhelm Joseph Hendricks

Leonard Franciscus Mallee

Original Assignee

Campina Bv

Nutricia Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-06

Filing date

1999-10-06

Publication date

2005-07-15

1999-10-06 Application filed by Campina Bv, Nutricia Nv filed Critical Campina Bv

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE297948T1 publication Critical patent/ATE297948T1/de

Links

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
102000004218 Insulin-Like Growth Factor I Human genes 0.000 title 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 title 1
238000011109 contamination Methods 0.000 title 1
235000013365 dairy product Nutrition 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 4
102100037852 Insulin-like growth factor I Human genes 0.000 abstract 4
229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
239000008267 milk Substances 0.000 abstract 2
210000004080 milk Anatomy 0.000 abstract 2
235000013336 milk Nutrition 0.000 abstract 2
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
108010023244 Lactoperoxidase Proteins 0.000 abstract 1
102000045576 Lactoperoxidases Human genes 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
239000003480 eluent Substances 0.000 abstract 1
229940057428 lactoperoxidase Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Feed For Specific Animals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99949462T 1999-10-06 1999-10-06 Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten ATE297948T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/NL1999/000621 WO2001025276A1 (en)	1999-10-06	1999-10-06	Process for obtaining growth factor preparations (tgf-beta and igf-1) from milk products having low mutual cross-contamination

Publications (1)

Publication Number	Publication Date
ATE297948T1 true ATE297948T1 (de)	2005-07-15

Family

ID=19866618

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99949462T ATE297948T1 (de)	1999-10-06	1999-10-06	Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten

Country Status (8)

Country	Link
EP (1)	EP1218410B1 (de)
AT (1)	ATE297948T1 (de)
AU (1)	AU782573B2 (de)
CA (1)	CA2387686A1 (de)
DE (1)	DE69925870T2 (de)
DK (1)	DK1218410T3 (de)
NZ (1)	NZ518217A (de)
WO (1)	WO2001025276A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827290B1 (fr) *	2001-07-13	2004-07-09	Pierre Jouan Biotechnologies Sa	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
EP1409538B1 (de) *	2001-07-20	2009-01-07	Campina B.V.	Verfahren zur herstellung von preparationen aus milchprodukten, welche wachstumsfaktoren (tgf-beta und igf-1), lactoperoxidase und immunglobuline mit niedriger gegenseitiger verunreinigung enthalten
US7572474B2 (en)	2005-06-01	2009-08-11	Mead Johnson Nutrition Company	Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en)	2008-10-24	2011-12-13	Mead Johnson Nutrition Company	Nutritional composition with improved digestibility
FR2889068B1 (fr) *	2005-07-29	2012-03-02	Cie Laitiere Europeenne	Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques
US8350006B2 (en)	2008-10-24	2013-01-08	Mead Johnson Nutrition Company	Methods for determining the bioactivity of TGF-β in a composition
US8367354B2 (en)	2008-10-24	2013-02-05	Mead Johnson Nutrition Company	Methods for determining the levels of TGF-β in a composition
US8986769B2 (en)	2008-10-24	2015-03-24	Mead Johnson Nutrition Company	Methods for preserving endogenous TGF-β
DK3740087T3 (da)	2018-01-16	2022-08-08	Frieslandcampina Nederland Bv	Hypoallergen modermælkserstatning og fremgangsmåder til fremstillig deraf
US11109604B2 (en)	2019-05-09	2021-09-07	Memtec LLC	Dairy processing systems and methods
MX2024005465A (es)	2021-11-05	2024-05-22	Frieslandcampina Nederland Bv	Uso de tgf en la prevencion de una infeccion virica de las vias respiratorias.
WO2025149372A1 (en)	2024-01-09	2025-07-17	Frieslandcampina Nederland B.V.	Milk extracellular vesicle enrichment process using peg

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8806893D0 (en) *	1988-03-23	1988-04-27	Unilever Plc	Cosmetic composition
FR2663816B1 (fr) *	1990-06-28	1993-08-06	Clar	Procede de traitement du colostrum par chromatographie d'adsorption sur hydroxyapatite, fraction active de colostrum obtenue et milieu cellulaire contenant ladite fraction active.
NZ238890A (en) *	1990-07-13	1994-08-26	Gropep Pty Ltd	Cell growth stimulating factor composition extracted from milk products and its use in culturing cells
JPH05202098A (ja) *	1992-01-29	1993-08-10	Snow Brand Milk Prod Co Ltd	乳質原料から生理活性物質の製造法
JP3544213B2 (ja) *	1993-03-31	2004-07-21	雪印乳業株式会社	インスリン様増殖因子−１含有組成物の製造法
NL1005677C2 (nl) *	1997-03-27	1998-09-29	Campina Melkunie Bv	Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.

1999
- 1999-10-06 AT AT99949462T patent/ATE297948T1/de not_active IP Right Cessation
- 1999-10-06 AU AU62329/99A patent/AU782573B2/en not_active Ceased
- 1999-10-06 EP EP99949462A patent/EP1218410B1/de not_active Expired - Lifetime
- 1999-10-06 DK DK99949462T patent/DK1218410T3/da active
- 1999-10-06 NZ NZ518217A patent/NZ518217A/en not_active IP Right Cessation
- 1999-10-06 WO PCT/NL1999/000621 patent/WO2001025276A1/en not_active Ceased
- 1999-10-06 DE DE69925870T patent/DE69925870T2/de not_active Expired - Lifetime
- 1999-10-06 CA CA002387686A patent/CA2387686A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69925870T2 (de)	2005-12-08
EP1218410A1 (de)	2002-07-03
NZ518217A (en)	2003-09-26
WO2001025276A1 (en)	2001-04-12
DK1218410T3 (da)	2005-08-08
EP1218410B1 (de)	2005-06-15
AU782573B2 (en)	2005-08-11
DE69925870D1 (de)	2005-07-21
CA2387686A1 (en)	2001-04-12
AU6232999A (en)	2001-05-10

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Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties