ATE297948T1 - Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten - Google Patents

Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten

Info

Publication number: ATE297948T1
Authority: AT; Austria
Prior art keywords: beta; igf; tgf; fraction; preparations
Prior art date: 1999-10-06

Application number

AT99949462T

Other languages

English (en)

Inventor

Marinus Gerardus Cornel Kivits

Andor Wilhelm Joseph Hendricks

Leonard Franciscus Mallee

Original Assignee

Campina Bv

Nutricia Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-06

Filing date

1999-10-06

Publication date

2005-07-15

1999-10-06 Application filed by Campina Bv, Nutricia Nv filed Critical Campina Bv

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE297948T1 publication Critical patent/ATE297948T1/de

Links

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
102000004218 Insulin-Like Growth Factor I Human genes 0.000 title 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 title 1
238000011109 contamination Methods 0.000 title 1
235000013365 dairy product Nutrition 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 4
102100037852 Insulin-like growth factor I Human genes 0.000 abstract 4
229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
239000008267 milk Substances 0.000 abstract 2
210000004080 milk Anatomy 0.000 abstract 2
235000013336 milk Nutrition 0.000 abstract 2
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
108010023244 Lactoperoxidase Proteins 0.000 abstract 1
102000045576 Lactoperoxidases Human genes 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
239000003480 eluent Substances 0.000 abstract 1
229940057428 lactoperoxidase Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Feed For Specific Animals (AREA)

AT99949462T 1999-10-06 1999-10-06 Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten ATE297948T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/NL1999/000621 WO2001025276A1 (en)	1999-10-06	1999-10-06	Process for obtaining growth factor preparations (tgf-beta and igf-1) from milk products having low mutual cross-contamination

Publications (1)

Publication Number	Publication Date
ATE297948T1 true ATE297948T1 (de)	2005-07-15

Family

ID=19866618

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99949462T ATE297948T1 (de)	1999-10-06	1999-10-06	Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten

Country Status (8)

Country	Link
EP (1)	EP1218410B1 (de)
AT (1)	ATE297948T1 (de)
AU (1)	AU782573B2 (de)
CA (1)	CA2387686A1 (de)
DE (1)	DE69925870T2 (de)
DK (1)	DK1218410T3 (de)
NZ (1)	NZ518217A (de)
WO (1)	WO2001025276A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827290B1 (fr)	2001-07-13	2004-07-09	Pierre Jouan Biotechnologies Sa	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
CN1555384B (zh) *	2001-07-20	2010-05-26	坎皮纳公司	从乳制品获得具有低相互交叉污染的生长因子(TGF-β和IGF-1)、乳过氧化物酶和免疫球蛋白制剂的方法
US7572474B2 (en)	2005-06-01	2009-08-11	Mead Johnson Nutrition Company	Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en)	2008-10-24	2011-12-13	Mead Johnson Nutrition Company	Nutritional composition with improved digestibility
FR2889068B1 (fr)	2005-07-29	2012-03-02	Cie Laitiere Europeenne	Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques
US8986769B2 (en)	2008-10-24	2015-03-24	Mead Johnson Nutrition Company	Methods for preserving endogenous TGF-β
US8350006B2 (en)	2008-10-24	2013-01-08	Mead Johnson Nutrition Company	Methods for determining the bioactivity of TGF-β in a composition
US8367354B2 (en)	2008-10-24	2013-02-05	Mead Johnson Nutrition Company	Methods for determining the levels of TGF-β in a composition
WO2019141662A1 (en)	2018-01-16	2019-07-25	Frieslandcampina Nederland B.V.	Hypoallergenic infant formula and methods for preparing the same
US11109604B2 (en)	2019-05-09	2021-09-07	Memtec LLC	Dairy processing systems and methods
EP4426333A1 (de)	2021-11-05	2024-09-11	FrieslandCampina Nederland B.V.	Verwendung von tgf zur vorbeugung von virusinfektionen der atemwege
WO2025149372A1 (en)	2024-01-09	2025-07-17	Frieslandcampina Nederland B.V.	Milk extracellular vesicle enrichment process using peg

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8806893D0 (en) *	1988-03-23	1988-04-27	Unilever Plc	Cosmetic composition
FR2663816B1 (fr) *	1990-06-28	1993-08-06	Clar	Procede de traitement du colostrum par chromatographie d'adsorption sur hydroxyapatite, fraction active de colostrum obtenue et milieu cellulaire contenant ladite fraction active.
DE69133442T2 (de) *	1990-07-13	2006-01-12	Gropep Ltd., Thebarton	Wachstumsfördernder wirkstoff
JPH05202098A (ja) *	1992-01-29	1993-08-10	Snow Brand Milk Prod Co Ltd	乳質原料から生理活性物質の製造法
JP3544213B2 (ja) *	1993-03-31	2004-07-21	雪印乳業株式会社	インスリン様増殖因子−１含有組成物の製造法
NL1005677C2 (nl) *	1997-03-27	1998-09-29	Campina Melkunie Bv	Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.

1999
- 1999-10-06 DE DE69925870T patent/DE69925870T2/de not_active Expired - Lifetime
- 1999-10-06 EP EP99949462A patent/EP1218410B1/de not_active Expired - Lifetime
- 1999-10-06 CA CA002387686A patent/CA2387686A1/en not_active Abandoned
- 1999-10-06 DK DK99949462T patent/DK1218410T3/da active
- 1999-10-06 WO PCT/NL1999/000621 patent/WO2001025276A1/en not_active Ceased
- 1999-10-06 AU AU62329/99A patent/AU782573B2/en not_active Ceased
- 1999-10-06 AT AT99949462T patent/ATE297948T1/de not_active IP Right Cessation
- 1999-10-06 NZ NZ518217A patent/NZ518217A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6232999A (en)	2001-05-10
CA2387686A1 (en)	2001-04-12
AU782573B2 (en)	2005-08-11
NZ518217A (en)	2003-09-26
WO2001025276A1 (en)	2001-04-12
DE69925870T2 (de)	2005-12-08
EP1218410A1 (de)	2002-07-03
DE69925870D1 (de)	2005-07-21
DK1218410T3 (da)	2005-08-08
EP1218410B1 (de)	2005-06-15

Similar Documents

Publication	Publication Date	Title
Schwartz et al.	2001	Comparison of hydrophobic charge induction chromatography with affinity chromatography on protein A for harvest and purification of antibodies
JP3403066B2 (ja)	2003-05-06	牛乳あるいは牛乳誘導物から細胞増殖因子あるいは１種または２種以上の細胞増殖因子を含む組成物を回収する方法
El-Hatmi et al.	2007	Characterisation of whey proteins of camel (Camelus dromedarius) milk and colostrum
DE69925870D1 (de)	2005-07-21	Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten
Ye et al.	2000	Isolation of lactoperoxidase, lactoferrin, α-lactalbumin, β-lactoglobulin B and β-lactoglobulin A from bovine rennet whey using ion exchange chromatography
Doultani et al.	2004	Fractionation of proteins from whey using cation exchange chromatography
ATE209862T1 (de)	2001-12-15	Isolierung von lactoferrin aus milch
ATE425181T1 (de)	2009-03-15	Therapeutische zusammensetzungen aus antikorper und antisens nukleinsäuren gegen serrate
SI2895188T1 (en)	2018-05-31	CORRECTED QUALITY ETHANERCEPT WITH HIGH QUALITY AND EXCELLENT EXPERIENCE
DE3881801D1 (de)	1993-07-22	Menschliche somatomedin-traeger-protein-untereinheiten und verfahren zu ihrer herstellung.
DE3672973D1 (de)	1990-08-30	Verfahren zur spezifischen abtrennung von lactose aus milch.
ATE420108T1 (de)	2009-01-15	Verfahren zur herstellung von preparationen aus milchprodukten, welche wachstumsfaktoren (tgf- beta und igf-1), lactoperoxidase und immunglobuline mit niedriger gegenseitiger verunreinigung enthalten
DE69618614D1 (de)	2002-02-21	NUKLEINSÄUREMOLEKÜLE MIT DER FÄHIGKEIT ZUR UNTERSCHEIDUNG VON PrPc UND PrPSc-PRIONPROTEIN-ISOFORMEN UND VERFAHREN ZU DEREN HERSTELLUNG
AU2015248461B2 (en)	2017-05-04	Novel purification process of gonadotropin
WO2002102487A3 (en)	2003-03-27	Process for preparing protein isolate from milk, whey, colostrum, and the like
CN105764915B (zh)	2019-08-13	纯化达依泊汀α的方法
DE60034117D1 (de)	2007-05-10	Verfahren zur herstelllung von gonadotropin-zusammensetzungen
EP1879908B1 (de)	2014-01-08	Immunglobulinfraktion und verfahren dafür
DE69222361D1 (de)	1997-10-30	Verfahren zur Isolierung von Proteinen aus Milch und Verfahren zur Behandlung von Milch
Haro et al.	1998	Divalent metal cation chelators enhance chromatographic separation of structurally similar macromolecules: separation of human growth hormone isoforms
KR100297927B1 (ko)	2001-10-29	인간에리스로포이에틴의정제방법
Mori et al.	1979	Synthesis of glycinin in a wheat germ cell-free system
Georgi et al.	1989	Molecular weight determination of protein hydrolysates (FPLC)
AU4464699A (en)	1999-11-04	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative
AU5068602A (en)	2002-08-08	Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties