ATE298250T1 - Verfahren und potenzierte zusammensetzung zur behandlung von migräne - Google Patents
Verfahren und potenzierte zusammensetzung zur behandlung von migräneInfo
- Publication number
- ATE298250T1 ATE298250T1 AT97910772T AT97910772T ATE298250T1 AT E298250 T1 ATE298250 T1 AT E298250T1 AT 97910772 T AT97910772 T AT 97910772T AT 97910772 T AT97910772 T AT 97910772T AT E298250 T1 ATE298250 T1 AT E298250T1
- Authority
- AT
- Austria
- Prior art keywords
- potented
- composition
- treating migraines
- treating
- migraines
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 206010027599 migraine Diseases 0.000 abstract 2
- 239000012848 Dextrorphan Substances 0.000 abstract 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 abstract 1
- 229960001985 dextromethorphan Drugs 0.000 abstract 1
- JAQUASYNZVUNQP-PVAVHDDUSA-N dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 abstract 1
- 229950006878 dextrorphan Drugs 0.000 abstract 1
- 229960003133 ergot alkaloid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72792396A | 1996-10-09 | 1996-10-09 | |
| US08/736,370 US5891885A (en) | 1996-10-09 | 1996-10-24 | Method for treating migraine |
| PCT/US1997/017828 WO1998015275A2 (en) | 1996-10-09 | 1997-10-06 | Method and potentiated composition for treating migraine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE298250T1 true ATE298250T1 (de) | 2005-07-15 |
Family
ID=27111608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97910772T ATE298250T1 (de) | 1996-10-09 | 1997-10-06 | Verfahren und potenzierte zusammensetzung zur behandlung von migräne |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5891885A (de) |
| EP (1) | EP0932416B1 (de) |
| JP (1) | JP2000508341A (de) |
| AT (1) | ATE298250T1 (de) |
| AU (1) | AU4806197A (de) |
| CA (1) | CA2267893C (de) |
| DE (1) | DE69733611T2 (de) |
| ES (1) | ES2244992T3 (de) |
| WO (1) | WO1998015275A2 (de) |
Families Citing this family (85)
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|---|---|---|---|---|
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| US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US6432986B2 (en) | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
| DE69824730T2 (de) * | 1997-07-21 | 2005-07-14 | Levin, Bruce H. | Zusammensetzungen, kits und verfahren zur hemmung von zerebralen neurovasculären störungen und muskulärem kopfschmerzen |
| US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
| EP1102589B1 (de) * | 1998-07-16 | 2006-11-02 | Memorial Sloan-Kettering Institute For Cancer Research | Topische zusammensetzung enthaltend ein opioid-analgetikum und einen nmda-antagonisten |
| GB9816899D0 (en) | 1998-08-05 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
| ES2234324T3 (es) | 1998-11-02 | 2005-06-16 | MERCK & CO., INC. | Combinaciones de un agonista 5ht1b/1d y un inhibidor selectivo de cox-2 para el tratamiento de la migraña. |
| US7163705B2 (en) * | 1998-12-15 | 2007-01-16 | Wm. Wrigley Jr. Company | Coated chewing gum product and method of making |
| AU3596500A (en) * | 1999-02-19 | 2000-09-04 | Pozen, Inc. | Formulation of 5-ht agonists with cox-2 inhibitors |
| IL136023A0 (en) * | 1999-05-14 | 2001-05-20 | Pfizer Prod Inc | 5ht1 receptor agonists and either a cox-2 inhibitor or nsaid for the treatment of migraine |
| JP2001064205A (ja) * | 1999-06-25 | 2001-03-13 | Dai Ichi Seiyaku Co Ltd | 製剤組成物 |
| IL136961A0 (en) * | 1999-06-30 | 2001-06-14 | Pfizer Prod Inc | 5ht1 receptor agonists, caffeine and either a cox-2 inhibitor or nsaid for the treatment of migraine |
| CO5190664A1 (es) * | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
| CO5190678A1 (es) * | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia combinada para el tratamiento de la migrana |
| CA2375679C (en) * | 1999-07-12 | 2008-09-23 | Capnia, Incorporated | Methods and apparatus for relieving headaches, rhinitis and other common ailments |
| DE60027921D1 (de) * | 1999-11-08 | 2006-06-14 | Capnia Inc | Vorrichtung zur gleichzeitigen verabreichung von gasen und medikamenten |
| US20070039615A1 (en) * | 1999-11-08 | 2007-02-22 | Capnia, Incorporated | Methods and apparatus for treating rhinitis |
| US20060172017A1 (en) | 1999-11-08 | 2006-08-03 | Capnia, Incorporated | Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces |
| US6492334B1 (en) | 1999-12-30 | 2002-12-10 | Robert James Generale | Tri-compound analgesic for treating inflammation and pain |
| DE10035865C2 (de) * | 2000-07-24 | 2003-02-06 | Norbert Over | Verwendung von wässrigen Spraylösungen des lokalanästhetischen Mittels Lidocain zur prophylaktischen Behandlung von Migräne |
| FR2815873B1 (fr) * | 2000-09-29 | 2002-12-06 | Adir | Composition pharmaceutique pour l'administration transmucosale d'une association dihydroergotamine/ metoclopramide |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| GB0104554D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New uses |
| DE60143671D1 (de) * | 2001-06-07 | 2011-01-27 | Sang Christine | Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists |
| US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
| US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
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| US20030008005A1 (en) * | 2001-07-05 | 2003-01-09 | R.T. Alamo Ventures, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
| WO2003011269A1 (de) * | 2001-07-31 | 2003-02-13 | Lothar Saiger | Mittel zur behandlung der symptome von demenzerkrankungen enthalten ein zusatzliches lokalanasthetikum |
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| DE102004040630A1 (de) * | 2004-08-21 | 2006-03-09 | Balaban, Romulus, Dr.med. | Kombinationstherapie mit Procain |
| WO2006024018A2 (en) * | 2004-08-24 | 2006-03-02 | Neuromolecular Pharmaceuticals, Inc. | Compositions for treating nociceptive pain |
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| EP2623099A1 (de) | 2004-11-24 | 2013-08-07 | Neuromolecular Pharmaceuticals, Inc | Zusammensetzung und Verfahren zur Behandlung neurologischer Erkrankungen |
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| PL2425820T3 (pl) | 2007-02-11 | 2015-08-31 | Map Pharmaceuticals Inc | Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych |
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| US9050330B2 (en) * | 2012-12-06 | 2015-06-09 | Jose C. Ramon-de-Jesus | Method, composition and kit for treating frequent headaches |
| EP2935280A4 (de) | 2012-12-21 | 2016-05-25 | Map Pharmaceuticals Inc | 8'-hydroxy-dihydroergotamin-verbindungen und -zusammensetzungen |
| WO2014204933A1 (en) | 2013-06-17 | 2014-12-24 | Adamas Pharmaceuticals, Inc. | Amantadine compositions and methods of use |
| US20150290174A1 (en) * | 2014-04-11 | 2015-10-15 | Resuscitate MOE LLC | Pharmaceutical formulations and method of using the same for alleviating symptoms of hangover, stomach flu or migraine |
| US10179109B2 (en) | 2016-03-04 | 2019-01-15 | Charleston Laboratories, Inc. | Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates |
| CA3034895A1 (en) | 2016-08-26 | 2018-03-01 | Exciva Ug (Haftungsbeschrankt) | Compositions and methods thereof |
| EP3618819A4 (de) * | 2017-05-04 | 2021-01-20 | Exciva GmbH | Gezielte arzneimittelrettung mit neuartigen zusammensetzungen, kombinationen und verfahren dafür |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| KR20220008824A (ko) | 2019-04-17 | 2022-01-21 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법 |
| WO2022113069A1 (en) | 2020-11-24 | 2022-06-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | E protein channel blockers and orf3 inhibitors as anti-covid-19 agents |
| BR112022022243A2 (pt) | 2020-05-01 | 2022-12-20 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Bloqueadores do canal de proteína e e inibidores de orf3 como agentes anti-covid-19. |
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| CZ288351B6 (en) * | 1990-06-07 | 2001-05-16 | Astrazeneca Ab | Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof |
| CA2020018A1 (en) * | 1990-06-27 | 1991-12-28 | Don L. Simmons | Method and composition for treating the migraine complex |
| EP0505374B1 (de) * | 1990-10-16 | 1997-04-23 | Mayor Pharmaceuticals Laboratories,Inc. | Verfahren sowie zusammensetzungen zur behandlung mit vitaminmineral |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
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| GB9113802D0 (en) * | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
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| GB9221761D0 (en) * | 1992-10-16 | 1992-12-02 | Glaxo Group Ltd | Chemical compounds |
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| WO1995006468A1 (en) * | 1993-09-01 | 1995-03-09 | Smithkline Beecham Corporation | Method for treating migraine headaches |
| GB9321812D0 (en) * | 1993-10-22 | 1993-12-15 | Smithkline Beecham Plc | Pharmaceuticals |
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-
1996
- 1996-10-24 US US08/736,370 patent/US5891885A/en not_active Expired - Lifetime
-
1997
- 1997-05-19 US US08/858,269 patent/US5939425A/en not_active Expired - Lifetime
- 1997-10-06 EP EP97910772A patent/EP0932416B1/de not_active Expired - Lifetime
- 1997-10-06 WO PCT/US1997/017828 patent/WO1998015275A2/en not_active Ceased
- 1997-10-06 AU AU48061/97A patent/AU4806197A/en not_active Abandoned
- 1997-10-06 AT AT97910772T patent/ATE298250T1/de not_active IP Right Cessation
- 1997-10-06 ES ES97910772T patent/ES2244992T3/es not_active Expired - Lifetime
- 1997-10-06 JP JP10517619A patent/JP2000508341A/ja active Pending
- 1997-10-06 DE DE69733611T patent/DE69733611T2/de not_active Expired - Lifetime
- 1997-10-06 CA CA2267893A patent/CA2267893C/en not_active Expired - Fee Related
-
1999
- 1999-01-07 US US09/226,297 patent/US6043244A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998015275A3 (en) | 1998-08-06 |
| WO1998015275A2 (en) | 1998-04-16 |
| JP2000508341A (ja) | 2000-07-04 |
| US5891885A (en) | 1999-04-06 |
| CA2267893A1 (en) | 1998-04-16 |
| EP0932416B1 (de) | 2005-06-22 |
| DE69733611D1 (de) | 2005-07-28 |
| US6043244A (en) | 2000-03-28 |
| DE69733611T2 (de) | 2006-05-04 |
| CA2267893C (en) | 2010-12-14 |
| EP0932416A2 (de) | 1999-08-04 |
| US5939425A (en) | 1999-08-17 |
| ES2244992T3 (es) | 2005-12-16 |
| AU4806197A (en) | 1998-05-05 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |