ATE298765T1 - Beta-amyloid peptidaggregation regulierende peptide mit d-aminosäuren - Google Patents

Beta-amyloid peptidaggregation regulierende peptide mit d-aminosäuren

Info

Publication number: ATE298765T1
Authority: AT; Austria
Prior art keywords: beta; peptide; amyloid peptide; compounds; amino
Prior art date: 1996-08-27

Application number

AT97940663T

Other languages

English (en)

Inventor

Mark A Findeis

Malcolm L Gefter

Gary Musso

Ethan R Signer

James Wakefield

Susan Molineaux

Joseph Chin

Jung-Ja Lee

Michael Kelley

Sonja Komar-Panicucci

Christopher C Arico-Muendel

Kathryn Phillips

Neil J Hayward

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

1997-08-27

Publication date

2005-07-15

1996-08-27 Priority claimed from US08/703,675 external-priority patent/US6303567B1/en

1997-08-27 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE298765T1 publication Critical patent/ATE298765T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
150000008574 D-amino acids Chemical class 0.000 title abstract 4
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 4
230000006919 peptide aggregation Effects 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
230000001105 regulatory effect Effects 0.000 title 1
125000003368 amide group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
229930182819 D-leucine Natural products 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
229930182832 D-phenylalanine Natural products 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000003367 polycyclic group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Hospice & Palliative Care (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Psychiatry (AREA)
Zoology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT97940663T 1996-08-27 1997-08-27 Beta-amyloid peptidaggregation regulierende peptide mit d-aminosäuren ATE298765T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/703,675 US6303567B1 (en)	1995-03-14	1996-08-27	Modulators of β-amyloid peptide aggregation comprising D-amino acids
US89734297A	1997-07-21	1997-07-21
PCT/US1997/015166 WO1998008868A1 (en)	1996-08-27	1997-08-27	MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS

Publications (1)

Publication Number	Publication Date
ATE298765T1 true ATE298765T1 (de)	2005-07-15

Family

ID=27107183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97940663T ATE298765T1 (de)	1996-08-27	1997-08-27	Beta-amyloid peptidaggregation regulierende peptide mit d-aminosäuren

Country Status (10)

Country	Link
EP (2)	EP0929574B1 (de)
JP (1)	JP2001500852A (de)
AT (1)	ATE298765T1 (de)
AU (1)	AU741199B2 (de)
CA (1)	CA2262453A1 (de)
DE (1)	DE69733655T2 (de)
DK (1)	DK0929574T3 (de)
ES (1)	ES2245003T3 (de)
PT (1)	PT929574E (de)
WO (1)	WO1998008868A1 (de)

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US5985242A (en) *	1995-10-27	1999-11-16	Praecis Pharmaceuticals, Inc.	Modulators of β-amyloid peptide aggregation comprising D-amino acids
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ATE366259T1 (de)	1999-03-04	2007-07-15	Praecis Pharm Inc	Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren
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JPWO2007020888A1 (ja)	2005-08-12	2009-02-26	武田薬品工業株式会社	脳・神経細胞保護剤および睡眠障害治療薬
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JP6249952B2 (ja)	2012-10-16	2017-12-20	武田薬品工業株式会社	複素環化合物
HUE039922T2 (hu)	2012-12-11	2019-02-28	Takeda Pharmaceuticals Co	Heterociklusos vegyületek
EP2982666B1 (de)	2013-04-04	2019-08-07	Takeda Pharmaceutical Company Limited	Heterocyclische verbindung
JP6272833B2 (ja)	2013-04-04	2018-01-31	武田薬品工業株式会社	複素環化合物
CA2951521A1 (en)	2014-06-09	2015-12-17	Takeda Pharmaceutical Company Limited	Radiolabeled compounds
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WO2018164191A1 (ja)	2017-03-08	2018-09-13	武田薬品工業株式会社	置換ピロリジン化合物およびその用途
JP7114594B2 (ja)	2017-07-28	2022-08-08	武田薬品工業株式会社	複素環化合物
US20200207734A1 (en)	2017-08-03	2020-07-02	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof
JP7279067B2 (ja)	2018-03-28	2023-05-22	武田薬品工業株式会社	複素環化合物及びその用途
US12077522B2 (en)	2018-06-29	2024-09-03	Takeda Pharmaceutical Company Limited	Heterocyclic compound and application thereof
EP3915638A4 (de)	2019-01-24	2022-10-19	Takeda Pharmaceutical Company Limited	Heterocyclische verbindung und verwendung davon
TW202523658A (zh)	2019-05-24	2025-06-16	美商賽吉醫療公司	化合物、組合物及使用方法
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JP2021050161A (ja)	2019-09-25	2021-04-01	武田薬品工業株式会社	複素環化合物及びその用途
JP2021080177A (ja)	2019-11-14	2021-05-27	武田薬品工業株式会社	複素環化合物及びその用途
WO2021106975A1 (ja)	2019-11-27	2021-06-03	武田薬品工業株式会社	複素環化合物
JP2021183587A (ja)	2020-05-22	2021-12-02	武田薬品工業株式会社	複素環化合物
WO2022115620A1 (en)	2020-11-25	2022-06-02	Sage Therapeutics, Inc.	4-fluoro-(4-(4-benzyl)piperidin-1-yl)(2-(pyrimidin-4-yl)pyridin-3-yl)methanone derivatives and similar compounds as cyp46a1 inhibitors for the treatment of neurodegenerative disorders
TW202302100A (zh)	2021-03-12	2023-01-16	日商武田藥品工業股份有限公司	食慾激素２受體促效劑於治療食慾激素介導之疾病或病症之用途
BR112023020104A2 (pt)	2021-04-02	2023-11-14	Takeda Pharmaceuticals Co	Métodos para recuperação pós-operação, para facilitar a recuperação ou reduzir o tempo de recuperação da anestesia, para prevenir ou tratar distúrbios/depressão respiratória pós-operatória ou distúrbios/depressão respiratória induzida por opioides, sedação pós-operatória ou sedação induzida por opioides e para reduzir um efeito colateral de opioides
JPWO2023090268A1 (de)	2021-11-17	2023-05-25

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US5854204A (en) *	1995-03-14	1998-12-29	Praecis Pharmaceuticals, Inc.	Aβ peptides that modulate β-amyloid aggregation
WO1997021728A1 (en) *	1995-12-12	1997-06-19	Karolinska Innovations Ab	PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)

1997
- 1997-08-27 JP JP10511914A patent/JP2001500852A/ja not_active Ceased
- 1997-08-27 AT AT97940663T patent/ATE298765T1/de not_active IP Right Cessation
- 1997-08-27 EP EP97940663A patent/EP0929574B1/de not_active Expired - Lifetime
- 1997-08-27 WO PCT/US1997/015166 patent/WO1998008868A1/en not_active Ceased
- 1997-08-27 ES ES97940663T patent/ES2245003T3/es not_active Expired - Lifetime
- 1997-08-27 CA CA002262453A patent/CA2262453A1/en not_active Abandoned
- 1997-08-27 EP EP05013789A patent/EP1586584A1/de not_active Withdrawn
- 1997-08-27 DE DE69733655T patent/DE69733655T2/de not_active Expired - Fee Related
- 1997-08-27 AU AU42387/97A patent/AU741199B2/en not_active Ceased
- 1997-08-27 DK DK97940663T patent/DK0929574T3/da active
- 1997-08-27 PT PT97940663T patent/PT929574E/pt unknown

Also Published As

Publication number	Publication date
EP1586584A1 (de)	2005-10-19
EP0929574A1 (de)	1999-07-21
JP2001500852A (ja)	2001-01-23
CA2262453A1 (en)	1998-03-05
HK1021741A1 (en)	2000-06-30
PT929574E (pt)	2005-11-30
EP0929574B1 (de)	2005-06-29
AU741199B2 (en)	2001-11-22
DK0929574T3 (da)	2005-10-31
AU4238797A (en)	1998-03-19
DE69733655D1 (de)	2005-08-04
DE69733655T2 (de)	2006-04-27
WO1998008868A1 (en)	1998-03-05
ES2245003T3 (es)	2005-12-16

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2006-05-15

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Publication	Publication Date	Title
DE69733655D1 (de)	2005-08-04	beta-AMYLOID PEPTIDAGGREGATION REGULIERENDE PEPTIDE MIT D-AMINOSÄUREN
ATE366259T1 (de)	2007-07-15	Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren
DE69739035D1 (de)	2008-11-20	Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
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DE60041119D1 (de)	2009-01-29	Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
NO920671L (no)	1992-08-24	Fremgangsmaate for aktivering av rekombinante proteiner
ATE14226T1 (de)	1985-07-15	Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
DK0506748T3 (da)	1996-01-22	Aminosyrer, peptider eller derivater deraf bundet til fedtstoffer
DE69315730D1 (de)	1998-01-29	Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
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