DK0929574T3 - Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer - Google Patents

Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer

Info

Publication number: DK0929574T3
Authority: DK; Denmark
Prior art keywords: beta; peptide; amyloid peptide; compounds; amino
Prior art date: 1996-08-27

Application number

DK97940663T

Other languages

Danish (da)

English (en)

Inventor

Mark A Findeis

Malcolm L Gefter

Gary Musso

Ethan R Signer

Susan Molineaux

Joseph Chin

Jung-Ja Lee

Michael Kelley

Christopher C Arico-Muendel

James Wakefield

Sonja Komar-Panicucci

Kathryn Phillips

Neil J Hayward

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

1997-08-27

Publication date

2005-10-31

1996-08-27 Priority claimed from US08/703,675 external-priority patent/US6303567B1/en

1997-08-27 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2005-10-31 Application granted granted Critical

2005-10-31 Publication of DK0929574T3 publication Critical patent/DK0929574T3/da

Links

150000008574 D-amino acids Chemical class 0.000 title abstract 4
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 4
230000006919 peptide aggregation Effects 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
125000003368 amide group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
229930182819 D-leucine Natural products 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
229930182832 D-phenylalanine Natural products 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000003367 polycyclic group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK97940663T 1996-08-27 1997-08-27 Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer DK0929574T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/703,675 US6303567B1 (en)	1995-03-14	1996-08-27	Modulators of β-amyloid peptide aggregation comprising D-amino acids
US89734297A	1997-07-21	1997-07-21
PCT/US1997/015166 WO1998008868A1 (en)	1996-08-27	1997-08-27	MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS

Publications (1)

Publication Number	Publication Date
DK0929574T3 true DK0929574T3 (da)	2005-10-31

Family

ID=27107183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97940663T DK0929574T3 (da)	1996-08-27	1997-08-27	Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer

Country Status (10)

Country	Link
EP (2)	EP0929574B1 (de)
JP (1)	JP2001500852A (de)
AT (1)	ATE298765T1 (de)
AU (1)	AU741199B2 (de)
CA (1)	CA2262453A1 (de)
DE (1)	DE69733655T2 (de)
DK (1)	DK0929574T3 (de)
ES (1)	ES2245003T3 (de)
PT (1)	PT929574E (de)
WO (1)	WO1998008868A1 (de)

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US7964192B1 (en)	1997-12-02	2011-06-21	Janssen Alzheimer Immunotherapy	Prevention and treatment of amyloidgenic disease
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US7067550B2 (en)	2000-11-03	2006-06-27	Massachusetts Institute Of Technology	Treatments for neurotoxicity in Alzheimer's Disease
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TWI255272B (en)	2000-12-06	2006-05-21	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
US7700751B2 (en)	2000-12-06	2010-04-20	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize β-amyloid peptide
CA2434831C (en) *	2001-01-17	2012-03-06	Robert H. Zimmer	Polypeptide drug substances
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US20040052928A1 (en)	2002-09-06	2004-03-18	Ehud Gazit	Peptides and methods using same for diagnosing and treating amyloid-associated diseases
KR101011657B1 (ko)	2002-03-01	2011-01-28	다케다 야쿠힌 고교 가부시키가이샤	항우울제
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
US6846640B2 (en)	2002-04-30	2005-01-25	Pharmacia & Upjohn Company	Time-resolved fluorescence assay for the detection of multimeric forms of A-beta 1-40
PE20050627A1 (es)	2003-05-30	2005-08-10	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido beta amiloideo
JP5137400B2 (ja) *	2003-06-30	2013-02-06	テルアヴィヴユニヴァーシティフューチャーテクノロジーディヴェロップメントエル．ピー．	アミロイド関連疾患を診断および処置するためのペプチド、それに対する抗体、ならびにその使用方法
WO2006066089A1 (en)	2004-12-15	2006-06-22	Neuralab Limited	Humanized amyloid beta antibodies for use in improving cognition
TW200636066A (en)	2004-12-15	2006-10-16	Elan Pharm Inc	Humanized antibodies that recognize beta amyloid peptide
WO2007020888A1 (ja)	2005-08-12	2007-02-22	Takeda Pharmaceutical Company Limited	脳・神経細胞保護剤および睡眠障害治療薬
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
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US8236766B2 (en)	2006-11-10	2012-08-07	Cara Therapeutics, Inc.	Uses of synthetic peptide amides
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US8003097B2 (en)	2007-04-18	2011-08-23	Janssen Alzheimer Immunotherapy	Treatment of cerebral amyloid angiopathy
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US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies
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US9296746B2 (en)	2012-10-16	2016-03-29	Takeda Pharmaceutical Company Limited	Heterocyclic compound
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JP6272832B2 (ja)	2013-04-04	2018-01-31	武田薬品工業株式会社	複素環化合物
EP2982670B1 (de)	2013-04-04	2018-11-07	Takeda Pharmaceutical Company Limited	Heterocyclische verbindung
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US11059780B2 (en)	2017-03-08	2021-07-13	Takeda Pharmaceutical Company Limited	Substituted pyrrolidine compound and use thereof
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US5338837A (en) *	1991-12-13	1994-08-16	The Trustees Of Princeton University	Glycosylated steroid derivatives for transport across biological membranes and process for making same
WO1994019692A1 (en) *	1993-02-18	1994-09-01	The General Hospital Corporation	Alzheimer's disease therapeutics
EP0815134B1 (de) *	1995-03-14	2002-06-05	Praecis Pharmaceuticals Incorporated	VERBINDUNGEN MIT AGGREGATIONS-MODULIERENDEN WIRKUNG AUF DAS AMYLOiD PROTEIN
WO1997021728A1 (en) *	1995-12-12	1997-06-19	Karolinska Innovations Ab	PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)

1997
- 1997-08-27 PT PT97940663T patent/PT929574E/pt unknown
- 1997-08-27 JP JP10511914A patent/JP2001500852A/ja not_active Ceased
- 1997-08-27 WO PCT/US1997/015166 patent/WO1998008868A1/en not_active Ceased
- 1997-08-27 DK DK97940663T patent/DK0929574T3/da active
- 1997-08-27 ES ES97940663T patent/ES2245003T3/es not_active Expired - Lifetime
- 1997-08-27 EP EP97940663A patent/EP0929574B1/de not_active Expired - Lifetime
- 1997-08-27 DE DE69733655T patent/DE69733655T2/de not_active Expired - Fee Related
- 1997-08-27 CA CA002262453A patent/CA2262453A1/en not_active Abandoned
- 1997-08-27 AT AT97940663T patent/ATE298765T1/de not_active IP Right Cessation
- 1997-08-27 AU AU42387/97A patent/AU741199B2/en not_active Ceased
- 1997-08-27 EP EP05013789A patent/EP1586584A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
WO1998008868A1 (en)	1998-03-05
HK1021741A1 (en)	2000-06-30
PT929574E (pt)	2005-11-30
AU4238797A (en)	1998-03-19
JP2001500852A (ja)	2001-01-23
DE69733655D1 (de)	2005-08-04
AU741199B2 (en)	2001-11-22
ES2245003T3 (es)	2005-12-16
EP0929574A1 (de)	1999-07-21
ATE298765T1 (de)	2005-07-15
EP1586584A1 (de)	2005-10-19
DE69733655T2 (de)	2006-04-27
CA2262453A1 (en)	1998-03-05
EP0929574B1 (de)	2005-06-29

Publication	Publication Date	Title
DK0929574T3 (da)	2005-10-31	Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer
DK1161449T3 (da)	2007-11-05	Modulatorer af beta-amyloidpeptidaggregering, der omfatter d-aminosyrer
DE69713112D1 (de)	2002-07-11	Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin-analogen
DK0792287T3 (da)	2004-08-30	Peptidanaloger af humant basisk myelinprotein
BR0209434A (pt)	2006-02-07	Peptìdeos antimicrobianos e composições
ATE417925T1 (de)	2009-01-15	Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
DE69635493D1 (de)	2005-12-29	Verfahren zur herstellung von l-aminosäuren
ES2071815T3 (es)	1995-07-01	Analogos de delecion de los peptidos conocidos como magaininas.
WO2005060683A3 (en)	2007-04-12	Small peptides for the treatment of alzheimer’s disease and other beta-amyloid protein fibrillogenesis disorders
DK0506748T3 (da)	1996-01-22	Aminosyrer, peptider eller derivater deraf bundet til fedtstoffer
DK0896615T3 (da)	2003-01-06	Peptid fra opløselig form af acetylcholinesterase, der er aktivt som calcium-kanal-modulator
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