ATE299181T1 - Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren - Google Patents

Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren

Info

Publication number: ATE299181T1
Authority: AT; Austria
Prior art keywords: fibroblast growth; amino acid; growth factors; surface loop; beta
Prior art date: 1993-09-24

Application number

AT94929876T

Other languages

English (en)

Inventor

Andrew Peter Seddon

Lu-Yuan Li

Peter Boehlen

Magdalena Eisinger

Avner Yayon

Original Assignee

Wyeth Corp

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-24

Filing date

1994-09-23

Publication date

2005-07-15

1994-08-15 Priority claimed from US08/290,373 external-priority patent/US5491220A/en

1994-09-23 Application filed by Wyeth Corp, Yeda Res & Dev filed Critical Wyeth Corp

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE299181T1 publication Critical patent/ATE299181T1/de

Links

102000018233 Fibroblast Growth Factor Human genes 0.000 title abstract 3
108050007372 Fibroblast Growth Factor Proteins 0.000 title abstract 3
125000003275 alpha amino acid group Chemical group 0.000 abstract 3
108091008794 FGF receptors Proteins 0.000 abstract 1
102000003971 Fibroblast Growth Factor 1 Human genes 0.000 abstract 1
108090000386 Fibroblast Growth Factor 1 Proteins 0.000 abstract 1
102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 abstract 1
102000003974 Fibroblast growth factor 2 Human genes 0.000 abstract 1
108090000379 Fibroblast growth factor 2 Proteins 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
102000015696 Interleukins Human genes 0.000 abstract 1
108010063738 Interleukins Proteins 0.000 abstract 1
229940126864 fibroblast growth factor Drugs 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Prostheses (AREA)

AT94929876T 1993-09-24 1994-09-23 Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren ATE299181T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12697393A	1993-09-24	1993-09-24
US08/290,373 US5491220A (en)	1993-09-24	1994-08-15	Surface loop structural analogues of fibroblast growth factors
PCT/US1994/010800 WO1995008630A1 (en)	1993-09-24	1994-09-23	Surface loop structural analogues of fibroblast growth factors

Publications (1)

Publication Number	Publication Date
ATE299181T1 true ATE299181T1 (de)	2005-07-15

Family

ID=26825210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94929876T ATE299181T1 (de)	1993-09-24	1994-09-23	Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren

Country Status (8)

Country	Link
EP (1)	EP0730651B1 (de)
JP (1)	JPH09503661A (de)
AT (1)	ATE299181T1 (de)
AU (1)	AU687455B2 (de)
CA (1)	CA2172137C (de)
DE (1)	DE69434420D1 (de)
NZ (1)	NZ274667A (de)
WO (1)	WO1995008630A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2201762C (en) *	1994-10-13	2001-12-18	Eric W. Hsu	Method for purifying keratinocyte growth factors
AU3893195A (en) *	1994-10-13	1996-05-06	Amgen, Inc.	Keratinocyte growth factor analogs
AU722626B2 (en) *	1996-05-20	2000-08-10	Abburi Ramaiah	Cosmetic preparation
US6743422B1 (en)	1996-10-15	2004-06-01	Amgen, Inc.	Keratinocyte growth factor-2 products
US6274712B1 (en)	1997-12-23	2001-08-14	3-Dimensional Pharmaceuticals, Inc.	Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
AU3170499A (en) *	1998-04-28	1999-11-16	Eisai Co. Ltd.	Fibroblast growth factor mutein compositions and methods of use therefor
IL139380A0 (en) *	2000-10-31	2001-11-25	Prochon Biotech Ltd	Active variants of fibroblast growth factor
IL149562A0 (en) *	2002-05-09	2002-11-10	Prochon Ltd	Fgf variants and methods for use thereof
EP3380508B1 (de) *	2015-11-27	2020-07-22	Masarykova Univerzita	Thermostabiles fgf2-polypeptid, verwendung davon und kulturmedium thermostabilem fgf2-polypeptid
EP4067374A4 (de)	2019-11-25	2024-03-06	Korea Institute of Ocean Science and Technology	Fgf2-polypeptid mit verbesserter temperaturstabilität und proteaseresistenz und seine verwendung
KR102428940B1 (ko) *	2019-11-25	2022-08-03	한국해양과학기술원	온도안정성 및 단백질 분해효소 저항성을 향상시킨 fgf2 폴리펩타이드 및 그 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2526965B2 (ja) *	1987-02-24	1996-08-21	武田薬品工業株式会社	ムテイン，ｄｎａおよびその用途

1994
- 1994-09-23 AT AT94929876T patent/ATE299181T1/de not_active IP Right Cessation
- 1994-09-23 EP EP94929876A patent/EP0730651B1/de not_active Expired - Lifetime
- 1994-09-23 NZ NZ274667A patent/NZ274667A/en unknown
- 1994-09-23 CA CA002172137A patent/CA2172137C/en not_active Expired - Fee Related
- 1994-09-23 DE DE69434420T patent/DE69434420D1/de not_active Expired - Lifetime
- 1994-09-23 WO PCT/US1994/010800 patent/WO1995008630A1/en not_active Ceased
- 1994-09-23 AU AU78784/94A patent/AU687455B2/en not_active Ceased
- 1994-09-23 JP JP7509963A patent/JPH09503661A/ja not_active Ceased

Also Published As

Publication number	Publication date
EP0730651A4 (de)	1997-12-03
JPH09503661A (ja)	1997-04-15
EP0730651A1 (de)	1996-09-11
DE69434420D1 (de)	2005-08-11
WO1995008630A1 (en)	1995-03-30
AU687455B2 (en)	1998-02-26
CA2172137C (en)	1999-12-14
AU7878494A (en)	1995-04-10
EP0730651B1 (de)	2005-07-06
NZ274667A (en)	1997-03-24

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Legal Events

Date	Code	Title	Description
2006-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties