ATE299890T1 - Inhibitoren von gamma-secretase - Google Patents

Inhibitoren von gamma-secretase

Info

Publication number
ATE299890T1
ATE299890T1 AT01907933T AT01907933T ATE299890T1 AT E299890 T1 ATE299890 T1 AT E299890T1 AT 01907933 T AT01907933 T AT 01907933T AT 01907933 T AT01907933 T AT 01907933T AT E299890 T1 ATE299890 T1 AT E299890T1
Authority
AT
Austria
Prior art keywords
inhibitors
gamma secretase
secretase
gamma
alzheimer
Prior art date
Application number
AT01907933T
Other languages
English (en)
Inventor
Pineiro Jose Luis Castro
Adrian Leonard Smith
Graeme Irvine Stevenson
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE299890T1 publication Critical patent/ATE299890T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT01907933T 2000-03-03 2001-02-28 Inhibitoren von gamma-secretase ATE299890T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0005251.4A GB0005251D0 (en) 2000-03-03 2000-03-03 Therapeutic compounds
PCT/GB2001/000855 WO2001066564A2 (en) 2000-03-03 2001-02-28 Gamma-secretase inhibitors

Publications (1)

Publication Number Publication Date
ATE299890T1 true ATE299890T1 (de) 2005-08-15

Family

ID=9886973

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01907933T ATE299890T1 (de) 2000-03-03 2001-02-28 Inhibitoren von gamma-secretase

Country Status (10)

Country Link
US (1) US7049296B2 (de)
EP (1) EP1263774B1 (de)
JP (1) JP2003525947A (de)
AT (1) ATE299890T1 (de)
AU (1) AU782884B2 (de)
CA (1) CA2401525A1 (de)
DE (1) DE60112055T2 (de)
ES (1) ES2243452T3 (de)
GB (1) GB0005251D0 (de)
WO (1) WO2001066564A2 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6696488B2 (en) 2000-08-11 2004-02-24 The Brigham And Women's Hospital, Inc. (Hydroxyethyl)ureas as inhibitors of alzheimer's β-amyloid production
WO2002098849A2 (en) * 2001-06-01 2002-12-12 Elan Pharmaceuticals, Inc. Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer’s disease and similar diseases
MXPA04005428A (es) 2001-12-06 2004-12-06 Elan Pharm Inc Hidroxietilaminas substituidas.
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
WO2005037316A1 (ja) * 2003-10-20 2005-04-28 Locomogene, Inc. セクレターゼ活性を抑制する方法
ATE552851T1 (de) 2004-02-03 2012-04-15 Univ Michigan Zusammensetzungen zur behandlung von brust- und bauchspeicheldrüsenkrebs
CA2554779A1 (en) * 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
CA2617294A1 (en) * 2005-08-03 2007-02-08 Boehringer Ingelheim International Gmbh Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii
US7723112B2 (en) 2005-10-31 2010-05-25 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1998785A4 (de) * 2006-02-21 2009-06-17 Univ Michigan Krebsbehandlung mithilfe eines hedgehog-signalisierungspfades
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2094836B1 (de) 2006-11-15 2016-06-08 Massachusetts Eye & Ear Infirmary Erzeugung von innerohrzellen
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
WO2008092002A2 (en) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
EP2481408A3 (de) 2007-03-01 2013-01-09 Probiodrug AG Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8377886B2 (en) * 2007-09-14 2013-02-19 Albert Einstein College Of Medicine Of Yeshiva University Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease
JP5539221B2 (ja) 2007-12-21 2014-07-02 リガンド・ファーマシューティカルズ・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用
US20110200618A1 (en) * 2008-02-14 2011-08-18 Chang-Gyu Hahn Erbb4 inhibitors and uses thereof in treatment of neuropsychiatric disorders
US10143711B2 (en) 2008-11-24 2018-12-04 Massachusetts Eye & Ear Infirmary Pathways to generate hair cells
US20110177061A1 (en) 2009-07-10 2011-07-21 Martek Biosciences Corporation Methods of treating and preventing neurological disorders using docosahexaenoic acid
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
EP3970725B1 (de) 2012-09-07 2025-08-20 Massachusetts Eye & Ear Infirmary Ein gamma-sekretase-inhibitor zur behandlung von gehörverlust
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
KR102580225B1 (ko) 2013-06-11 2023-09-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
WO2015108988A2 (en) 2014-01-17 2015-07-23 Ligand Pharmaceuticals, Inc. Methods and compositions for modulating hormone levels
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
US20170314027A1 (en) 2014-08-06 2017-11-02 Massachusetts Eye And Ear Infirmary Increasing atoh1 life to drive sensorineural hair cell differentiantion
EP3662909A1 (de) 2015-07-24 2020-06-10 Oncotracker, Inc. Gamma-sekretase-modulatoren zur behandlung von immunsystemstörungen
US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
CA3013038A1 (en) 2016-01-29 2017-08-03 Massachusetts Eye And Ear Infirmary Expansion and differentiation of inner ear supporting cells and methods of use thereof
WO2017200762A2 (en) 2016-05-16 2017-11-23 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
CN110337291A (zh) 2016-12-16 2019-10-15 帕珀莱恩医疗公司 治疗耳蜗突触病变的方法
JP2020507605A (ja) 2017-02-17 2020-03-12 フレッド ハッチンソン キャンサー リサーチ センター Ｂｃｍａ関連癌および自己免疫疾患の治療のための併用療法
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN118497104A (zh) 2017-11-15 2024-08-16 沃泰克斯药物股份有限公司 胰岛细胞制备性组合物和使用方法
EP3833365A4 (de) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Aus stammzellen gewonnene inseldifferenzierung
KR20220003554A (ko) 2019-04-19 2022-01-10 리간드 파마슈티칼스 인코포레이티드 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법
AU2021244215A1 (en) 2020-03-26 2022-10-13 Seagen Inc. Methods of treating multiple myeloma
EP4647080A3 (de) 2020-07-31 2026-02-18 Vertex Pharmaceuticals Incorporated Differenzierung endokriner pankreaszellen
AU2022377078A1 (en) 2021-11-01 2024-04-04 Vertex Pharmaceuticals Incorporated Stem cell derived pancreatic islet differentiation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0554400B1 (de) * 1990-11-19 1997-07-23 Monsanto Company Retrovirale protease-inhibitoren
WO2001053255A1 (en) * 2000-01-24 2001-07-26 Merck Sharp & Dohme Limited Gamma-secretase inhibitors

Also Published As

Publication number Publication date
ES2243452T3 (es) 2005-12-01
WO2001066564A3 (en) 2002-01-03
AU3579901A (en) 2001-09-17
EP1263774B1 (de) 2005-07-20
AU782884B2 (en) 2005-09-08
EP1263774A2 (de) 2002-12-11
CA2401525A1 (en) 2001-09-13
WO2001066564A2 (en) 2001-09-13
US7049296B2 (en) 2006-05-23
DE60112055T2 (de) 2006-04-27
JP2003525947A (ja) 2003-09-02
US20030055005A1 (en) 2003-03-20
GB0005251D0 (en) 2000-04-26
DE60112055D1 (de) 2005-08-25

Similar Documents

Publication Publication Date Title
DE60112055D1 (de) Inhibitoren von gamma-secretase
ATE401314T1 (de) Benzodiazepin-derivate als gamma-secretase inhibitoren
ATE346039T1 (de) Sulfonamido-substituierte verbrückte bicycloalkylderivative
ATE386028T1 (de) Zyklohexylsulfone als gamma-sekretase-inhibitoren
DE60312017D1 (de) Sulfonderivate zur hemmung von gamma-secretase
ATE464287T1 (de) Cyclohexyl-sulphone als gamma-sekretase- inhibitoren
DE60237725D1 (de) Vervendung von dexrazoxane in der prävention und behandlung der alzeheimer-krankheit
ATE302753T1 (de) Sulfamide als gamma-secretase-inhibitoren
GB0225474D0 (en) Therapeutic agents
ATE368031T1 (de) Neue gamma secretase inhibitoren
DE60144064D1 (de) Sulfone, die die aktivität von gamma-secretase modulieren
TR200000059T2 (tr) Piridin türevleri
ATE444293T1 (de) Cyclische sulfamide zur inhibierung von gamma- sekretase
ATE427300T1 (de) Heterocyclisch substituierte amide als calpainhemmer
DE60116313D1 (de) Verbindungen zur behandlung der alzheimerischen krankheit
ATE443043T1 (de) Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
AP2001002318A0 (en) Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
ATE396174T1 (de) Hydroxyalkylaminderivate als beta-secretase- inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
DE60121461D1 (de) Kondensierte pyridoindolderivate
ATE402149T1 (de) Heterozyklische substituierte amide, deren herstellung und anwendung
TR200201205T2 (tr) N-ikame edilmiş karbamoiloksialkil-azolyum türevleri.
ATE316962T1 (de) Pyrimidin-derivate als selective inhibitoren von cox-2
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
DE60115466D1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
ATE275143T1 (de) Verbindungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties