ATE301635T1 - Naphthalen verbindungen, verfahren zu deren herstellung und deren pharmazeutischen zusammensetzungen - Google Patents

Naphthalen verbindungen, verfahren zu deren herstellung und deren pharmazeutischen zusammensetzungen

Info

Publication number: ATE301635T1
Authority: AT; Austria
Prior art keywords: alkyl; groups; dihydronaphthalene; biphenyl; heteroaryl
Prior art date: 1997-11-28

Application number

AT98402963T

Other languages

English (en)

Inventor

Francois Lefoulon

Luc Demuynck

Daniel Lesieur

Patrick Depreux

Caroline Bennejean

Pierre Renard

Philippe Delagrange

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-28

Filing date

1998-11-27

Publication date

2005-08-15

1998-11-27 Application filed by Servier Lab filed Critical Servier Lab

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE301635T1 publication Critical patent/ATE301635T1/de

Links

UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 6
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
235000010290 biphenyl Nutrition 0.000 abstract 3
239000004305 biphenyl Substances 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
KEIFWROAQVVDBN-UHFFFAOYSA-N 1,2-dihydronaphthalene Chemical compound C1=CC=C2C=CCCC2=C1 KEIFWROAQVVDBN-UHFFFAOYSA-N 0.000 abstract 1
FUPIVZHYVSCYLX-UHFFFAOYSA-N 1,4-dihydronaphthalene Chemical compound C1=CC=C2CC=CCC2=C1 FUPIVZHYVSCYLX-UHFFFAOYSA-N 0.000 abstract 1
QVEYCDLEISDMDG-UHFFFAOYSA-N 2,3-dihydronaphthalene Chemical compound C1=CC=CC2=CCCC=C21 QVEYCDLEISDMDG-UHFFFAOYSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
-1 diastereoisomers Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 1
125000004385 trihaloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
- C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
- C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)

AT98402963T 1997-11-28 1998-11-27 Naphthalen verbindungen, verfahren zu deren herstellung und deren pharmazeutischen zusammensetzungen ATE301635T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9714975A FR2771739B1 (fr)	1997-11-28	1997-11-28	Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE301635T1 true ATE301635T1 (de)	2005-08-15

Family

ID=9513915

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98402963T ATE301635T1 (de)	1997-11-28	1998-11-27	Naphthalen verbindungen, verfahren zu deren herstellung und deren pharmazeutischen zusammensetzungen

Country Status (18)

Country	Link
US (1)	US6143789A (de)
EP (1)	EP0919541B1 (de)
JP (1)	JP3776608B2 (de)
CN (1)	CN1155562C (de)
AT (1)	ATE301635T1 (de)
AU (1)	AU757436B2 (de)
BR (1)	BR9805031A (de)
CA (1)	CA2254658C (de)
DE (1)	DE69831121T2 (de)
DK (1)	DK0919541T3 (de)
ES (1)	ES2247668T3 (de)
FR (1)	FR2771739B1 (de)
HU (1)	HUP9802757A3 (de)
NO (1)	NO985516L (de)
NZ (1)	NZ333046A (de)
PL (1)	PL329906A1 (de)
PT (1)	PT919541E (de)
ZA (1)	ZA9810872B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2814165B1 (fr)	2000-09-15	2002-11-22	Adir	Nouveaux derives biphenyles substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6849761B2 (en)	2002-09-05	2005-02-01	Wyeth	Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia
FR2846963B1 (fr) *	2002-11-07	2006-07-14	Servier Lab	Nouveaux derives du phenylnaphtalene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2857010B1 (fr) *	2003-07-01	2005-09-16	Servier Lab	Nouveaux derives bicycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005078444A1 (en) *	2004-02-18	2005-08-25	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with human melatonin receptor type 1b (mtnr1b)
FR2903101B1 (fr) *	2006-06-30	2008-09-26	Servier Lab	Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2903102B1 (fr) *	2006-06-30	2010-08-13	Servier Lab	Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2903103B1 (fr) *	2006-06-30	2010-08-13	Servier Lab	Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP5485704B2 (ja)	2007-02-15	2014-05-07	シュサント−ジュスティーヌ	骨吸収と骨形成の不均衡を是正するための方法ならびにキット及び組成物
FR2918372B1 (fr) *	2007-07-02	2009-08-28	Servier Lab	Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2918370B1 (fr) *	2007-07-02	2009-08-28	Servier Lab	Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BRPI0916395A2 (pt) *	2008-07-30	2016-02-16	Ferrer Int	compostos de 1,6-di-hidro-2h-3-oxa-6-aza-as-indaceno
US20140256767A1 (en)	2011-10-31	2014-09-11	The Broad Institute, Inc.	Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators
FR3014437B1 (fr) *	2013-12-05	2016-12-23	Servier Lab	Nouveau procede de synthese de l'agomelatine
CN104292125B (zh) *	2014-08-14	2016-06-01	广东东阳光药业有限公司	萘衍生物及其在药物上的应用
CN104230742B (zh) *	2014-08-14	2016-08-24	广东东阳光药业有限公司	萘衍生物及其在药物上的应用
CN104292126B (zh) *	2014-08-14	2016-08-24	广东东阳光药业有限公司	萘衍生物及其在药物上的应用
CN109251151A (zh)	2017-07-12	2019-01-22	北京广为医药科技有限公司	N-(2-(取代-萘-1-基)乙基)取代酰胺类化合物、其制备及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3467710A (en) *	1968-05-27	1969-09-16	Parke Davis & Co	Beta-(4- or 5-phenyl-1-naphthalene) ethylamines
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) *	1992-10-02	1994-12-23	Adir	Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
FR2713636B1 (fr) *	1993-12-07	1996-01-05	Adir	Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
AU3399895A (en) *	1994-09-12	1996-03-29	Takeda Chemical Industries Ltd.	Benzocycloalkene compounds, their production and use
FR2729147A1 (fr) *	1995-01-11	1996-07-12	Adir	Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU4569496A (en) *	1995-02-24	1996-09-05	Bristol-Myers Squibb Company	Tetralinyl- and indanyl-ethylamides
FR2734816B1 (fr) *	1995-05-31	1997-07-04	Adir	Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2734814B1 (fr) *	1995-05-31	1997-07-04	Adir	Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2734815B1 (fr) *	1995-05-31	1997-07-04	Adir	Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2737725B1 (fr) *	1995-08-08	1997-10-31	Valentonine	Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament

1997
- 1997-11-28 FR FR9714975A patent/FR2771739B1/fr not_active Expired - Fee Related
1998
- 1998-11-25 US US09/199,531 patent/US6143789A/en not_active Expired - Fee Related
- 1998-11-26 PL PL98329906A patent/PL329906A1/xx unknown
- 1998-11-26 NO NO985516A patent/NO985516L/no unknown
- 1998-11-27 CA CA002254658A patent/CA2254658C/fr not_active Expired - Fee Related
- 1998-11-27 HU HU9802757A patent/HUP9802757A3/hu unknown
- 1998-11-27 PT PT98402963T patent/PT919541E/pt unknown
- 1998-11-27 EP EP98402963A patent/EP0919541B1/de not_active Expired - Lifetime
- 1998-11-27 BR BR9805031-1A patent/BR9805031A/pt not_active Application Discontinuation
- 1998-11-27 NZ NZ333046A patent/NZ333046A/xx unknown
- 1998-11-27 ES ES98402963T patent/ES2247668T3/es not_active Expired - Lifetime
- 1998-11-27 AT AT98402963T patent/ATE301635T1/de not_active IP Right Cessation
- 1998-11-27 DK DK98402963T patent/DK0919541T3/da active
- 1998-11-27 CN CNB981227155A patent/CN1155562C/zh not_active Expired - Fee Related
- 1998-11-27 DE DE69831121T patent/DE69831121T2/de not_active Expired - Fee Related
- 1998-11-27 AU AU94213/98A patent/AU757436B2/en not_active Ceased
- 1998-11-30 JP JP33866998A patent/JP3776608B2/ja not_active Expired - Fee Related
1999
- 1999-06-01 ZA ZA9810872A patent/ZA9810872B/xx unknown

Also Published As

Publication number	Publication date
CA2254658C (fr)	2004-08-17
JPH11263761A (ja)	1999-09-28
CA2254658A1 (fr)	1999-05-28
NO985516D0 (no)	1998-11-26
EP0919541A1 (de)	1999-06-02
PT919541E (pt)	2005-11-30
HU9802757D0 (en)	1999-01-28
JP3776608B2 (ja)	2006-05-17
ZA9810872B (en)	1999-06-01
FR2771739B1 (fr)	2001-04-20
DE69831121D1 (de)	2005-09-15
HUP9802757A3 (en)	2000-03-28
HUP9802757A2 (hu)	1999-06-28
NZ333046A (en)	2000-04-28
EP0919541B1 (de)	2005-08-10
CN1221734A (zh)	1999-07-07
BR9805031A (pt)	2000-03-28
US6143789A (en)	2000-11-07
PL329906A1 (en)	1999-06-07
DE69831121T2 (de)	2006-06-14
HK1020717A1 (en)	2000-05-19
AU757436B2 (en)	2003-02-20
DK0919541T3 (da)	2005-10-17
ES2247668T3 (es)	2006-03-01
FR2771739A1 (fr)	1999-06-04
CN1155562C (zh)	2004-06-30
AU9421398A (en)	1999-06-17
NO985516L (no)	1999-05-31

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