ATE303063T1 - Synthetische analoge des ecteinascidin-743 - Google Patents

Synthetische analoge des ecteinascidin-743

Info

Publication number: ATE303063T1
Authority: AT; Austria
Prior art keywords: substituted; unsubstituted; co2h; nhc; alkynyl
Prior art date: 1998-09-30

Application number

AT99948484T

Other languages

English (en)

Inventor

Elias J Corey

Original Assignee

Harvard College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-30

Filing date

1999-09-30

Publication date

2005-09-15

1999-09-30 Application filed by Harvard College filed Critical Harvard College

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE303063T1 publication Critical patent/ATE303063T1/de

Links

PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical class C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
125000006710 (C2-C12) alkenyl group Chemical group 0.000 abstract 2
125000006711 (C2-C12) alkynyl group Chemical group 0.000 abstract 2
-1 CO2R′ Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
238000012512 characterization method Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT99948484T 1998-09-30 1999-09-30 Synthetische analoge des ecteinascidin-743 ATE303063T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/165,892 US6124292A (en)	1998-09-30	1998-09-30	Synthetic analogs of ecteinascidin-743
PCT/US1999/022405 WO2000018233A1 (en)	1998-09-30	1999-09-30	Synthetic analogs of ecteinascidin-743

Publications (1)

Publication Number	Publication Date
ATE303063T1 true ATE303063T1 (de)	2005-09-15

Family

ID=22600906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99948484T ATE303063T1 (de)	1998-09-30	1999-09-30	Synthetische analoge des ecteinascidin-743

Country Status (13)

Country	Link
US (3)	US6124292A (de)
EP (1)	EP1117297B1 (de)
JP (1)	JP4638985B2 (de)
AT (1)	ATE303063T1 (de)
AU (1)	AU765439B2 (de)
CA (1)	CA2345297C (de)
DE (1)	DE69927039T2 (de)
DK (1)	DK1117297T3 (de)
ES (1)	ES2249028T3 (de)
HK (1)	HK1039727B (de)
MX (1)	MXPA01003339A (de)
NZ (1)	NZ510734A (de)
WO (1)	WO2000018233A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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CA2331593C (en) *	1998-05-11	2008-08-05	Pharma Mar, S.A.	Metabolites of ecteinascidin 743
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
AR035842A1 (es) *	1999-05-14	2004-07-21	Pharma Mar Sa	Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
GB9918178D0 (en) *	2000-05-15	1999-10-06	Pharma Mar Sa	Synthetic methods
CA2397597A1 (en)	2000-01-19	2001-07-26	The Trustees Of Columbia University In The City Of New York	Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
RU2267492C2 (ru) *	2000-02-11	2006-01-10	Президент Энд Феллоуз Оф Гарвард Колледж	Способ синтеза фталасцидина и промежуточных продуктов и промежуточные соединения
US6815544B2 (en)	2000-02-11	2004-11-09	President And Fellows Of Harvard College	Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
WO2001077115A1 (en) *	2000-04-12	2001-10-18	Pharma Mar, S.A.	Antitumoral ecteinascidin derivatives
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
CA2447553A1 (en) *	2000-11-03	2002-05-23	President And Fellows Of Harvard College	Saframycins, analogues and uses thereof
BR0115162A (pt) *	2000-11-06	2003-10-21	Pharma Mar Sa	Tratamentos antitumorais eficazes
GB0117402D0 (en) *	2001-07-17	2001-09-05	Pharma Mar Sa	New antitumoral derivatives of et-743
GB0119243D0 (en) *	2001-08-07	2001-10-03	Pharma Mar Sa	Antitumoral analogs of ET-743
GB0202544D0 (en)	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
US7183054B2 (en) *	2003-06-03	2007-02-27	President And Fellows Of Harvard College	Assay for identifying biological targets of polynucleotide-binding compounds
EP1827500B1 (de) *	2004-10-26	2009-05-06	Pharma Mar S.A., Sociedad Unipersonal	Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
ATE368461T1 (de)	2004-10-29	2007-08-15	Pharma Mar Sa	Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
JP2011520921A (ja) *	2008-05-16	2011-07-21	ファルマ・マール・ソシエダード・アノニマ	抗腫瘍アルカロイドとの併用療法
NZ589270A (en) *	2008-05-16	2011-12-22	Pharma Mar Sa	Multiple myeloma treatments
WO2011048210A1 (en)	2009-10-22	2011-04-28	Pharma Mar, S.A.	PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
CN103038240A (zh)	2010-05-25	2013-04-10	法马马有限公司	制备海鞘素化合物的合成方法
RS54648B1 (sr)	2010-11-12	2016-08-31	Pharma Mar S.A.	Kombinovana terapija sa antitumorskim alkaloidom
CN107522698B (zh) *	2016-06-20	2021-12-28	浙江海正药业股份有限公司	一种曲贝替定的制备方法及其中间体
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물
US10597378B2 (en)	2017-09-08	2020-03-24	National Health Research Institutes	Tetrahydroisoquinolines for use as MOR/NOP dual agonists
CN111518110B (zh) *	2019-02-01	2023-11-03	博瑞生物医药（苏州）股份有限公司	一种海鞘素化合物及其中间体的制备方法
PE20252386A1 (es)	2019-11-21	2025-10-10	Pharma Mar Sa	Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives

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Publication number	Priority date	Publication date	Assignee	Title
JPS5937952B2 (ja)	1977-09-12	1984-09-12	正新井	抗生物質サフラマイシンａ，ｂ，ｃ，ｄ，ｅおよびその製造法
JPS56135486A (en)	1980-03-26	1981-10-22	Tadashi Arai	Antibiotic saframycin s and its preparative method
JPS5942382A (ja) *	1982-09-02	1984-03-08	Yoshitomi Pharmaceut Ind Ltd	サフラシン誘導体
JPS6158593A (ja) *	1984-08-30	1986-03-25	Tadashi Arai	新規サフラマイシンａ誘導体およびその製造法
EP0233841A1 (de) *	1986-02-18	1987-08-26	Arai, Tadashi, Prof.	Chinon-Derivate und Verfahren zu ihrer Herstellung
US5256663A (en) *	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) *	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
JPS632991A (ja) *	1986-06-23	1988-01-07	Akinori Kubo	新規イソキノリン誘導体
EP0262085A1 (de) *	1986-08-15	1988-03-30	Gesellschaft für Biotechnologische Forschung mbH (GBF)	Antibiotika aus Myxococcus
EP0329606A3 (de) *	1988-02-12	1991-04-03	Ciba-Geigy Ag	Neue Antibiotika aus Myxococcus
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743

1998
- 1998-09-30 US US09/165,892 patent/US6124292A/en not_active Expired - Lifetime
1999
- 1999-09-30 EP EP99948484A patent/EP1117297B1/de not_active Expired - Lifetime
- 1999-09-30 AU AU61650/99A patent/AU765439B2/en not_active Expired
- 1999-09-30 JP JP2000571761A patent/JP4638985B2/ja not_active Expired - Lifetime
- 1999-09-30 DK DK99948484T patent/DK1117297T3/da active
- 1999-09-30 WO PCT/US1999/022405 patent/WO2000018233A1/en not_active Ceased
- 1999-09-30 AT AT99948484T patent/ATE303063T1/de active
- 1999-09-30 HK HK02100545.8A patent/HK1039727B/en not_active IP Right Cessation
- 1999-09-30 MX MXPA01003339A patent/MXPA01003339A/es active IP Right Grant
- 1999-09-30 CA CA002345297A patent/CA2345297C/en not_active Expired - Lifetime
- 1999-09-30 ES ES99948484T patent/ES2249028T3/es not_active Expired - Lifetime
- 1999-09-30 NZ NZ510734A patent/NZ510734A/en not_active IP Right Cessation
- 1999-09-30 DE DE69927039T patent/DE69927039T2/de not_active Expired - Lifetime
2000
- 2000-02-22 US US09/510,315 patent/US6348467B1/en not_active Ceased
2003
- 2003-12-17 US US10/738,973 patent/USRE41614E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU6165099A (en)	2000-04-17
NZ510734A (en)	2003-10-31
HK1039727B (en)	2006-01-06
HK1039727A1 (en)	2002-05-10
CA2345297A1 (en)	2000-04-06
AU765439B2 (en)	2003-09-18
MXPA01003339A (es)	2002-07-02
CA2345297C (en)	2009-12-22
ES2249028T3 (es)	2006-03-16
EP1117297A1 (de)	2001-07-25
EP1117297B1 (de)	2005-08-31
US6124292A (en)	2000-09-26
EP1117297A4 (de)	2002-02-27
DK1117297T3 (da)	2006-01-09
JP2002525296A (ja)	2002-08-13
JP4638985B2 (ja)	2011-02-23
WO2000018233A1 (en)	2000-04-06
DE69927039D1 (de)	2005-10-06
DE69927039T2 (de)	2006-06-22
USRE41614E1 (en)	2010-08-31
US6348467B1 (en)	2002-02-19

Legal Events

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2006-05-15

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Publication	Publication Date	Title
DE69927039D1 (de)	2005-10-06	Synthetische analoge des ecteinascidin-743
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
DE60033857D1 (de)	2007-04-19	Derivate des N-((Chinolinyl)oxy)-phenyl)-Harnstoffs und des N-((Chinazolinyl)oxy)-phenyl)-Harnstoffs mit Antitumor Aktivität
EA200600509A1 (ru)	2006-08-25	Соединения пиримидотиофена
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
CY1109283T1 (el)	2014-07-02	Παραγωγα βαριολινης ως αντικαρκινικα μεσα
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MXPA02012121A (es)	2003-06-06	Compuestos antitumorales.
DE60237652D1 (de)	2010-10-21	Variolinderivate und ihre Verwendung als Cytostatika
BR9709791A (pt)	1999-08-10	Intermediários para a síntese de oligonucleotíedeos
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