NO20051037L - Totalsyntese av myriaporoner - Google Patents
Totalsyntese av myriaporonerInfo
- Publication number
- NO20051037L NO20051037L NO20051037A NO20051037A NO20051037L NO 20051037 L NO20051037 L NO 20051037L NO 20051037 A NO20051037 A NO 20051037A NO 20051037 A NO20051037 A NO 20051037A NO 20051037 L NO20051037 L NO 20051037L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- unsubstituted
- group
- aralkyl
- aryl
- Prior art date
Links
- 238000006257 total synthesis reaction Methods 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910006080 SO2X Inorganic materials 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 229940126214 compound 3 Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Forbindelser av generell formel (I) eller et farmasøytisk akseptabelt salt, derivat, prolegemiddel eller stereoisomer derav er tilveiebrakt: hvori substituentgruppene definert ved R, er hver uavhengig valgt fra gruppen bestående av H, SiR'3, SOR, SO2X, e(=0)R, e(=0)OR', e(=0)NR', substltiiert eller usubstittiert alkyl, substituert eller usubstittiert alkenyl, substituert eller usubstituert alkynyl, aryl, heteroaryl eller aralkyl; gruppen R er valgt fra substituert eller usubstituert alkyl, substituert eller usubstituert alkenyl, substituert eller usubstituert alkynyl, aminoalkyl, aryl, aralkyl og heterosykliske grupper; og gruppen R" er valgt fra gruppen bestående av H, OH, OR, OeORI, SH, SR, SOR, SO2R, NO2, NH2, NHR, N(R)2, NHeOR, N(eOR)2, NHSO2R, eN, halogen, e(=0)H, e(=0)R, eOzH, e02R, eH20R, substitiiert eller usubstituert alkyl, substituert eller usubstituert haloalkyl, substituert eller usubstituert alkenyl, substituert eller usubstituert alkyliden, substituert eller usubstituert alkynyl, substituert eller usubstituert atyl, substituert eller usubstituert aralkyl og substituert eller usubstituert heteroaromatisk; forutsatt at forbindelsen ikke er forbindelse 1, 3 eller 4 ifølge US patent 5 514 708. Forbindelsene har antitumoraktivitet. En synteserute er også tilveiebrakt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0217638.6A GB0217638D0 (en) | 2002-07-30 | 2002-07-30 | Total synthesis of myriaporones |
| PCT/GB2003/003327 WO2004011458A1 (en) | 2002-07-30 | 2003-07-30 | Total synthesis of myriaporones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20051037L true NO20051037L (no) | 2005-04-13 |
Family
ID=9941374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051037A NO20051037L (no) | 2002-07-30 | 2005-02-25 | Totalsyntese av myriaporoner |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7521478B2 (no) |
| EP (1) | EP1532139B1 (no) |
| JP (1) | JP2006504659A (no) |
| KR (1) | KR20050053599A (no) |
| CN (1) | CN100390167C (no) |
| AT (1) | ATE364603T1 (no) |
| AU (1) | AU2003248984A1 (no) |
| CA (1) | CA2494532A1 (no) |
| DE (1) | DE60314426T2 (no) |
| DK (1) | DK1532139T3 (no) |
| ES (1) | ES2289337T3 (no) |
| GB (1) | GB0217638D0 (no) |
| IL (1) | IL166484A0 (no) |
| MX (1) | MXPA05001176A (no) |
| NO (1) | NO20051037L (no) |
| NZ (1) | NZ537678A (no) |
| PT (1) | PT1532139E (no) |
| RU (1) | RU2328492C2 (no) |
| SI (1) | SI1532139T1 (no) |
| WO (1) | WO2004011458A1 (no) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514708A (en) * | 1994-02-18 | 1996-05-07 | Pharmamar, S.A. | Cytotoxic metabolites from Myriapora truncata |
| HRP970141A2 (en) * | 1997-03-12 | 1999-02-28 | Banić-Tomaueić Zrinka | New secomacrolydes of erythromicin a, and a process for the preparation thereof |
-
2002
- 2002-07-30 GB GBGB0217638.6A patent/GB0217638D0/en not_active Ceased
-
2003
- 2003-07-30 RU RU2005105329/04A patent/RU2328492C2/ru not_active IP Right Cessation
- 2003-07-30 AT AT03771210T patent/ATE364603T1/de not_active IP Right Cessation
- 2003-07-30 CN CNB038233142A patent/CN100390167C/zh not_active Expired - Fee Related
- 2003-07-30 AU AU2003248984A patent/AU2003248984A1/en not_active Abandoned
- 2003-07-30 MX MXPA05001176A patent/MXPA05001176A/es active IP Right Grant
- 2003-07-30 CA CA002494532A patent/CA2494532A1/en not_active Abandoned
- 2003-07-30 JP JP2004523987A patent/JP2006504659A/ja active Pending
- 2003-07-30 EP EP03771210A patent/EP1532139B1/en not_active Expired - Lifetime
- 2003-07-30 DE DE60314426T patent/DE60314426T2/de not_active Expired - Fee Related
- 2003-07-30 SI SI200330909T patent/SI1532139T1/sl unknown
- 2003-07-30 KR KR1020057001661A patent/KR20050053599A/ko not_active Ceased
- 2003-07-30 DK DK03771210T patent/DK1532139T3/da active
- 2003-07-30 PT PT03771210T patent/PT1532139E/pt unknown
- 2003-07-30 ES ES03771210T patent/ES2289337T3/es not_active Expired - Lifetime
- 2003-07-30 WO PCT/GB2003/003327 patent/WO2004011458A1/en not_active Ceased
- 2003-07-30 NZ NZ537678A patent/NZ537678A/en unknown
- 2003-07-30 US US10/523,172 patent/US7521478B2/en not_active Expired - Fee Related
-
2005
- 2005-01-25 IL IL16648405A patent/IL166484A0/xx unknown
- 2005-02-25 NO NO20051037A patent/NO20051037L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05001176A (es) | 2005-09-12 |
| DE60314426D1 (de) | 2007-07-26 |
| KR20050053599A (ko) | 2005-06-08 |
| NZ537678A (en) | 2006-11-30 |
| IL166484A0 (en) | 2006-01-15 |
| CN100390167C (zh) | 2008-05-28 |
| ES2289337T3 (es) | 2008-02-01 |
| EP1532139B1 (en) | 2007-06-13 |
| CA2494532A1 (en) | 2004-02-05 |
| US20060084819A1 (en) | 2006-04-20 |
| US20080103320A2 (en) | 2008-05-01 |
| RU2005105329A (ru) | 2005-08-27 |
| JP2006504659A (ja) | 2006-02-09 |
| RU2328492C2 (ru) | 2008-07-10 |
| EP1532139A1 (en) | 2005-05-25 |
| PT1532139E (pt) | 2007-09-20 |
| GB0217638D0 (en) | 2002-09-11 |
| US7521478B2 (en) | 2009-04-21 |
| ATE364603T1 (de) | 2007-07-15 |
| CN1684956A (zh) | 2005-10-19 |
| SI1532139T1 (sl) | 2007-10-31 |
| WO2004011458A1 (en) | 2004-02-05 |
| US20080269511A2 (en) | 2008-10-30 |
| DK1532139T3 (da) | 2007-10-15 |
| AU2003248984A1 (en) | 2004-02-16 |
| DE60314426T2 (de) | 2008-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |