ATE305032T1 - Chondroitin lyase enzymen - Google Patents

Chondroitin lyase enzymen

Info

Publication number: ATE305032T1
Authority: AT; Austria
Prior art keywords: enzymes; degrading; chondroitin; chondroitinase; chromatography
Prior art date: 1994-07-08

Application number

AT95926207T

Other languages

English (en)

Inventor

Joseph Zimmermann

D Clark Bennett

Maryse Laliberte

Kangfu Gu

Anna Lydia Tkalec

Dominique Fink

Robert Linhardt

Original Assignee

Biomarin Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-08

Filing date

1995-07-07

Publication date

2005-10-15

1995-07-07 Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc

2005-10-15 Application granted granted Critical

2005-10-15 Publication of ATE305032T1 publication Critical patent/ATE305032T1/de

Links

102000004190 Enzymes Human genes 0.000 title abstract 3
108090000790 Enzymes Proteins 0.000 title abstract 3
229920002567 Chondroitin Polymers 0.000 title 1
DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 title 1
230000000593 degrading effect Effects 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
229920001287 Chondroitin sulfate Polymers 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
101710106625 Chondroitinase-AC Proteins 0.000 abstract 1
229920000045 Dermatan sulfate Polymers 0.000 abstract 1
238000001042 affinity chromatography Methods 0.000 abstract 1
238000005277 cation exchange chromatography Methods 0.000 abstract 1
229940059329 chondroitin sulfate Drugs 0.000 abstract 1
-1 chondroitin sulfate polysaccharides Chemical class 0.000 abstract 1
229940107200 chondroitin sulfates Drugs 0.000 abstract 1
108010048429 chondroitinase B Proteins 0.000 abstract 1
AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 1
229940051593 dermatan sulfate Drugs 0.000 abstract 1
230000007717 exclusion Effects 0.000 abstract 1
238000012872 hydroxylapatite chromatography Methods 0.000 abstract 1
238000004255 ion exchange chromatography Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT95926207T 1994-07-08 1995-07-07 Chondroitin lyase enzymen ATE305032T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/272,247 US6093563A (en)	1994-07-08	1994-07-08	Chondroitin lyase enzymes
PCT/US1995/008560 WO1996001894A1 (en)	1994-07-08	1995-07-07	Chondroitin lyase enzymes

Publications (1)

Publication Number	Publication Date
ATE305032T1 true ATE305032T1 (de)	2005-10-15

Family

ID=23039019

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT05075080T ATE428774T1 (de)	1994-07-08	1995-07-07	Chondroitinlyase-enzyme
AT95926207T ATE305032T1 (de)	1994-07-08	1995-07-07	Chondroitin lyase enzymen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT05075080T ATE428774T1 (de)	1994-07-08	1995-07-07	Chondroitinlyase-enzyme

Country Status (10)

Country	Link
US (2)	US6093563A (de)
EP (2)	EP1607478B1 (de)
JP (2)	JPH10506263A (de)
AT (2)	ATE428774T1 (de)
AU (1)	AU693916B2 (de)
CA (1)	CA2194375C (de)
DE (2)	DE69534466T2 (de)
DK (1)	DK0764205T3 (de)
ES (1)	ES2255062T3 (de)
WO (1)	WO1996001894A1 (de)

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CA2493509C (en) *	2002-06-03	2010-03-09	Massachusetts Institute Of Technology	Rationally designed polysaccharide lyases derived from chondroitinase b
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AU2013201097B2 (en) *	2003-05-16	2016-03-31	Acorda Therapeutics, Inc.	Proteoglycan degrading mutants for treatment of cns
EP3211084B1 (de) *	2003-05-16	2019-03-27	Acorda Therapeutics, Inc.	Proteoglycan-abbauende mutanten zur behandlung des zns
US7959914B2 (en)	2003-05-16	2011-06-14	Acorda Therapeutics, Inc.	Methods of reducing extravasation of inflammatory cells
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US7507570B2 (en) *	2004-03-10	2009-03-24	Massachusetts Institute Of Technology	Recombinant chondroitinase ABC I and uses thereof
MXPA06013345A (es) *	2004-05-18	2008-10-31	Acorda Therapeutics Inc	Metodos para purificar condrointinasa y sus formulaciones estables.
US20050261241A1 (en) *	2004-05-19	2005-11-24	Celsus Biopharmaceuticals, Inc.	Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
JP5189985B2 (ja)	2005-09-26	2013-04-24	アコーダセラピューティクス、インク．	コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
CA3009034C (en)	2006-10-10	2020-08-18	Acorda Therapeutics, Inc.	Compositions and methods of using chondroitinase abci mutants
US20080299622A1 (en) *	2007-02-07	2008-12-04	Paulson Bradley A	Starch Hydrolysis Using Phytase with an Alpha Amylase
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TWI395593B (zh)	2008-03-06	2013-05-11	Halozyme Inc	可活化的基質降解酵素之活體內暫時性控制
US20090286289A1 (en) *	2008-03-10	2009-11-19	Pang Danny Z	Production of Hyaluronate Unsaturated Disaccharides and its Application
KR20130116386A (ko)	2008-04-14	2013-10-23	할로자임, 아이엔씨	히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
TWI394580B (zh)	2008-04-28	2013-05-01	Halozyme Inc	超快起作用胰島素組成物
US9913634B2 (en) *	2009-02-20	2018-03-13	Boston Scientific Scimed, Inc.	Locking element for vascular closure device
US8529598B2 (en)	2009-02-20	2013-09-10	Boston Scientific Scimed, Inc.	Tissue puncture closure device
US8052914B2 (en) *	2009-02-20	2011-11-08	Boston Scientific Scimed, Inc.	Modified plug for arteriotomy closure
US8292918B2 (en)	2009-02-20	2012-10-23	Boston Scientific Scimed, Inc.	Composite plug for arteriotomy closure and method of use
US8375553B2 (en) *	2009-02-20	2013-02-19	Boston Scientific Scimed, Inc.	Locking element for vascular closure device
US8317824B2 (en) *	2009-02-20	2012-11-27	Boston Scientific Scimed, Inc.	Tissue puncture closure device
US20100217309A1 (en) *	2009-02-20	2010-08-26	Boston Scientific Scimed, Inc.	Plug for arteriotomy closure and method of use
EP2533698B1 (de)	2010-02-11	2018-03-28	Boston Scientific Scimed, Inc.	Vorrichtungen für den automatischen einsatz von gefässverschlüssen
WO2012012300A2 (en)	2010-07-20	2012-01-26	Halozyme, Inc.	Adverse side-effects associated with administration of an anti-hyaluronan agent and methods for ameliorating or preventing the side-effects
US8758402B2 (en)	2010-12-17	2014-06-24	Boston Scientific Scimed, Inc.	Tissue puncture closure device
WO2012109387A1 (en)	2011-02-08	2012-08-16	Halozyme, Inc.	Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
US20130011378A1 (en)	2011-06-17	2013-01-10	Tzung-Horng Yang	Stable formulations of a hyaluronan-degrading enzyme
CA2839512C (en)	2011-06-17	2018-01-02	Halozyme, Inc.	Continuous subcutaneous insulin infusion methods with a hyaluronan-degrading enzyme
NZ618331A (en)	2011-06-17	2016-04-29	Halozyme Inc	Stable formulations of a hyaluronan-degrading enzyme
WO2013040501A1 (en)	2011-09-16	2013-03-21	Pharmathene, Inc.	Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
JP6162707B2 (ja)	2011-10-24	2017-07-12	ハロザイムインコーポレイテッド	抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法
CN108686203A (zh)	2012-04-04	2018-10-23	哈洛齐梅公司	使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
WO2014062856A1 (en)	2012-10-16	2014-04-24	Halozyme, Inc.	Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
CA2893270C (en)	2012-12-11	2024-01-02	Danisco Us Inc.	Trichoderma reesei host cells expressing a glucoamylase from aspergillus fumigatus and methods of use thereof
PT3186281T (pt)	2014-08-28	2019-07-10	Halozyme Inc	Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
US9796970B1 (en)	2017-04-24	2017-10-24	Advantek Serum Laboratories Ltd.	Production of high purity chondroitinase ABC
US20190351031A1 (en)	2018-05-16	2019-11-21	Halozyme, Inc.	Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN114480182B (zh) *	2022-01-10	2023-10-31	中国农业大学	一种假节杆菌pl-410及其在产软骨素裂解酶中的应用

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1994
- 1994-07-08 US US08/272,247 patent/US6093563A/en not_active Expired - Fee Related
1995
- 1995-07-07 DE DE69534466T patent/DE69534466T2/de not_active Expired - Fee Related
- 1995-07-07 WO PCT/US1995/008560 patent/WO1996001894A1/en not_active Ceased
- 1995-07-07 JP JP8504422A patent/JPH10506263A/ja not_active Withdrawn
- 1995-07-07 EP EP05075080A patent/EP1607478B1/de not_active Expired - Lifetime
- 1995-07-07 DE DE69535939T patent/DE69535939D1/de not_active Expired - Fee Related
- 1995-07-07 EP EP95926207A patent/EP0764205B1/de not_active Expired - Lifetime
- 1995-07-07 DK DK95926207T patent/DK0764205T3/da active
- 1995-07-07 CA CA002194375A patent/CA2194375C/en not_active Expired - Fee Related
- 1995-07-07 AU AU30044/95A patent/AU693916B2/en not_active Ceased
- 1995-07-07 AT AT05075080T patent/ATE428774T1/de not_active IP Right Cessation
- 1995-07-07 ES ES95926207T patent/ES2255062T3/es not_active Expired - Lifetime
- 1995-07-07 AT AT95926207T patent/ATE305032T1/de not_active IP Right Cessation
1997
- 1997-09-17 US US08/931,952 patent/US6054569A/en not_active Expired - Fee Related
2007
- 2007-11-02 JP JP2007286768A patent/JP2008086325A/ja active Pending

Also Published As

Publication number	Publication date
US6054569A (en)	2000-04-25
EP1607478A2 (de)	2005-12-21
ATE428774T1 (de)	2009-05-15
DE69534466T2 (de)	2006-06-22
EP1607478A3 (de)	2006-02-22
EP0764205B1 (de)	2005-09-21
ES2255062T3 (es)	2006-06-16
AU693916B2 (en)	1998-07-09
JP2008086325A (ja)	2008-04-17
CA2194375C (en)	2002-06-11
WO1996001894A1 (en)	1996-01-25
EP1607478B1 (de)	2009-04-15
DK0764205T3 (da)	2005-11-28
DE69535939D1 (de)	2009-05-28
EP0764205A1 (de)	1997-03-26
AU3004495A (en)	1996-02-09
DE69534466D1 (de)	2006-02-02
US6093563A (en)	2000-07-25
JPH10506263A (ja)	1998-06-23
CA2194375A1 (en)	1996-01-25

Legal Events

Date	Code	Title	Description
2006-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE305032T1 (de)	2005-10-15	Chondroitin lyase enzymen
DE69637509D1 (de)	2008-06-05	Verfahren zur reinigung von faktor-ix
PL306812A1 (en)	1995-04-18	Novel lipase variants suitable for use in detergents
AU702557C (en)	2004-11-04	Novel protein and methods for producing the proteins
IT1260468B (it)	1996-04-09	Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
BR9405720A (pt)	1995-11-28	Alfa-amilase mutante DNA vetores de expressão células hospedeiras composição detergente composição de liquefação de amido e processo para liquefazer uma suspensão de amido granular
AU559190B2 (en)	1987-02-26	Bifocal soft contact lens
AU4067985A (en)	1985-09-24	Hosts and methods for producing recombinant products in high yields
BR9508981A (pt)	1997-12-30	Mutantes de subtilisina isentos de cálcio
ATE239785T1 (de)	2003-05-15	Funktionelle domänen der restriktionsendonukleasen aus -i(flavobakterium okeanokoites)(foki)
AU3981985A (en)	1985-09-19	Site specific mutagenesis in alpha-1-antitrypsin
NZ510356A (en)	2004-12-24	Molecules designated LDCAM
AU6234596A (en)	1997-01-30	Ion channel
ATE246516T1 (de)	2003-08-15	Neue enzyme und prodrugs für adept
ITFI920078A1 (it)	1993-09-27	Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano
AU2609297A (en)	1997-11-07	Glycopeptide compounds
BR9506862A (pt)	1997-09-23	Sequência de nucleotídeos polipeptídeo vetor célula hospedeira planta hospedeira ou parte da mesma planta ou parte da mesma e processo para alterar as caracteristica fisicas da uma planta ou parte da mesma
DK0801075T3 (da)	1999-11-22	Kovalent forbundne dimerer af glycopeptid-antibiotika
NZ239249A (en)	1992-10-28	Pure gelonin toxin and its corresponding dna sequence
AU2430588A (en)	1989-04-27	Mutant acidic fibroblast growth factor
AU3676193A (en)	1993-10-14	Human antithrombin III mutant
FR2613936B1 (fr)	1990-03-30	Application des resines constituees par des polymeres fonctionnels comme phase stationnaire en chromatographie d'affinite pour la purification des facteurs de croissance et procede de purification correspondant
AU3817495A (en)	1996-05-31	Use of erythropoietin in the treatment of rheumatoid arthritis
KR960703943A (ko)	1996-08-31	신규단백질 및 그 제조방법
Smith et al.	1979	Purification of phosphotransacetylase by affinity chromatography