ATE305612T1 - Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität - Google Patents

Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität

Info

Publication number
ATE305612T1
ATE305612T1 AT00936829T AT00936829T ATE305612T1 AT E305612 T1 ATE305612 T1 AT E305612T1 AT 00936829 T AT00936829 T AT 00936829T AT 00936829 T AT00936829 T AT 00936829T AT E305612 T1 ATE305612 T1 AT E305612T1
Authority
AT
Austria
Prior art keywords
methods
protease activity
specific protease
entity
reporter compounds
Prior art date
Application number
AT00936829T
Other languages
English (en)
Inventor
Acker Koenraad Lodewijk Au Van
Inge Dierynck
Rudi Wilfried Jan Pauwels
Original Assignee
Tibotec Bvba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Bvba filed Critical Tibotec Bvba
Application granted granted Critical
Publication of ATE305612T1 publication Critical patent/ATE305612T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
AT00936829T 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität ATE305612T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201659A EP1055929A1 (de) 1999-05-26 1999-05-26 Mittel und Verfahren für Medizinentdeckung und phenotypische Charakterisierung von Zellen
PCT/EP2000/004923 WO2000073802A1 (en) 1999-05-26 2000-05-26 Reporter molecules and methods for assaying high specificity protease activity

Publications (1)

Publication Number Publication Date
ATE305612T1 true ATE305612T1 (de) 2005-10-15

Family

ID=8240238

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00941999T ATE361374T1 (de) 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur bestimmung des lipidisierungsstatus einer zelle
AT00936829T ATE305612T1 (de) 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00941999T ATE361374T1 (de) 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur bestimmung des lipidisierungsstatus einer zelle

Country Status (9)

Country Link
US (1) US7129036B1 (de)
EP (3) EP1055929A1 (de)
AT (2) ATE361374T1 (de)
AU (2) AU778272B2 (de)
CA (2) CA2374047A1 (de)
DE (2) DE60034672D1 (de)
DK (1) DK1185873T3 (de)
ES (1) ES2249273T3 (de)
WO (2) WO2000073802A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756207B1 (en) 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
EP1412487B1 (de) * 2001-07-30 2010-06-16 Meso Scale Technologies LLC Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung
CN101684161A (zh) * 2001-08-10 2010-03-31 阿赫姆生物系统公司 蛋白酶检测系统
US8367318B2 (en) 2007-07-23 2013-02-05 Dharmacon, Inc. Screening of micro-RNA cluster inhibitor pools
WO2009100760A1 (en) * 2008-02-13 2009-08-20 Novartis Ag Cellular screening assay for modulators of mevalonate pathway
WO2013134499A1 (en) * 2012-03-07 2013-09-12 The Johns Hopkins University Anastasis biosensor
US11650201B2 (en) 2016-11-16 2023-05-16 The Johns Hopkins University Anastasis biosensor
US11649509B2 (en) 2017-11-16 2023-05-16 The Johns Hopkins University Anastasis biosensor caspase tracker
CN113444834B (zh) * 2020-03-27 2026-02-10 天津师范大学 2019新型冠状病毒lamp检测的引物组、双重恒温显色试剂盒及检测方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226065D0 (en) * 1992-12-14 1993-02-10 Ici Plc Peptides
DK0815257T3 (da) * 1995-01-31 2002-04-22 Bioimage As Fremgangsmåde til karakterisering af biologisk aktive stoffer
DK0877752T3 (da) 1996-01-23 2003-09-15 Univ Leland Stanford Junior Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler
DE69804446T3 (de) * 1997-04-07 2006-08-24 Bioimage A/S Verfahren um quantitativen informationen über einflüsse auf zelluläre reaktionen zu entnehmen
EA200000408A1 (ru) * 1997-10-10 2000-12-25 Сайтовиэ, Инк. Новые флуоресцентные сигнальные молекулы и их применение, в том числе, в анализах каспаз

Also Published As

Publication number Publication date
WO2000073802A1 (en) 2000-12-07
CA2374038A1 (en) 2000-12-07
US7129036B1 (en) 2006-10-31
EP1185873B1 (de) 2005-09-28
AU777118B2 (en) 2004-09-30
EP1185689B1 (de) 2007-05-02
AU5217700A (en) 2000-12-18
DK1185873T3 (da) 2006-01-30
AU778272B2 (en) 2004-11-25
DE60022879D1 (de) 2006-02-09
CA2374047A1 (en) 2000-12-07
AU5676700A (en) 2000-12-18
DE60022879T2 (de) 2006-07-20
WO2000073497A1 (en) 2000-12-07
EP1185873B8 (de) 2005-11-23
DE60034672D1 (de) 2007-06-14
EP1055929A1 (de) 2000-11-29
ES2249273T3 (es) 2006-04-01
ATE361374T1 (de) 2007-05-15
EP1185689A1 (de) 2002-03-13
EP1185873A1 (de) 2002-03-13

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