ATE305933T1 - Piperazin derivate - Google Patents

Piperazin derivate

Info

Publication number: ATE305933T1
Authority: AT; Austria
Prior art keywords: piperazine derivatives; piperazine; derivatives
Prior art date: 2000-07-31

Application number

AT01962869T

Other languages

English (en)

Inventor

Jonathan Mark Bentley

Paul Hebeisen

Marc Muller

Hans Richter

Stephan Roever

Patrizio Mattei

Sven Taylor

Original Assignee

Hoffmann La Roche

Vernalis Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2001-07-24

Publication date

2005-10-15

2001-07-24 Application filed by Hoffmann La Roche, Vernalis Res Ltd filed Critical Hoffmann La Roche

2005-10-15 Application granted granted Critical

2005-10-15 Publication of ATE305933T1 publication Critical patent/ATE305933T1/de

Links

GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT01962869T 2000-07-31 2001-07-24 Piperazin derivate ATE305933T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00116517		2000-07-31
PCT/EP2001/008520 WO2002010169A1 (en)	2000-07-31	2001-07-24	Piperazine derivatives

Publications (1)

Publication Number	Publication Date
ATE305933T1 true ATE305933T1 (de)	2005-10-15

Family

ID=8169405

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01962869T ATE305933T1 (de)	2000-07-31	2001-07-24	Piperazin derivate

Country Status (20)

Country	Link
US (4)	US20020035110A1 (de)
EP (1)	EP1325008B1 (de)
JP (1)	JP4180365B2 (de)
KR (1)	KR100539139B1 (de)
CN (1)	CN1277828C (de)
AR (1)	AR030306A1 (de)
AT (1)	ATE305933T1 (de)
AU (2)	AU8395501A (de)
BR (1)	BR0112918A (de)
CA (1)	CA2417106C (de)
DE (1)	DE60113865T2 (de)
DK (1)	DK1325008T3 (de)
ES (1)	ES2250459T3 (de)
GT (1)	GT200100155A (de)
MX (1)	MXPA03000906A (de)
PA (1)	PA8523601A1 (de)
PE (1)	PE20020366A1 (de)
UY (1)	UY26863A1 (de)
WO (1)	WO2002010169A1 (de)
ZA (1)	ZA200300525B (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1277828C (zh) *	2000-07-31	2006-10-04	霍夫曼-拉罗奇有限公司	哌嗪衍生物
GB0106177D0 (en) *	2001-03-13	2001-05-02	Hoffmann La Roche	Piperazine derivatives
DK1491212T3 (da)	2002-03-29	2012-10-29	Mitsubishi Tanabe Pharma Corp	Middel til behandling af søvnforstyrrelser
BR0311970A (pt)	2002-06-19	2005-03-29	Biovitrum Ab	Novos compostos, seu uso e preparação
US7105526B2 (en)	2002-06-28	2006-09-12	Banyu Pharmaceuticals Co., Ltd.	Benzimidazole derivatives
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
DE10319612A1 (de)	2003-05-02	2004-11-18	Bayer Healthcare Ag	Substituierte Dihydrochinazoline
DE10320780A1 (de) *	2003-05-09	2005-01-20	Bayer Healthcare Ag	Heterocyclyl-substituierte Dihydrochinazoline
GB0314967D0 (en) *	2003-06-26	2003-07-30	Hoffmann La Roche	Piperazine derivatives
US20050032930A1 (en) *	2003-07-02	2005-02-10	Christian Jackson	Inkjet ink
WO2005028438A1 (ja)	2003-09-22	2005-03-31	Banyu Pharmaceutical Co., Ltd.	新規ピペリジン誘導体
DE10352499A1 (de) *	2003-11-11	2005-06-09	Bayer Healthcare Ag	Substituierte Dihydrochinazoline II
EP1734963A4 (de)	2004-04-02	2008-06-18	Merck & Co Inc	Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen
DE102004022672A1 (de) *	2004-05-07	2005-11-24	Bayer Healthcare Ag	Substituierte Azachinazoline
US8685924B2 (en)	2004-08-25	2014-04-01	Takeda Pharmaceutical Company Limited	Preventives/remedies for stress urinary incontinence and method of screening the same
ES2325773T5 (es)	2004-11-01	2014-02-24	Amylin Pharmaceuticals, Llc.	Tratamiento de la obesidad y de los trastornos relacionados
ES2534304T3 (es)	2004-11-12	2015-04-21	Asuragen, Inc.	Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
US20090286723A1 (en)	2005-02-11	2009-11-19	Amylin Pharmaceuticals, Inc.	Hybrid Polypeptides with Selectable Properties
US7790712B2 (en)	2005-03-17	2010-09-07	Boehringer Ingelheim Pharmaceutical, Inc.	Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
KR100895758B1 (ko) *	2005-05-03	2009-04-30	에프. 호프만-라 로슈 아게	5-ｈｔ2 리간드로서 테트라사이클릭 아자피라지노인돌린
US7737155B2 (en)	2005-05-17	2010-06-15	Schering Corporation	Nitrogen-containing heterocyclic compounds and methods of use thereof
NZ562766A (en)	2005-05-30	2011-03-31	Banyu Pharma Co Ltd	Piperidine derivatives as histamine-H3 receptor antagonists
DE102005027517A1 (de)	2005-06-15	2006-12-21	Bayer Healthcare Ag	Verfahren zur Herstellung von Dihydrochinazolinen
EP1916239A4 (de)	2005-08-10	2009-10-21	Banyu Pharma Co Ltd	Pyridolverbindung
BRPI0614649A2 (pt)	2005-08-11	2011-04-12	Amylin Pharmaceuticals Inc	polipeptìdeos hìbridos com propriedades selecionáveis
AU2006282260A1 (en)	2005-08-24	2007-03-01	Msd K.K.	Phenylpyridone derivative
US20090264426A1 (en)	2005-09-07	2009-10-22	Shunji Sakuraba	Bicyclic aromatic substituted pyridone derivative
US8293900B2 (en)	2005-09-29	2012-10-23	Merck Sharp & Dohme Corp	Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
CA2625835A1 (en) *	2005-10-14	2007-05-10	Forest Laboratories, Inc.	Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
US20080255084A1 (en)	2005-10-21	2008-10-16	Randy Lee Webb	Combination of Organic Compounds
EP1944301A4 (de)	2005-10-27	2012-01-04	Msd Kk	Neue benzoxathiinderivate
CA2629018C (en)	2005-11-10	2013-12-31	Banyu Pharmaceutical Co., Ltd.	Aza-substituted spiro derivative
US7579351B2 (en)	2005-12-09	2009-08-25	Hoffmann-La Roche Inc.	Tricyclic amide derivatives
UA95788C2 (en)	2005-12-15	2011-09-12	Ф. Хоффманн-Ля Рош Аг	Fused pyrrole derivatives
EP2018863B9 (de)	2006-05-16	2015-02-18	Takeda Pharmaceutical Company Limited	Kondensierte, heterocyclische Verbindung und ihre Verwendung
EP2698157B1 (de)	2006-09-22	2015-05-20	Merck Sharp & Dohme Corp.	Verfahren zur Behandlung von Fettsäure-Synthese-Hemmern
WO2008038692A1 (en)	2006-09-28	2008-04-03	Banyu Pharmaceutical Co., Ltd.	Diaryl ketimine derivative
CN101631859B (zh)	2007-01-16	2017-10-13	Ipintl有限责任公司	用于治疗代谢综合征的新组合物
FR2912145B1 (fr) *	2007-02-02	2009-03-06	Servier Lab	Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8106086B2 (en)	2007-04-02	2012-01-31	Msd K.K.	Indoledione derivative
CA2682356C (en) *	2007-04-16	2016-06-14	Abbott Laboratories	7-substituted indole mcl-1 inhibitors
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
EP2789338A3 (de)	2007-11-15	2015-01-14	Takeda Pharmaceutical Company Limited	Kondensiertes Pyridinderivat und seine Verwendung
EP2264026A4 (de)	2008-03-06	2012-03-28	Msd Kk	Alkylaminopyridinderivate
US8207165B2 (en)	2008-03-28	2012-06-26	Nerviano Medical Sciences S.R.L.	3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
JPWO2009119726A1 (ja)	2008-03-28	2011-07-28	Ｍｓｄ株式会社	メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
WO2009133911A1 (ja) *	2008-04-28	2009-11-05	クラレメディカル株式会社	歯科用組成物及びコンポジットレジン
CA2666036C (en)	2008-05-16	2017-09-12	Chien-Hung Chen	Novel compositions and methods for treating hyperproliferative diseases
CA2726917C (en)	2008-06-04	2018-06-26	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20110071129A1 (en)	2008-06-19	2011-03-24	Makoto Ando	Spirodiamine-diaryl ketoxime derivative
EP2321341B1 (de)	2008-07-16	2017-02-22	Synergy Pharmaceuticals Inc.	Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
WO2010013595A1 (ja)	2008-07-30	2010-02-04	萬有製薬株式会社	５員－５員又は５員－６員縮環シクロアルキルアミン誘導体
US8410284B2 (en)	2008-10-22	2013-04-02	Merck Sharp & Dohme Corp	Cyclic benzimidazole derivatives useful as anti-diabetic agents
MX2011004551A (es)	2008-10-30	2011-05-25	Merck Sharp & Dohme	Antagonistas del receptor de orexina de isonicotinamida.
CA2741672A1 (en)	2008-10-31	2010-05-06	Merck Sharp & Dohme Corp.	Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010075069A1 (en)	2008-12-16	2010-07-01	Schering Corporation	Bicyclic pyranone derivatives as nicotinic acid receptor agonists
EP2379547A1 (de)	2008-12-16	2011-10-26	Schering Corporation	Pyridopyrimidinderivate und verfahren zu deren anwendung
FI122466B (fi) *	2009-08-21	2012-01-31	Hollming Oy	Menetelmä työstettävän metallikappaleen kuumentamiseksi ja induktiokuumennustyökalu
US20120253036A1 (en)	2009-12-11	2012-10-04	Yukinori Nagakura	Agent for treating fibromyalgia
AU2011218830B2 (en)	2010-02-25	2014-07-24	Merck Sharp & Dohme Corp.	Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CA2826649C (en)	2011-02-25	2016-07-26	Merck Sharp & Dohme Corp.	Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
EA201391254A1 (ru)	2011-03-01	2014-02-28	Синерджи Фармасьютикалз Инк.	Способ получения агонистов гуанилатциклазы c
AR088352A1 (es)	2011-10-19	2014-05-28	Merck Sharp & Dohme	Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
EP2825541B1 (de)	2012-03-16	2016-06-22	Vitae Pharmaceuticals, Inc.	Leber-x-rezeptormodulatoren
JP6114815B2 (ja)	2012-03-16	2017-04-12	ヴァイティーファーマシューティカルズ，インコーポレイテッド	肝臓ｘレセプターモジュレーター
TWI579274B (zh) *	2012-04-20	2017-04-21	龍馬躍公司	製備１－芳基－５－烷基吡唑化合物的改良方法
RU2015106909A (ru)	2012-08-02	2016-09-27	Мерк Шарп И Доум Корп.	Антидиабетические трициклические соединения
EP2970119B1 (de)	2013-03-14	2021-11-03	Merck Sharp & Dohme Corp.	Neuartige indolderivate als antidiabetika
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
CA2909894A1 (en) *	2013-04-23	2014-10-30	Ramon Merce-Vidal	Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
AU2014257578B2 (en)	2013-04-23	2017-11-16	Laboratorios Del Dr. Esteve, S.A.	Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
CN105764916B (zh)	2013-06-05	2021-05-18	博士医疗爱尔兰有限公司	鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
HRP20191283T1 (hr)	2014-01-24	2019-10-18	Turning Point Therapeutics, Inc.	Diaril makrocikli kao modulatori protein kinaze
MX389591B (es)	2014-08-29	2025-03-20	Tes Pharma S R L	INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA
BR112017026191B1 (pt)	2015-06-17	2023-10-10	Pfizer Inc	Compostos tricíclicos inibidores de fosfodiesterase, sua composição farmacêutica e uso dos mesmos
AU2016287568B2 (en)	2015-07-02	2020-08-20	Turning Point Therapeutics, Inc.	Chiral diaryl macrocycles as modulators of protein kinases
EP4397665A3 (de)	2015-07-06	2024-08-21	Turning Point Therapeutics, Inc.	Diarylmakrozykluspolymorph
MX2019004321A (es)	2016-10-14	2019-06-12	Tes Pharma S R L	Inhibidores de la acido alfa-amino-beta-carboximuconico semialdehido descarboxilasa.
US20210052600A1 (en)	2017-12-27	2021-02-25	Takeda Pharmaceutical Company Limited	Therapeutic agents for stress urinary incontinence and incotinence of feces
CN118496217A (zh)	2018-11-20	2024-08-16	Tes制药有限责任公司	α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
EP3924058B1 (de)	2019-02-13	2026-01-07	Merck Sharp & Dohme LLC	5-alkyl-pyrrolidinorexinrezeptor-agonisten
US12331018B2 (en)	2019-02-13	2025-06-17	Merck Sharp & Dohme Llc	Pyrrolidine orexin receptor agonists
US12312332B2 (en)	2019-08-08	2025-05-27	Merck Sharp & Dohme Llc	Heteroaryl pyrrolidine and piperidine orexin receptor agonists
US20230365533A1 (en)	2020-08-18	2023-11-16	Merck Sharp & Dohme Llc	Bicycloheptane pyrrolidine orexin receptor agonists
WO2026006356A1 (en) *	2024-06-25	2026-01-02	Vanderbilt University	6-(pyrimidin-5-yl)-3,4-dihydropyrazino[l,2-a]imdol-l(2h)-one mcl-1 inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US652018A (en) *	1900-02-15	1900-06-19	John C Duner	Gate.
US3317524A (en)	1965-02-04	1967-05-02	American Home Prod	Substituted 1, 2, 3, 4-tetrahydro-pyrazino[1, 2-a]indoles
DE2162422A1 (de)	1971-12-16	1973-06-20	Merck Patent Gmbh	Pyrazinoindol-derivate und verfahren zu ihrer herstellung
EP0572863A1 (de) *	1992-06-05	1993-12-08	F. Hoffmann-La Roche Ag	ZNS Pyrazinoindole
US5622950A (en)	1993-03-01	1997-04-22	Merck, Sharp & Dohme Ltd.	Pyrrolo-pyridine derivatives
CZ224195A3 (en)	1993-03-01	1996-03-13	Merck Sharp & Dohme	The use of pyrrolopyridine derivatives for preparing pharmaceutical preparations
US5576319A (en)	1993-03-01	1996-11-19	Merck, Sharp & Dohme Ltd.	Pyrrolo-pyridine derivatives
US6169086B1 (en)	1997-01-27	2001-01-02	Daiichi Pharmaceutical Co., Ltd.	Pyrazole derivatives
JP2000169475A (ja)	1998-07-24	2000-06-20	Dai Ichi Seiyaku Co Ltd	ピラゾ―ル誘導体およびその塩
SK8192001A3 (en) *	1998-12-17	2001-12-03	American Home Prod	2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivatives being 5ht2c agonists
GB9902047D0 (en) *	1999-01-29	1999-03-17	Cerebrus Ltd	Chemical compounds XI
CN1277828C (zh) *	2000-07-31	2006-10-04	霍夫曼-拉罗奇有限公司	哌嗪衍生物

2001
- 2001-07-24 CN CNB018152260A patent/CN1277828C/zh not_active Expired - Fee Related
- 2001-07-24 BR BR0112918-0A patent/BR0112918A/pt not_active IP Right Cessation
- 2001-07-24 KR KR10-2003-7001439A patent/KR100539139B1/ko not_active Expired - Fee Related
- 2001-07-24 WO PCT/EP2001/008520 patent/WO2002010169A1/en not_active Ceased
- 2001-07-24 ES ES01962869T patent/ES2250459T3/es not_active Expired - Lifetime
- 2001-07-24 AU AU8395501A patent/AU8395501A/xx active Pending
- 2001-07-24 DE DE60113865T patent/DE60113865T2/de not_active Expired - Fee Related
- 2001-07-24 EP EP01962869A patent/EP1325008B1/de not_active Expired - Lifetime
- 2001-07-24 JP JP2002515898A patent/JP4180365B2/ja not_active Expired - Fee Related
- 2001-07-24 AT AT01962869T patent/ATE305933T1/de not_active IP Right Cessation
- 2001-07-24 MX MXPA03000906A patent/MXPA03000906A/es active IP Right Grant
- 2001-07-24 CA CA002417106A patent/CA2417106C/en not_active Expired - Fee Related
- 2001-07-24 DK DK01962869T patent/DK1325008T3/da active
- 2001-07-24 AU AU2001283955A patent/AU2001283955B2/en not_active Ceased
- 2001-07-25 PE PE2001000749A patent/PE20020366A1/es not_active Application Discontinuation
- 2001-07-25 US US09/912,949 patent/US20020035110A1/en not_active Abandoned
- 2001-07-27 AR ARP010103589A patent/AR030306A1/es unknown
- 2001-07-30 PA PA20018523601A patent/PA8523601A1/es unknown
- 2001-07-30 UY UY26863A patent/UY26863A1/es not_active Application Discontinuation
- 2001-07-30 GT GT200100155A patent/GT200100155A/es unknown
2003
- 2003-01-20 ZA ZA200300525A patent/ZA200300525B/en unknown
- 2003-03-25 US US10/396,242 patent/US6933387B2/en not_active Expired - Fee Related
2005
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Also Published As

Publication number	Publication date
US20050239789A1 (en)	2005-10-27
JP4180365B2 (ja)	2008-11-12
DE60113865T2 (de)	2006-07-20
US6933387B2 (en)	2005-08-23
UY26863A1 (es)	2002-01-31
GT200100155A (es)	2002-05-16
KR100539139B1 (ko)	2005-12-26
CA2417106C (en)	2007-09-18
US7253281B2 (en)	2007-08-07
PA8523601A1 (es)	2002-10-24
CN1452622A (zh)	2003-10-29
DK1325008T3 (da)	2006-02-13
MXPA03000906A (es)	2005-02-24
ES2250459T3 (es)	2006-04-16
BR0112918A (pt)	2003-07-01
ZA200300525B (en)	2004-04-20
AR030306A1 (es)	2003-08-20
AU2001283955B2 (en)	2006-05-18
CA2417106A1 (en)	2002-02-07
US20020035110A1 (en)	2002-03-21
PE20020366A1 (es)	2002-05-17
WO2002010169A1 (en)	2002-02-07
JP2004505085A (ja)	2004-02-19
US20070106076A1 (en)	2007-05-10
EP1325008B1 (de)	2005-10-05
DE60113865D1 (de)	2006-02-16
US20030216401A1 (en)	2003-11-20
CN1277828C (zh)	2006-10-04
AU8395501A (en)	2002-02-13
EP1325008A1 (de)	2003-07-09
KR20030020954A (ko)	2003-03-10

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