ATE307103T1 - Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen - Google Patents

Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen

Info

Publication number: ATE307103T1
Authority: AT; Austria
Prior art keywords: preparations containing; hyperforin derivatives; hyperforin; derivatives; glicoside
Prior art date: 1998-06-10

Application number

AT99926516T

Other languages

English (en)

Inventor

Ezio Bombardelli

Paolo Marazzoni

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

1999-06-04

Publication date

2005-11-15

1999-06-04 Application filed by Indena Spa filed Critical Indena Spa

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE307103T1 publication Critical patent/ATE307103T1/de

Links

238000002360 preparation method Methods 0.000 title abstract 2
KGSZHKRKHXOAMG-HQKKAZOISA-N (1r,5r,6r,7s)-2-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione Chemical class O=C1C(CC=C(C)C)=C(O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O KGSZHKRKHXOAMG-HQKKAZOISA-N 0.000 title 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002448 hyperforins Chemical class 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
- C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

AT99926516T 1998-06-10 1999-06-04 Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen ATE307103T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI001312A IT1301679B1 (it)	1998-06-10	1998-06-10	Derivati dell'iperforina, loro uso e formulazioni che licontengono.
PCT/EP1999/003880 WO1999064388A1 (en)	1998-06-10	1999-06-04	Hyperforin derivatives, the use thereof and formulations containing them

Publications (1)

Publication Number	Publication Date
ATE307103T1 true ATE307103T1 (de)	2005-11-15

Family

ID=11380210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99926516T ATE307103T1 (de)	1998-06-10	1999-06-04	Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen

Country Status (22)

Country	Link
US (1)	US6656510B2 (de)
EP (2)	EP1086071B1 (de)
JP (1)	JP4511726B2 (de)
KR (1)	KR100627933B1 (de)
CN (1)	CN1246278C (de)
AT (1)	ATE307103T1 (de)
AU (1)	AU763889B2 (de)
BR (1)	BR9910893B1 (de)
CA (1)	CA2334308C (de)
CZ (1)	CZ298859B6 (de)
DE (1)	DE69927813T2 (de)
DK (1)	DK1086071T3 (de)
ES (1)	ES2249893T3 (de)
HU (1)	HUP0102226A3 (de)
IL (2)	IL140151A0 (de)
IT (1)	IT1301679B1 (de)
MX (1)	MXPA00012177A (de)
NO (1)	NO328444B1 (de)
PL (1)	PL195797B1 (de)
RU (1)	RU2240304C2 (de)
SK (1)	SK286049B6 (de)
WO (1)	WO1999064388A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1126882B1 (de) *	1998-11-04	2009-12-30	Dr. Willmar Schwabe GmbH & Co. KG	Stabile zubereitungen mit hyperforin
ITMI20020872A1 (it)	2002-04-23	2003-10-23	Indena Spa	Derivati dell'iperforina loro uso e formulazioni che li contengono
ITMI20020871A1 (it)	2002-04-23	2003-10-23	Indena Spa	Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono
US20060115556A1 (en) *	2004-12-01	2006-06-01	Foulger Sidney W	Nutritional supplement drink containing xanthone extracts
US20060115555A1 (en) *	2004-12-01	2006-06-01	Foulger Sidney W	Nutritional supplements containing xanthone extracts
BRPI0900614A2 (pt)	2009-02-13	2011-06-28	Univ Fed Do Rio Grande Do Sul Ufrgs	extrato vegetal neuroativo, composição farmacêutica compreendendo o mesmo e processo para sua produção
EP2714638A4 (de) *	2011-06-03	2015-09-23	Harvard College	Hyperforin-analoga, verfahren zu ihrer synthese und verwendungen davon
ITMI20131012A1 (it)	2013-06-19	2014-12-20	Indena Spa	Derivati dell'iperforina e loro uso nella malattia di alzheimer
RU2676100C1 (ru) *	2018-10-05	2018-12-26	федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ")	Применение производных пиперазина для лечения болезни Альцгеймера и деменций альцгеймеровского типа с нарушенной внутриклеточной кальциевой сигнализацией
CN118724815A (zh) *	2024-06-20	2024-10-01	中日友好医院(中日友好临床医学研究所)	一种间苯三酚类化合物Hyperforidiol E及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2550266A (en) *	1948-12-11	1951-04-24	Swift & Co	Preservation of food products
DE4239959A1 (de) *	1992-11-27	1994-06-01	Schwabe Willmar Gmbh & Co	Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
DE19646977A1 (de) *	1995-09-29	1998-01-15	Schwabe Willmar Gmbh & Co	Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
DE19714450A1 (de) *	1997-04-08	1998-10-15	Schwabe Willmar Gmbh & Co	Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitung
WO1999036080A1 (en) *	1998-01-13	1999-07-22	Rexall Sundown, Inc.	St. john's wort and methyl donor composition and uses thereof
US6224906B1 (en) *	1999-08-31	2001-05-01	Natreon Inc.	St. John's wort composition

1998
- 1998-06-10 IT IT1998MI001312A patent/IT1301679B1/it active IP Right Grant
1999
- 1999-06-04 CA CA002334308A patent/CA2334308C/en not_active Expired - Fee Related
- 1999-06-04 KR KR1020007013866A patent/KR100627933B1/ko not_active Expired - Lifetime
- 1999-06-04 SK SK1871-2000A patent/SK286049B6/sk not_active IP Right Cessation
- 1999-06-04 JP JP2000553398A patent/JP4511726B2/ja not_active Expired - Fee Related
- 1999-06-04 CN CNB998071218A patent/CN1246278C/zh not_active Expired - Fee Related
- 1999-06-04 DE DE69927813T patent/DE69927813T2/de not_active Expired - Lifetime
- 1999-06-04 RU RU2000131214/04A patent/RU2240304C2/ru not_active IP Right Cessation
- 1999-06-04 PL PL99344696A patent/PL195797B1/pl not_active IP Right Cessation
- 1999-06-04 AU AU43739/99A patent/AU763889B2/en not_active Ceased
- 1999-06-04 HU HU0102226A patent/HUP0102226A3/hu unknown
- 1999-06-04 MX MXPA00012177A patent/MXPA00012177A/es active IP Right Grant
- 1999-06-04 AT AT99926516T patent/ATE307103T1/de active
- 1999-06-04 DK DK99926516T patent/DK1086071T3/da active
- 1999-06-04 CZ CZ20004562A patent/CZ298859B6/cs not_active IP Right Cessation
- 1999-06-04 ES ES99926516T patent/ES2249893T3/es not_active Expired - Lifetime
- 1999-06-04 IL IL14015199A patent/IL140151A0/xx active IP Right Grant
- 1999-06-04 WO PCT/EP1999/003880 patent/WO1999064388A1/en not_active Ceased
- 1999-06-04 EP EP99926516A patent/EP1086071B1/de not_active Expired - Lifetime
- 1999-06-04 EP EP05015870A patent/EP1607099A1/de not_active Withdrawn
- 1999-06-04 BR BRPI9910893-3B1A patent/BR9910893B1/pt not_active IP Right Cessation
2000
- 2000-12-07 US US09/730,536 patent/US6656510B2/en not_active Expired - Lifetime
- 2000-12-07 NO NO20006230A patent/NO328444B1/no not_active IP Right Cessation
- 2000-12-07 IL IL140151A patent/IL140151A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US20010020040A1 (en)	2001-09-06
DE69927813D1 (de)	2006-03-02
IT1301679B1 (it)	2000-07-07
JP4511726B2 (ja)	2010-07-28
DK1086071T3 (da)	2006-01-23
NO328444B1 (no)	2010-02-22
BR9910893B1 (pt)	2013-10-29
SK286049B6 (sk)	2008-01-07
RU2240304C2 (ru)	2004-11-20
AU763889B2 (en)	2003-07-31
AU4373999A (en)	1999-12-30
IL140151A0 (en)	2002-02-10
CA2334308A1 (en)	1999-12-16
EP1607099A1 (de)	2005-12-21
CN1304397A (zh)	2001-07-18
MXPA00012177A (es)	2004-09-06
CN1246278C (zh)	2006-03-22
KR20010052637A (ko)	2001-06-25
WO1999064388A1 (en)	1999-12-16
BR9910893A (pt)	2001-03-06
CZ20004562A3 (en)	2001-06-13
HUP0102226A2 (hu)	2001-10-28
EP1086071A1 (de)	2001-03-28
CA2334308C (en)	2009-06-02
KR100627933B1 (ko)	2006-09-22
PL344696A1 (en)	2001-11-19
ITMI981312A1 (it)	1999-12-10
EP1086071B1 (de)	2005-10-19
JP2002517478A (ja)	2002-06-18
NO20006230L (no)	2001-02-01
DE69927813T2 (de)	2006-04-20
IL140151A (en)	2006-12-10
US6656510B2 (en)	2003-12-02
ES2249893T3 (es)	2006-04-01
NO20006230D0 (no)	2000-12-07
CZ298859B6 (cs)	2008-02-27
HK1036791A1 (en)	2002-01-18
SK18712000A3 (sk)	2001-06-11
HUP0102226A3 (en)	2003-07-28
PL195797B1 (pl)	2007-10-31

Legal Events

Date

Code

Title

Description

2006-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1086071

Country of ref document: EP

Publication	Publication Date	Title
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
DK0889876T3 (da)	2001-09-24	Meta-substituerede phenylensulfonamidderivater
DE59009074D1 (de)	1995-06-22	Diarylsubstituierte heterocyclische Verbindung, ihre Herstellung und Arzneimittel und Kosmetika daraus.
KR870700620A (ko)	1987-12-30	신규 약리학적 화합물
TR199902626T2 (xx)	2000-06-21	Enflamasyon tedavisi i�in ikameli benzopiran t�revleri.
NO953305D0 (no)	1995-08-23	Antranilsyrederivat
NO870241D0 (no)	1987-01-20	Hypoglykemiske tiazolidindioner.
ES2191208T3 (es)	2003-09-01	Oxiimino-pregnano-carbolactonas.
DZ1468A1 (fr)	2004-09-13	Composés nouveaux.
MX9300222A (es)	1993-07-01	Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion.
DE59104205D1 (de)	1995-02-23	Substituierte Aminoalkylbiphenylderivate, antimykotische Präparate damit und Zwischenprodukte für ihre Herstellung.
DE69927813D1 (de)	2006-03-02	Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen
NO952743D0 (no)	1995-07-11	Ny benzotiadiazinforbindelse, dens fremstilling og farmasöytiske preparater
AU4609701A (en)	2001-06-06	Colouring agent for keratin containing fibres
BR0210746A (pt)	2004-07-20	Derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral
DE60128100D1 (de)	2007-06-06	Analgetisches arzneimittel
DE50101861D1 (de)	2004-05-06	Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
DE69600231D1 (de)	1998-05-20	N-Arylalkylphenylacetamidderivate
ATE183502T1 (de)	1999-09-15	Octahydro-2-naphthalincarbonsäure-derivate, ihre herstellung und verwendung
ATE101139T1 (de)	1994-02-15	(alkylthio-3-propyl)-3-benzothiazolinderivate, ihre herstellung und diese enthaltende arzneimittel.
WO2001083423A3 (en)	2002-02-21	2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof
FI934468A0 (fi)	1993-10-11	Bensenborsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som sytesmellanprodukter
IT1199339B (it)	1988-12-30	N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono
ATE224401T1 (de)	2002-10-15	Thiocolchicosid-derivate, ihre herstellung und verwendung als arzneimittel
AU579416B2 (en)	1988-11-24	3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds