ATE307814T1 - Neue pyridin- und cyclohexenyl-enthaltende pyrrolobenzodiazepin-carboxamide und derivative davon; tokolytische oxytocin-rezeptor- antagonisten - Google Patents

Neue pyridin- und cyclohexenyl-enthaltende pyrrolobenzodiazepin-carboxamide und derivative davon; tokolytische oxytocin-rezeptor- antagonisten

Info

Publication number: ATE307814T1
Authority: AT; Austria
Prior art keywords: carboxamides; suppression; treatment; prevention; pyrrolobenzodiazepine
Prior art date: 2001-04-12

Application number

AT02721728T

Other languages

English (en)

Inventor

Amedeo Arturo Failli

William Jennings Sanders

Eugene John Trybulski

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-11

Publication date

2005-11-15

2002-04-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE307814T1 publication Critical patent/ATE307814T1/de

Links

-1 CYCLOHEXENYL Chemical class 0.000 title abstract 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
229940122828 Oxytocin receptor antagonist Drugs 0.000 title 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
230000003195 tocolytic effect Effects 0.000 title 1
230000002265 prevention Effects 0.000 abstract 3
230000001629 suppression Effects 0.000 abstract 3
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
230000002708 enhancing effect Effects 0.000 abstract 2
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000012173 estrus Effects 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000003336 oxytocin antagonist Substances 0.000 abstract 1
229940121361 oxytocin antagonists Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02721728T 2001-04-12 2002-04-11 Neue pyridin- und cyclohexenyl-enthaltende pyrrolobenzodiazepin-carboxamide und derivative davon; tokolytische oxytocin-rezeptor- antagonisten ATE307814T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28338801P	2001-04-12	2001-04-12
PCT/US2002/011535 WO2002083684A1 (en)	2001-04-12	2002-04-11	Novel pyridine- and cyclohexenyl-comprising pyrrolobenzodiazepi ne-carboxamides and derivatives thereof; tocolytic oxytocin receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE307814T1 true ATE307814T1 (de)	2005-11-15

Family

ID=23085822

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02721728T ATE307814T1 (de)	2001-04-12	2002-04-11	Neue pyridin- und cyclohexenyl-enthaltende pyrrolobenzodiazepin-carboxamide und derivative davon; tokolytische oxytocin-rezeptor- antagonisten

Country Status (10)

Country	Link
US (1)	US6903087B2 (de)
EP (1)	EP1381607B1 (de)
JP (1)	JP2004526770A (de)
CN (1)	CN1501930A (de)
AT (1)	ATE307814T1 (de)
BR (1)	BR0208942A (de)
CA (1)	CA2443568A1 (de)
DE (1)	DE60206898D1 (de)
MX (1)	MXPA03009334A (de)
WO (1)	WO2002083684A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7022699B2 (en) *	2001-04-12	2006-04-04	Wyeth	Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7326700B2 (en) *	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) *	2001-04-12	2006-09-19	Wyeth	Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7064120B2 (en) *	2001-04-12	2006-06-20	Wyeth	Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6900200B2 (en) *	2001-04-12	2005-05-31	Wyeth	Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7202239B2 (en) *	2001-04-12	2007-04-10	Wyeth	Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6977254B2 (en) *	2001-04-12	2005-12-20	Wyeth	Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7691848B2 (en)	2005-03-02	2010-04-06	Wyeth	Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
EP1879898A2 (de) *	2005-05-12	2008-01-23	Wyeth a Corporation of the State of Delaware	Pyrrolobenzodiazepine und heterozyklische carboxamid-derivate als follikelstimulierende hormonrezeptor-antagonisten
CN101238126A (zh) *	2005-05-12	2008-08-06	惠氏公司	作为促卵泡激素受体(fsh－r)拮抗剂的吡咯并苯并二氮杂䓬以及杂芳基、芳基和环烷基氨基酮衍生物
EP1893615A1 (de)	2005-06-09	2008-03-05	Wyeth a Corporation of the State of Delaware	Pyrrolobenzodiazepin-pyridin-carboxamide und deren derivate als follikelstimulierende hormonrezeptor-antagonisten
US8865084B2 (en)	2011-11-30	2014-10-21	Corning Incorporated	Pass-through catalytic substrate including porous ceramic beveled corner portions and methods
CN119977827A (zh) *	2025-01-02	2025-05-13	河南优凯制药有限公司	一种甲氧氯普胺中间体及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4159A (en) *		1845-08-20		Cooking-stove
US27815A (en) *		1860-04-10		Builder s scaffold
US198196A (en) *		1877-12-18		Improvement in monkey-wrenches
US55047A (en) *		1866-05-29		Improvement in locks
US8863A (en) *		1852-04-06		Mechanism for actuating ast adjustable eccentric
US18026A (en) *		1857-08-18		Joseph v
US183311A (en) *		1876-10-17		Improvement in stove-pipe thimbles
US5968930A (en)	1993-07-29	1999-10-19	American Cyanamid Company	Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5736540A (en)	1993-07-29	1998-04-07	American Cyanamid Company	Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) *	1995-01-17	1996-05-28	American Home Products Corporation	Tricyclic benzazepine vasopressin antagonists
US5880122A (en) *	1996-11-01	1999-03-09	American Home Products Corporation	3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
NZ335483A (en)	1996-11-01	2001-09-28	American Home Prod	3-carboxamide derivatives of 5H-pyrrolo[2,1-c][1,4]-benzodiazepines as vasopressin antagonists
BR9811585A (pt)	1997-07-30	2000-09-26	American Home Prod	Agonistas de vasopressinas tricìclicas
US7326700B2 (en)	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7022699B2 (en)	2001-04-12	2006-04-04	Wyeth	Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US6977254B2 (en)	2001-04-12	2005-12-20	Wyeth	Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7202239B2 (en)	2001-04-12	2007-04-10	Wyeth	Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en)	2001-04-12	2005-05-31	Wyeth	Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7064120B2 (en)	2001-04-12	2006-06-20	Wyeth	Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en)	2001-04-12	2006-09-19	Wyeth	Tricyclic diazepines tocolytic oxytocin receptor antagonists

2002
- 2002-04-10 US US10/119,894 patent/US6903087B2/en not_active Expired - Fee Related
- 2002-04-11 BR BR0208942-4A patent/BR0208942A/pt not_active IP Right Cessation
- 2002-04-11 CN CNA028080335A patent/CN1501930A/zh active Pending
- 2002-04-11 CA CA002443568A patent/CA2443568A1/en not_active Abandoned
- 2002-04-11 WO PCT/US2002/011535 patent/WO2002083684A1/en not_active Ceased
- 2002-04-11 DE DE60206898T patent/DE60206898D1/de not_active Expired - Lifetime
- 2002-04-11 EP EP02721728A patent/EP1381607B1/de not_active Expired - Lifetime
- 2002-04-11 MX MXPA03009334A patent/MXPA03009334A/es unknown
- 2002-04-11 AT AT02721728T patent/ATE307814T1/de not_active IP Right Cessation
- 2002-04-11 JP JP2002581439A patent/JP2004526770A/ja active Pending

Also Published As

Publication number	Publication date
MXPA03009334A (es)	2004-11-12
CA2443568A1 (en)	2002-10-24
DE60206898D1 (de)	2005-12-01
JP2004526770A (ja)	2004-09-02
CN1501930A (zh)	2004-06-02
US6903087B2 (en)	2005-06-07
BR0208942A (pt)	2004-04-27
WO2002083684A1 (en)	2002-10-24
EP1381607A1 (de)	2004-01-21
US20030055046A1 (en)	2003-03-20
EP1381607B1 (de)	2005-10-26

Legal Events

Date	Code	Title	Description
2006-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE321047T1 (de)	2006-04-15	Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten
ATE309244T1 (de)	2005-11-15	Neue 10-cyclohexenyl-phenyl-pyrrolobenzodiazepin- 3-carboxamide und derivate davon; tokolytische oxytocin-rezeptor-antagonisten
ATE307814T1 (de)	2005-11-15	Neue pyridin- und cyclohexenyl-enthaltende pyrrolobenzodiazepin-carboxamide und derivative davon; tokolytische oxytocin-rezeptor- antagonisten
MX2007006301A (es)	2007-06-15	Derivados pirrolidilo de compuestos heteroaromaticos como inhibidores de fosfodiesterasa.
EA200700097A1 (ru)	2007-06-29	Производные хиназолин-4-илпиперидина и циннолин-4-илпиперидина в качестве ингибиторов pde10 для лечения расстройств цнс
UA74419C2 (uk)	2005-12-15	Заміщені піридини та їх застосування як антагоністів рецептору метаботропного глутамату
DOP2005000022A (es)	2005-08-30	"derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina"
DK1196397T3 (da)	2006-01-02	Metabotrope glutamatreceptorantagonister og anvendelse deraf til behandling af sygdomme i centralnervesystemet
MXPA02001306A (es)	2004-06-22	Composiciones farmaceuticas para el tratamiento de enfermedades del sistema nervioso central y otras enfermedades.
IL146403A0 (en)	2002-07-25	Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
DK1377584T3 (da)	2005-05-23	Nye cyclohexenylphenyldiazepiner som vasopressin- og oxytocinreceptormodulatorer
BR0209015A (pt)	2005-01-11	Novas 10-ciclohexilbenzoil pirrolobenzodiazepinas substituìdas com 3-c(o)r e antagonistas receptores de ocitocina tocolìticos
MA28706B1 (fr)	2007-06-01	Antagoniste des recepteurs du glucagon, preparation et utilisations therapeutiques
EA200801184A1 (ru)	2008-08-29	Производные пипередин-4-ил-пиридазин-3-иламина как быстро диссоциирующие антагонисты рецептора дофамина 2
ATE449074T1 (de)	2009-12-15	2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors
BR0209017A (pt)	2005-01-11	Novas piridil benzazepina carboxamidas tricìclicas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas
DE60213629D1 (de)	2006-09-14	Piperidinverbindungen als muscarinantagonisten
EA200970553A1 (ru)	2009-10-30	Пиперидиниламинопиридазины и их применение в качестве быстро диссоциирующих антагонистов рецептора допамина 2
BR0208941A (pt)	2004-08-03	Novos antagonistas receptores de ocitocina tocolìticos de hidróxi ciclohexenil fenil carboxamidas
TW200631956A (en)	2006-09-16	Azabenzoxazoles for the treatment of CNS disorders
IS8377A (is)	2006-03-27	Arýlindenópyridín og arýlindenópyrimidín og notkun þeirra sem mótlyf A2A viðtaka adenósíns
TW200508203A (en)	2005-03-01	3-azabicyclo 3.2.1 octane derivatives
BRPI0809873A2 (pt)	2018-11-13	"composto, processo para a preparação do composto, método para o tratamento de uma desordem do sistema nervoso central, composição farmacêutica, uso do composto, método para testar antagonistas e antagonistas com seletividade para o receptor 5-th6 e método de tratamento"
BRPI0409958A (pt)	2006-04-25	quinolinas de benzofuranil- e benzotienil-piperazinil quinolinas e métodos para o seu uso
GB0311349D0 (en)	2003-06-25	Therapeutic agents, compositions, preparations and uses