ATE449074T1 - 2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors - Google Patents

2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors

Info

Publication number: ATE449074T1
Authority: AT; Austria
Prior art keywords: derivatives; azabicyclo; nonan; antagonists; opioid receptor
Prior art date: 2003-04-14

Application number

AT04725453T

Other languages

English (en)

Inventor

Jotham Wadsworth Coe

Stanton Furst Mchardy

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-14

Filing date

2004-04-02

Publication date

2009-12-15

2004-04-02 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2009-12-15 Application granted granted Critical

2009-12-15 Publication of ATE449074T1 publication Critical patent/ATE449074T1/de

Links

102000003840 Opioid Receptors Human genes 0.000 title abstract 2
108090000137 Opioid Receptors Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical class CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
208000007848 Alcoholism Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
ZPAPCUKKKOSLPZ-UHFFFAOYSA-N morphan Chemical class C1CNC2CCCC1C2 ZPAPCUKKKOSLPZ-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Materials For Medical Uses (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT04725453T 2003-04-14 2004-04-02 2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors ATE449074T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US46260503P	2003-04-14	2003-04-14
PCT/IB2004/001237 WO2004089909A1 (en)	2003-04-14	2004-04-02	2-azabicyclo[3.3.1]nonane derivatives as opioid receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE449074T1 true ATE449074T1 (de)	2009-12-15

Family

ID=33159854

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04725453T ATE449074T1 (de)	2003-04-14	2004-04-02	2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors

Country Status (11)

Country	Link
US (2)	US7056930B2 (de)
EP (1)	EP1615893B1 (de)
JP (1)	JP4493648B2 (de)
AT (1)	ATE449074T1 (de)
BR (1)	BRPI0409369A (de)
CA (1)	CA2522180C (de)
DE (1)	DE602004024188D1 (de)
DK (1)	DK1615893T3 (de)
ES (1)	ES2334570T3 (de)
MX (1)	MXPA05011060A (de)
WO (1)	WO2004089909A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60226161T2 (de) *	2001-10-22	2009-07-02	Pfizer Products Inc., Groton	3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren
MXPA05011070A (es) *	2003-04-14	2005-12-12	Pfizer Prod Inc	Derivados de 3-azabiciclo [3.2.1] octano.
US20050043345A1 (en) *	2003-08-22	2005-02-24	Pfizer Inc	Pharmaceutical composition for the prevention and treatment of addiction in a mammal
MY145633A (en)	2006-03-01	2012-03-15	Theravance Inc	8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) *	2007-02-28	2013-09-21	Theravance Inc	８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI425945B (zh) *	2007-05-28	2014-02-11	Seldar Pharma Inc	四氫異喹啉－１－酮衍生物或其鹽
US7947710B2 (en) *	2007-08-27	2011-05-24	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ES2390195T3 (es) *	2007-08-27	2012-11-07	Theravance, Inc.	Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
WO2009029253A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
GB0721178D0 (en) *	2007-10-29	2007-12-05	Glaxo Group Ltd	Chemical compounds
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
CA2927527C (en) *	2013-11-20	2021-06-01	Sanwa Kagaku Kenkyusho Co., Ltd.	Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof as u-opioid receptor antagonist
HK1246778A1 (zh) *	2015-05-20	2018-09-14	株式会社三和化学研究所	一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
WO2017210105A1 (en) *	2016-06-02	2017-12-07	Virginia Commonwealth University	Dual modulators of both mu and kappa opioid receptors
BR112020015712A2 (pt)	2018-02-05	2020-12-08	Alkermes, Inc.	Compostos para tratamento de dor
US11352365B2 (en)	2018-03-19	2022-06-07	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Biased potent opioid-like agonists as improved medications to treat chronic and acute pain and methods of using the same
KR102266854B1 (ko) *	2019-11-06	2021-06-18	계명대학교 산학협력단	마약 중독 예방 또는 치료용 약학조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2143145A (en) *	1934-11-06	1939-01-10	Farnsworth Television Inc	Projection means
US6559159B2 (en) *	2001-02-01	2003-05-06	Research Triangle Institute	Kappa opioid receptor ligands

2004
- 2004-01-22 US US10/762,730 patent/US7056930B2/en not_active Ceased
- 2004-04-02 JP JP2006506512A patent/JP4493648B2/ja not_active Expired - Fee Related
- 2004-04-02 BR BRPI0409369-0A patent/BRPI0409369A/pt not_active IP Right Cessation
- 2004-04-02 AT AT04725453T patent/ATE449074T1/de not_active IP Right Cessation
- 2004-04-02 WO PCT/IB2004/001237 patent/WO2004089909A1/en not_active Ceased
- 2004-04-02 DK DK04725453.7T patent/DK1615893T3/da active
- 2004-04-02 CA CA002522180A patent/CA2522180C/en not_active Expired - Fee Related
- 2004-04-02 DE DE602004024188T patent/DE602004024188D1/de not_active Expired - Lifetime
- 2004-04-02 MX MXPA05011060A patent/MXPA05011060A/es not_active Application Discontinuation
- 2004-04-02 EP EP04725453A patent/EP1615893B1/de not_active Expired - Lifetime
- 2004-04-02 ES ES04725453T patent/ES2334570T3/es not_active Expired - Lifetime
2007
- 2007-10-18 US US11/874,253 patent/USRE40838E1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE602004024188D1 (de)	2009-12-31
EP1615893A1 (de)	2006-01-18
EP1615893B1 (de)	2009-11-18
JP2006522797A (ja)	2006-10-05
CA2522180C (en)	2009-12-08
USRE40838E1 (en)	2009-07-07
US7056930B2 (en)	2006-06-06
US20040204445A1 (en)	2004-10-14
MXPA05011060A (es)	2005-12-12
CA2522180A1 (en)	2004-10-21
JP4493648B2 (ja)	2010-06-30
WO2004089909A1 (en)	2004-10-21
BRPI0409369A (pt)	2006-04-25
ES2334570T3 (es)	2010-03-12
DK1615893T3 (da)	2010-01-18

Legal Events

Date	Code	Title	Description
2010-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DK1615893T3 (da)	2010-01-18	2-azabicylo3.3.1 nonan-derivater som opioidreceptorantagonister
MXPA05011018A (es)	2005-12-12	Compuestos de 4-fenil piperidna y sus usos como moduladores de receptores opioides.
BG101806A (bg)	1998-04-30	Индолови производни като антагонисти на 5-нт рецептори
DE602004011401D1 (de)	2008-03-06	Benzazepinderivate als histamin-h3-antagonisten
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DE602006009773D1 (de)	2009-11-26	Substituierte thiophenderivate als glucagonrezeptorantagonisten, herstellung und therapeutische anwendungen
PY0225353A (es)	2004-05-03	Derivados del 3-azabiciclo [3.1.0] hexano
ATE293448T1 (de)	2005-05-15	Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten
EA200500172A1 (ru)	2005-08-25	Азабициклопроизводные в качестве антагонистов мускариновых рецепторов
HRP20050556A2 (en)	2006-07-31	Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
EA200801184A1 (ru)	2008-08-29	Производные пипередин-4-ил-пиридазин-3-иламина как быстро диссоциирующие антагонисты рецептора дофамина 2
TW200508203A (en)	2005-03-01	3-azabicyclo 3.2.1 octane derivatives
WO2006044293A3 (en)	2006-06-29	Bicyclic compounds as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
EP1505063A1 (de)	2005-02-09	Benzimidazolderivate
ATE429421T1 (de)	2009-05-15	Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten
EA200970553A1 (ru)	2009-10-30	Пиперидиниламинопиридазины и их применение в качестве быстро диссоциирующих антагонистов рецептора допамина 2
ATE307814T1 (de)	2005-11-15	Neue pyridin- und cyclohexenyl-enthaltende pyrrolobenzodiazepin-carboxamide und derivative davon; tokolytische oxytocin-rezeptor- antagonisten
ATE362364T1 (de)	2007-06-15	Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
MXPA05012572A (es)	2006-02-08	Derivado de 5-h-benzo[d]naft[2,1-b]azepina como antagonistas selectivos del receptor d1/d5 para el tratamiento de la obesidad y trastornos del sistema nervioso central.
HRP20050554B1 (hr)	2014-02-28	Supstituirani 1- piperidin-3-il-4-piperidin-4-il-piperazinski derivati i njihova primjena kao neurokininskih antagonista
ATE419246T1 (de)	2009-01-15	Als antagonisten des muscarinrezeptors geeignete xanthinderivate
WO2005063697A3 (en)	2005-12-22	Substituted n-aryl amidines as selective d1 dopamine receptor antagonists for the treatment of obesity and cns disorders
DE602005013094D1 (de)	2009-04-16	Chinolinderivate als neurokininrezeptor-antagonisten
AU2003262926A1 (en)	2004-03-19	Selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders
DOP2004000878A (es)	2004-10-15	Derivados de 3-azabiciclo[3.2.1]octano