ATE310098T1 - Dna kodierend für glutaminsäure-gesteuerte chloridkanäle - Google Patents

Dna kodierend für glutaminsäure-gesteuerte chloridkanäle

Info

Publication number: ATE310098T1
Authority: AT; Austria
Prior art keywords: host cells; chloride channels; glutamic acid; dna coding; recombinant host
Prior art date: 1995-05-05

Application number

AT96913285T

Other languages

English (en)

Inventor

Doris F Cully

Joseph P Arena

Philip S Paress

Ken K Liu

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-05

Filing date

1996-05-01

Publication date

2005-12-15

1996-05-01 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE310098T1 publication Critical patent/ATE310098T1/de

Links

108010062745 Chloride Channels Proteins 0.000 title 1
102000011045 Chloride Channels Human genes 0.000 title 1
102000005962 receptors Human genes 0.000 abstract 3
108020003175 receptors Proteins 0.000 abstract 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
229930195712 glutamate Natural products 0.000 abstract 2
239000005660 Abamectin Substances 0.000 abstract 1
108091006146 Channels Proteins 0.000 abstract 1
108050006905 Glutamate-Gated Chloride Channel Proteins 0.000 abstract 1
230000000895 acaricidal effect Effects 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 1
239000002299 complementary DNA Substances 0.000 abstract 1
239000013057 ectoparasiticide Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000002917 insecticide Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Cell Biology (AREA)
Genetics & Genomics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT96913285T 1995-05-05 1996-05-01 Dna kodierend für glutaminsäure-gesteuerte chloridkanäle ATE310098T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/435,933 US5693492A (en)	1995-05-05	1995-05-05	DNA encoding glutamate gated chloride channels
PCT/US1996/006035 WO1996034940A1 (en)	1995-05-05	1996-05-01	Dna encoding glutamate gated chloride channels

Publications (1)

Publication Number	Publication Date
ATE310098T1 true ATE310098T1 (de)	2005-12-15

Family

ID=23730421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96913285T ATE310098T1 (de)	1995-05-05	1996-05-01	Dna kodierend für glutaminsäure-gesteuerte chloridkanäle

Country Status (8)

Country	Link
US (1)	US5693492A (de)
EP (1)	EP0871703B1 (de)
JP (1)	JP3862278B2 (de)
AT (1)	ATE310098T1 (de)
CA (1)	CA2220116C (de)
DE (1)	DE69635455T2 (de)
ES (1)	ES2250989T3 (de)
WO (1)	WO1996034940A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5527703A (en) *	1994-05-25	1996-06-18	Merck & Co., Inc.	DNA encoding glutamate gated chloride channels
US6358701B1 (en) *	1997-08-11	2002-03-19	Merck & Co., Inc.	DNA molecules encoding Ctenocephalides felis glutamate gated chloride channels
DE19819829A1 (de) *	1998-05-04	1999-11-11	Bayer Ag	Nukleinsäuren, die für Acetylcholinrezeptor-Untereinheiten von Insekten kodieren
EP1226174A4 (de) *	1999-10-22	2003-07-30	Merck & Co Inc	Für l-glutamat-abhängige chloridkanäle kodierende dns-moleküle von schistocerca americana
JP4769401B2 (ja) *	2000-03-02	2011-09-07	メルク・シャープ・エンド・ドーム・コーポレイション	Ｄｒｏｓｏｐｈｉｌａｍｅｌａｎｏｇａｓｔｅｒ中のリガンド依存性塩素イオンチャネルをコードするＤＮＡ分子
DE10013619A1 (de) *	2000-03-18	2001-10-11	Bayer Ag	Ligandengesteuerte Anionenkanäle von Insekten
DE60123943T2 (de)	2000-03-31	2007-06-14	Merial Ltd.	Ligandengesteuerte ionenkanäle aus dermacentor variabilis codierende dns-moleküle
WO2001074884A1 (en) *	2000-03-31	2001-10-11	Merck & Co., Inc.	Dermacentor variabilis gaba-gated chloride channels
ES2361489T3 (es) *	2000-03-31	2011-06-17	Merial Limited	Moléculas de adn que codifican canales de cloruro regulados por l-glutamato de rhipicephalus sanguineus.
US7267964B2 (en) *	2000-03-31	2007-09-11	Merial Limited	DNA molecules encoding ligand gated ion channels from Dermacentor variabilis
US6329174B1 (en)	2000-06-13	2001-12-11	Aventis Cropscience Sa	Nucleic acid encoding lepidoteran glutamate-gated chloride channel
WO2006040153A2 (en) *	2004-10-13	2006-04-20	Ablynx N.V.	Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
AU2006249144B2 (en)	2005-05-18	2011-11-17	Ablynx Nv	Improved NanobodiesTM against Tumor Necrosis Factor-alpha
LT2444424T (lt)	2005-05-20	2018-10-25	Ablynx N.V.	Pagerintos tm nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui
US9156914B2 (en)	2006-12-19	2015-10-13	Ablynx N.V.	Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
AU2007336242B2 (en)	2006-12-19	2012-08-30	Ablynx N.V.	Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
US8557965B2 (en)	2008-04-07	2013-10-15	Ablynx N.V.	Single variable domains against notch pathway members
CA2747644C (en)	2008-12-19	2023-01-24	Ablynx N.V.	Method for generation of immunoglobulin sequences
MX2011010681A (es)	2009-04-10	2012-01-20	Ablynx Nv	Secuencias mejoradas de aminoacidos dirigidas contra il-6r y polipeptidos que comprenden el mismo para el tratamiento de enfermedades y trastornos relacionados con il-6r.
CN102459332B (zh)	2009-06-05	2015-08-19	埃博灵克斯股份有限公司	用于预防和/或治疗呼吸道感染的单价、二价和三价抗人呼吸道合胞病毒(hrsv)纳米抗体构建体
WO2011064382A1 (en)	2009-11-30	2011-06-03	Ablynx N.V.	Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
WO2011083140A1 (en)	2010-01-08	2011-07-14	Ablynx Nv	Immunoglobulin single variable domain directed against human cxcr4
NL2013661B1 (en)	2014-10-21	2016-10-05	Ablynx Nv	KV1.3 Binding immunoglobulins.
US11840569B2 (en)	2016-11-16	2023-12-12	Ablynx N.V.	T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta
US20200392512A1 (en)	2018-02-26	2020-12-17	Ablynx N.V.	Nucleotide sequences encoding peptide linkers
TW202528354A (zh)	2024-01-03	2025-07-16	中國商北京泰德製藥股份有限公司	B7-h3結合蛋白及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ240921A (en) *	1990-12-12	1994-06-27	Zymogenetics Inc	G protein coupled glutamate receptor (neurotransmitters), recombinant production
US5385831A (en) *	1990-12-12	1995-01-31	Zymogenetics, Inc.	Method for producing a mammalian G protein coupled glutamate receptor
WO1992019717A1 (en) *	1991-04-02	1992-11-12	Baylor College Of Medicine	A high-affinity human glutamate/aspartate uptake system
GB9112504D0 (en) *	1991-06-11	1991-07-31	Merck Sharp & Dohme	Cell line
WO1993007161A1 (en) *	1991-10-04	1993-04-15	Cornell Research Foundation, Inc.	Molecular cloning and transformation of cyclodiene resistance
US5527703A (en) *	1994-05-25	1996-06-18	Merck & Co., Inc.	DNA encoding glutamate gated chloride channels

1995
- 1995-05-05 US US08/435,933 patent/US5693492A/en not_active Expired - Lifetime
1996
- 1996-05-01 EP EP96913285A patent/EP0871703B1/de not_active Expired - Lifetime
- 1996-05-01 DE DE69635455T patent/DE69635455T2/de not_active Expired - Lifetime
- 1996-05-01 JP JP53343596A patent/JP3862278B2/ja not_active Expired - Lifetime
- 1996-05-01 ES ES96913285T patent/ES2250989T3/es not_active Expired - Lifetime
- 1996-05-01 CA CA2220116A patent/CA2220116C/en not_active Expired - Lifetime
- 1996-05-01 AT AT96913285T patent/ATE310098T1/de not_active IP Right Cessation
- 1996-05-01 WO PCT/US1996/006035 patent/WO1996034940A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0871703A4 (de)	2000-03-01
EP0871703A1 (de)	1998-10-21
DE69635455D1 (de)	2005-12-22
DE69635455T2 (de)	2006-08-03
WO1996034940A1 (en)	1996-11-07
JP3862278B2 (ja)	2006-12-27
JPH11506906A (ja)	1999-06-22
EP0871703B1 (de)	2005-11-16
US5693492A (en)	1997-12-02
CA2220116C (en)	2011-04-19
ES2250989T3 (es)	2006-04-16
CA2220116A1 (en)	1996-11-07

Legal Events

Date	Code	Title	Description
2006-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69635455D1 (de)	2005-12-22	Dna kodierend für glutaminsäure-gesteuerte chloridkanäle
DE69633825D1 (de)	2004-12-16	Modifiziertes enzym mit lipolytischer aktivität
DE69638032D1 (de)	2009-11-05	Modifiziertes bacillus thuringiensis gen zur kontrolle von lepidoptera in pflanzen
BR9508981A (pt)	1997-12-30	Mutantes de subtilisina isentos de cálcio
ATE389666T1 (de)	2008-04-15	Hohe expressionsrate von proteinen
DE69635452D1 (de)	2005-12-22	Hohe expressionsrate des grün-fluoreszierenden proteins
ATE449175T1 (de)	2009-12-15	Bakterielle produktion von interferon-beta polypeptiden
ATE283368T1 (de)	2004-12-15	Für die glutamatabhängigen chloridkanäle kodierende dna
EP0967283A4 (de)	2004-06-09	Gene, die für proteine mit transglykolysierungsaktivität kodieren.
DE69736389D1 (de)	2006-09-07	Proteine mit zellulase-aktivitäten und prozess für ihre herstellung
WO2000063415A8 (en)	2001-01-18	Dna encoding the human vanilloid receptor vr1
CA2032167A1 (en)	1990-11-02	Dna coding for protein binds to enhancer of.alpha.-fetoprotein gene
ATE372375T1 (de)	2007-09-15	Für den bradykinin-b1-rezeptor kodierende dna
ATE384739T1 (de)	2008-02-15	Für den menschlichen vanilloid-rezeptor vr3 kodierende dns
ATE345382T1 (de)	2006-12-15	2,6-beta-d-fruktanhydrolase enzym und verfahren zu dessen verwendung
DE60129688D1 (de)	2007-09-13	Die menschliche beta-1a-untereinheit des potential-abhängigen natriumkanals und deren verwendungen
DE60033297D1 (de)	2007-03-22	Für die humane untereinheit 5-ht3-c des serotoninrezeptors 5-ht3 kodierende dna
MY104405A (en)	1994-03-31	Structural gene comprising dna coding for an endotoxin protein having toxic activity against insects.
ATE266094T1 (de)	2004-05-15	Produktion des proteins ingap mit hoher expressionsrate
AU654155B2 (en)	1994-10-27	A DNA encoding a protein which binds to the enhancer of alpha-fetoprotein gene
ATE309371T1 (de)	2005-11-15	Protein mit dnase-aktivität
KR950704352A (ko)	1995-11-20	테라포시데 아포노펠마로부터의 칼슘 통로 차단 폴리펩티드(calcium channel blocking polypeptides from theraphosidae aphonopelma)
FI883775A7 (fi)	1988-08-15	Kloonatut streptokokkigeenit, jotka koodaavat proteiinia G, ja niiden käyttö proteiinia G tuottavien rekombinantti-mikro-organismien konstru oimiseksi.