ATE311365T1 - Verfahren zur herstellung der amorphen form von atorvastatin calzium salz - Google Patents

Verfahren zur herstellung der amorphen form von atorvastatin calzium salz

Info

Publication number
ATE311365T1
ATE311365T1 AT03727362T AT03727362T ATE311365T1 AT E311365 T1 ATE311365 T1 AT E311365T1 AT 03727362 T AT03727362 T AT 03727362T AT 03727362 T AT03727362 T AT 03727362T AT E311365 T1 ATE311365 T1 AT E311365T1
Authority
AT
Austria
Prior art keywords
calcium salt
atorvastatin calcium
producing
amorphic form
water
Prior art date
Application number
AT03727362T
Other languages
English (en)
Inventor
Stefano Turchetta
Pietro Massardo
Angela Tuozzi
Original Assignee
Chemi Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemi Spa filed Critical Chemi Spa
Application granted granted Critical
Publication of ATE311365T1 publication Critical patent/ATE311365T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT03727362T 2002-04-29 2003-04-25 Verfahren zur herstellung der amorphen form von atorvastatin calzium salz ATE311365T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000907A ITMI20020907A1 (it) 2002-04-29 2002-04-29 Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
PCT/EP2003/004313 WO2003093233A1 (en) 2002-04-29 2003-04-25 Process for the preparation of the amorphous form of atorvastatin calcium salt

Publications (1)

Publication Number Publication Date
ATE311365T1 true ATE311365T1 (de) 2005-12-15

Family

ID=11449799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03727362T ATE311365T1 (de) 2002-04-29 2003-04-25 Verfahren zur herstellung der amorphen form von atorvastatin calzium salz

Country Status (9)

Country Link
US (1) US20060128971A1 (de)
EP (1) EP1509500B1 (de)
AT (1) ATE311365T1 (de)
AU (1) AU2003233064A1 (de)
CA (1) CA2483862A1 (de)
DE (1) DE60302571T2 (de)
ES (1) ES2253674T3 (de)
IT (1) ITMI20020907A1 (de)
WO (1) WO2003093233A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004228607B2 (en) 2003-04-11 2011-01-27 Lek Pharmaceuticals D.D. Process for the preparation of amorphous calcium salt of atorvastatin
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
WO2006011155A1 (en) * 2004-07-26 2006-02-02 Apollo International Limited One pot process for amorphous atorvastain calcium
ES2263370B1 (es) * 2005-02-16 2007-12-01 Ercros Industrial, S.A. Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion.
WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
KR100833439B1 (ko) * 2007-01-02 2008-05-29 씨제이제일제당 (주) 비결정형 아토르바스타틴 칼슘의 개선된 제조방법
EP2075246A1 (de) 2007-12-27 2009-07-01 M. J. Institute of Research Verfahren zur Herstellung einer amorphen Form von Atorvastatin-Hemicalcium-Salz
US9334266B2 (en) 2009-09-04 2016-05-10 The University Of Toledo Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
HRP960312B1 (en) * 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
KR100431038B1 (ko) * 1995-07-17 2004-05-12 워너-램버트 캄파니 엘엘씨 결정질[ｒ-(ｒ*,ｒ*)]-2-(4-플루오로페닐)-베타,델타-디히드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카르보닐]-1ｈ-피롤-1-헵탄산 헤미 칼슘염 (아토르바스타틴)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
IN191236B (de) * 1999-05-25 2003-10-11 Ranbaxy Lab Ltd
HU226640B1 (en) * 1999-10-18 2009-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing amorphous atorvastatin calcium salt
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
WO2003018547A2 (en) * 2001-08-31 2003-03-06 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)

Also Published As

Publication number Publication date
WO2003093233A1 (en) 2003-11-13
ITMI20020907A0 (it) 2002-04-29
ITMI20020907A1 (it) 2003-10-29
AU2003233064A1 (en) 2003-11-17
EP1509500B1 (de) 2005-11-30
US20060128971A1 (en) 2006-06-15
ES2253674T3 (es) 2006-06-01
DE60302571D1 (de) 2006-01-05
EP1509500A1 (de) 2005-03-02
DE60302571T2 (de) 2006-08-03
CA2483862A1 (en) 2003-11-13

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