ATE311447T1 - Herstellung von rekombinantem faktor viii in gegenwart von liposom-ähnliche verbindung- zusammensetzungen - Google Patents

Herstellung von rekombinantem faktor viii in gegenwart von liposom-ähnliche verbindung- zusammensetzungen

Info

Publication number: ATE311447T1
Authority: AT; Austria
Prior art keywords: liposome; factor viii; recombinant factor; preparation; compound compositions
Prior art date: 1995-05-04

Application number

AT96106482T

Other languages

English (en)

Inventor

Sham-Yuen Chan

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-04

Filing date

1996-04-25

Publication date

2005-12-15

1995-05-04 Priority claimed from US08/434,900 external-priority patent/US5679549A/en

1996-04-25 Application filed by Bayer Ag filed Critical Bayer Ag

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE311447T1 publication Critical patent/ATE311447T1/de

Links

229960000301 factor viii Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000000126 substance Substances 0.000 abstract 3
239000001963 growth medium Substances 0.000 abstract 2
SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 abstract 1
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
102100026735 Coagulation factor VIII Human genes 0.000 abstract 1
108010054218 Factor VIII Proteins 0.000 abstract 1
102000001690 Factor VIII Human genes 0.000 abstract 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
238000004113 cell culture Methods 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Hematology (AREA)
Toxicology (AREA)
Microbiology (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)

AT96106482T 1995-05-04 1996-04-25 Herstellung von rekombinantem faktor viii in gegenwart von liposom-ähnliche verbindung- zusammensetzungen ATE311447T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/434,900 US5679549A (en)	1995-05-04	1995-05-04	Production of recombinant factor VIII in the presence of liposome-like substances of mixed composition
US08/634,001 US5952198A (en)	1995-05-04	1996-04-17	Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition

Publications (1)

Publication Number	Publication Date
ATE311447T1 true ATE311447T1 (de)	2005-12-15

Family

ID=27030345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96106482T ATE311447T1 (de)	1995-05-04	1996-04-25	Herstellung von rekombinantem faktor viii in gegenwart von liposom-ähnliche verbindung- zusammensetzungen

Country Status (7)

Country	Link
US (1)	US5952198A (de)
EP (1)	EP0745672B1 (de)
JP (1)	JP3996655B2 (de)
AT (1)	ATE311447T1 (de)
AU (1)	AU710853B2 (de)
CA (1)	CA2175628C (de)
DE (1)	DE69635504T2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6200560B1 (en) *	1998-10-20	2001-03-13	Avigen, Inc.	Adeno-associated virus vectors for expression of factor VIII by target cells
US6358703B1 (en)	1998-12-10	2002-03-19	Bayer Corporation	Expression system for factor VIII
WO2002061036A2 (en) *	2000-11-30	2002-08-08	The Research Foundation Of State University Of New York	Method of complexing a protein by the use of a dispersed system and proteins thereof
US7625584B2 (en) *	2000-11-30	2009-12-01	The Research Foundation Of State University Of New York	Method of complexing a protein by the use of a dispersed system and proteins thereof
AU2002239607A1 (en) *	2000-11-30	2002-06-11	Baxter Healthcare Corporation	Ahf associated dispersion system and method for preparation
US8110218B2 (en) *	2000-11-30	2012-02-07	The Research Foundation Of State University Of New York	Compositions and methods for less immunogenic protein-lipid complexes
US20050221414A1 (en)	2004-03-31	2005-10-06	Katalin Varadi	Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
EP1988101A1 (de) *	2007-05-04	2008-11-05	Novo Nordisk A/S	Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen
WO2013160005A1 (en) *	2012-04-24	2013-10-31	Novo Nordisk A/S	Pharmaceutical composition suitable for treatment of haemophilia
KR20160125352A (ko) *	2013-12-20	2016-10-31	이센셜 파마수티컬스 엘엘씨	세포 배양용 배지
EA202190827A1 (ru) *	2015-11-13	2021-11-30	Баксалта Инкорпорейтед	Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a
JP2018023356A (ja) *	2016-08-04	2018-02-15	三洋化成工業株式会社	有用物質の生産方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5198349A (en) *	1986-01-03	1993-03-30	Genetics Institute, Inc.	Method for producing factor VIII:C and analogs
US5250421A (en) *	1986-01-03	1993-10-05	Genetics Institute, Inc.	Method for producing factor VIII:C-type proteins
DE3785102T2 (de) *	1986-01-03	1993-07-22	Genetics Inst	Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
EP0254076B1 (de) *	1986-07-11	1991-05-08	Miles Inc.	Herstellung von rekombinantem Protein

1996
- 1996-04-17 US US08/634,001 patent/US5952198A/en not_active Expired - Lifetime
- 1996-04-25 EP EP19960106482 patent/EP0745672B1/de not_active Expired - Lifetime
- 1996-04-25 AT AT96106482T patent/ATE311447T1/de not_active IP Right Cessation
- 1996-04-25 DE DE1996635504 patent/DE69635504T2/de not_active Expired - Lifetime
- 1996-05-01 JP JP13254696A patent/JP3996655B2/ja not_active Expired - Fee Related
- 1996-05-02 CA CA 2175628 patent/CA2175628C/en not_active Expired - Fee Related
- 1996-05-03 AU AU52071/96A patent/AU710853B2/en not_active Ceased

Also Published As

Publication number	Publication date
DE69635504D1 (de)	2006-01-05
EP0745672A3 (de)	1998-05-20
AU5207196A (en)	1996-11-28
JP3996655B2 (ja)	2007-10-24
CA2175628A1 (en)	1996-11-05
JPH0998796A (ja)	1997-04-15
CA2175628C (en)	2007-02-20
AU710853B2 (en)	1999-09-30
EP0745672B1 (de)	2005-11-30
US5952198A (en)	1999-09-14
EP0745672A2 (de)	1996-12-04
DE69635504T2 (de)	2006-06-14

Similar Documents

Publication	Publication Date	Title
DE69635504D1 (de)	2006-01-05	Herstellung von rekombinantem Faktor VIII in Gegenwart von Liposom-ähnliche Verbindung-Zusammensetzungen
AU5914186A (en)	1987-12-24	Method and composition for making lipsomes
GR1000247B (el)	1992-05-12	Σταθεραι λυοφιλιωμεναι διαμορφωσεις περιεχουσαι παραγοντας αναπτυξεως.
AU1724097A (en)	1997-09-02	Lipids and their use, for example, in liposomes
CA2318566A1 (en)	1999-07-15	Gelled foods and process for producing the same
EP0283713A3 (en)	1990-03-07	Complexes of saponins with phospholipids and pharmaceutical and cosmetic compositions containing them
CA2250219A1 (en)	1997-10-02	Materials and methods for making improved liposome compositions
NZ306156A (en)	1999-02-25	Stable protein-phospholipid composition and its use as a carrier
CA2270396A1 (en)	1998-05-14	Cationic reagents for transfection
NO2004004I2 (no)	2007-09-10	Bortezomib eller en farmasøytisk akseptabel ester derav, eventuelt i form av et farmasøytisk akseptabelt salt derav
EP0675136A3 (de)	1996-03-13	Antikörper gegen Saugetier-Interleukin-4 und Peptide verwendbar als Antigenen für deren Herstellung.
NO20013862L (no)	2001-10-08	Fremgangsmåte for å regulere liposomstörrelse
CA2079685A1 (en)	1992-08-03	Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems
WO1998017319A3 (en)	1998-06-11	Platelet substitutes and conjugation methods suitable for their preparation
TR200000175T2 (tr)	2001-01-22	Endogenik gen aktivasyonu ile eritropoietinin hazırlanması.
DE3879803D1 (de)	1993-05-06	Reinigung von faktor viii:c durch phospholipid-affinitaet.
CH692199A8 (fr)	2002-06-14	Composes pyridiques et compositions pharmaceutique
IL75315A0 (en)	1985-09-29	Vesicle stabilization
AU588994B2 (en)	1989-09-28	Novel benzodiazepine derivatives and their preparation and use
GR3019592T3 (en)	1996-07-31	Drug formulations by liposomes and the process for their manufacture
AU9532198A (en)	1999-03-08	Ribonucleoside-derivative and method for preparing the same
CA2150939A1 (en)	1995-04-13	Stable protein: phospholipid compositions and methods
RU94038254A (ru)	1996-09-10	Циклические аминопроизводные, способ их получения, фармацевтические композиции и способ их получения
AU6922891A (en)	1991-07-11	Improvements in or relating to topical compositions containing 1 alpha 25-dihydroxycholecalciferol
DE69128455D1 (de)	1998-01-29	Liposomale Mittel sowie Verfahren zu deren Herstellung

Legal Events

Date	Code	Title	Description
2006-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties