ATE312196T1 - Auflösung von trans-2 (alkoxycarbonylethyl)- lactamen, nützlich bei der synthese von 1-(4- fluorophenyl)-3(r)-3(s)-hydroxy-3-(4- fluorophenyl)propyl)-4(s)-(4-hydroxyphenyl)-2- azetidinone - Google Patents

Auflösung von trans-2 (alkoxycarbonylethyl)- lactamen, nützlich bei der synthese von 1-(4- fluorophenyl)-3(r)-3(s)-hydroxy-3-(4- fluorophenyl)propyl)-4(s)-(4-hydroxyphenyl)-2- azetidinone

Info

Publication number: ATE312196T1
Authority: AT; Austria
Prior art keywords: fluorophenyl; alkoxycarbonylethyl; trans; lactamen; azetidinone
Prior art date: 1998-10-02

Application number

AT99949706T

Other languages

English (en)

Inventor

Michael J Homann

William Brian Morgan

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-02

Filing date

1999-10-01

Publication date

2005-12-15

1999-10-01 Application filed by Schering Corp filed Critical Schering Corp

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312196T1 publication Critical patent/ATE312196T1/de

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000004090 dissolution Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
150000003951 lactams Chemical class 0.000 abstract 1
-1 methoxyethoxyethyl Chemical group 0.000 abstract 1
230000002906 microbiologic effect Effects 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/874—Pseudomonas
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
- Y10S435/917—Aspergillus niger
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/931—Mucor
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT99949706T 1998-10-02 1999-10-01 Auflösung von trans-2 (alkoxycarbonylethyl)- lactamen, nützlich bei der synthese von 1-(4- fluorophenyl)-3(r)-3(s)-hydroxy-3-(4- fluorophenyl)propyl)-4(s)-(4-hydroxyphenyl)-2- azetidinone ATE312196T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/165,951 US5919672A (en)	1998-10-02	1998-10-02	Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
PCT/US1999/021436 WO2000020623A1 (en)	1998-10-02	1999-10-01	Resolution of trans-2 -(alkoxycarbonylethyl) -lactams useful in the synthesis of 1- (4-fluorophenyl) -3(r) -[3(s) -hydroxy-3 -(4-fluorophenyl) -propyl)] -4(s) -(4-hydroxyphenyl) -2-azetidinone

Publications (1)

Publication Number	Publication Date
ATE312196T1 true ATE312196T1 (de)	2005-12-15

Family

ID=22601155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99949706T ATE312196T1 (de)	1998-10-02	1999-10-01	Auflösung von trans-2 (alkoxycarbonylethyl)- lactamen, nützlich bei der synthese von 1-(4- fluorophenyl)-3(r)-3(s)-hydroxy-3-(4- fluorophenyl)propyl)-4(s)-(4-hydroxyphenyl)-2- azetidinone

Country Status (10)

Country	Link
US (1)	US5919672A (de)
EP (1)	EP1117823B1 (de)
JP (1)	JP3703719B2 (de)
CN (1)	CN1191372C (de)
AT (1)	ATE312196T1 (de)
AU (1)	AU6252599A (de)
CA (1)	CA2345750C (de)
DE (1)	DE69928821T2 (de)
ES (1)	ES2249917T3 (de)
WO (1)	WO2000020623A1 (de)

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US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
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BRPI0208384B1 (pt)	2001-03-28	2016-05-31	Merck Sharp & Dohme	síntese enantiosseletiva de compostos intermediários de azetidinona
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1429756B1 (de)	2001-09-21	2006-11-22	Schering Corporation	Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US20030204096A1 (en) *	2002-03-25	2003-10-30	Schering Corporation	Enantioselective synthesis of azetidinone intermediate compounds
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CA2504916A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004081002A1 (en)	2003-03-07	2004-09-23	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
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AR041089A1 (es)	2003-05-15	2005-05-04	Merck & Co Inc	Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
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ATE485267T1 (de) *	2003-12-23	2010-11-15	Astrazeneca Ab	Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
JP4590417B2 (ja) *	2004-01-16	2010-12-01	メルク・シャープ・エンド・ドーム・コーポレイション	Ｎｐｃ１ｌ１（ｎｐｃ３）およびこのリガンドの同定方法
US20060211752A1 (en)	2004-03-16	2006-09-21	Kohn Leonard D	Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US20070244107A1 (en) *	2004-08-25	2007-10-18	Waters M Gerard	Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
DE602006010870D1 (de) *	2005-06-20	2010-01-14	Schering Corp	Als antagonisten von histamin h3 geeignete piperidinderivate
AR054482A1 (es) *	2005-06-22	2007-06-27	Astrazeneca Ab	Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar) *	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
RU2008119687A (ru)	2005-10-21	2009-11-27	Новартис АГ (CH)	Комбинации органических соединений
HU0501164D0 (en) *	2005-12-20	2006-02-28	Richter Gedeon Vegyeszet	New industrial process for the production of ezetimibe
US7910698B2 (en) *	2006-02-24	2011-03-22	Schering Corporation	NPC1L1 orthologues
AR060623A1 (es) *	2006-04-27	2008-07-02	Astrazeneca Ab	Compuestos derivados de 2-azetidinona y un metodo de preparacion
WO2008030382A1 (en) *	2006-09-05	2008-03-13	Schering Corporation	Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
EP1953140A1 (de) *	2007-01-24	2008-08-06	Krka	Verfahren zur Herstellung von Ezetimib und seinen Derivaten
US20080318920A1 (en) *	2007-06-19	2008-12-25	Protia, Llc	Deuterium-enriched ezetimibe
FR2918885B1 (fr) *	2007-07-17	2009-08-28	Oreal	Utilisation d'extrait de bacterie cultivee sur eau thermale pour diminuer les poches et/ou les cernes perioculaires
EP2414529A2 (de)	2009-04-01	2012-02-08	Matrix Laboratories Ltd	Enzymatisches verfahren zur herstellung von (s)-5-(4-fluorphenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-on, einer zwischenstufe von ezetimib, und weitere umwandlung zu ezetimib
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CN110169964A (zh) *	2016-09-29	2019-08-27	广东海洋大学	一种丁内酯-vii的新应用
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1998
- 1998-10-02 US US09/165,951 patent/US5919672A/en not_active Expired - Lifetime
1999
- 1999-10-01 CA CA002345750A patent/CA2345750C/en not_active Expired - Fee Related
- 1999-10-01 WO PCT/US1999/021436 patent/WO2000020623A1/en not_active Ceased
- 1999-10-01 AT AT99949706T patent/ATE312196T1/de not_active IP Right Cessation
- 1999-10-01 DE DE69928821T patent/DE69928821T2/de not_active Expired - Lifetime
- 1999-10-01 ES ES99949706T patent/ES2249917T3/es not_active Expired - Lifetime
- 1999-10-01 EP EP99949706A patent/EP1117823B1/de not_active Expired - Lifetime
- 1999-10-01 AU AU62525/99A patent/AU6252599A/en not_active Abandoned
- 1999-10-01 JP JP2000574715A patent/JP3703719B2/ja not_active Expired - Fee Related
- 1999-10-01 CN CNB998139424A patent/CN1191372C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6252599A (en)	2000-04-26
JP3703719B2 (ja)	2005-10-05
US5919672A (en)	1999-07-06
EP1117823B1 (de)	2005-12-07
JP2002526119A (ja)	2002-08-20
EP1117823A1 (de)	2001-07-25
DE69928821D1 (de)	2006-01-12
HK1037684A1 (en)	2002-02-15
CA2345750C (en)	2005-12-06
CN1330721A (zh)	2002-01-09
WO2000020623A1 (en)	2000-04-13
CA2345750A1 (en)	2000-04-13
CN1191372C (zh)	2005-03-02
DE69928821T2 (de)	2006-09-07
ES2249917T3 (es)	2006-04-01

Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69928821D1 (de)	2006-01-12	Auflösung von trans-2 (alkoxycarbonylethyl)-lactamen, nützlich bei der synthese von 1-(4-fluorophenyl)-3(r)-3(s)-hydroxy-3-(4-fluorophenyl)propyl]-4(s)-(4-hydroxyphenyl)-2-azetidinone
DE69530511D1 (de)	2003-05-28	Enantioselective herstellung von pharmazeutisch aktiven sulfoxiden durch bioreduktion
ES2126697T3 (es)	1999-04-01	Inhibidores de enzimas de conversion de angiotensina que contienen lactamas de anillos multiples.
CA2239245A1 (en)	1997-06-26	N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same
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