DK1054996T3 - Fremgangsmåde til den enzymatiske adskillelse af lactamer - Google Patents

Fremgangsmåde til den enzymatiske adskillelse af lactamer

Info

Publication number
DK1054996T3
DK1054996T3 DK99908070T DK99908070T DK1054996T3 DK 1054996 T3 DK1054996 T3 DK 1054996T3 DK 99908070 T DK99908070 T DK 99908070T DK 99908070 T DK99908070 T DK 99908070T DK 1054996 T3 DK1054996 T3 DK 1054996T3
Authority
DK
Denmark
Prior art keywords
lactams
enzyme
lactam esters
enzymatic resolution
enzymatic separation
Prior art date
Application number
DK99908070T
Other languages
English (en)
Inventor
Donald W Hansen Jr
Mahima Trivedi
Rolando E Gapud
John S Ng
Alok K Asthi
Ping T Wang
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK1054996T3 publication Critical patent/DK1054996T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK99908070T 1998-02-17 1999-02-16 Fremgangsmåde til den enzymatiske adskillelse af lactamer DK1054996T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7483098P 1998-02-17 1998-02-17
PCT/US1999/001485 WO1999041405A1 (en) 1998-02-17 1999-02-16 Process for the enzymatic resolution of lactams

Publications (1)

Publication Number Publication Date
DK1054996T3 true DK1054996T3 (da) 2004-05-24

Family

ID=22121926

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99908070T DK1054996T3 (da) 1998-02-17 1999-02-16 Fremgangsmåde til den enzymatiske adskillelse af lactamer

Country Status (10)

Country Link
US (2) US6277626B1 (da)
EP (1) EP1054996B1 (da)
JP (1) JP2003517266A (da)
AT (1) ATE258604T1 (da)
AU (1) AU2758899A (da)
DE (1) DE69914458T2 (da)
DK (1) DK1054996T3 (da)
ES (1) ES2216495T3 (da)
PT (1) PT1054996E (da)
WO (1) WO1999041405A1 (da)

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GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
US6548293B1 (en) 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
KR20080072105A (ko) * 2004-08-26 2008-08-05 화이자 인코포레이티드 단백질 티로신 키나제 저해제 중간체의 제조를 위한거울상이성질선택적 생물학적 전환
PT2404919E (pt) 2005-11-08 2013-10-22 Vertex Pharma Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
US8338142B2 (en) * 2007-02-19 2012-12-25 Kaneka Corporation Method for producing optically active 3-aminopiperidine or salt thereof
EP2164840A2 (en) 2007-05-09 2010-03-24 Vertex Pharmaceuticals Incorporated Modulators of cftr
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
HUE049642T2 (hu) 2007-12-07 2020-09-28 Vertex Pharma 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái
CA2989620C (en) 2007-12-07 2022-05-03 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
CA2716109C (en) 2008-02-28 2016-07-19 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
ES2900353T3 (es) 2010-04-07 2022-03-16 Vertex Pharma Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiriidin-2-il)benzoico y administración de las mismas
NZ727015A (en) 2012-01-25 2017-12-22 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
CA2930199C (en) 2013-11-12 2022-10-25 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
HUE055423T2 (hu) 2014-11-18 2021-11-29 Vertex Pharma Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
CN111621541B (zh) * 2019-02-27 2025-10-31 广安摩珈生物科技有限公司 使用电渗析技术拆分光学异构体的方法

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EP0115860B1 (en) 1983-02-03 1988-10-12 Sumitomo Chemical Company, Limited Optically active 4-hydroxy-2-cyclopentenones, and their production
US5106750A (en) 1988-08-30 1992-04-21 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
US5585252A (en) 1988-08-30 1996-12-17 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
DE3921593A1 (de) 1989-06-28 1991-01-10 Schering Ag Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester
US5420037A (en) 1989-09-26 1995-05-30 E. R. Squibb & Sons, Inc. Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds
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US5447865A (en) 1992-06-10 1995-09-05 Amprost Pharmaceutical, Inc. Method of resolution of hydroxy substituted cyclopentanone enantiomers using lipase and lithium salt complexation
IT1259583B (it) 1992-06-19 1996-03-20 Gianfranco Palumbo Imballaggio per confezioni, ad esempio confezioni di prodotti igenico sanitari.
US5258517A (en) 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
NL9202208A (nl) 1992-12-18 1994-07-18 Dsm Nv Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
JPH06192221A (ja) * 1992-12-25 1994-07-12 Taiho Yakuhin Kogyo Kk 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸の製造方法
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US5516676A (en) 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
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BR9714099A (pt) * 1996-12-27 2000-03-21 Smithkline Beecham Plc Revolução enzimática de ésteres de ácido acético-benzodiazepina com lipase
JPH11113594A (ja) * 1997-10-20 1999-04-27 Taiho Yakuhin Kogyo Kk 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸および／またはその鏡像対掌体エステルの製造方法

Also Published As

Publication number Publication date
ATE258604T1 (de) 2004-02-15
DE69914458T2 (de) 2004-10-28
JP2003517266A (ja) 2003-05-27
PT1054996E (pt) 2004-05-31
ES2216495T3 (es) 2004-10-16
US6277626B1 (en) 2001-08-21
EP1054996A1 (en) 2000-11-29
US6638758B2 (en) 2003-10-28
US20010055798A1 (en) 2001-12-27
WO1999041405A1 (en) 1999-08-19
EP1054996B1 (en) 2004-01-28
AU2758899A (en) 1999-08-30
DE69914458D1 (de) 2004-03-04

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