ATE312845T1 - Verfahren zur herstellung von katalytischen antikörpern - Google Patents

Verfahren zur herstellung von katalytischen antikörpern

Info

Publication number
ATE312845T1
ATE312845T1 AT98943578T AT98943578T ATE312845T1 AT E312845 T1 ATE312845 T1 AT E312845T1 AT 98943578 T AT98943578 T AT 98943578T AT 98943578 T AT98943578 T AT 98943578T AT E312845 T1 ATE312845 T1 AT E312845T1
Authority
AT
Austria
Prior art keywords
growth factor
present
factor precursor
catalytic antibodies
nucleic acid
Prior art date
Application number
AT98943578T
Other languages
English (en)
Inventor
Frank Koentgen
Gabriele Maria Suess
David Mathew Tarlinton
Herbert Rudolf Treutlein
Original Assignee
Frank Koentgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Koentgen filed Critical Frank Koentgen
Application granted granted Critical
Publication of ATE312845T1 publication Critical patent/ATE312845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98943578T 1997-09-19 1998-09-18 Verfahren zur herstellung von katalytischen antikörpern ATE312845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO9306A AUPO930697A0 (en) 1997-09-19 1997-09-19 Catalytic antibodies and a method of producing same
PCT/AU1998/000783 WO1999015563A1 (en) 1997-09-19 1998-09-18 Catalytic antibodies and a method of producing same

Publications (1)

Publication Number Publication Date
ATE312845T1 true ATE312845T1 (de) 2005-12-15

Family

ID=3803589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98943578T ATE312845T1 (de) 1997-09-19 1998-09-18 Verfahren zur herstellung von katalytischen antikörpern

Country Status (11)

Country Link
US (3) US6590080B1 (de)
EP (1) EP1015494B1 (de)
AT (1) ATE312845T1 (de)
AU (1) AUPO930697A0 (de)
CA (1) CA2304365A1 (de)
DE (1) DE69832804T2 (de)
DK (1) DK1015494T3 (de)
ES (1) ES2253824T3 (de)
GB (1) GB2345694B (de)
NZ (3) NZ515603A (de)
WO (1) WO1999015563A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
EP1539959A2 (de) * 2002-09-18 2005-06-15 Centre Hospitalier de l'Université de Montréal (CHUM) Ghrh-analoge
US7700097B2 (en) 2003-06-27 2010-04-20 Biogen Idec Ma Inc. Purification and preferential synthesis of binding molecules
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
US20070275873A1 (en) * 2004-04-29 2007-11-29 Heidner Hans W Methods and Compositions Comprising Protein L Immunoglobulin Binding Domains for Cell-Specific Targeting
WO2008035894A1 (en) 2006-09-19 2008-03-27 Sungkyunkwan University Foundation For Corporate Collaboration Antiviral agent against animal viruses
US10288611B2 (en) 2009-11-23 2019-05-14 The Johns Hopkins University Lateral flow device for diagnosing microbial infections
US10585098B2 (en) 2009-11-23 2020-03-10 The Johns Hopkins University Optimizing diagnostics for galactofuranose containing antigens
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP2565667A1 (de) 2011-08-31 2013-03-06 Friedrich-Alexander-Universität Erlangen-Nürnberg Ankunftsrichtungsschätzung mittels mit einem Wasserzeichen versehenen Audiosignalen und Mikrofonanordnungen
KR20250051130A (ko) 2013-09-25 2025-04-16 싸이톰스 테라퓨틱스, 인크. 매트릭스 메탈로프로테이나제 기질 및 다른 절단성 모이어티 및 이의 사용 방법
US10107822B2 (en) 2013-12-16 2018-10-23 The Johns Hopkins University Interferon-gamma release assays for diagnosis of invasive fungal infections
EP3628328B1 (de) 2014-01-31 2022-09-14 Cytomx Therapeutics Inc. Matriptase- und u-plasminogenaktivator-substrate und andere spaltbare teile und verfahren zur verwendung davon
IL300408B2 (en) 2015-01-20 2025-11-01 Cytomx Therapeutics Inc Matrix metalloprotease-cleavable and serine protease cleavable substrates and methods of use thereof
JP2022512124A (ja) 2018-12-06 2022-02-02 シートムエックス セラピューティクス，インコーポレイテッド マトリックスメタロプロテアーゼ切断可能なおよびセリンまたはシステインプロテアーゼ切断可能な基質ならびにそれらの使用方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002414A1 (en) * 1983-11-29 1985-06-06 Igen, Inc. Method of catalyzing chemical reactions
US5126258A (en) * 1984-09-07 1992-06-30 Scripps Clinic And Research Foundation Molecules with antibody combining sites that exhibit catalytic properties
US4900674A (en) * 1987-05-28 1990-02-13 Scripps Clinic And Research Foundation Antibody combining sites that exhibit amide or ester synthase activity
US5215889A (en) * 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5190865A (en) * 1988-11-18 1993-03-02 The Regents Of The University Of California Antibody-enhanced stereospecific hydrolyses
US5219732A (en) * 1989-09-05 1993-06-15 The Regents Of The University Of California Antibody-mediated cofactor-driven reactions
US5187086A (en) * 1990-01-26 1993-02-16 Scripps Clinic And Research Foundation Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten
SE9002212D0 (sv) * 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
CA2114934A1 (en) * 1991-08-05 1993-02-18 Mark T. Martin Prodrugs activated by targeted catalytic proteins
ZA931263B (en) * 1992-02-24 1993-11-02 Igen Inc Reaction-based selection for expression of and concentration of catalytic moieties
US5439812A (en) * 1992-04-08 1995-08-08 The Pennsylvania Research Corporation Antibodies catalyzing deamidation of proteins
SE9201331D0 (sv) * 1992-04-28 1992-04-28 Hightech Receptor C O Active Protein l och hybridproteiner daerav
GB9209804D0 (en) * 1992-05-07 1992-06-24 Health Lab Service Board Novel immunoglobulin binding proteins process for their production and recombinant dna molecules coding therefor
US6043069A (en) * 1996-03-26 2000-03-28 Amrad Operations Pty. Ltd. Catalytic antibodies and a method of producing same
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
US7253178B2 (en) * 2001-03-28 2007-08-07 Eisai Co., Ltd. Carboxylic acids
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2002098840A1 (en) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
US7371777B2 (en) * 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist

Also Published As

Publication number Publication date
CA2304365A1 (en) 1999-04-01
GB2345694B (en) 2002-07-17
HK1029350A1 (en) 2001-03-30
US6590080B1 (en) 2003-07-08
NZ515603A (en) 2003-04-29
US20090269355A1 (en) 2009-10-29
EP1015494A4 (de) 2001-12-12
DE69832804T2 (de) 2006-08-10
DE69832804D1 (de) 2006-01-19
NZ503454A (en) 2004-01-30
WO1999015563A9 (en) 1999-06-03
GB2345694A (en) 2000-07-19
WO1999015563A1 (en) 1999-04-01
EP1015494A1 (de) 2000-07-05
GB0009758D0 (en) 2000-06-07
DK1015494T3 (da) 2006-05-01
US20030148484A1 (en) 2003-08-07
EP1015494B1 (de) 2005-12-14
NZ524429A (en) 2004-06-25
AUPO930697A0 (en) 1997-10-09
ES2253824T3 (es) 2006-06-01

Similar Documents

Publication Publication Date Title
DE69832804D1 (de) Verfahren zur herstellung von katalytischen antikörpern
ATE414162T1 (de) Verfahren und materialien zur herstellung von glucosamin
EP1064308A4 (de) Verfahren zur identifizierung von induktoren und inhibitoren proteolytischer antikörper, zusammensetzungen sowie deren verwendungen
ATE233270T1 (de) Verfahren zur herstellung von dialkylphosphinsäuren
EP1077719A4 (de) Verabreichungssystem für impfstoffe
DE60238745D1 (de) Glucosamin und verfahren zur herstellung von glucosamin aus mikrobieller biomasse
DE60227525D1 (de) Verfahren zur Herstellung von Nukleinsäuremolekülen
ATE306252T1 (de) Verfahren zur herstellung kristalliner partikel zur inhalation
HU9303023D0 (en) Peptide nucleicadis and method for producing them
ATE322252T1 (de) Verfahren zur herstellung und sammlung von kristallinen partikeln
FI981718A0 (fi) Katalysaattorikomponentti, joka käsittää magnesiumia, titaania, halogeenia ja elektrodonorin, sen valmistus ja käyttö
ATE326523T1 (de) Verfahren zur fermentativen herstellung von l- methionin
ATE194142T1 (de) Verfahren zur herstellung von nukleotiden
ATE232193T1 (de) Verfahren zur herstellung von citral
EP0642507A4 (en) Catalytic antibodies against cocaine and methods of using and producing same.
ATE97896T1 (de) Verfahren zur herstellung von d,l-lactid.
ATE297937T1 (de) Verfahren zur herstellung von siliconverbindungen
GB2326643B (en) Precursors of catalytic antibodies
DE50007399D1 (de) Verfahren zur kontinuierlichen herstellung von glutaraldehyd
DE60227595D1 (de) Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen
DE59807664D1 (de) Verfahren zur herstellung von 3-cyano-2,4-dihalogen-5-fluor-benzoesäuren
WO2001030989A3 (en) Method for creating divergent populations of nucleic acid molecules and proteins
DE602005019421D1 (de) Grosstechnisch geeigneter mikroorganismus
DK1030867T3 (da) Vækstfaktor af mælk fra pattedyr
ATE309371T1 (de) Protein mit dnase-aktivität

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1015494

Country of ref document: EP

REN Ceased due to non-payment of the annual fee