ATE312845T1 - Verfahren zur herstellung von katalytischen antikörpern - Google Patents

Verfahren zur herstellung von katalytischen antikörpern

Info

Publication number
ATE312845T1
ATE312845T1 AT98943578T AT98943578T ATE312845T1 AT E312845 T1 ATE312845 T1 AT E312845T1 AT 98943578 T AT98943578 T AT 98943578T AT 98943578 T AT98943578 T AT 98943578T AT E312845 T1 ATE312845 T1 AT E312845T1
Authority
AT
Austria
Prior art keywords
growth factor
present
factor precursor
catalytic antibodies
nucleic acid
Prior art date
Application number
AT98943578T
Other languages
English (en)
Inventor
Frank Koentgen
Gabriele Maria Suess
David Mathew Tarlinton
Herbert Rudolf Treutlein
Original Assignee
Frank Koentgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Koentgen filed Critical Frank Koentgen
Application granted granted Critical
Publication of ATE312845T1 publication Critical patent/ATE312845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98943578T 1997-09-19 1998-09-18 Verfahren zur herstellung von katalytischen antikörpern ATE312845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO9306A AUPO930697A0 (en) 1997-09-19 1997-09-19 Catalytic antibodies and a method of producing same
PCT/AU1998/000783 WO1999015563A1 (en) 1997-09-19 1998-09-18 Catalytic antibodies and a method of producing same

Publications (1)

Publication Number Publication Date
ATE312845T1 true ATE312845T1 (de) 2005-12-15

Family

ID=3803589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98943578T ATE312845T1 (de) 1997-09-19 1998-09-18 Verfahren zur herstellung von katalytischen antikörpern

Country Status (11)

Country Link
US (3) US6590080B1 (de)
EP (1) EP1015494B1 (de)
AT (1) ATE312845T1 (de)
AU (1) AUPO930697A0 (de)
CA (1) CA2304365A1 (de)
DE (1) DE69832804T2 (de)
DK (1) DK1015494T3 (de)
ES (1) ES2253824T3 (de)
GB (1) GB2345694B (de)
NZ (3) NZ503454A (de)
WO (1) WO1999015563A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
NZ544924A (en) 2003-06-27 2009-03-31 Biogen Idec Inc Modified binding molecules comprising connecting peptides
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
WO2005113584A1 (en) * 2004-04-29 2005-12-01 Board Of Regents, University Of Texas System Methods and compositions comprising protein l immunoglobulin binding domains for cell-specific targeting
EP2068906B1 (de) * 2006-09-19 2012-08-01 Sungkyunkwan University Foundation for Corporate Collaboration Antivirales mittel gegen tierische viren
WO2011063395A2 (en) * 2009-11-23 2011-05-26 The Johns Hopkins University Lateral flow device for diagnosing microbial infections
US10585098B2 (en) 2009-11-23 2020-03-10 The Johns Hopkins University Optimizing diagnostics for galactofuranose containing antigens
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP2565667A1 (de) 2011-08-31 2013-03-06 Friedrich-Alexander-Universität Erlangen-Nürnberg Ankunftsrichtungsschätzung mittels mit einem Wasserzeichen versehenen Audiosignalen und Mikrofonanordnungen
NZ718283A (en) 2013-09-25 2022-05-27 Cytomx Therapeutics Inc Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
US10107822B2 (en) 2013-12-16 2018-10-23 The Johns Hopkins University Interferon-gamma release assays for diagnosis of invasive fungal infections
US9562073B2 (en) 2014-01-31 2017-02-07 Cytomx Therapeutics, Inc. Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
CA3120327A1 (en) 2018-12-06 2020-06-11 Cytomx Therapeutics, Inc. Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3745285A (en) * 1983-11-29 1985-06-13 Igen, Inc. Method of catalyzing chemical reactions
US5126258A (en) * 1984-09-07 1992-06-30 Scripps Clinic And Research Foundation Molecules with antibody combining sites that exhibit catalytic properties
US4900674A (en) * 1987-05-28 1990-02-13 Scripps Clinic And Research Foundation Antibody combining sites that exhibit amide or ester synthase activity
US5190865A (en) * 1988-11-18 1993-03-02 The Regents Of The University Of California Antibody-enhanced stereospecific hydrolyses
US5215889A (en) * 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5219732A (en) * 1989-09-05 1993-06-15 The Regents Of The University Of California Antibody-mediated cofactor-driven reactions
US5187086A (en) * 1990-01-26 1993-02-16 Scripps Clinic And Research Foundation Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten
SE9002212D0 (sv) * 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
WO1993002703A1 (en) * 1991-08-05 1993-02-18 Igen, Inc. Prodrugs activated by targeted catalytic proteins
IL104829A (en) * 1992-02-24 1999-04-11 Igen Inc Selection is based on a response to the expression and concentration of catalytic units
US5439812A (en) * 1992-04-08 1995-08-08 The Pennsylvania Research Corporation Antibodies catalyzing deamidation of proteins
SE9201331D0 (sv) * 1992-04-28 1992-04-28 Hightech Receptor C O Active Protein l och hybridproteiner daerav
GB9209804D0 (en) * 1992-05-07 1992-06-24 Health Lab Service Board Novel immunoglobulin binding proteins process for their production and recombinant dna molecules coding therefor
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
CA2249455A1 (en) * 1996-03-26 1997-10-02 Amrad Operations Pty. Ltd. Precursors of catalytic antibodies
JP4256166B2 (ja) * 2001-03-28 2009-04-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルボン酸化合物
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2002098840A1 (en) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
US7371777B2 (en) * 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist

Also Published As

Publication number Publication date
DE69832804D1 (de) 2006-01-19
EP1015494A4 (de) 2001-12-12
NZ515603A (en) 2003-04-29
WO1999015563A9 (en) 1999-06-03
US20030148484A1 (en) 2003-08-07
US20090269355A1 (en) 2009-10-29
GB2345694B (en) 2002-07-17
HK1029350A1 (en) 2001-03-30
EP1015494B1 (de) 2005-12-14
GB2345694A (en) 2000-07-19
EP1015494A1 (de) 2000-07-05
WO1999015563A1 (en) 1999-04-01
DK1015494T3 (da) 2006-05-01
GB0009758D0 (en) 2000-06-07
US6590080B1 (en) 2003-07-08
DE69832804T2 (de) 2006-08-10
NZ503454A (en) 2004-01-30
NZ524429A (en) 2004-06-25
ES2253824T3 (es) 2006-06-01
CA2304365A1 (en) 1999-04-01
AUPO930697A0 (en) 1997-10-09

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