ATE312946T1 - Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten - Google Patents
Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeitenInfo
- Publication number
- ATE312946T1 ATE312946T1 AT02004954T AT02004954T ATE312946T1 AT E312946 T1 ATE312946 T1 AT E312946T1 AT 02004954 T AT02004954 T AT 02004954T AT 02004954 T AT02004954 T AT 02004954T AT E312946 T1 ATE312946 T1 AT E312946T1
- Authority
- AT
- Austria
- Prior art keywords
- determining
- amount
- free floating
- dna
- floating dna
- Prior art date
Links
- 210000001124 body fluid Anatomy 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000010839 body fluid Substances 0.000 title 1
- 210000000056 organ Anatomy 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02004954A EP1342794B1 (de) | 2002-03-05 | 2002-03-05 | Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312946T1 true ATE312946T1 (de) | 2005-12-15 |
Family
ID=27741132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02004954T ATE312946T1 (de) | 2002-03-05 | 2002-03-05 | Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050221314A1 (de) |
| EP (2) | EP1342794B1 (de) |
| JP (1) | JP4727149B2 (de) |
| AT (1) | ATE312946T1 (de) |
| AU (1) | AU2003218691B2 (de) |
| CA (1) | CA2478493A1 (de) |
| DE (1) | DE60207979T2 (de) |
| DK (1) | DK1342794T3 (de) |
| ES (1) | ES2253461T3 (de) |
| WO (1) | WO2003074730A1 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060183128A1 (en) * | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| DE10348407A1 (de) * | 2003-10-17 | 2005-05-19 | Widschwendter, Martin, Prof. | Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben |
| EP1969139A1 (de) * | 2005-11-17 | 2008-09-17 | Epigenomics AG | Verfahren zur bestimmung des dna-methylierungsniveaus einer cpg-position in identischen zellen in einer gewebeprobe |
| JPWO2008090930A1 (ja) * | 2007-01-23 | 2010-05-20 | オリンパス株式会社 | 癌の診断方法 |
| JP5378687B2 (ja) * | 2007-03-02 | 2013-12-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｂａｓｐ１遺伝子および／またはｓｒｄ５ａ２遺伝子中のメチル化シトシンを利用する、肝臓癌、肝臓癌発症リスク、肝臓癌再発リスク、肝臓癌悪性度および肝臓癌の経時的進展の検出方法 |
| WO2009003654A2 (en) * | 2007-06-29 | 2009-01-08 | Medizinische Universität Innsbruck | Selecting nucleic acid samples suitable for genotyping |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| DE202013012824U1 (de) | 2012-09-04 | 2020-03-10 | Guardant Health, Inc. | Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| PL3354747T3 (pl) | 2012-09-20 | 2021-07-26 | The Chinese University Of Hong Kong | Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| WO2014113204A1 (en) | 2013-01-17 | 2014-07-24 | Personalis, Inc. | Methods and systems for genetic analysis |
| EP3039161B1 (de) | 2013-08-30 | 2021-10-06 | Personalis, Inc. | Verfahren und system zur genomanalyse |
| JP6295578B2 (ja) | 2013-09-30 | 2018-03-20 | 凸版印刷株式会社 | 反応容器、核酸解析装置、および核酸解析方法 |
| GB2535066A (en) | 2013-10-03 | 2016-08-10 | Personalis Inc | Methods for analyzing genotypes |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| WO2015159293A2 (en) * | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
| TWI895765B (zh) | 2014-07-18 | 2025-09-01 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| US10125399B2 (en) | 2014-10-30 | 2018-11-13 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| CN109072300B (zh) * | 2015-12-17 | 2023-01-31 | 伊路敏纳公司 | 区分复杂生物样品中的甲基化水平 |
| CN117174167A (zh) | 2015-12-17 | 2023-12-05 | 夸登特健康公司 | 通过分析无细胞dna确定肿瘤基因拷贝数的方法 |
| WO2017181146A1 (en) * | 2016-04-14 | 2017-10-19 | Guardant Health, Inc. | Methods for early detection of cancer |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| CN115161390B (zh) * | 2016-05-30 | 2025-12-05 | 香港中文大学 | 使用血液中的无细胞dna检测血液病症 |
| EP3497220A4 (de) | 2016-08-10 | 2020-04-01 | Grail, Inc. | Verfahren zur herstellung von dual-indexierten dna-bibliotheken zur bisulfitumwandlungssequenzierung |
| KR20240155386A (ko) | 2016-09-30 | 2024-10-28 | 가던트 헬쓰, 인크. | 무세포 핵산의 다중-해상도 분석 방법 |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| CA3041647A1 (en) | 2016-10-24 | 2018-05-03 | The Chinese University Of Hong Kong | Methods and systems for tumor detection |
| CA3039685A1 (en) | 2016-11-30 | 2018-06-07 | The Chinese University Of Hong Kong | Analysis of cell-free dna in urine and other samples |
| ES2990117T3 (es) | 2017-01-25 | 2024-11-28 | Univ Hong Kong Chinese | Aplicaciones de diagnóstico que utilizan fragmentos de ácido nucleico |
| EP3366780B1 (de) | 2017-02-23 | 2020-05-06 | Siemens Healthcare GmbH | Sequenzanalyse von einzelmolekülen und hochempfindliche methylierungsanalyse zur gewebespezifischen analyse |
| US11179516B2 (en) | 2017-06-22 | 2021-11-23 | Baxter International Inc. | Systems and methods for incorporating patient pressure into medical fluid delivery |
| ES2959360T3 (es) | 2017-07-26 | 2024-02-23 | Univ Hong Kong Chinese | Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares |
| US12378543B2 (en) | 2017-10-19 | 2025-08-05 | Streck Llc | Compositions for hemolysis and coagulation regulation and stabilization of extracellular vesicles |
| EP3765637A1 (de) | 2018-03-13 | 2021-01-20 | Grail, Inc. | Detektion und klassifizierung von anomalen fragmenten |
| AU2019249422B2 (en) | 2018-04-02 | 2025-09-25 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| US10801064B2 (en) | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
| US11814750B2 (en) | 2018-05-31 | 2023-11-14 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
| IL281741B2 (en) | 2018-09-27 | 2026-04-01 | Grail Inc | Methylation markers and a targeted methylation detection panel |
| WO2020132572A1 (en) | 2018-12-21 | 2020-06-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free-dna samples |
| CA3126428A1 (en) | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| US11427874B1 (en) | 2019-08-26 | 2022-08-30 | Epi One Inc. | Methods and systems for detection of prostate cancer by DNA methylation analysis |
| WO2021092066A1 (en) | 2019-11-05 | 2021-05-14 | Personalis, Inc. | Estimating tumor purity from single samples |
| EP4096694A4 (de) | 2020-01-30 | 2024-01-24 | Prognomiq Inc | Lungenbiomarker und verfahren zur verwendung davon |
| US20220328134A1 (en) | 2021-03-31 | 2022-10-13 | PrognomIQ, Inc. | Multi-omic assessment |
| WO2022256617A1 (en) | 2021-06-03 | 2022-12-08 | Inherent Biosciences, Inc. | Dna methylation analysis to identify cell type |
| US12387508B2 (en) | 2021-09-10 | 2025-08-12 | PrognomIQ, Inc. | Direct classification of raw biomolecule measurement data |
| AU2022341187A1 (en) | 2021-09-13 | 2024-03-21 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
| EP4413580A4 (de) | 2021-10-05 | 2025-08-13 | Personalis Inc | Personalisierte tests zur personalisierten krebsüberwachung |
| CN116042848B (zh) * | 2021-10-28 | 2024-08-09 | 北京干细胞与再生医学研究院 | 一种通过血样检测判断动物体内存在移植物的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| JP2001507921A (ja) * | 1992-04-27 | 2001-06-19 | トラスティーズ オブ ダートマス カレッジ | 生物学的液体中の遺伝子配列の検出 |
| US6020124A (en) * | 1992-04-27 | 2000-02-01 | Trustees Of Dartmouth College | Detection of soluble gene sequences in biological fluids |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| US5552277A (en) * | 1994-07-19 | 1996-09-03 | The Johns Hopkins University School Of Medicine | Genetic diagnosis of prostate cancer |
| DE4441057C2 (de) * | 1994-11-17 | 1999-02-25 | Wacker Chemie Gmbh | Verfahren zur kontinuierlichen Herstellung von Organopolysiloxanen |
| EP0826066B1 (de) * | 1995-05-05 | 2000-09-13 | The Perkin-Elmer Corporation | Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay |
| US6156504A (en) * | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
| US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| WO1998008980A1 (en) * | 1996-08-28 | 1998-03-05 | The Johns Hopkins University School Of Medicine | Method for detecting cell proliferative disorders |
| WO1998056952A1 (en) * | 1997-06-09 | 1998-12-17 | University Of Southern California | A cancer diagnostic method based upon dna methylation differences |
| DE19754482A1 (de) * | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| DE69913654T2 (de) * | 1999-05-12 | 2004-06-09 | Hamamatsu Photonics K.K., Hamamatsu | Nachweis von Nukleinsäuren im Zytoplasma |
| US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| JP2003534005A (ja) * | 2000-05-22 | 2003-11-18 | ザ ジョンズ ホプキンス ユニバーシティ | 遺伝子インプリンティングおよびメチル化ＣｐＧアイランドのアッセイ法 |
| US6927028B2 (en) * | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| US7045319B2 (en) * | 2001-10-30 | 2006-05-16 | Ribomed Biotechnologies, Inc. | Molecular detection systems utilizing reiterative oligonucleotide synthesis |
-
2002
- 2002-03-05 ES ES02004954T patent/ES2253461T3/es not_active Expired - Lifetime
- 2002-03-05 DK DK02004954T patent/DK1342794T3/da active
- 2002-03-05 EP EP02004954A patent/EP1342794B1/de not_active Expired - Lifetime
- 2002-03-05 AT AT02004954T patent/ATE312946T1/de active
- 2002-03-05 DE DE60207979T patent/DE60207979T2/de not_active Expired - Lifetime
-
2003
- 2003-03-05 AU AU2003218691A patent/AU2003218691B2/en not_active Expired
- 2003-03-05 WO PCT/EP2003/002245 patent/WO2003074730A1/en not_active Ceased
- 2003-03-05 CA CA002478493A patent/CA2478493A1/en not_active Abandoned
- 2003-03-05 EP EP03711926A patent/EP1483410A1/de not_active Withdrawn
- 2003-03-05 US US10/506,693 patent/US20050221314A1/en not_active Abandoned
- 2003-03-05 JP JP2003573175A patent/JP4727149B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003218691A1 (en) | 2003-09-16 |
| DK1342794T3 (da) | 2006-04-24 |
| JP4727149B2 (ja) | 2011-07-20 |
| AU2003218691B2 (en) | 2008-06-12 |
| EP1342794A1 (de) | 2003-09-10 |
| DE60207979T2 (de) | 2006-09-28 |
| CA2478493A1 (en) | 2003-09-12 |
| JP2005518809A (ja) | 2005-06-30 |
| US20050221314A1 (en) | 2005-10-06 |
| ES2253461T3 (es) | 2006-06-01 |
| DE60207979D1 (de) | 2006-01-19 |
| WO2003074730A1 (en) | 2003-09-12 |
| EP1342794B1 (de) | 2005-12-14 |
| EP1483410A1 (de) | 2004-12-08 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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