ATE314357T1 - Halb-synthetisches verfahren für die herstellung von n-debenzoylpaclitaxel - Google Patents

Halb-synthetisches verfahren für die herstellung von n-debenzoylpaclitaxel

Info

Publication number: ATE314357T1
Authority: AT; Austria
Prior art keywords: debenzoylpaclitaxel; semi; production; synthetic process; formula
Prior art date: 2002-04-12

Application number

AT03714874T

Other languages

English (en)

Inventor

Ezio Bombardelli

Gabriele Fontana

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-12

Filing date

2003-03-24

Publication date

2006-01-15

2003-03-24 Application filed by Indena Spa filed Critical Indena Spa

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE314357T1 publication Critical patent/ATE314357T1/de

Links

DLACRDONFBNRSP-KWIOUIIFSA-N 3'-N-debenzoyltaxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](N)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 DLACRDONFBNRSP-KWIOUIIFSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
229930012538 Paclitaxel Natural products 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT03714874T 2002-04-12 2003-03-24 Halb-synthetisches verfahren für die herstellung von n-debenzoylpaclitaxel ATE314357T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2002MI000782A ITMI20020782A1 (it)	2002-04-12	2002-04-12	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
PCT/EP2003/003017 WO2003087077A1 (en)	2002-04-12	2003-03-24	A semi-synthetic process for the preparation of n debenzoylpaclitaxel

Publications (1)

Publication Number	Publication Date
ATE314357T1 true ATE314357T1 (de)	2006-01-15

Family

ID=11449694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03714874T ATE314357T1 (de)	2002-04-12	2003-03-24	Halb-synthetisches verfahren für die herstellung von n-debenzoylpaclitaxel

Country Status (17)

Country	Link
US (1)	US7053222B2 (de)
EP (1)	EP1495011B1 (de)
JP (2)	JP5197908B2 (de)
KR (2)	KR20100036394A (de)
CN (1)	CN1310897C (de)
AT (1)	ATE314357T1 (de)
AU (1)	AU2003219094B2 (de)
CA (1)	CA2482131C (de)
DE (1)	DE60303023T2 (de)
DK (1)	DK1495011T3 (de)
ES (1)	ES2254921T3 (de)
IL (2)	IL164486A0 (de)
IT (1)	ITMI20020782A1 (de)
NO (1)	NO328960B1 (de)
PL (1)	PL209650B1 (de)
RU (1)	RU2302415C2 (de)
WO (1)	WO2003087077A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20020782A1 (it) *	2002-04-12	2003-10-13	Indena Spa	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
US7446126B2 (en) *	2004-10-08	2008-11-04	Indena S.P.A.	Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
WO2008074178A1 (fr) *	2006-11-23	2008-06-26	Shanghai Bailing Pharmaceutical Technology Co., Ltd	Nouveau procédé de préparation de paclitaxel semi-synthétique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3031715B2 (ja) *	1993-02-05	2000-04-10	ブリンモーアーカレッジ	様々なａ環側鎖を有するタキソール、類似体及び中間体の合成
NZ332475A (en) *	1996-05-08	2000-05-26	Upjohn Co	silylated baccatin derivatives, 3-(substituted amino)-3-phenyl-(2R,3S)-isoserinate derivatives, the oxazolidine ester thereof and other immediates used to prepare baccatin derivatives
AU3740997A (en) *	1996-08-26	1998-03-19	Bristol-Myers Squibb Company	Sulfenamide taxane derivatives
US5917062A (en) *	1997-11-21	1999-06-29	Indena S.P.A	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
RU2186652C1 (ru) *	2001-08-01	2002-08-10	Землянушнова Надежда Юрьевна	Способ изготовления многожильных витых пружин
ITMI20020782A1 (it) *	2002-04-12	2003-10-13	Indena Spa	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel

2002
- 2002-04-12 IT IT2002MI000782A patent/ITMI20020782A1/it unknown
2003
- 2003-03-24 WO PCT/EP2003/003017 patent/WO2003087077A1/en not_active Ceased
- 2003-03-24 IL IL16448603A patent/IL164486A0/xx active IP Right Grant
- 2003-03-24 DE DE60303023T patent/DE60303023T2/de not_active Expired - Lifetime
- 2003-03-24 CA CA2482131A patent/CA2482131C/en not_active Expired - Lifetime
- 2003-03-24 ES ES03714874T patent/ES2254921T3/es not_active Expired - Lifetime
- 2003-03-24 JP JP2003584033A patent/JP5197908B2/ja not_active Expired - Lifetime
- 2003-03-24 PL PL371673A patent/PL209650B1/pl unknown
- 2003-03-24 KR KR1020107006006A patent/KR20100036394A/ko not_active Ceased
- 2003-03-24 DK DK03714874T patent/DK1495011T3/da active
- 2003-03-24 RU RU2004130316/04A patent/RU2302415C2/ru active
- 2003-03-24 EP EP03714874A patent/EP1495011B1/de not_active Expired - Lifetime
- 2003-03-24 KR KR1020047015090A patent/KR101159837B1/ko not_active Expired - Lifetime
- 2003-03-24 AT AT03714874T patent/ATE314357T1/de active
- 2003-03-24 CN CNB038081881A patent/CN1310897C/zh not_active Expired - Lifetime
- 2003-03-24 AU AU2003219094A patent/AU2003219094B2/en not_active Expired
2004
- 2004-10-11 IL IL164486A patent/IL164486A/en unknown
- 2004-10-11 NO NO20044291A patent/NO328960B1/no not_active IP Right Cessation
- 2004-10-12 US US10/961,044 patent/US7053222B2/en not_active Expired - Lifetime
2010
- 2010-06-16 JP JP2010137314A patent/JP2010265274A/ja active Pending

Also Published As

Publication number	Publication date
RU2302415C2 (ru)	2007-07-10
PL371673A1 (en)	2005-06-27
NO20044291L (no)	2004-10-11
CA2482131C (en)	2012-07-17
KR101159837B1 (ko)	2012-06-25
ES2254921T3 (es)	2006-06-16
RU2004130316A (ru)	2005-06-27
ITMI20020782A1 (it)	2003-10-13
DK1495011T3 (da)	2006-05-15
US7053222B2 (en)	2006-05-30
JP5197908B2 (ja)	2013-05-15
CA2482131A1 (en)	2003-10-23
AU2003219094B2 (en)	2008-06-26
US20050049297A1 (en)	2005-03-03
IL164486A (en)	2008-11-26
ITMI20020782A0 (it)	2002-04-12
EP1495011A1 (de)	2005-01-12
EP1495011B1 (de)	2005-12-28
WO2003087077A1 (en)	2003-10-23
JP2005530729A (ja)	2005-10-13
JP2010265274A (ja)	2010-11-25
KR20040105795A (ko)	2004-12-16
DE60303023D1 (de)	2006-02-02
AU2003219094A1 (en)	2003-10-27
CN1646512A (zh)	2005-07-27
HK1075661A1 (en)	2005-12-23
IL164486A0 (en)	2005-12-18
DE60303023T2 (de)	2006-09-28
KR20100036394A (ko)	2010-04-07
NO328960B1 (no)	2010-06-28
PL209650B1 (pl)	2011-09-30
CN1310897C (zh)	2007-04-18

Legal Events

Date

Code

Title

Description

2006-06-15

UEP

Publication of translation of european patent specification

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