DK1495011T3 - Semisyntetisk fremgangsmåde til fremstilling af N-debenzoylpaclitaxel - Google Patents

Semisyntetisk fremgangsmåde til fremstilling af N-debenzoylpaclitaxel

Info

Publication number: DK1495011T3
Authority: DK; Denmark
Prior art keywords: preparation; semi; synthetic process; paclitaxel; formula
Prior art date: 2002-04-12

Application number

DK03714874T

Other languages

Danish (da)

English (en)

Inventor

Ezio Bombardelli

Gabriele Fontana

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-12

Filing date

2003-03-24

Publication date

2006-05-15

2003-03-24 Application filed by Indena Spa filed Critical Indena Spa

2006-05-15 Application granted granted Critical

2006-05-15 Publication of DK1495011T3 publication Critical patent/DK1495011T3/da

Links

DLACRDONFBNRSP-KWIOUIIFSA-N 3'-N-debenzoyltaxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](N)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 DLACRDONFBNRSP-KWIOUIIFSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
229930012538 Paclitaxel Natural products 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

DK03714874T 2002-04-12 2003-03-24 Semisyntetisk fremgangsmåde til fremstilling af N-debenzoylpaclitaxel DK1495011T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2002MI000782A ITMI20020782A1 (it)	2002-04-12	2002-04-12	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel

Publications (1)

Publication Number	Publication Date
DK1495011T3 true DK1495011T3 (da)	2006-05-15

Family

ID=11449694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03714874T DK1495011T3 (da)	2002-04-12	2003-03-24	Semisyntetisk fremgangsmåde til fremstilling af N-debenzoylpaclitaxel

Country Status (17)

Country	Link
US (1)	US7053222B2 (de)
EP (1)	EP1495011B1 (de)
JP (2)	JP5197908B2 (de)
KR (2)	KR101159837B1 (de)
CN (1)	CN1310897C (de)
AT (1)	ATE314357T1 (de)
AU (1)	AU2003219094B2 (de)
CA (1)	CA2482131C (de)
DE (1)	DE60303023T2 (de)
DK (1)	DK1495011T3 (de)
ES (1)	ES2254921T3 (de)
IL (2)	IL164486A0 (de)
IT (1)	ITMI20020782A1 (de)
NO (1)	NO328960B1 (de)
PL (1)	PL209650B1 (de)
RU (1)	RU2302415C2 (de)
WO (1)	WO2003087077A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20020782A1 (it) *	2002-04-12	2003-10-13	Indena Spa	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
US7446126B2 (en) *	2004-10-08	2008-11-04	Indena S.P.A.	Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
WO2008074178A1 (fr) *	2006-11-23	2008-06-26	Shanghai Bailing Pharmaceutical Technology Co., Ltd	Nouveau procédé de préparation de paclitaxel semi-synthétique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994018186A1 (en) *	1993-02-05	1994-08-18	Bryn Mawr College	Synthesis of taxol, analogs and intermediates with variable a-ring side chains
DE69715417T2 (de) *	1996-05-08	2003-06-05	Pharmacia & Upjohn Co., Kalamazoo	Oxazolidinester
WO1998008833A1 (en) *	1996-08-26	1998-03-05	Bristol-Myers Squibb Company	Sulfenamide taxane derivatives
US5917062A (en) *	1997-11-21	1999-06-29	Indena S.P.A	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
RU2186652C1 (ru) *	2001-08-01	2002-08-10	Землянушнова Надежда Юрьевна	Способ изготовления многожильных витых пружин
ITMI20020782A1 (it) *	2002-04-12	2003-10-13	Indena Spa	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel

2002
- 2002-04-12 IT IT2002MI000782A patent/ITMI20020782A1/it unknown
2003
- 2003-03-24 CN CNB038081881A patent/CN1310897C/zh not_active Expired - Lifetime
- 2003-03-24 DK DK03714874T patent/DK1495011T3/da active
- 2003-03-24 WO PCT/EP2003/003017 patent/WO2003087077A1/en not_active Ceased
- 2003-03-24 DE DE60303023T patent/DE60303023T2/de not_active Expired - Lifetime
- 2003-03-24 JP JP2003584033A patent/JP5197908B2/ja not_active Expired - Lifetime
- 2003-03-24 KR KR1020047015090A patent/KR101159837B1/ko not_active Expired - Lifetime
- 2003-03-24 AT AT03714874T patent/ATE314357T1/de active
- 2003-03-24 RU RU2004130316/04A patent/RU2302415C2/ru active
- 2003-03-24 CA CA2482131A patent/CA2482131C/en not_active Expired - Lifetime
- 2003-03-24 PL PL371673A patent/PL209650B1/pl unknown
- 2003-03-24 KR KR1020107006006A patent/KR20100036394A/ko not_active Ceased
- 2003-03-24 AU AU2003219094A patent/AU2003219094B2/en not_active Expired
- 2003-03-24 EP EP03714874A patent/EP1495011B1/de not_active Expired - Lifetime
- 2003-03-24 IL IL16448603A patent/IL164486A0/xx active IP Right Grant
- 2003-03-24 ES ES03714874T patent/ES2254921T3/es not_active Expired - Lifetime
2004
- 2004-10-11 IL IL164486A patent/IL164486A/en unknown
- 2004-10-11 NO NO20044291A patent/NO328960B1/no not_active IP Right Cessation
- 2004-10-12 US US10/961,044 patent/US7053222B2/en not_active Expired - Lifetime
2010
- 2010-06-16 JP JP2010137314A patent/JP2010265274A/ja active Pending

Also Published As

Publication number	Publication date
IL164486A0 (en)	2005-12-18
AU2003219094B2 (en)	2008-06-26
HK1075661A1 (en)	2005-12-23
CN1646512A (zh)	2005-07-27
NO328960B1 (no)	2010-06-28
PL209650B1 (pl)	2011-09-30
US20050049297A1 (en)	2005-03-03
AU2003219094A1 (en)	2003-10-27
CA2482131C (en)	2012-07-17
EP1495011A1 (de)	2005-01-12
KR20040105795A (ko)	2004-12-16
KR101159837B1 (ko)	2012-06-25
WO2003087077A1 (en)	2003-10-23
ES2254921T3 (es)	2006-06-16
IL164486A (en)	2008-11-26
KR20100036394A (ko)	2010-04-07
US7053222B2 (en)	2006-05-30
JP5197908B2 (ja)	2013-05-15
ITMI20020782A0 (it)	2002-04-12
RU2302415C2 (ru)	2007-07-10
DE60303023D1 (de)	2006-02-02
CN1310897C (zh)	2007-04-18
ITMI20020782A1 (it)	2003-10-13
JP2005530729A (ja)	2005-10-13
DE60303023T2 (de)	2006-09-28
CA2482131A1 (en)	2003-10-23
RU2004130316A (ru)	2005-06-27
PL371673A1 (en)	2005-06-27
EP1495011B1 (de)	2005-12-28
NO20044291L (no)	2004-10-11
ATE314357T1 (de)	2006-01-15
JP2010265274A (ja)	2010-11-25

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