NO329026B1 - Heteroarylderivater, farmasoytiske preparater som omfatter forbindelsene og eventuelt forbindelsene sammen med ett eller flere andre midler, samt anvendelse av forbindelsene eventuelt sammen med andre midler til fremstilling av preparater for behandling av hoste, smerte, angst, astma, depresjon eller alkoholmisbruk - Google Patents

Heteroarylderivater, farmasoytiske preparater som omfatter forbindelsene og eventuelt forbindelsene sammen med ett eller flere andre midler, samt anvendelse av forbindelsene eventuelt sammen med andre midler til fremstilling av preparater for behandling av hoste, smerte, angst, astma, depresjon eller alkoholmisbruk Download PDF

Info

Publication number: NO329026B1
Authority: NO; Norway
Prior art keywords: mmol; compounds; compound according; agents; stir
Prior art date: 2001-11-07

Application number

NO20042294A

Other languages

English (en)

Norwegian (no)

Other versions

NO20042294L (no

Inventor

Deen Tulshian

Ginny D Ho

Fay W Ng

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-07

Filing date

2004-06-04

Publication date

2010-08-02

2004-06-04 Application filed by Schering Corp filed Critical Schering Corp

2004-07-15 Publication of NO20042294L publication Critical patent/NO20042294L/no

2010-08-02 Publication of NO329026B1 publication Critical patent/NO329026B1/no

Links

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125000001072 heteroaryl group Chemical group 0.000 title claims description 12
208000006673 asthma Diseases 0.000 title claims description 11
208000007848 Alcoholism Diseases 0.000 title claims description 6
208000019901 Anxiety disease Diseases 0.000 title claims description 6
208000002193 Pain Diseases 0.000 title claims description 6
206010001584 alcohol abuse Diseases 0.000 title claims description 6
208000025746 alcohol use disease Diseases 0.000 title claims description 6
230000036506 anxiety Effects 0.000 title claims description 6
239000008194 pharmaceutical composition Substances 0.000 title 1
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150000003839 salts Chemical class 0.000 claims description 19
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239000003795 chemical substances by application Substances 0.000 claims description 16
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239000000867 Lipoxygenase Inhibitor Substances 0.000 claims description 7
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
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- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

NO20042294A 2001-11-07 2004-06-04 Heteroarylderivater, farmasoytiske preparater som omfatter forbindelsene og eventuelt forbindelsene sammen med ett eller flere andre midler, samt anvendelse av forbindelsene eventuelt sammen med andre midler til fremstilling av preparater for behandling av hoste, smerte, angst, astma, depresjon eller alkoholmisbruk NO329026B1 (no)

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US33328401P	2001-11-07	2001-11-07
PCT/US2002/035539 WO2003039469A2 (en)	2001-11-07	2002-11-06	Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1

Publications (2)

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NO20042294L NO20042294L (no)	2004-07-15
NO329026B1 true NO329026B1 (no)	2010-08-02

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Country Status (26)

Country	Link
US (1)	US6727254B2 (de)
EP (1)	EP1442036B1 (de)
JP (2)	JP4246066B2 (de)
KR (1)	KR100596261B1 (de)
CN (1)	CN1252068C (de)
AR (1)	AR037211A1 (de)
AT (1)	ATE315566T1 (de)
BR (1)	BR0213907A (de)
CA (1)	CA2465871C (de)
CY (1)	CY1105208T1 (de)
DE (1)	DE60208724T2 (de)
DK (1)	DK1442036T3 (de)
EC (1)	ECSP045096A (de)
ES (1)	ES2256590T3 (de)
HU (1)	HUP0402329A2 (de)
IL (2)	IL161120A0 (de)
MX (1)	MXPA04004276A (de)
MY (1)	MY126268A (de)
NO (1)	NO329026B1 (de)
NZ (1)	NZ532088A (de)
PE (1)	PE20030719A1 (de)
PL (1)	PL370269A1 (de)
RU (1)	RU2327698C2 (de)
TW (1)	TWI317360B (de)
WO (1)	WO2003039469A2 (de)
ZA (1)	ZA200403404B (de)

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US6262066B1 (en) *	1998-07-27	2001-07-17	Schering Corporation	High affinity ligands for nociceptin receptor ORL-1
US20040067950A1 (en) *	1998-07-27	2004-04-08	Schering-Plough Corporation	High affinity ligands for nociceptin receptor ORL-1
US8729107B2 (en) *	2002-12-06	2014-05-20	Purdue Research Foundation	Pyridines for treating injured mammalian nerve tissue
EP1567497B1 (de) *	2002-12-06	2009-09-23	Purdue Research Foundation	Pyridine zur behandlung von verletztemsäugetiernervengewebe
WO2005089761A1 (en) *	2004-03-17	2005-09-29	Pfizer Limited	Combination for treating inflammatory diseases
WO2006031788A2 (en) *	2004-09-15	2006-03-23	Schering-Plough Ltd.	Process for preparing substituted 8-azabicyclo[3.2.1] octan-3-ols
DE102005016460A1 (de) *	2005-04-11	2006-10-19	Grünenthal GmbH	Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
PE20071159A1 (es) *	2005-10-31	2007-11-30	Schering Corp	Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina
DE102006046745A1 (de) *	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
HRP20120841T4 (hr) *	2008-07-21	2015-07-03	Purdue Pharma L.P.	Premošteni piperidinski spojevi substituiranog kinoksalin-tipa i njihova uporaba
GB201004311D0 (en)	2010-03-15	2010-04-28	Proximagen Ltd	New enzyme inhibitor compounds
GB201115853D0 (en)	2011-09-14	2011-10-26	Proximagen Ltd	New enzyme inhibitor compounds
US9724340B2 (en) *	2015-07-31	2017-08-08	Attenua, Inc.	Antitussive compositions and methods
AU2024364388A1 (en) *	2023-10-19	2026-03-19	Purdue Pharma L.P.	Sunobinop for use in method of treating alcohol use disorder

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US5352707A (en)	1992-03-26	1994-10-04	Harbor Branch Oceanographic Institution, Inc.	Method for treating airway congestion
US6262066B1 (en) *	1998-07-27	2001-07-17	Schering Corporation	High affinity ligands for nociceptin receptor ORL-1
TW590268U (en) *	2000-08-08	2004-06-01	Wistron Corp	Heat dissipating device

2002
- 2002-11-05 TW TW091132573A patent/TWI317360B/zh not_active IP Right Cessation
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- 2002-11-06 CN CNB028220226A patent/CN1252068C/zh not_active Expired - Fee Related
- 2002-11-06 EP EP02802860A patent/EP1442036B1/de not_active Expired - Lifetime
- 2002-11-06 BR BR0213907-3A patent/BR0213907A/pt not_active Application Discontinuation
- 2002-11-06 WO PCT/US2002/035539 patent/WO2003039469A2/en not_active Ceased
- 2002-11-06 ES ES02802860T patent/ES2256590T3/es not_active Expired - Lifetime
- 2002-11-06 NZ NZ532088A patent/NZ532088A/en not_active IP Right Cessation
- 2002-11-06 AT AT02802860T patent/ATE315566T1/de active
- 2002-11-06 RU RU2004117542/04A patent/RU2327698C2/ru not_active IP Right Cessation
- 2002-11-06 JP JP2003541761A patent/JP4246066B2/ja not_active Expired - Fee Related
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- 2004-05-05 ZA ZA200403404A patent/ZA200403404B/en unknown
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2006
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Also Published As

Publication number	Publication date
ECSP045096A (es)	2004-06-28
TWI317360B (en)	2009-11-21
ES2256590T3 (es)	2006-07-16
KR20050043725A (ko)	2005-05-11
RU2327698C2 (ru)	2008-06-27
EP1442036A2 (de)	2004-08-04
WO2003039469A3 (en)	2003-10-16
RU2004117542A (ru)	2006-01-10
IL161120A (en)	2010-11-30
TW200301765A (en)	2003-07-16
DE60208724T2 (de)	2006-11-02
US6727254B2 (en)	2004-04-27
PL370269A1 (en)	2005-05-16
EP1442036B1 (de)	2006-01-11
ZA200403404B (en)	2005-08-15
CY1105208T1 (el)	2010-03-03
HK1063019A1 (en)	2004-12-10
KR100596261B1 (ko)	2006-06-30
MY126268A (en)	2006-09-29
WO2003039469A2 (en)	2003-05-15
MXPA04004276A (es)	2004-08-11
BR0213907A (pt)	2004-09-28
US20030119847A1 (en)	2003-06-26
JP2009035556A (ja)	2009-02-19
JP4246066B2 (ja)	2009-04-02
HUP0402329A2 (hu)	2005-02-28
ATE315566T1 (de)	2006-02-15
CA2465871C (en)	2009-01-20
IL161120A0 (en)	2004-08-31
PE20030719A1 (es)	2003-08-28
CN1252068C (zh)	2006-04-19
DE60208724D1 (de)	2006-04-06
JP2005508367A (ja)	2005-03-31
AR037211A1 (es)	2004-10-27
CN1582288A (zh)	2005-02-16
NZ532088A (en)	2006-05-26
CA2465871A1 (en)	2003-05-15
NO20042294L (no)	2004-07-15
DK1442036T3 (da)	2006-05-15

Legal Events

Date	Code	Title	Description
2012-06-25	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
AU768607B2 (en)	2003-12-18	High affinity ligands for nociceptin receptor ORL-1
JP2009035556A (ja)	2009-02-19	ノシセプチンレセプタｏｒｌ−１用の優れたリガンドとしてのヘテロアリール誘導体
NL1026959C2 (nl)	2006-01-23	Benzimidazolonverbindingen met 5-HT4 receptor agonistische werking.
US7910603B2 (en)	2011-03-22	3-monosubstituted tropane derivatives as nociceptin receptor ligands
CA2379398A1 (en)	2001-02-01	Nociceptin receptor orl-1 agonists for use in treating cough
ES2259106T3 (es)	2006-09-16	Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1.
AU2002363330B2 (en)	2006-03-23	Heteroaryl derivatives as superior ligands for nociceptin receptor ORL-1
AU2002363330A1 (en)	2003-07-24	Heteroaryl derivatives as superior ligands for nociceptin receptor ORL-1
HK1063019B (en)	2006-03-31	Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1