ATE316524T1 - Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität - Google Patents

Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität

Info

Publication number: ATE316524T1
Authority: AT; Austria
Prior art keywords: substituted; unsubstituted; oxy; derivatives; amino
Prior art date: 2000-02-16

Application number

AT01905903T

Other languages

English (en)

Inventor

Tatsuo Higa

Junichi Tanaka

Gravalos Dolores Garcia

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-16

Filing date

2001-02-16

Publication date

2006-02-15

2000-02-16 Priority claimed from GB0003629A external-priority patent/GB0003629D0/en

2000-09-05 Priority claimed from GB0021774A external-priority patent/GB0021774D0/en

2001-02-16 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE316524T1 publication Critical patent/ATE316524T1/de

Links

-1 AMINO-SUBSTITUTED TETRAHYDROFURYL Chemical class 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000304 alkynyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 3
229920006395 saturated elastomer Polymers 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT01905903T 2000-02-16 2001-02-16 Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität ATE316524T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0003629A GB0003629D0 (en)	2000-02-16	2000-02-16	Antitumour agent
GB0021774A GB0021774D0 (en)	2000-09-05	2000-09-05	Anti-tumour compound

Publications (1)

Publication Number	Publication Date
ATE316524T1 true ATE316524T1 (de)	2006-02-15

Family

ID=26243662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01905903T ATE316524T1 (de)	2000-02-16	2001-02-16	Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität

Country Status (17)

Country	Link
US (1)	US6864283B2 (de)
EP (1)	EP1255746B1 (de)
JP (1)	JP2003523338A (de)
KR (1)	KR20020092958A (de)
CN (1)	CN1318409C (de)
AT (1)	ATE316524T1 (de)
AU (2)	AU2001233873B2 (de)
BR (1)	BR0108448A (de)
CA (1)	CA2400612C (de)
CZ (1)	CZ20022791A3 (de)
DE (1)	DE60116855T2 (de)
ES (1)	ES2256199T3 (de)
IL (1)	IL151241A (de)
MX (1)	MXPA02007995A (de)
PL (1)	PL357193A1 (de)
RU (1)	RU2002124591A (de)
WO (1)	WO2001060810A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA02007995A (es)	2000-02-16	2003-05-23	Ruffles Graham Keith	Derivados de tetrahidrofurilo sustituidos por oxy y amino con actividad antitumoral.
CN102229585A (zh) *	2011-04-26	2011-11-02	中国人民解放军第二军医大学	具有抗肿瘤活性的γ-丁内酯聚酮类化合物
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2007507C (en) *	1989-02-03	1998-05-19	Yasuyuki Igarashi	Sphingosine and n-methyl-sphingosine as inhibitor of cell growth
US5583160A (en) *	1989-02-03	1996-12-10	The Biomembrane Institute	Methylsphingosine used to treat apoptosis
US6107520A (en) *	1997-04-15	2000-08-22	The Board Of Trustees Of The University Of Illinois	Spisulosine compounds
MXPA02007995A (es)	2000-02-16	2003-05-23	Ruffles Graham Keith	Derivados de tetrahidrofurilo sustituidos por oxy y amino con actividad antitumoral.

2001
- 2001-02-16 MX MXPA02007995A patent/MXPA02007995A/es active IP Right Grant
- 2001-02-16 BR BR0108448-8A patent/BR0108448A/pt not_active IP Right Cessation
- 2001-02-16 CN CNB018080421A patent/CN1318409C/zh not_active Expired - Fee Related
- 2001-02-16 KR KR1020027010697A patent/KR20020092958A/ko not_active Ceased
- 2001-02-16 RU RU2002124591/04A patent/RU2002124591A/ru not_active Application Discontinuation
- 2001-02-16 ES ES01905903T patent/ES2256199T3/es not_active Expired - Lifetime
- 2001-02-16 PL PL01357193A patent/PL357193A1/xx not_active Application Discontinuation
- 2001-02-16 EP EP01905903A patent/EP1255746B1/de not_active Expired - Lifetime
- 2001-02-16 AT AT01905903T patent/ATE316524T1/de not_active IP Right Cessation
- 2001-02-16 JP JP2001560195A patent/JP2003523338A/ja active Pending
- 2001-02-16 CA CA2400612A patent/CA2400612C/en not_active Expired - Fee Related
- 2001-02-16 US US10/203,918 patent/US6864283B2/en not_active Expired - Fee Related
- 2001-02-16 DE DE60116855T patent/DE60116855T2/de not_active Expired - Lifetime
- 2001-02-16 CZ CZ20022791A patent/CZ20022791A3/cs unknown
- 2001-02-16 AU AU2001233873A patent/AU2001233873B2/en not_active Ceased
- 2001-02-16 AU AU3387301A patent/AU3387301A/xx active Pending
- 2001-02-16 WO PCT/GB2001/000655 patent/WO2001060810A1/en not_active Ceased
2002
- 2002-08-13 IL IL151241A patent/IL151241A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2001060810A1 (en)	2001-08-23
AU2001233873B2 (en)	2006-03-02
DE60116855D1 (de)	2006-04-13
BR0108448A (pt)	2003-04-01
CZ20022791A3 (cs)	2003-02-12
US20030092738A1 (en)	2003-05-15
EP1255746A1 (de)	2002-11-13
CN1318409C (zh)	2007-05-30
ES2256199T3 (es)	2006-07-16
RU2002124591A (ru)	2004-01-10
CA2400612C (en)	2010-05-11
CN1423642A (zh)	2003-06-11
WO2001060810B1 (en)	2001-11-29
JP2003523338A (ja)	2003-08-05
DE60116855T2 (de)	2006-09-14
US6864283B2 (en)	2005-03-08
AU3387301A (en)	2001-08-27
MXPA02007995A (es)	2003-05-23
CA2400612A1 (en)	2001-08-23
EP1255746B1 (de)	2006-01-25
KR20020092958A (ko)	2002-12-12
IL151241A (en)	2006-10-31
PL357193A1 (en)	2004-07-26

Legal Events

Date	Code	Title	Description
2006-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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