ATE317262T1 - Verwendung von tetracyclinderivaten zur steigerung der interleukin-10 produktion - Google Patents
Verwendung von tetracyclinderivaten zur steigerung der interleukin-10 produktionInfo
- Publication number
- ATE317262T1 ATE317262T1 AT99948198T AT99948198T ATE317262T1 AT E317262 T1 ATE317262 T1 AT E317262T1 AT 99948198 T AT99948198 T AT 99948198T AT 99948198 T AT99948198 T AT 99948198T AT E317262 T1 ATE317262 T1 AT E317262T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- interleukin
- tetracycline
- effective amount
- administering
- Prior art date
Links
- 230000031261 interleukin-10 production Effects 0.000 title abstract 3
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical class C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 title 1
- 239000004098 Tetracycline Substances 0.000 abstract 4
- 229960002180 tetracycline Drugs 0.000 abstract 4
- 229930101283 tetracycline Natural products 0.000 abstract 4
- 235000019364 tetracycline Nutrition 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- -1 tetracycline compounds Chemical class 0.000 abstract 2
- 150000003522 tetracyclines Chemical class 0.000 abstract 2
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000019171 interleukin-1 alpha production Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000006433 tumor necrosis factor production Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/151,534 US6015804A (en) | 1998-09-11 | 1998-09-11 | Method of using tetracycline compounds to enhance interleukin-10 production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317262T1 true ATE317262T1 (de) | 2006-02-15 |
Family
ID=22539191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99948198T ATE317262T1 (de) | 1998-09-11 | 1999-09-10 | Verwendung von tetracyclinderivaten zur steigerung der interleukin-10 produktion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6015804A (de) |
| EP (1) | EP1119362B1 (de) |
| JP (3) | JP2002524521A (de) |
| KR (1) | KR100691654B1 (de) |
| AT (1) | ATE317262T1 (de) |
| AU (1) | AU754515B2 (de) |
| CA (1) | CA2339667C (de) |
| CY (1) | CY1107495T1 (de) |
| DE (1) | DE69929810T2 (de) |
| DK (1) | DK1119362T3 (de) |
| ES (1) | ES2258854T3 (de) |
| NZ (1) | NZ509799A (de) |
| PT (1) | PT1119362E (de) |
| WO (1) | WO2000015235A1 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6429204B1 (en) * | 1997-01-15 | 2002-08-06 | University Of Miami | Method of inhibiting cancer growth |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US6673843B2 (en) * | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| EP2311440A1 (de) * | 2001-04-05 | 2011-04-20 | Collagenex Pharmaceuticals, Inc. | Gesteuerte Freigabe von Tetracyclinverbindungen und Tetracyclinderivaten |
| US7211267B2 (en) | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
| ATE330615T1 (de) * | 2001-04-05 | 2006-07-15 | Collagenex Pharm Inc | Doxycyclin zur behandlung von akne |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2332547A1 (de) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclinverbindungen zur Behandlung von entzündlicher Darmerkrankung |
| US20110092677A1 (en) * | 2001-08-30 | 2011-04-21 | Biorexis Technology, Inc. | Modified transferin-antibody fusion proteins |
| EP2995610A1 (de) | 2002-01-08 | 2016-03-16 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino-tetracyclin-verbindungen |
| EA201000491A1 (ru) | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| CA2478522A1 (en) * | 2002-03-08 | 2003-09-18 | Emory University | Novel curcuminoid-factor viia constructs as suppressors of tumor growth and angiogenesis |
| CN101712632A (zh) | 2002-03-21 | 2010-05-26 | 帕拉特克药品公司 | 取代的四环素化合物 |
| AU2003226112B9 (en) * | 2002-03-29 | 2008-06-05 | The Research Foundation Of State University Of New York | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
| US6958161B2 (en) | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
| US8192749B2 (en) | 2003-04-16 | 2012-06-05 | Galderma Laboratories Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
| US20050153943A1 (en) * | 2002-05-06 | 2005-07-14 | Ashley Robert A. | Methods of simultaneously treating mucositis and fungal infection |
| CA2492273C (en) | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| CA2894736C (en) * | 2003-04-07 | 2019-07-16 | Supernus Pharmaceuticals, Inc. | Once daily formulations of tetracyclines |
| EP1656341A1 (de) | 2003-07-09 | 2006-05-17 | Paratek Pharmaceuticals, Inc. | Prodrugs von 9-aminomethyltetracyclinverbindungen |
| EP2298323A3 (de) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
| EP1684768A4 (de) * | 2003-11-06 | 2007-06-06 | Univ New York State Res Found | Verfahren zur behandlung von ekzem |
| JP5010284B2 (ja) * | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族a環誘導体 |
| EP2295419A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclinverbindungen |
| EP2301912A3 (de) | 2004-10-25 | 2012-07-11 | Paratek Pharmaceuticals, Inc. | 4-Aminotetracycline und Verfahren zu ihrer Verwendung |
| AU2006247249A1 (en) * | 2005-05-16 | 2006-11-23 | Children's Medical Center Corporation | Method of treating Lymphangioleiomyomatosis (LAM) |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
| US8252776B2 (en) * | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| RU2008121238A (ru) * | 2005-12-22 | 2010-01-27 | Вайет (Us) | Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина |
| KR20080080205A (ko) * | 2005-12-22 | 2008-09-02 | 와이어쓰 | 티게사이클린을 포함하는 경구 제형 |
| PT2120963T (pt) | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| EP2452935A3 (de) | 2006-12-21 | 2012-08-29 | Paratek Pharmaceuticals, Inc. | Tetracyxlin-Derivate zur Behandlung bakterieller, viraler und parasitärer Infektionen |
| EP2213655A1 (de) | 2007-04-27 | 2010-08-04 | Paratek Pharmaceuticals, Inc. | Verfahren zur Reinigung von Aminoalkyl-Tetracyclinverbindungen |
| PT2176216E (pt) * | 2007-07-06 | 2012-07-27 | Paratek Pharm Innc | Métodos de síntese de minociclina substituída na posição 9 |
| TWI585071B (zh) | 2008-05-19 | 2017-06-01 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| HUE026562T2 (hu) | 2008-08-08 | 2016-06-28 | Tetraphase Pharmaceuticals Inc | C7-fluor-helyettesített tetraciklin vegyületek |
| CN107021887A (zh) | 2009-05-08 | 2017-08-08 | 四相制药公司 | 四环素类化合物 |
| ES2654987T3 (es) | 2009-08-28 | 2018-02-15 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
| WO2011123536A1 (en) | 2010-03-31 | 2011-10-06 | Tetraphase Pharmaceuticals, Inc. | Polycyclic tetracycline compounds |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| SG11201501516YA (en) | 2012-08-31 | 2015-07-30 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds |
| US20190002188A1 (en) * | 2015-06-30 | 2019-01-03 | Philip Morris Products S.A. | Container with improved opening |
| CN110582486B (zh) | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
| WO2020097450A1 (en) | 2018-11-09 | 2020-05-14 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
| CN118045037A (zh) * | 2022-11-17 | 2024-05-17 | 中南大学湘雅二医院 | 一种地美环素盐滴眼液或注射液及其制备方法以及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| US5368854A (en) * | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
| DK0599397T3 (da) * | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
| US5665345A (en) * | 1993-05-24 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of inhibiting viral replication using IL-10 |
| US5726156A (en) * | 1995-03-06 | 1998-03-10 | Trega Biosciences, Inc. | Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| US5650396A (en) * | 1994-03-15 | 1997-07-22 | Celtrix Pharmaceuticals, Inc. | Methods of modulating inflammatory cytokines in the CNS using TGF-β |
| EP0736302A3 (de) * | 1995-03-23 | 1997-06-04 | Stichting Rega V Z W | Proteaseinhibitoren, eine DNA-Konstruktion zur Expression einer Protease und ein Verfahren zur Messung der Protease und/oder Proteaseinhibitoren |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| JP2908375B2 (ja) * | 1997-04-01 | 1999-06-21 | ザ リサーチ ファンデーション オブ ステート ユニバーシティ オブ ニューヨーク | 非抗バクテリア性テトラサイクリン組成物 |
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1998
- 1998-09-11 US US09/151,534 patent/US6015804A/en not_active Expired - Lifetime
-
1999
- 1999-09-10 CA CA2339667A patent/CA2339667C/en not_active Expired - Fee Related
- 1999-09-10 WO PCT/US1999/020972 patent/WO2000015235A1/en not_active Ceased
- 1999-09-10 KR KR1020017002727A patent/KR100691654B1/ko not_active Expired - Fee Related
- 1999-09-10 DK DK99948198T patent/DK1119362T3/da active
- 1999-09-10 NZ NZ509799A patent/NZ509799A/en not_active IP Right Cessation
- 1999-09-10 DE DE69929810T patent/DE69929810T2/de not_active Expired - Lifetime
- 1999-09-10 EP EP99948198A patent/EP1119362B1/de not_active Expired - Lifetime
- 1999-09-10 AT AT99948198T patent/ATE317262T1/de active
- 1999-09-10 AU AU61426/99A patent/AU754515B2/en not_active Ceased
- 1999-09-10 PT PT99948198T patent/PT1119362E/pt unknown
- 1999-09-10 JP JP2000569819A patent/JP2002524521A/ja active Pending
- 1999-09-10 ES ES99948198T patent/ES2258854T3/es not_active Expired - Lifetime
-
2006
- 2006-04-07 CY CY20061100490T patent/CY1107495T1/el unknown
-
2009
- 2009-12-07 JP JP2009277751A patent/JP4929341B2/ja not_active Expired - Fee Related
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2011
- 2011-05-06 JP JP2011103656A patent/JP2011148838A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69929810T2 (de) | 2006-11-02 |
| CA2339667A1 (en) | 2000-03-23 |
| US6015804A (en) | 2000-01-18 |
| EP1119362A1 (de) | 2001-08-01 |
| ES2258854T3 (es) | 2006-09-01 |
| KR100691654B1 (ko) | 2007-03-09 |
| CY1107495T1 (el) | 2013-03-13 |
| JP2010053146A (ja) | 2010-03-11 |
| WO2000015235A1 (en) | 2000-03-23 |
| JP2002524521A (ja) | 2002-08-06 |
| EP1119362B1 (de) | 2006-02-08 |
| PT1119362E (pt) | 2006-06-30 |
| CA2339667C (en) | 2010-05-18 |
| KR20010074919A (ko) | 2001-08-09 |
| JP4929341B2 (ja) | 2012-05-09 |
| DE69929810D1 (de) | 2006-04-20 |
| AU754515B2 (en) | 2002-11-21 |
| JP2011148838A (ja) | 2011-08-04 |
| DK1119362T3 (da) | 2006-06-12 |
| EP1119362A4 (de) | 2003-03-12 |
| NZ509799A (en) | 2003-08-29 |
| AU6142699A (en) | 2000-04-03 |
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